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Santiago Elena

@sfelena.bsky.social
1.4K followers 286 following 7 posts

Virology, evolution, genomics, systems biology, and computational biology. All at once.

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Reposted by Santiago Elena
Molecular Biology and Evolution @molbioevol.bsky.social · 17/09/2026
Carrasco, @christinatoft.bsky.social & @sfelena.bsky.social reveal host age structure is a major ecological driver of virulence evolution, shaping trade-offs between disease progression and severity and determining specialization vs. generalism. 🔗 academic.oup.com/mbe/article/... #societyjournal
academic.oup.com
Evolution of virulence of a plant RNA virus in developmental stage-structured host populations
Abstract. Natural host populations are age-structured, and developmental stages differ in susceptibility and within-host pathogen dynamics, potentially imp
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Reposted by Santiago Elena
Ricard Solé @ricardsole.bsky.social · 04/09/2026
Starting from the idea of "language as a virus", we study the propagation dynamics of LLMs using an epidemic model with cooperation. A great collaboration with @brigan.bsky.social @marktas.bsky.social @sfelena.bsky.social @manlius.bsky.social D Krakauer $ @drmichaellevin.bsky.social
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PLOS Biology @plosbiology.org · 20/08/2026
Why do most cross-species #virus jumps fail? @sfelenalab.bsky.social &co use Orsay virus across multiple Caenorhabditis species to reveal how mismatches in replication, genome balance and transmission create layered barriers to #spillover @plosbiology.org 🧪 plos.io/4gCVoxg
Top: Barrier-resolved framework for OrV host competence across Caenorhabditis species. Conceptual summary of the seven barriers evaluated in this study and the expected empirical signature if each barrier limits OrV host competence. The framework distinguishes early susceptibility/establishment, within-host replication kinetics, RNA2:RNA1 genome-segment balance, luminal localization consistent with egress or viral material accumulation, functional transmission, virulence, and evolutionary persistence under serial passage. Bottom: Representative smiFISH images of OrV infection in alternative host species, showing C. elegans and the alternative host species at 24 hours post-inoculation (hpi).
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Reposted by Santiago Elena
Ricard Solé @ricardsole.bsky.social · 02/08/2026
What separates life from death? What makes the cell on the left different from the one on the right? These are questions I explore in my new @princetonupress.bsky.social book. At the cell scale, death begins when the distinction between inside & outside collapses. press.princeton.edu/books/hardco...
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molvigata.bsky.social @molvigata.bsky.social · 02/08/2026
Esto👇🏽
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Reposted by Santiago Elena
Javier Ruiz @javierruiz.bsky.social · 29/05/2026
¿Hay una operación de Trump para desestabilizar al Gobierno de España? youtu.be/EIjXBD5jnTU
youtu.be
¿Hay una operación Trump contra España para desestabilizar el Gobierno?
YouTube video by Javier Ruiz
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Ernesto Ekaizer @ernestoekaizer.bsky.social · 31/07/2026
APUNTE Guerra sucia en Ceuta. Elemental. El gobierno marroquí organiza la “invasión”. La secretaría de Estado de USA (Marco Rubio) ha calificado antes Ceuta como territorio ocupado por España. Y Feijóo culpa a Sánchez por la “invasión”.
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Wilma @wilma78.bsky.social · 31/07/2026
57 muertos, hasta el momento, ha costado la jugada de la ultraderecha internacional y del rey de Marruecos para desestabilizar el país y echar a Pedro Sánchez... PP y Vox aplaudiendo.
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Judit 🔻 @juditsinhache.bsky.social · 31/07/2026
A ver si entiendo, a Begoña Gómez se la juzgará por presunta MALVERSACIÓN de 113.000 € por un software cuya FINANCIACIÓN PRIVADA (176.000 €) cubrió el coste de sobra A Ayuso, por el ático de lujo de ~6M que le compró su Gobierno con DINERO PÚBLICO, ni se investiga, es así, no?
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Malas Lenguas @malaslenguastve.bsky.social · 01/08/2026
▶️ Ceutíes critican la presencia de ultras: "¡Fuera, fascistas, de nuestra ciudad!" "Nosotros sí que luchamos por España".
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Diario Público @publico.es · 01/08/2026
OPINIÓN | “Y los ‘pseudopatriotas’ de Vox y PP, dando alas a los planes de Mohamed VI con su histerismo xenófobo. Habría que reírse si no fuera una tragedia con muertos, o más bien, asesinados por su propio rey”, por Ana Pardo de Vera … diario.publico.es/90h…
diario.publico.es
Y todos juntos desestabilizamos España
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Julia Otero @juliaoteroradio.bsky.social · 02/08/2026
La prioridad nacional era aliarse con las indisimuladas injerencias extranjeras contra España. ¡Felicidades a esos patriotas!
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I2SysBio @i2sysbio.es · 22/04/2026
Today, 22/04/2026, Ana Villena Giménez defends her PhD at #I2SysBio. This thesis, supervised by Victoria Castiglioni and Santiago Elena @sfelena.bsky.social, studies the effect of below-background radiation and microgravity on host and virus mutual responses.👏🎉 www.i2sysbio.es/communicatio... 🧪🧫🦠
i2sysbio.es
Ana Villena defends her thesis on host-pathogen interactions under environmental stress
<p><strong>This thesis, supervised by Victoria G. Castiglioni, Santiago F. Elena, studies the effect of below-background radiation and microgravity on host and virus mutual responses. Part of the resu...
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Maria Dzunkova @dzunkovam.bsky.social · 23/04/2026
Yesterday Ana Villena from @sfelena.bsky.social group defended her PhD at @i2sysbio.es #microsky #viruses
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I2SysBio @i2sysbio.es · 01/04/2026
En À Punt Radiotelevisió Valenciana @apuntmedia.es han entrevistat Santiago Elena @sfelena.bsky.social, catedràtic del @csic.es i antic codirector de l’I2SysBio, pel seu nomenament com a nou membre de l’Acadèmia Americana de Microbiologia.👏🏆 #virus #microsky 🦠🧬🖥️🧪 🌐 www.apuntmedia.es/programes/l-...
apuntmedia.es
30.03.2026 | Com evolucionen els virus? Santiago Elena ens dona les claus
Conversem amb Santiago Elena, catedràtic del CSIC i codirector de l’Institut de Biologia Integrativa i de Sistemes (I2SysBio), pel seu nomenament com a nou membre de l’Acadèmia Americana de Microbiolo...
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PLOS Biology @plosbiology.org · 20/03/2026
Pathogen host-jumps pose major risks to health, but how can we predict them? This study shows that #pathogen novelty, rather than #spillover rate, is a stronger predictor of host-jump risk, so we should monitor emerging pathogens with limited spillover histories @plosbiology.org 🧪 plos.io/4ss5WCY
Conceptual framework for relating spillover rate and the past spillover window to host jump risk. In order to successfully host jump, a pathogen must overcome barriers to spillover and barriers to sustained transmission in the novel host. Pathogens may or may not be limited at either step in this process, leading conceptually to four classes of nonnative pathogens (A–D). In practice, and in the authors' model, spillover limitation and transmission limitation are continuous traits meaning that there is no discrete separation between the “types” of pathogens shown in A–D but thy discuss pathogens in this framework because it is useful for illustration.
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Santiago Elena @sfelena.bsky.social · 20/03/2026
More good news! I’m happy to announce my election as a new fellow of the European Academy of Microbiology! fems-microbiology.org/european-aca...
fems-microbiology.org
Fellows
The European Academy of Microbiology (EAM) proudly brings together a distinguished community of leading scientists whose contributions have shaped and advanced the field of microbiology. Below, you wi...
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Santa Fe Institute @sfiscience.bsky.social · 17/02/2026
SFI’s Santiago Elena has been elected a fellow of the American Academy of Microbiology. He joins 62 fellows in the 2026 class. His work explores how RNA viruses adapt to hosts and manipulate cellular resources. Since joining SFI in 2008, he has organized several working groups on virus evolution.
santafe.edu
SFI External Professor Santiago Elena elected to the American Academy of Microbiology
SFI External Professor Santiago Elena has been elected as a fellow of the American Academy of Microbiology, joining 62 other fellows in the class of 2026, each selected for their contributions in the ...
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Te Pūnaha Matatini @tepunahamatatini.bsky.social · 14/02/2026
"Nothing like this has existed before, and we don't quite know what it does to people." @carlbergstrom.com spoke to Mihingarangi Forbes about living with AI on Saturday Morning this morning → www.rnz.co.nz/national/pro... #cccss26 🧪
rnz.co.nz
Professor Carl Bergstrom: Living with AI
Internationally acclaimed scientist Carl Bergstrom on why humans are so psychologically wired for online and whether we are living with "modern-day oracles or bullsh*t machines."
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Santiago Elena @sfelena.bsky.social · 13/02/2026
Honored to be elected as a Fellow of the American Academy of Microbiology! I look forward to working alongside my colleagues to advance microbial science for the benefit of society. Learn more about the 2026 Fellowship Class: press release link
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Santiago Elena @sfelena.bsky.social · 04/09/2025
More than 70 people attend the 2nd Public-Private Collaboration Workshop organised by I2SysBio www.i2sysbio.es/communicatio...
i2sysbio.es
More than 70 people attend the 2nd Public-Private Collaboration Workshop organised by I2SysBio
<p><strong>The Institute of Integrative Systems Biology (I2SysBio), a joint centre of the CSIC and the University of Valencia, held its Second Public-Private Collaboration Workshop under the title &#3...
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Reposted by Santiago Elena
Vicente Arnau @vicentarnau.bsky.social · 01/09/2025
The 14th edition of the Master's Degree in Bioinformatics begins. With many teachers from the @i2sysbio.es and the @cipfvalencia.bsky.social
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UCC+i UV @ucciuv.bsky.social · 02/09/2025
@i2sysbio.es @uv.es @sfelena.bsky.social @dicv.csic.es ‬ www.uv.es/uvweb/uv-not...
uv.es
Troben en cucs un mecanisme que ‘recorda’ la resposta immunitària davant d’un virus per a defensar-se enfront de reinfeccions
Un estudi de l’Institut de Biologia Integrativa de Sistemes (I2SysBio), centre mixt del Consell Superior d’Investigacions Científiques (CSIC) i la Universitat de València (UV), mostra que el virus Ors...
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Conesa Lab @conesalab.bsky.social · 04/09/2025
Tuesday was an amazing day. The @i2sysbio.es organized the II Jornada de Colaboración Público-privada. We could meet the private sector and share our dreams and concerns with them. www.i2sysbio.es/communicatio...
i2sysbio.es
More than 70 people attend the 2nd Public-Private Collaboration Workshop organised by I2SysBio
<p><strong>The Institute of Integrative Systems Biology (I2SysBio), a joint centre of the CSIC and the University of Valencia, held its Second Public-Private Collaboration Workshop under the title &#3...
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Reposted by Santiago Elena
Ricard Solé @ricardsole.bsky.social · 05/08/2025
How to deal with the multiscale nature of evolution, which displays different time scales of change? We need to replace classic genotype spaces with multiscapes. Here's a great paper by my friend Susanna Manrubia and coworkers @mncn-csic.bsky.social rsob.royalsocietypublishing.org/content/royo... …
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Santiago Elena @sfelena.bsky.social · 05/08/2025
Evolutionary features in a minimal physical system: Diversity, selection, growth, inheritance, and adaptation | PNAS www.pnas.org/doi/epub/10....
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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SFElena laboratory at I2SysBio - EvolSysVir @sfelenalab.bsky.social · 04/08/2025
Check the latest publication from our group! rdcu.be/ey1Fj @i2sysbio.es @csic.es
rdcu.be
Latent infection of Caenorhabditis elegans by Orsay virus induces age-dependent immunity and cross-protection
Nature Communications - Orsay virus establishes a latent infection in C. elegans, triggering age-dependent immunity and RNAi based cross-protection that limits secondary infections and reveals...
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Ana Conesa @anaconesa.bsky.social · 17/04/2025
Fantástica jornada "¿Cómo tu ciencia puede ayudar a la sostenibilidad?" organizada por @iatacsic.bsky.social y el @i2sysbio.bsky.social. Conocimos la ciencia en sostenibilidad de @dicv.csic.es y nos inspiramos para aplicar nuestros conocimientos a este problema. Pensando ya en futuras actividades!
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Arnau Montagud @arnaumontagud.bsky.social · 18/03/2025
Con las prisas, se me olvidaron otras JAE Intros disponibles en otros labs del @i2sysbio.bsky.social: @sfelena.bsky.social, @rafa-sanjuan.bsky.social, @rongellerlab.bsky.social y Carlos Garcia y Gustavo Gomez.
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Alexandria Ocasio-Cortez @aoc.bsky.social · 22/02/2025
It may not be cool or hip in some circles, but we legitimately do need a massive amount of people to run for office. Flood the school boards, councils, county seats, state legislatures, Congress, etc. Big changes at the top happen when the ground shifts at the bottom. And that can start now.
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I2SysBio @i2sysbio.es · 23/02/2025
#ESTALMAT ha visitado nuestro instituto en su proyecto para la detección, orientación y estímulo del talento matemático de estudiantes escolares @raciencias.bsky.social #matemáticas #divulgación #OVS #FECYT @javierbuceta.bsky.social @pathogenomics.bsky.social 💻🧬
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Santiago Elena @sfelena.bsky.social · 20/02/2025
Experimental evolution of evolvability | Science www.science.org/doi/10.1126/...
science.org
Experimental evolution of evolvability
Evolvability—the capacity to generate adaptive variation—is a trait that can itself evolve through natural selection. However, the idea that mutation can become biased toward adaptive outcomes remains...
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Joshua Weitz @joshuasweitz.bsky.social · 02/12/2024
Delighted to share this paper out via Virus Evolution: academic.oup.com/ve/advance-a... in which we develop and assess a quantitative method to infer phage and bacterial mutations driving changes in infection phenotypes arising in coevolutionary dynamics. a 🧵 about people (and some science)
Predicted infections with phage/host mutation models
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elDiario.es @eldiario.es · 03/01/2025
"“Una vez más, la banalidad nos rodea”, lamenta pesaroso el arzobispo Luis Argüello. La misma banalidad que reacciona con más dolor y rapidez ante una estampita satírica que ante el escándalo de la pedofilia en la Iglesia" La Santa Vaquilla vs. los ultras de Torquemada ✍️ Por Iñigo Sáenz de Ugarte
eldiario.es
La Santa Vaquilla vs. los ultras de Torquemada
Otra imagen satírica relacionada con la religión provoca amenazas de querellas de organizaciones ultraderechistas mientras la jerarquía católica vuelve a reaccionar con una rapidez que no acostumbra c...
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European Virus Bioinformatics Center @evbc.bsky.social · 04/12/2024
Investigating tomato black ring virus DVGs! This study uncovers the impact of host-to-host transmission on viral evolution, with deletions dominating in diverse host species. #VirusBioinformatics #DVGs #PlantVirology 📄 doi.org/10.1128/jvi.... EVBC👤: @sfelena.bsky.social
doi.org
Population dynamics of defective viral genomes of tomato black ring virus during host-to-host transmission | Journal of Virology
Defective viral genomes (DVGs) have been identified in vivo and in vitro for different virus species infecting humans, animals, and plants. The ability to form DVGs during the passaging of virus in on...
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Britt Koskella @bkoskella.bsky.social · 27/11/2024
A reminder for any academics who needs to hear it: there are SO many ways to serve the scientific community. Choose the ones that fulfill you, bring you joy (even if they are hard), and are in line with your values. It’s okay to say no/ resign/change tracks! And put your efforts/energy elsewhere.
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Joshua Weitz @joshuasweitz.bsky.social · 27/11/2024
Policy makers, journalists, and the public should consider what it means if the incoming head of NIH failed to design, execute, interpret, and communicate a public health study in a critical moment in the pandemic, and continued to double-down on the interpretation.
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Darren Obbard @darrenobbard.bsky.social · 27/11/2024
#PhD Advert: Please share! Are you looking for a PhD studentship in comparative- or population-genomics, using 300+ species of #Drosophila and 1000+ genomes of #melanogaster? #Entomology #Genomics #PopGen #Phylogenetics
Diverse species of Drosophilidae
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Simon Roux @simrouxvirus.bsky.social · 27/11/2024
Early Abstract closes on Dec. 3, and Regular Abstract submission closes on Jan. 22, 2025, so get your microbiome data analysis abstracts ready, remember to submit, and join us to talk all about data management best practices and how to make the most out of your microbiome data !
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Kristina Anderson-Teixeira @k-andersonteixeira.bsky.social · 25/11/2024
FANTASTIC PERMANENT RESEARCH POSITION for Ecologist/Statistician (Interdisciplinary) focused on conservation at Smithsonian's National Zoo & Conservation Biology Institute (Front Royal, VA)! www.usajobs.gov/job/819535900. Come be my colleague! Please repost/ send to qualified candidates.
usajobs.gov
Ecologist Statistician (Interdisciplinary)
<p>The Smithsonian Institution is the world&rsquo;s largest museum, education, and research complex, with 21 museums and the National Zoo. The mission of the National Zoo and Conservation&nbsp;Biology...
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Friedemann Weber @friedemann.bsky.social · 27/11/2024
Open position: young group leader in the infection area preferably in virology for the Nordic EMBL node MIMS (Laboratory for Molecular Infection Sweden) in Umea, Sweden See also www.umu.se/en/mims/ or the QR code provided below
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Science News @scinews.bsky.social · 24/11/2024
Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 1. The importance of stupidity in scientific research Open Access journals.biologists.com/jcs/article/...
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Revista Mètode @revistametode.bsky.social · 26/11/2024
«Les teories conspiratives proliferen sempre en moments d'incertesa» Des de la DANA, científics com @fernadovalladares.bsky.social han sigut el blanc d'un assetjament creixent en xarxes socials per part de grups que promouen l'escepticisme climàtic. ✍️ @anacamps25.bsky.social
metode.cat
Entrevista a Fernando Valladares - Revista Mètode
Des de la DANA, científics com Fernando Valladares han sigut el blanc d'un assetjament creixent en xarxes socials per part de grups que promouen l'escepticisme climàtic.
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I2SysBio @i2sysbio.es · 20/11/2024
Our research institute I2SysBio🇪🇸 has created a starter pack for researchers in systems biology, everybody is welcome, write us if you want to be added 🔬🧫🧬🖥🦑🦠🌱🦟🪳🪸🌾
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Science News @scinews.bsky.social · 23/11/2024
How to write an excellent Review article @natrevbioeng.bsky.social #scisky #Science #REVIEW Open Access www.nature.com/articles/s44...
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Sergi Valverde @svalver.bsky.social · 22/11/2024
Research on cultural and technological evolution is thriving at our Institute of Evolutionary Biology, which makes me very happy. It is an exciting time for multidisciplinary approaches to biological evolution! #CultEvo
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Ricard Solé @ricardsole.bsky.social · 19/11/2024
Are the major evolutionary transitions describable as phase transitions, as in statistical physics? A great example of this is the transition to eukaryotic cells, as shown by this excellent paper by Jordi Bascompte and co-workers europepmc.org/api/fulltext...
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Esther Palomera @estherpalomera.bsky.social · 19/11/2024
LO que viene siendo estatr a la altura de la reconsrucción www.eldiario.es/comunitat-va...
eldiario.es
Mazón adjudica 3,9 millones a dedo para reparar la presa dañada por la DANA a un constructor de la caja B del PP en Gürtel
El Consell selecciona a Becsa SA, de un empresario que confesó en la Audiencia Nacional la financiación de los populares valencianos, para las obras en la presa de Buseo, con "peligro de rotura o aver...
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Hannibal Lecter 🦋 @hannibal.bsky.social · 18/11/2024
El ruido se mide en abascales y el silencio en mazones.
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Hannibal Lecter 🦋 @hannibal.bsky.social · 18/11/2024
Es menester compartir aquí tambien esto que me curré con el Paint.
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