Mucosa-associated invariant T (MAIT) cells are an evolutionarily conserved unconventional T cell subset that responds to riboflavin pathway-derived antigens from a range of microbes. Here, we found th...

Abstract. Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that recognizes bacterial-derived antigens presented o

Obesity leaves a lasting epigenetic imprint on adaptive immunity. A recent work by Niven et al. demonstrates that obesity-associated DNA methylation in CD4+ T lymphocytes persists after weight loss, sustaining inflammatory memory and delaying immune recovery. These findings suggest that treatment of obesity may require the restoration of immune homeostasis.

Nutrients are important environmental factors that affect the functional responses of MAIT cells to challenge.

Nutrients are important environmental factors that affect the functional responses of MAIT cells to challenge.

Abstract. Mucosal-associated invariant T (MAIT) cells are unconventional T cells, which upon activation can display potent cytotoxic and cytokine-producing

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Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…

This multicenter randomized clinical trial assesses the effect of once-weekly administration of the glucagon-like peptide-1 receptor agonist semaglutide in adults treated with second-generation antips...

Dysregulation of bodyweight systemic metabolism is intrinsically linked to an inflammatory phenotype, with each underpinning the other. Over the past decade, new classes of drug, such as glucagon-like...

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

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AbstractIntroduction. Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of

Lactate shows immunomodulatory properties. Mauro et al. review how lactate serves a fuel for the TCA cycle and an immunomodulatory molecule with context-dependent effects, and how its immunomodulatory properties are mediated via sensing through…

This cohort study compares the risks of developing different hematologic cancers in patients with type 2 diabetes treated with glucagon-like peptide–1 receptor agonists (GLP-1RAs) compared with metfor...

Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...

AbstractIntroduction. Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Medical experts have warned of significant health risks to members of the public after it emerged that an experimental weight loss medication, which has no regulatory approval worldwide, is being sold...

Combining rabies-based connectomics with single-nucleus transcriptomics, the authors identify a neural circuit through which GLP-1 receptor agonists suppress appetite in mice.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...