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SFElena laboratory at I2SysBio - EvolSysVir

@sfelenalab.bsky.social
282 followers 297 following 7 posts

Virus evolution, virus ecology and epidemiology, host-virus interactions, systems biology, mathematical modeling, complex systems. Arabidposis thaliana/potyvirus and Caenorhabditis elegans/Orsay virus

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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
PLOS Biology @plosbiology.org · 21/08/2026
Why do most cross-species #virus jumps fail? @sfelenalab.bsky.social &co use Orsay virus across multiple Caenorhabditis species to reveal how mismatches in replication, genome balance and transmission create layered barriers to #spillover @plosbiology.org 🧪 plos.io/4gCVoxg
Top: Barrier-resolved framework for OrV host competence across Caenorhabditis species. Conceptual summary of the seven barriers evaluated in this study and the expected empirical signature if each barrier limits OrV host competence. The framework distinguishes early susceptibility/establishment, within-host replication kinetics, RNA2:RNA1 genome-segment balance, luminal localization consistent with egress or viral material accumulation, functional transmission, virulence, and evolutionary persistence under serial passage. Bottom: Representative smiFISH images of OrV infection in alternative host species, showing C. elegans and the alternative host species at 24 hours post-inoculation (hpi).
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
PLOS Biology @plosbiology.org · 20/08/2026
Why do most cross-species #virus jumps fail? @sfelenalab.bsky.social &co use Orsay virus across multiple Caenorhabditis species to reveal how mismatches in replication, genome balance and transmission create layered barriers to #spillover @plosbiology.org 🧪 plos.io/4gCVoxg
Top: Barrier-resolved framework for OrV host competence across Caenorhabditis species. Conceptual summary of the seven barriers evaluated in this study and the expected empirical signature if each barrier limits OrV host competence. The framework distinguishes early susceptibility/establishment, within-host replication kinetics, RNA2:RNA1 genome-segment balance, luminal localization consistent with egress or viral material accumulation, functional transmission, virulence, and evolutionary persistence under serial passage. Bottom: Representative smiFISH images of OrV infection in alternative host species, showing C. elegans and the alternative host species at 24 hours post-inoculation (hpi).
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
PLOS Biology @plosbiology.org · 20/03/2026
What concrete steps can we take to reinforce #biorisk management? In this Perspective, an international group of experts advocate for better global standards for #pathogen research. 🧪 #MicroSky #DURC plos.io/3NN7451
No matter where they are performed, studies with infectious agents need ironclad biorisk management. This can be promoted through robust gatekeeping of funding and publication, using a new formal reporting standard for pathogen research.
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SFElena laboratory at I2SysBio - EvolSysVir @sfelenalab.bsky.social · 20/03/2026
Santiago Elena elected fellow of the European Academy of Microbiology!!! fems-microbiology.org/european-aca...
fems-microbiology.org
Fellows
The European Academy of Microbiology (EAM) proudly brings together a distinguished community of leading scientists whose contributions have shaped and advanced the field of microbiology. Below, you wi...
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Santa Fe Institute @sfiscience.bsky.social · 17/02/2026
SFI’s Santiago Elena has been elected a fellow of the American Academy of Microbiology. He joins 62 fellows in the 2026 class. His work explores how RNA viruses adapt to hosts and manipulate cellular resources. Since joining SFI in 2008, he has organized several working groups on virus evolution.
santafe.edu
SFI External Professor Santiago Elena elected to the American Academy of Microbiology
SFI External Professor Santiago Elena has been elected as a fellow of the American Academy of Microbiology, joining 62 other fellows in the class of 2026, each selected for their contributions in the ...
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SFElena laboratory at I2SysBio - EvolSysVir @sfelenalab.bsky.social · 13/02/2026
Congratulations to Santiago F. Elena on being elected as a Fellow of the American Academy of Microbiology! This prestigious honor recognizes their outstanding contributions to advancing microbiology. Learn more about the 2026 Fellowship Class: asm.org/press-releas...
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SFElena laboratory at I2SysBio - EvolSysVir @sfelenalab.bsky.social · 19/12/2025
Izan Melero defends his thesis on how host developmental stage shapes viral evolution www.i2sysbio.es/communicatio...
i2sysbio.es
Izan Melero defends his thesis on how host developmental stage shapes viral evolution
<p><strong>This thesis, supervised by Santiago F. Elena and Rub&eacute;n Gonz&aacute;lez, explores the relationships between host developmental stages and virus infection and evolution on different ho...
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SFElena laboratory at I2SysBio - EvolSysVir @sfelenalab.bsky.social · 11/12/2025
Look at our newest publication on the cross-talking between viral infection and larval development! www.cell.com/iscience/ful...
cell.com
The interplay between Caenorhabditis elegans larval development and Orsay virus infection
Immunology; virology; developmental biology
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
EVOMG-Doctoral Network @evomg-dn.bsky.social · 25/09/2025
🚀 Exciting news: the Evolutionary Medical Genomics Doctoral Network (EVOMG-DN) launches soon! 🔍 15 fully funded PhD positions: ready to shape the future of genomic medicine? Stay tuned for details! #PhD #EvolutionaryBiology #MSCA #PhDPositions
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
EvoMG Program @evomg-bcn.bsky.social · 12/10/2025
And the last speaker of the first session was Santiago F. Elena ( @sfelena.bsky.social ), from CSIC I2SysBio, talking about viral evolution from a system biology perspective.
Santiago F. Elena	CSIC, I2SysBio
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Brian Wasik @brianrwasik.bsky.social · 05/09/2025
Current Ebola outbreak in DRC is a new spillover event. virological.org/t/the-16th-e...
Maximum likelihood tree of sequence alignment of 71 complete EBOV genomes, including new ones generated from current outbreak. Figure 1.
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
SFElena laboratory at I2SysBio - EvolSysVir @sfelenalab.bsky.social · 04/08/2025
Check the latest publication from our group! rdcu.be/ey1Fj @i2sysbio.es @csic.es
rdcu.be
Latent infection of Caenorhabditis elegans by Orsay virus induces age-dependent immunity and cross-protection
Nature Communications - Orsay virus establishes a latent infection in C. elegans, triggering age-dependent immunity and RNAi based cross-protection that limits secondary infections and reveals...
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SFElena laboratory at I2SysBio - EvolSysVir @sfelenalab.bsky.social · 04/09/2025
More than 70 people attend the 2nd Public-Private Collaboration Workshop organised by I2SysBio www.i2sysbio.es/communicatio...
i2sysbio.es
More than 70 people attend the 2nd Public-Private Collaboration Workshop organised by I2SysBio
<p><strong>The Institute of Integrative Systems Biology (I2SysBio), a joint centre of the CSIC and the University of Valencia, held its Second Public-Private Collaboration Workshop under the title &#3...
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SFElena laboratory at I2SysBio - EvolSysVir @sfelenalab.bsky.social · 04/08/2025
Check the latest publication from our group! rdcu.be/ey1Fj @i2sysbio.es @csic.es
rdcu.be
Latent infection of Caenorhabditis elegans by Orsay virus induces age-dependent immunity and cross-protection
Nature Communications - Orsay virus establishes a latent infection in C. elegans, triggering age-dependent immunity and RNAi based cross-protection that limits secondary infections and reveals...
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Ayoub Maachi @amaachi.bsky.social · 19/07/2025
Pleased to share our recent study, exploring viral small RNAs in four monocot plant species, shedding light on virus–host interactions and characterizing the RNA silencing response triggered by viral infection. link.springer.com/article/10.1... #PlantVirology #RNASilencing #VirusHostInteractions
link.springer.com
Detection of viruses/viroid and characterization of their derived small RNAs in four monocotyledonous plants - Tropical Plant Pathology
RNA interference based antiviral defense generates small interfering RNAs.To gain insight into this mechanism during viral infections, we analyzed public small RNA sequencing (sRNA-seq) data and chara...
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SFElena laboratory at I2SysBio - EvolSysVir @sfelenalab.bsky.social · 12/04/2025
youtube.com/watch?v=TtvL...
youtube.com
Landscape and Flux Theory for Nonequilibrium Biological Systems
YouTube video by Santa Fe Institute
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Susana Wadgymar🌿🔬 @smwadgymar.bsky.social · 26/02/2025
🎉microPublications EEB is looking for new editors! -Editorial load is extremely light (but we work quickly) -Awesome format and journal, serves the EEB community well IMO -We cover all of EEB so we're looking for breath/generalists/complimentary expertise -DM me if interested (or suggest someone)!
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Nature Portfolio @natureportfolio.nature.com · 24/02/2025
At present, 1 in 20 women globally are diagnosed with breast cancer, and a projected 1 in 70 may are likely to die from the disease in their lifetime, suggests research published in Nature Medicine. go.nature.com/4hPNwXD #Medsky 🧪
This is figure 1, which shows a map of the global burden of female breast cancer in 2022.
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Charles Scanga @cscanga.bsky.social · 23/02/2025
Students, faculty, and staff of the University of Pittsburgh- please note that March 7 is a university holiday. So if you're looking for some way to make your voice heard....
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
BioinfOmics INRAE @bioinfomics.bsky.social · 23/02/2025
You are looking for a postdoc position in bioinformatics and you are interested in understanding to what extent transposable elements contribute to the evolution of regulatory pathways in plants? 👇Have a look at this position in one of our teams.
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 23/02/2025
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Utrecht Virology Lab @utrechtvirology.bsky.social · 23/02/2025
"Norovirus replication, host interactions and vaccine advances" www.nature.com/articles/s41...
nature.com
Norovirus replication, host interactions and vaccine advances - Nature Reviews Microbiology
In this Review, the authors highlight recent advances in human norovirus biology, including classification, strain-specific differences in cell entry and innate immune responses. They also highlight p...
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
I2SysBio @i2sysbio.es · 23/02/2025
#ESTALMAT is a project of the Spanish Royal Academy of Sciences @raciencias.bsky.social for detection and encouragement of mathematical talent in 12-13 years old students. They visited our research institite to learn about #DNA 🧪💻🧬 #outreach @javierbuceta.bsky.social @pathogenomics.bsky.social
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Harmit Singh Malik @harmitmalik.bsky.social · 23/02/2025
I think people both within science and outside science don’t fully appreciate the miracle that were the Covid-19 vaccines. How much courage it took to get the sequence out, how much work had already gone into figuring out the best viral antigen and how best to present it. 1/
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Maria Dzunkova @dzunkovam.bsky.social · 23/02/2025
Middle school kids having extraordinary #math skills visited our research institute @i2sysbio.bsky.social to learn about how we use mathematics to understand #DNA 🧬🖥🧪
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Hannibal Lecter 🦋 @hannibal.bsky.social · 29/12/2024
Ahora mismo está en marcha la 3ª manifestación pidiendo la dimisión de Carlos Mazón. En las 2 anteriores acudieron 230.000 personas en total. Pues el tío, con sus santos cojonazos, que no dimite, oye.
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Saúl Ares @omeuxeito.bsky.social · 22/12/2024
¡He llegado el día de la #loteriadenavidad 🎄! ¡Qué nervios! No por si me toca, sino porque a la una saldrá el nuevo episodio de #LaVacaEsférica 🐄, dedicado justamente a la #Loteria! Enhorabuena si os toca, y si no, os esperamos para hacer más digerible la decepción 🤷🏽 #Podcast
media.tenor.com
a man is sitting on a couch eating a bag of food with the words `` mom nerves '' above him .
ALT: a man is sitting on a couch eating a bag of food with the words `` mom nerves '' above him .
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
CSIC @csic.es · 04/12/2024
“La abundancia de microplásticos en el agua del grifo es menor que en el agua embotellada” La investigadora Victoria Moreno, del CIAL-CSIC-UAM, explica el impacto de estas partículas en la #salud y el #medioambiente. vía Eroski Consumer ➡️ www.consumer.es/seguridad-al...
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Friedemann Weber @friedemann.bsky.social · 27/11/2024
Open position: young group leader in the infection area preferably in virology for the Nordic EMBL node MIMS (Laboratory for Molecular Infection Sweden) in Umea, Sweden See also www.umu.se/en/mims/ or the QR code provided below
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Kristina Anderson-Teixeira @k-andersonteixeira.bsky.social · 25/11/2024
FANTASTIC PERMANENT RESEARCH POSITION for Ecologist/Statistician (Interdisciplinary) focused on conservation at Smithsonian's National Zoo & Conservation Biology Institute (Front Royal, VA)! www.usajobs.gov/job/819535900. Come be my colleague! Please repost/ send to qualified candidates.
usajobs.gov
Ecologist Statistician (Interdisciplinary)
<p>The Smithsonian Institution is the world&rsquo;s largest museum, education, and research complex, with 21 museums and the National Zoo. The mission of the National Zoo and Conservation&nbsp;Biology...
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Simon Roux @simrouxvirus.bsky.social · 27/11/2024
Early Abstract closes on Dec. 3, and Regular Abstract submission closes on Jan. 22, 2025, so get your microbiome data analysis abstracts ready, remember to submit, and join us to talk all about data management best practices and how to make the most out of your microbiome data !
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Darren Obbard @darrenobbard.bsky.social · 27/11/2024
#PhD Advert: Please share! Are you looking for a PhD studentship in comparative- or population-genomics, using 300+ species of #Drosophila and 1000+ genomes of #melanogaster? #Entomology #Genomics #PopGen #Phylogenetics
Diverse species of Drosophilidae
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Joshua Weitz @joshuasweitz.bsky.social · 27/11/2024
Policy makers, journalists, and the public should consider what it means if the incoming head of NIH failed to design, execute, interpret, and communicate a public health study in a critical moment in the pandemic, and continued to double-down on the interpretation.
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
I2SysBio @i2sysbio.es · 20/11/2024
Our research institute I2SysBio🇪🇸 has created a starter pack for researchers in systems biology, everybody is welcome, write us if you want to be added 🔬🧫🧬🖥🦑🦠🌱🦟🪳🪸🌾
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Reposted by SFElena laboratory at I2SysBio - EvolSysVir
Science News @scinews.bsky.social · 23/11/2024
How to write an excellent Review article @natrevbioeng.bsky.social #scisky #Science #REVIEW Open Access www.nature.com/articles/s44...
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