Abstract. Segmental duplications are major drivers of evolutionary innovation; yet, their dynamics across vertebrates remain poorly understood. Here, we id

Abstract. Segmental duplications are major drivers of evolutionary innovation; yet, their dynamics across vertebrates remain poorly understood. Here, we id

Polymorphic gene duplications absent from the reference genome can generate spurious trans-eQTLs. Specifically, variants tagging the polymorphic duplicate may masquerade as trans-eQTLs regulating the ...

GLAM-Evogen will be held on August 15, 2026 at University at Buffalo, NY. We aim to bring together faculty and trainees from a range of backgrounds with a particular focus on work at the interface bet...

Structurally complex loci can repeatedly generate similar traits; Karageorgiou et al. established primate amylase locus as a structural variation hotspot, potentially seeded by transposable elements. ...

The salivary amylase gene exhibits copy-number variation linked to dietary shifts. Here, the authors describe an adaptive expansion of the amylase gene in Indigenous Andean populations coinciding with...

See more information on the new Heredity special issue on functional and adaptive effects of genomic structural variation.

Gene duplicates are traditionally viewed as evolutionarily unstable, as one copy can freely accumulate deleterious mutations and be lost. A new study reveals that paralog interference exposes certain ...

Abstract. Understanding genomic function has historically relied on sequence conservation across evolutionary time. However, advances in genomics have reve

Abstract. Understanding genomic function has historically relied on sequence conservation across evolutionary time. However, advances in genomics have reve

Heritable variation in gene regulation shapes both disease risk and evolution. Trans -acting quantitative trait loci ( trans -QTLs) are the primary source of this variation within species, yet they re...

Abstract. Genes within the secretory calcium-binding phosphoprotein locus diversified along with the formation of a calcified skeleton in vertebrates, the

Atilla Lab – at the University at Buffalo

Structurally complex regions of the genome are increasingly recognized as engines of evolutionary convergence due to their propensity to generate recurrent gene duplications that give rise to similar ...

Structurally complex regions of the genome are increasingly recognized as engines of evolutionary convergence due to their propensity to generate recurrent gene duplications that give rise to similar ...

The University at Buffalo School of Dental Medicine (SDM) invites applications from qualified early- to mid-career oral health scientists and/or clinician-scientists for a full-time tenure track acade...

University of Buffalo researchers conducted a systematic analysis of switch-like genes by analyzing genomes, transcriptomes and methylomes from 943 individuals and 27 different tissues.

West Anatolia has been a crucial yet elusive element in the Neolithic expansion from the Fertile Crescent to Europe. In this work, we describe the changing genetic and cultural landscapes of early Hol...

While switch-like expression (“on” in some individuals and “off” in others) has been linked to biological variation and disease susceptibility, a systematic analysis across tissues is lacking. Here, w...

Previous studies suggested that the copy number of the human salivary amylase gene, AMY1, correlates with starch-rich diets. However, evolutionary analyses are hampered by the absence of accurate, seq...