Abstract. Mitotic fidelity requires proper chromosome alignment at the spindle equator, a process known as chromosome congression, mediated by well-establi

LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...

PhD Project - Evolutionary dynamics of transposable elements in the genome ecosystem of eukaryotes at University of Sussex, listed on FindAPhD.com

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We're excited to announce that we're looking for a postdoctoral research to join our team!

Wnt/β-catenin signalling is dysregulated across several haematological malignancies, including acute myeloid leukaemia (AML), where is lacks effective targeting strategies. Previously, we discovered that β-catenin interacts with several RNA-binding proteins (RBP), and binds mRNA indirectly, indicating contributions to the post-transcriptional landscape of leukaemia cells. Here, we found the most frequent RBP-binding motif amongst β-catenin-bound mRNAs was the GGAG motif targeted by the oncofoetal expressed miRNA-regulating RBP LIN28B. We detected the β-catenin:LIN28B interaction in lymphoid and myeloid cell lines, and primary human CD34⁺ fetal liver-derived haematopoietic stem cells. LIN28B positively regulated Wnt signalling capacity by regulating LEF1 expression through a post-transcriptional mechanism requiring the let7 miRNA axis. Further miRNA sequencing of β-catenin- and LIN28B-depleted myeloid cells revealed both potential cooperative and antagonistic function in miRNA regulation. Finally, dual-targeting both β-catenin and LIN28B through either genetic or pharmacological means preferentially killed AML cells. These data reveal a potential novel synthetically lethal relationship in AML which could be exploited in the rare AML subsets where LIN28B expression becomes reactivated ### Competing Interest Statement The authors have declared no competing interest. Kay Kendall Leukaemia Fund, https://ror.org/03j2wfg84, KKL1051, KKL1446 Leukaemia & Myeloma Research UK, 4-5/06.21R Children’s Cancer & Leukaemia Group, CCLGA 2023 16 Morgan Republic of Türkiye Ministry of National Education

18 fully funded studentships for October 2026 start: interdisciplinary infection bioscience training to address disease threats to human and animal health.

This year’s Clarivate Highly Cited Researchers list included four Sussex academics plus one from the Institute of Development Studies

Abstract. Crossover formation during meiosis generates genetic diversity. In many species most crossovers display interference, meaning they are spaced mor

Researchers at the Living Systems Institute (LSI), University of Exeter, have been awarded a £3.5 million Wellcome Discovery Award to investigate how cells exchange information to coordinate the forma...

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Announcing the launch of the Lab Heroes Awards™ 2025! Now in its ninth year, our annual awards recognize the mentors, innovators, and team players whose perseverance and passion are inspirational - no...

RNA biology, RNA polymerase II, Exosome, Lidia Vasilieva, VasilievaLab

Kindling Bio have teamed up with the University of Sussex to deliver their exciting proof-of-concept data.

PhD Project - (MRC DTP) Corrupting the roots: How leukaemia reshapes its ancestors at The University of Manchester, listed on FindAPhD.com