Reposted by Michal Galdzicki samuel mehr @mehr.nz · 20/09/2025this is wild - i was aware of Mary-Claire King's absurdly important discoveries on BRCA / inherited breast cancer but I had no idea that her first PhD paper (King & Wilson 1975, Science, not bad lol) is the "99% of protein coding shared btwn chimps and humans" result www.science.org/doi/abs/10.1... 312231
Reposted by Michal Galdzicki Chaitanya K. Joshi @chaitjo.bsky.social · 15/08/2025RosettaFold 3 is here! 🧬🚀 AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release! Congratulations @simonmathis.bsky.social and team!!! ❤️ bioRxiv preprint: www.biorxiv.org/content/10.1... 05418
Michal Galdzicki @mgaldzic.bsky.social · 27/04/2025Boltz-1 update Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training. www.biorxiv.org/content/10.1...biorxiv.orgBoltz-1: Democratizing Biomolecular Interaction ModelingUnderstanding biomolecular interactions is fundamental to advancing fields like drug discovery and protein design. In this paper, we introduce Boltz-1, an open-source deep learning model incorporating... 221
Reposted by Michal Galdzicki bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 07/04/2025BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design www.biorxiv.org/content/10.1101/202… 041
Reposted by Michal Galdzicki Jim Haseloff @jimhaseloff.bsky.social · 06/04/2025...where a powerful toy slingshot can be used to mount the LoRa node in a tree for better line-of-sight communications with other devices. www.instructables.com/Meshtastic-S... 072
Reposted by Michal Galdzicki Guilhem Faure @guilhemfaure.bsky.social · 28/02/2025🚀 Thrilled to share our latest work from Zhang Lab, now published in Science (www.science.org/doi/10.1126/...) We introduce TIGR-Tas, a PAM-free, compact, modular RNA-guided DNA-targeting system in prokaryotes & their viruses. More details coming soon 👀 #TIGR #RNA #GeneEditing #CRISPR 14312
Reposted by Michal Galdzicki bioRxiv Genomics @biorxiv-genomic.bsky.social · 24/02/2025Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology www.biorxiv.org/content/10.1101/202… 03619
Michal Galdzicki @mgaldzic.bsky.social · 01/02/2025Wait-a-minute 3 in 1 COVID, Flu A, and B tests are already available from Amazon. Is the RSV one coming? I missed the memo. a.co/d/4s5izkO 010
Reposted by Michal Galdzicki Phil Plait @philplait.bsky.social · 25/01/2025This is pretty cool: Scientists have isolated the gene that may be responsible for the reason grapefruit interferes with some meds. It's not the solution, but it's a start. I love grapefruit but it messes with one of my meds, so this makes me happy. www.scientificamerican.com/article/why-...scientificamerican.comWhy Grapefruit Interferes with Medication, and What to Do about ItCould gene editing produce a tasty citrus fruit that doesn’t interfere with prescription drugs? 3153494
Michal Galdzicki @mgaldzic.bsky.social · 25/01/2025Arzeda has been awarded DARPA funding to advance AI-driven protein design—even with limited data! We're pushing the boundaries to create next-gen proteins for national security, sustainability, and beyond. #AI #ProteinDesign www.prnewswire.com/news-release...prnewswire.comArzeda Awarded DARPA Funding to Advance AI-Driven Protein Design for National Security/PRNewswire/ -- Arzeda, the industry-leading Protein Design Company™, today announced it has been selected for an award from the Defense Advanced Research... 052
Michal Galdzicki @mgaldzic.bsky.social · 23/01/2025Speculative writeup and the webinar Feb 20 web.cvent.com/event/e77566...web.cvent.comWelcome - Introducing Sequencing By Expansion (SBX): A versatile, high-throughput single-molecule sequencing technology 000
Reposted by Michal Galdzicki Rob Carlson @robcarlson.bsky.social · 16/01/2025From the dependably insightful @aukehoekstra.bsky.social . 0195
Reposted by Michal Galdzicki Dietram A. Scheufele @dietram.bsky.social · 21/12/2024Our inability to reliably study algorithmic info ecosystems, and why it matters for #scicomm. Pre-publication version of our forthcoming PNAS piece led by Nicky Krause and Isabelle Freiling : osf.io/preprints/so... (a 🧵) 26524
Reposted by Michal Galdzicki Nick Tsergas @nicktsergas.ca · 28/11/2024You guys remember TweetDeck? Bluesky has it, and it's free. Check out 🔗 deck.blue by @gildaswise.com for a multi-column interface. 2/10 1831299
Reposted by Michal Galdzicki Howard Salis @hsalis.bsky.social · 02/12/2024NEW paper 🚨! We engineered TNT sensors in soil bacteria for long-term detection of explosive in natural soil, enabling geospatial detection of contaminated soil. This work (led by Erin Essington) included new sensors, circuits, modeling, & a 28-day testing workflow. 1/ www.nature.com/articles/s41...nature.comAn autonomous microbial sensor enables long-term detection of TNT explosive in natural soil - Nature CommunicationsEngineered microbes can detect harmful chemicals, but may not work well in complex environments. Here, the authors built microbial sensors for detection of TNT explosive and tested their response over... 67530
Michal Galdzicki @mgaldzic.bsky.social · 03/12/2024This is a really cool paper. They developed a reasonably robust circuit to generate patterns. 010
Reposted by Michal Galdzicki Jonathan Jacobs @bioinformer.bsky.social · 27/11/2024🧬🖥🧪 Here are some healthy reminders on just how much Illumina still dominates the #genomics space... 😐 7308
Reposted by Michal Galdzicki Jon Lim, FRCP PhD @drjonlim.bsky.social · 23/11/2024🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov 441197491
Reposted by Michal Galdzicki Gabriele Corso @gcorso.bsky.social · 17/11/2024Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread! 18610204
Reposted by Michal Galdzicki Hana Ayoob @hanaayoob.co.uk · 10/11/2024The infographic & some extra info here if anyone is interested www.compoundchem.com/2014/08/21/c...compoundchem.comCompound Interest: Why Doesn’t Honey Spoil? – The Chemistry of HoneyHoney is something of an oddity, in that, unlike most foods, it doesn’t spoil over time. In fact, the oldest known sample of honey, found in an Ancient Egyptian tomb and dated to approximatel… 0165
Reposted by Michal Galdzicki Roland Dunbrack 🏳️🌈 @rolanddunbrack.bsky.social · 09/11/2024Rumors are that they will release model and weights next week. 181
Reposted by Michal Galdzicki Rob Carlson @robcarlson.bsky.social · 08/11/2024Arzeda has now produced and sold 10 tons of ProSweet RebM™ stevia, a natural, zero-calorie sweetener, marking a major step forward in sustainable production for the food industry. #biosky www.businesswire.com/news/home/20...businesswire.comArzeda, Co-founded by Nobel Laureate David Baker, Drives Industry Innovation with Intelligent Protein Design Technology™ and Delivers Performance Products to Fortune 500 CompaniesArzeda, the leading industrial protein design company co-founded in 2009 by Nobel laureate and University of Washington School of Medicine biochemistr 052
Michal Galdzicki @mgaldzic.bsky.social · 08/11/2024Washington's Dream, plants! youtube.com/shorts/Mz-Er...youtube.comGreenhouse Nursery Trade Gallons Part 2YouTube video by Smith's Gardentown 000
Reposted by Michal Galdzicki Jay 🦋 @jay.bsky.team · 24/10/2024Bluesky has grown to 13M users in a year and a half — thank you all for choosing us! We’ve raised a $15M Series A to support our growth and continue to build an open social network that is designed around you, the user. 802501245
Reposted by Michal Galdzicki Axel Visel @axelvisel.bsky.social · 14/10/2024New preprint by @jgi.doe.gov's Leo Baumgart, Ronan O'Malley and many others Mapping binding sites of 360 TFs across 10 🌿Brassicaceae genomes. 1.1 million TF-target gene assignments in Arabidopsis thaliana alone! 032
Reposted by Michal Galdzicki bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 12/10/2024Design of a biomolecular adaptive controller to restore sustained periodic behavior www.biorxiv.org/content/10.1101/202… biorxiv.orgDesign of a biomolecular adaptive controller to restore sustained periodic behavior https://www.biorxiv.org/content/10.1101/2024.10.11.617962v1 Periodic behavior is a widespread biological phenomenon occurring across various spatiotemporal scal 011
Michal Galdzicki @mgaldzic.bsky.social · 06/10/2024Part 1 had me in stitches youtu.be/JYqfVE-fykk?... Part 2 great work youtu.be/VJ62EfUKI3w?...youtu.beWashington's Dream 2 - SNLYouTube video by Saturday Night Live 000
Michal Galdzicki @mgaldzic.bsky.social · 01/10/2024Marburg in Rwanda, 20 cases reported taarifa.rw/rwandas-heal...taarifa.rwRwanda’s Health Ministry Provides Update on Marburg Virus Outbreak: Six Dead, 20 Infected - Taarifa RwandaOn Sunday afternoon, the Ministry of Health in Rwanda held a press conference to update the public on the country’s first-ever outbreak of the Marburg virus. Health Minister Dr. Sabin Nsanzimana confi... 000
Reposted by Michal Galdzicki Sebastian S. Cocioba @atinygreencell.bsky.social · 20/09/2024Here are some useful links to my work. Please bookmark for easy access! 💚 Open Laboratory Notebook: tinyurl.com/ATGCFFE Open Data Repository: tinyurl.com/ATGCSWEET Web Store for Plasmids and Goodies: atinygreencell.com Binomica Labs GitHub: github.com/Binomica-Labs 4276
Michal Galdzicki @mgaldzic.bsky.social · 18/09/2024Bluesky now has over 10 million users, and I was #1,292,419! 000
Reposted by Michal Galdzicki Diego del Alamo @delalamo.xyz · 09/09/2024Another group has more or less reproduced AF3, but has built in a way to add spatial constraints for PPI prediction. These constraints lead to huge increases in fraction of models that are correct-ish, without changing fraction that is high-accuracy chaiassets.com/chai-1/paper... 196
Reposted by Michal Galdzicki Mike Young @mkeyoung.bsky.social · 07/08/2024🌍 We have just extracted a NEW global network of researchers and a global 100 scientist top ‘influencers’ on Bluesky. @lassehjorthmadsen.bsky.social and I show that scientists are in a series of distinct communities: mikeyoungacademy.dk/communities-... 😀 All 'likes' and reshares appreciated!mikeyoungacademy.dkCommunities of scientists are emerging on Bluesky - Mike Young AcademyGlobal network data: The ‘nicer’ alternative to X is fortifying its presence in fields that range from philosophy to chemistry, finance, and beyond. 18283118
Reposted by Michal Galdzicki Compound Interest | Chemistry infographics @compoundchem.com · 07/09/2024Forgot to add that, while Kekulé’s benzene structure has endured, some of his other structural depictions were less successful. For some reason, his “sausage formulae” never caught on… 071
Reposted by Michal Galdzicki bioRxivpreprint @biorxivpreprint.bsky.social · 04/08/2024Computational design of highly active de novo enzymes www.biorxiv.org/content/10.1101/202… biorxiv.orgComputational design of highly active de novo enzymes https://www.biorxiv.org/content/10.1101/2024.08.02.606416v1 Custom designed enzymes can further enhance the use of biocatalysts in industrial biotransformations 032
Reposted by Michal Galdzicki bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 02/08/2024Accelerated enzyme engineering by machine-learning guided cell-free expression www.biorxiv.org/content/10.1101/202… biorxiv.orgAccelerated enzyme engineering by machine-learning guided cell-free expression https://www.biorxiv.org/content/10.1101/2024.07.30.605672v1 Enzyme engineering is limited by the challenge of rapidly generating and using large datasets of seq 131
Reposted by Michal Galdzicki bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 24/07/2024Preventing plasmid multimer formation in commonly used synthetic biology plasmids www.biorxiv.org/content/10.1101/202… biorxiv.orgPreventing plasmid multimer formation in commonly used synthetic biology plasmids https://www.biorxiv.org/content/10.1101/2024.07.23.604805v1 Plasmids are an essential tool for basic research and biotechnology applications. To optimize plasmi 022
Michal Galdzicki @mgaldzic.bsky.social · 04/07/2024Happy 4th. Transglutaminase fact: they're used to improve the texture of hot dogs 000
Reposted by Michal Galdzicki worobey.bsky.social @worobey.bsky.social · 07/06/2024Hi all - I have a couple of positions open for lab management and research! Please pass this on to creative and enthusiastic folks who might be interested. (And repost if you don't mind.) Ability to learn/adapt more important than specific skills! Thanks so much. arizona.csod.com/ux/ats/caree...arizona.csod.comResearch Professional II (Multiple Positions)-Work independently on defined experiments (e.g., set up, scheduling, data acquisition) and report on the findings to the PI.-Have a general understan... 22529
Reposted by Michal Galdzicki bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 01/06/2024Induction of Meiosis from Human Pluripotent Stem Cells www.biorxiv.org/content/10.1101/202… biorxiv.orgInduction of Meiosis from Human Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2024.05.31.596483v1 An in vitro model of human meiosis would accelerate research into this important reproductive proces 001
Reposted by Michal Galdzicki worobey.bsky.social @worobey.bsky.social · 03/05/2024If you're interesting in the #H5N1 outbreak in cattle in the US, please have a look at our preliminary analyses just posted. Part 1 of 2: virological.org/t/preliminar... 37027
Reposted by Michal Galdzicki RCSB Protein Data Bank @rcsbpdb.bsky.social · 20/05/2024Bagheera helps Molecule of the Month author David Goodsell create his amazing illustrations. Can you guess which molecule Bagheera is in? #NationalPetMonth #PetsofRCSBPDB pdb101.rcsb.org/motm... 041
Reposted by Michal Galdzicki Daniel Bolnick @danielbolnick.bsky.social · 15/05/2024Excited for this live public event with the @bigbiology.bsky.social podcast, addressing ecological restoration in Alaskan Lakes! If you know someone in Alaska who might be interested, please share it with them! 054
Reposted by Michal Galdzicki bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 06/05/2024MAIA: An open-source, modular, bioreactor for cities www.biorxiv.org/content/10.1101/202… biorxiv.orgMAIA: An open-source, modular, bioreactor for cities https://www.biorxiv.org/content/10.1101/2024.05.03.592196v1 This work presents the design and fabrication of MAIA, an open-source, modular, low-cost, and portab 011
Reposted by Michal Galdzicki Elinne Becket, PhD @bielleogy.bsky.social · 20/03/2024And AFTER ALL THAT.... #BlueSoup isolate has 98.7 ANI with the Pseudomonas carnis genomes from the Marina De León & @phylogenomics.bsky.social paper jgenomics.com/v09p0055.htm 💀 99.2 ANI with P. NBRC 111137; still digging!jgenomics.comDraft Genome Sequences and Genomic Analysis for Pigment Production in Bacteria Isolated from Blue Discolored Soymilk and Tofu 1235
Reposted by Michal Galdzicki Torsten Wittmann @microtubule.bsky.social · 19/03/2024No videos here ... yet. So, here is a cute AlphaFold2 model of the mEmerald labelled nanocages that we used to determine that there are ~120 DCX molecules bound per µm growth cone microtubule🧪 doi.org/10.1101/2024... 1161
Michal Galdzicki @mgaldzic.bsky.social · 19/03/2024De novo design of antibody variable heavy chains (VHH's) using RF diffusion www.biorxiv.org/content/10.1...biorxiv.orgAtomically accurate de novo design of single-domain antibodiesbioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution 000
Reposted by Michal Galdzicki Rob Carlson @robcarlson.bsky.social · 15/03/2024Nice list of community science projects here. www.seattletimes.com/pacific-nw-m... 122
Michal Galdzicki @mgaldzic.bsky.social · 13/03/2024Trikafta changed CF from a death sentence to a treatable condition. It overcomes the deficit of a chloride channel caused by a specific inherited mutation in the CFTR gene, discovered in 1989, and only 30 years later this story was possible. How much quicker will this take these days?theatlantic.comThe Cystic-Fibrosis Breakthrough That Changed EverythingThe disease once guaranteed an early death—but a new treatment has given many patients a chance to live decades longer than expected. What do they do now? 000
Michal Galdzicki @mgaldzic.bsky.social · 06/02/2024@bioandbaseball.bsky.social any chance you could share that www.liebertpub.com/doi/10.1089/... paper PDF? 110
Reposted by Michal Galdzicki Rob Carlson @robcarlson.bsky.social · 07/01/2024Next, an editorial from the Seattle Times on restoring salmon streams. "The course is not cheap, but it is clear: The state must fix the culverts, using the best science possible." WA must stay the course on culvert removal to save salmon www.seattletimes.com/opinion/edit...seattletimes.comWA must stay the course on culvert removal to save salmon | EditorialThe Legislature should ensure that the state's efforts to remove culverts that block salmon runs are carried through. 132