Abstract. Estrogen receptor-positive breast cancer (ER + BC) is one of the most prevalent cancers, but the evolutionary processes shaping genetic variation

Abstract. Saliva forms the first biochemical interface with the environment, mediating dietary exposure and oral defense. Proline-rich proteins in saliva p

Abstract. Homologous recombination is ubiquitous across evolution, generating variation through genetic reshuffling. Although bacteria lack meiotic recombi

How do bacteria adapt when resources run low? ISTA researchers have found that, under starvation stress, E. coli can use bacteriophages and CRISPR-Cas immunity to transfer and incorporate DNA, acceler...

Abstract. Amino acid-based phylogenetics usually relies on first clustering and aligning orthologous proteins. This approach is powerful but computationall

Abstract. The rhesus macaque (Macaca mulatta) is one of the most widely used animal models in biomedical research, both as it resembles humans in key biolo

Abstract. Dynamic patterns of gene gain and loss play a major role in the diversification of eukaryotes, reflecting adaptation to a broad range of ecologic

Abstract. During the European Neolithic, migrating Anatolian farmers admixed with local hunter-gatherers, coinciding with major shifts in diet, environment

Many conservation studies focus on counting individuals or tracking changes in species distributions to infer change. What does looking directly at genomic changes reveal about population dynamics tha...

Abstract. The fossil record is incomplete, as evidenced by the pervasive presence of ghost lineages throughout the Tree of Life. For example, across placen

Abstract. Global insect pollinator populations are under threat, with reported declines attributed to increasing habitat loss, pesticide use, and disease.

Abstract. Mitochondrial function depends on tight coordination between mitochondrial and nuclear genomes, which requires long-term coevolution to maintain

Abstract. Natural host populations are age-structured, and developmental stages differ in susceptibility and within-host pathogen dynamics, potentially imp

Taking a car trip through the countryside is an experience starkly different from what it was a few decades ago: for one, windshields are increasingly devo

Abstract. Natural host populations are age-structured, and developmental stages differ in susceptibility and within-host pathogen dynamics, potentially imp

Abstract. Although strict maternal transmission of mitochondria is a general feature of animals for ensuring homogeneity in mitochondrial DNA (mtDNA) acros

Abstract. Pleiotropy, the phenomenon where a single mutation influences multiple phenotypic traits, creates genetic correlations that can constrain evoluti

Abstract. Pleiotropy, the phenomenon where a single mutation influences multiple phenotypic traits, creates genetic correlations that can constrain evoluti

Abstract. Understanding how species adapt to new environments is a central goal in evolutionary biology, and a topical question in climate change research.

Abstract. The vast majority of plants form mycorrhizal symbioses. The ecological importance of these mutualistic interactions has sparked interest in their

Abstract. Transcriptional adaptation (TA) is a regulatory process in which loss or disruption of gene function caused by protein-truncating variants (PTVs)

Abstract. The distribution of fitness effects (DFE)—describing how harmful, neutral, or beneficial new mutations are—is central to understanding how popula