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Michal Galdzicki

@mgaldzic.bsky.social
142 followers 309 following 39 posts

I work on data at Arzeda the protein design company.

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Reposted by Michal Galdzicki
samuel mehr @mehr.nz · 20/09/2025
this is wild - i was aware of Mary-Claire King's absurdly important discoveries on BRCA / inherited breast cancer but I had no idea that her first PhD paper (King & Wilson 1975, Science, not bad lol) is the "99% of protein coding shared btwn chimps and humans" result www.science.org/doi/abs/10.1...
screenshot of the Science article
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Reposted by Michal Galdzicki
Chaitanya K. Joshi @chaitjo.bsky.social · 15/08/2025
RosettaFold 3 is here! 🧬🚀 AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release! Congratulations @simonmathis.bsky.social and team!!! ❤️ bioRxiv preprint: www.biorxiv.org/content/10.1...
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Michal Galdzicki @mgaldzic.bsky.social · 27/04/2025
Boltz-1 update Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training. www.biorxiv.org/content/10.1...
biorxiv.org
Boltz-1: Democratizing Biomolecular Interaction Modeling
Understanding biomolecular interactions is fundamental to advancing fields like drug discovery and protein design. In this paper, we introduce Boltz-1, an open-source deep learning model incorporating...
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Reposted by Michal Galdzicki
bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 07/04/2025
BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design www.biorxiv.org/content/10.1101/202…
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Jim Haseloff @jimhaseloff.bsky.social · 06/04/2025
...where a powerful toy slingshot can be used to mount the LoRa node in a tree for better line-of-sight communications with other devices. www.instructables.com/Meshtastic-S...
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Reposted by Michal Galdzicki
Guilhem Faure @guilhemfaure.bsky.social · 28/02/2025
🚀 Thrilled to share our latest work from Zhang Lab, now published in Science (www.science.org/doi/10.1126/...) We introduce TIGR-Tas, a PAM-free, compact, modular RNA-guided DNA-targeting system in prokaryotes & their viruses. More details coming soon 👀 #TIGR #RNA #GeneEditing #CRISPR
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 24/02/2025
Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology www.biorxiv.org/content/10.1101/202…
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Michal Galdzicki @mgaldzic.bsky.social · 01/02/2025
Wait-a-minute 3 in 1 COVID, Flu A, and B tests are already available from Amazon. Is the RSV one coming? I missed the memo. a.co/d/4s5izkO
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Reposted by Michal Galdzicki
Phil Plait @philplait.bsky.social · 25/01/2025
This is pretty cool: Scientists have isolated the gene that may be responsible for the reason grapefruit interferes with some meds. It's not the solution, but it's a start. I love grapefruit but it messes with one of my meds, so this makes me happy. www.scientificamerican.com/article/why-...
scientificamerican.com
Why Grapefruit Interferes with Medication, and What to Do about It
Could gene editing produce a tasty citrus fruit that doesn’t interfere with prescription drugs?
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Michal Galdzicki @mgaldzic.bsky.social · 25/01/2025
Arzeda has been awarded DARPA funding to advance AI-driven protein design—even with limited data! We're pushing the boundaries to create next-gen proteins for national security, sustainability, and beyond. #AI #ProteinDesign www.prnewswire.com/news-release...
prnewswire.com
Arzeda Awarded DARPA Funding to Advance AI-Driven Protein Design for National Security
/PRNewswire/ -- Arzeda, the industry-leading Protein Design Company™, today announced it has been selected for an award from the Defense Advanced Research...
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Michal Galdzicki @mgaldzic.bsky.social · 23/01/2025
Speculative writeup and the webinar Feb 20 web.cvent.com/event/e77566...
web.cvent.com
Welcome - Introducing Sequencing By Expansion (SBX): A versatile, high-throughput single-molecule sequencing technology
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Reposted by Michal Galdzicki
Rob Carlson @robcarlson.bsky.social · 16/01/2025
From the dependably insightful @aukehoekstra.bsky.social .
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Reposted by Michal Galdzicki
Dietram A. Scheufele @dietram.bsky.social · 21/12/2024
Our inability to reliably study algorithmic info ecosystems, and why it matters for #scicomm. Pre-publication version of our forthcoming PNAS piece led by Nicky Krause and Isabelle Freiling : osf.io/preprints/so... (a 🧵)
What (social) science cannot see
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Reposted by Michal Galdzicki
Nick Tsergas @nicktsergas.ca · 28/11/2024
You guys remember TweetDeck? Bluesky has it, and it's free. Check out 🔗 deck.blue by @gildaswise.com for a multi-column interface. 2/10
Screenshot of the deck.blue UI
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Reposted by Michal Galdzicki
Howard Salis @hsalis.bsky.social · 02/12/2024
NEW paper 🚨! We engineered TNT sensors in soil bacteria for long-term detection of explosive in natural soil, enabling geospatial detection of contaminated soil. This work (led by Erin Essington) included new sensors, circuits, modeling, & a 28-day testing workflow. 1/ www.nature.com/articles/s41...
nature.com
An autonomous microbial sensor enables long-term detection of TNT explosive in natural soil - Nature Communications
Engineered microbes can detect harmful chemicals, but may not work well in complex environments. Here, the authors built microbial sensors for detection of TNT explosive and tested their response over...
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Michal Galdzicki @mgaldzic.bsky.social · 03/12/2024
This is a really cool paper. They developed a reasonably robust circuit to generate patterns.
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Reposted by Michal Galdzicki
Jonathan Jacobs @bioinformer.bsky.social · 27/11/2024
🧬🖥🧪 Here are some healthy reminders on just how much Illumina still dominates the #genomics space... 😐
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Reposted by Michal Galdzicki
Jon Lim, FRCP PhD @drjonlim.bsky.social · 23/11/2024
🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov
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Reposted by Michal Galdzicki
Gabriele Corso @gcorso.bsky.social · 17/11/2024
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
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Reposted by Michal Galdzicki
Hana Ayoob @hanaayoob.co.uk · 10/11/2024
The infographic & some extra info here if anyone is interested www.compoundchem.com/2014/08/21/c...
compoundchem.com
Compound Interest: Why Doesn’t Honey Spoil? – The Chemistry of Honey
Honey is something of an oddity, in that, unlike most foods, it doesn’t spoil over time. In fact, the oldest known sample of honey, found in an Ancient Egyptian tomb and dated to approximatel…
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Reposted by Michal Galdzicki
Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 09/11/2024
Rumors are that they will release model and weights next week.
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Reposted by Michal Galdzicki
Rob Carlson @robcarlson.bsky.social · 08/11/2024
Arzeda has now produced and sold 10 tons of ProSweet RebM™ stevia, a natural, zero-calorie sweetener, marking a major step forward in sustainable production for the food industry. #biosky www.businesswire.com/news/home/20...
businesswire.com
Arzeda, Co-founded by Nobel Laureate David Baker, Drives Industry Innovation with Intelligent Protein Design Technology™ and Delivers Performance Products to Fortune 500 Companies
Arzeda, the leading industrial protein design company co-founded in 2009 by Nobel laureate and University of Washington School of Medicine biochemistr
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Michal Galdzicki @mgaldzic.bsky.social · 08/11/2024
Washington's Dream, plants! youtube.com/shorts/Mz-Er...
youtube.com
Greenhouse Nursery Trade Gallons Part 2
YouTube video by Smith's Gardentown
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Reposted by Michal Galdzicki
Jay 🦋 @jay.bsky.team · 24/10/2024
Bluesky has grown to 13M users in a year and a half — thank you all for choosing us! We’ve raised a $15M Series A to support our growth and continue to build an open social network that is designed around you, the user.
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Reposted by Michal Galdzicki
Axel Visel @axelvisel.bsky.social · 14/10/2024
New preprint by @jgi.doe.gov's Leo Baumgart, Ronan O'Malley and many others Mapping binding sites of 360 TFs across 10 🌿Brassicaceae genomes. 1.1 million TF-target gene assignments in Arabidopsis thaliana alone!
Illustration of a genomic DNA library construction process from different plant species (labeled 1 to 10), with each species' DNA uniquely barcoded. These DNA libraries are pooled together and incubated with 360 different in-vitro expressed transcription factors (TFs). The TFs bind to their target sequences within the pooled genomic DNA, and the resulting complexes are processed in a multiDAP assay using 96-well plates for analysis.
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Reposted by Michal Galdzicki
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 12/10/2024
Design of a biomolecular adaptive controller to restore sustained periodic behavior www.biorxiv.org/content/10.1101/202…
biorxiv.org
Design of a biomolecular adaptive controller to restore sustained periodic behavior https://www.biorxiv.org/content/10.1101/2024.10.11.617962v1
Periodic behavior is a widespread biological phenomenon occurring across various spatiotemporal scal
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Michal Galdzicki @mgaldzic.bsky.social · 06/10/2024
Part 1 had me in stitches youtu.be/JYqfVE-fykk?... Part 2 great work youtu.be/VJ62EfUKI3w?...
youtu.be
Washington's Dream 2 - SNL
YouTube video by Saturday Night Live
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Michal Galdzicki @mgaldzic.bsky.social · 01/10/2024
Marburg in Rwanda, 20 cases reported taarifa.rw/rwandas-heal...
taarifa.rw
Rwanda’s Health Ministry Provides Update on Marburg Virus Outbreak: Six Dead, 20 Infected - Taarifa Rwanda
On Sunday afternoon, the Ministry of Health in Rwanda held a press conference to update the public on the country’s first-ever outbreak of the Marburg virus. Health Minister Dr. Sabin Nsanzimana confi...
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Reposted by Michal Galdzicki
Sebastian S. Cocioba @atinygreencell.bsky.social · 20/09/2024
Here are some useful links to my work. Please bookmark for easy access! 💚 Open Laboratory Notebook: tinyurl.com/ATGCFFE Open Data Repository: tinyurl.com/ATGCSWEET Web Store for Plasmids and Goodies: atinygreencell.com Binomica Labs GitHub: github.com/Binomica-Labs
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Michal Galdzicki @mgaldzic.bsky.social · 18/09/2024
Bluesky now has over 10 million users, and I was #1,292,419!
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Diego del Alamo @delalamo.xyz · 09/09/2024
Another group has more or less reproduced AF3, but has built in a way to add spatial constraints for PPI prediction. These constraints lead to huge increases in fraction of models that are correct-ish, without changing fraction that is high-accuracy chaiassets.com/chai-1/paper...
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Reposted by Michal Galdzicki
Mike Young @mkeyoung.bsky.social · 07/08/2024
🌍 We have just extracted a NEW global network of researchers and a global 100 scientist top ‘influencers’ on Bluesky. @lassehjorthmadsen.bsky.social and I show that scientists are in a series of distinct communities: mikeyoungacademy.dk/communities-... 😀 All 'likes' and reshares appreciated!
mikeyoungacademy.dk
Communities of scientists are emerging on Bluesky - Mike Young Academy
Global network data: The ‘nicer’ alternative to X is fortifying its presence in fields that range from philosophy to chemistry, finance, and beyond.
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Compound Interest | Chemistry infographics @compoundchem.com · 07/09/2024
Forgot to add that, while Kekulé’s benzene structure has endured, some of his other structural depictions were less successful. For some reason, his “sausage formulae” never caught on…
Diagram showing several chemical formulae depicted using Kekulé’s sausage notation. This consists of sausage-shaped blobs for carbons and dots for hydrogen. A filled black dot is used to represent chlorine.
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Reposted by Michal Galdzicki
bioRxivpreprint @biorxivpreprint.bsky.social · 04/08/2024
Computational design of highly active de novo enzymes www.biorxiv.org/content/10.1101/202…
biorxiv.org
Computational design of highly active de novo enzymes https://www.biorxiv.org/content/10.1101/2024.08.02.606416v1
Custom designed enzymes can further enhance the use of biocatalysts in industrial biotransformations
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bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 02/08/2024
Accelerated enzyme engineering by machine-learning guided cell-free expression www.biorxiv.org/content/10.1101/202…
biorxiv.org
Accelerated enzyme engineering by machine-learning guided cell-free expression https://www.biorxiv.org/content/10.1101/2024.07.30.605672v1
Enzyme engineering is limited by the challenge of rapidly generating and using large datasets of seq
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Reposted by Michal Galdzicki
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 24/07/2024
Preventing plasmid multimer formation in commonly used synthetic biology plasmids www.biorxiv.org/content/10.1101/202…
biorxiv.org
Preventing plasmid multimer formation in commonly used synthetic biology plasmids https://www.biorxiv.org/content/10.1101/2024.07.23.604805v1
Plasmids are an essential tool for basic research and biotechnology applications. To optimize plasmi
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Michal Galdzicki @mgaldzic.bsky.social · 04/07/2024
Happy 4th. Transglutaminase fact: they're used to improve the texture of hot dogs
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worobey.bsky.social @worobey.bsky.social · 07/06/2024
Hi all - I have a couple of positions open for lab management and research! Please pass this on to creative and enthusiastic folks who might be interested. (And repost if you don't mind.) Ability to learn/adapt more important than specific skills! Thanks so much. arizona.csod.com/ux/ats/caree...
arizona.csod.com
Research Professional II (Multiple Positions)
-Work independently on defined experiments (e.g., set up, scheduling, data acquisition) and report on the findings to the PI.-Have a general understan...
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bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 01/06/2024
Induction of Meiosis from Human Pluripotent Stem Cells www.biorxiv.org/content/10.1101/202…
biorxiv.org
Induction of Meiosis from Human Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2024.05.31.596483v1
An in vitro model of human meiosis would accelerate research into this important reproductive proces
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Reposted by Michal Galdzicki
worobey.bsky.social @worobey.bsky.social · 03/05/2024
If you're interesting in the #H5N1 outbreak in cattle in the US, please have a look at our preliminary analyses just posted. Part 1 of 2: virological.org/t/preliminar...
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 20/05/2024
Bagheera helps Molecule of the Month author David Goodsell create his amazing illustrations. Can you guess which molecule Bagheera is in? #NationalPetMonth #PetsofRCSBPDB pdb101.rcsb.org/motm...
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Reposted by Michal Galdzicki
Daniel Bolnick @danielbolnick.bsky.social · 15/05/2024
Excited for this live public event with the @bigbiology.bsky.social podcast, addressing ecological restoration in Alaskan Lakes! If you know someone in Alaska who might be interested, please share it with them!
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Reposted by Michal Galdzicki
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 06/05/2024
MAIA: An open-source, modular, bioreactor for cities www.biorxiv.org/content/10.1101/202…
biorxiv.org
MAIA: An open-source, modular, bioreactor for cities https://www.biorxiv.org/content/10.1101/2024.05.03.592196v1
This work presents the design and fabrication of MAIA, an open-source, modular, low-cost, and portab
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Elinne Becket, PhD @bielleogy.bsky.social · 20/03/2024
And AFTER ALL THAT.... #BlueSoup isolate has 98.7 ANI with the Pseudomonas carnis genomes from the Marina De León & @phylogenomics.bsky.social paper jgenomics.com/v09p0055.htm 💀 99.2 ANI with P. NBRC 111137; still digging!
jgenomics.com
Draft Genome Sequences and Genomic Analysis for Pigment Production in Bacteria Isolated from Blue Discolored Soymilk and Tofu
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Torsten Wittmann @microtubule.bsky.social · 19/03/2024
No videos here ... yet. So, here is a cute AlphaFold2 model of the mEmerald labelled nanocages that we used to determine that there are ~120 DCX molecules bound per µm growth cone microtubule🧪 doi.org/10.1101/2024...
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Michal Galdzicki @mgaldzic.bsky.social · 19/03/2024
De novo design of antibody variable heavy chains (VHH's) using RF diffusion www.biorxiv.org/content/10.1...
biorxiv.org
Atomically accurate de novo design of single-domain antibodies
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Reposted by Michal Galdzicki
Rob Carlson @robcarlson.bsky.social · 15/03/2024
Nice list of community science projects here. www.seattletimes.com/pacific-nw-m...
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Michal Galdzicki @mgaldzic.bsky.social · 13/03/2024
Trikafta changed CF from a death sentence to a treatable condition. It overcomes the deficit of a chloride channel caused by a specific inherited mutation in the CFTR gene, discovered in 1989, and only 30 years later this story was possible. How much quicker will this take these days?
theatlantic.com
The Cystic-Fibrosis Breakthrough That Changed Everything
The disease once guaranteed an early death—but a new treatment has given many patients a chance to live decades longer than expected. What do they do now?
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Michal Galdzicki @mgaldzic.bsky.social · 06/02/2024
@bioandbaseball.bsky.social any chance you could share that www.liebertpub.com/doi/10.1089/... paper PDF?
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Rob Carlson @robcarlson.bsky.social · 07/01/2024
Next, an editorial from the Seattle Times on restoring salmon streams. "The course is not cheap, but it is clear: The state must fix the culverts, using the best science possible." WA must stay the course on culvert removal to save salmon www.seattletimes.com/opinion/edit...
seattletimes.com
WA must stay the course on culvert removal to save salmon | Editorial
The Legislature should ensure that the state's efforts to remove culverts that block salmon runs are carried through.
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