iiinova — where your digital self keeps evolving

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Mike Inouye @mikeinouye.bsky.social · 07/08/2026

Latest from our lab! A proteome-wide association study of cardiovascular diseases in 640,000 participants of multiple ancestries www.medrxiv.org/content/10.6... A truly global collaboration of computational and experimental researchers. h\t @yuxu.bsky.social, Doug Loesch, Henry Taylor among many!

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Yang Luo @y-luo.bsky.social · 28/11/2025

🚨 New preprint from the lab! We’re excited to share “Improving population-scale disease prediction through multi-omics integration” by Ng et al. www.medrxiv.org/content/10.1...

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Mike Inouye @mikeinouye.bsky.social · 22/11/2025

📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1... tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.

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Mike Inouye @mikeinouye.bsky.social · 25/07/2025

📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791... You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁

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Mike Inouye @mikeinouye.bsky.social · 16/06/2025

Super excited to see beginning integration of PredictDB into OmicsPred! We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org More on its way... a wonderful collab with @hakyim.bsky.social & co!

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OmicsPred @omicspred.bsky.social · 16/06/2025

We're working closely with our PredictDB colleagues to bring you an integrated resource for multi-omic predictors We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org More info www.omicspred.org/publication/...

omicspred.org

OmicsPred is an atlas of genetic scores for prediction of multi-omics data.

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Mike Inouye @mikeinouye.bsky.social · 08/04/2025

📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/ Flexible funding - many research areas in scope + ideas welcome Check out our group www.inouyelab.org/home And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social

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Shai Carmi @shaicarmi.bsky.social · 10/03/2025

Looks like a nice resource: * Array genetic data for 80,638 Japanese children * 1,163 child health and developmental traits (e.g. food allergy, anthropometric, developmental) * Parental environmental exposures www.medrxiv.org/content/10.1...

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Marios Georgakis @mariosgeorgakis.bsky.social · 09/03/2025

Interesting week reads and resources on human genetics, omics & precision medicine🧵 1⃣From a dog GWAS to a new obesity target! DENND1B variants were the top GWAS signal for obesity in 241 Labrador retrievers—DENND1B variants were also associated with BMI in UK Biobank 🔗 science.org/doi/10.1126/...

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Mike Inouye @mikeinouye.bsky.social · 03/03/2025

Wonderful to see our collaboration @astrazeneca.bsky.social @dphpc.bsky.social out! Identification of plasma proteomic markers underlying polygenic risk of T2D and related comorbidities @naturecomms.bsky.social www.nature.com/articles/s41... Well done Doug Loesch, Dirk Paul, Abhishek Nag and co!

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OmicsPred @omicspred.bsky.social · 06/02/2025

Introducing a major upgrade to OmicsPred platform (www.omicspred.org) — a resource to enhance the accessibility and usability of genetic scores for multi-omic traits and their phenotypic associations. (1/N)

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Hani Goodarzi @genophoria.bsky.social · 13/01/2025

A month ago we @vevotherapeutics.bsky.social announced that we have generated the largest single-cell perturbation atlas in history, Tahoe-100M. Today, we announce that we will fully open-source Tahoe-100M in Feb, as part of a collaboration with NVidia health to train cell state models.

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Sasha Gusev @sashagusevposts.bsky.social · 26/12/2024

I wrote about how polygenic heritable conditions present in families and the liability threshold model. This has some counterintuitive implications for considering the risk of a condition in offspring as well as the impact of multi-generational selection. A 🧵:

open.substack.com

What happens to heritable conditions across generations?

some counterintuitive properties of the polygenic liability threshold model

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Mike Inouye @mikeinouye.bsky.social · 11/01/2024

📣WOOT! Just out from the lab: Pitfalls of machine learning models for protein-protein interaction networks academic.oup.com/bioinformati... We benchmark various approaches then dig into why they do well and not so well. Led by @loiclnlg.bsky.social (also of Green Algorithms fame)!

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Dr. Scott C. Ritchie @sritchie73.bsky.social · 02/11/2023

For my debut to bluesky, I am pleased to announce a new preprint: medrxiv.org/content/10.1... Here, we show that NMR biomarker scores combined with PRSs and SCORE2 may have moderate population health benefits for 10-year CVD risk prediction prevention Thread 1/3:

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Mike Inouye @mikeinouye.bsky.social · 02/11/2023

📣Cool new print from Scott Ritchie & the lab (www.inouyelab.org)! Cardiovascular risk prediction using metabolomic biomarkers & polygenic risk scores: A cohort study & modelling analyses medrxiv.org/content/10.1... tldr Integrating NMR scores & PRSs with SCORE2 may have moderate pop health benefit

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