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Howard Salis

@hsalis.bsky.social
1.2K followers 821 following 117 posts

Professor of synthetic biology, biological, & chemical engineering. De Novo DNA founder. Engineering microbes with predictive models & algorithms.

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Reposted by Howard Salis
Ákos T Kovács @evolvedbiofilm.bsky.social · 24/11/2025
Synthetic bacterial community colonizes wheat roots grown in soil and mimics the assembly pattern of a field community bioRxiv from @fredebak.bsky.social et al #NNF_INTERACT www.biorxiv.org/content/10.1...
biorxiv.org
Synthetic bacterial community colonizes wheat roots grown in soil and mimics the assembly pattern of a field community
The root microbiome is important for plant development. The impact of the root microbiome is the sum of multiple complex interactions among microorganisms, the plant and the environment. This complexi...
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Howard Salis @hsalis.bsky.social · 27/07/2025
Passing through Coralville, IA! Shout out to IDT!!
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capitolhunters @capitolhunters.bsky.social · 15/06/2025
It's an OK article but the tag line should be "Trump illegally cancels Northwestern's contracts and refuses to pay them", not "Trump blew up Northwestern's business model". If you hold up a bank at gunpoint and abscond with bags of money you're not "blowing up its business model". You're stealing.
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Howard Salis @hsalis.bsky.social · 21/03/2025
What a shitty time to run out.
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Jason Rasgon @vectorgen.bsky.social · 10/03/2025
As a Jew looking at the administration's sudden "concern" over University antisemitism
media.tenor.com
a woman in a plaid shirt says that 's bullshirt
ALT: a woman in a plaid shirt says that 's bullshirt
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 01/03/2025
In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n www.nature.com/articles/s41...
Title, authors and abstract from link
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Mark Hamill @markhamillofficial.bsky.social · 28/02/2025
Could not agree more. The Prez & VP are shameful, embarrassing Putin puppets & a disgrace to our country. 🤮 #SlavaUkraine 🇺🇦
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Joseph Fasano @josephfasano.bsky.social · 27/02/2025
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A.R. Moxon @juliusgoat.bsky.social · 20/02/2025
Normalize calling Republicans Nazis.
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Howard Salis @hsalis.bsky.social · 18/02/2025
Wowzers the SNL 50th anniversary special was truly fantastic and man did I need to laugh a bit to cleanse the soul after the last two weeks. My favorite bit: youtu.be/l8GbTZ8v1-w?... The whole Shebang is streaming on Peacock.
youtu.be
New York 50th Musical – SNL50
YouTube video by Saturday Night Live
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Reposted by Howard Salis
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 16/02/2025
Simultaneous in vitro expression of minimal 21 transfer RNAs by tRNA array method www.biorxiv.org/content/10.1101/202…
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Jeremy Berg @jeremymberg.bsky.social · 14/02/2025
I am hearing that about 1/2 of the ARPA-H staff were probationary and are being let go. Many of these folks are long-time NIHers who were promoted into new positions in ARPA-H and became probationary in these new positions despite many years of NIH service.
media.tenor.com
a man is standing in front of a mirror talking to another man and says `` my god you cannot be that stupid '' .
ALT: a man is standing in front of a mirror talking to another man and says `` my god you cannot be that stupid '' .
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Angel Goñi-Moreno @angelgm.eurosky.social · 14/02/2025
Today's the day! Getting ready for the workshop on #AI in #Biology. While these fields aren’t new (of course!), the intersection of the two is having a major moment right now.
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Shockratees @thatshockratees.bsky.social · 11/02/2025
Ok folks. Time for me to pull my law rank and correct some shit. When a judge issues a civil contempt order, she does not hand it to the prosecutor or AG and say “enforce this if you feel like it.” The judge hands it directly to a law enforcement officer, who has no discretion on whether to serve it
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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 14/02/2025
Thrilled to have @hsalis.bsky.social as the keynote speaker for today’s workshop on AI in Biology! After a prologue of intense discussions, he follows the tradition of every visitor by stepping onto Km 0 at Puerta del Sol—the geographical center of Spain & a place of significance for every Madrileño
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Josh Gerstein @joshgerstein.bsky.social · 11/02/2025
BREAKING: Federal judge in Boston broadens block on Trump's NIH grant 15% overhead limit (indirect cost rates) to all recipients nationwide. Doc: www.documentcloud.org/documents/25... #TROpalooza ain't done
documentcloud.org
AAMCOrd021025
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Howard Salis @hsalis.bsky.social · 09/02/2025
What if CA, MA, & other high-GDP states passed State Law to redirect all federal tax collection to a State bureau, which would only redirect taxes to the Fed if Federal Law wasn’t blatantly ignored (by vote of State legislature)? Another lever of “checks & balances” & a “soft secession” when needed
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Katie Howland @katiehowland.bsky.social · 09/02/2025
Buckle up babes, it's time for a long thread about #USAID. Many of you know I've worked on USAID contracts and in humanitarian aid for the last decade. But very few know why. I studied international security in undergrad and my first job out of school was in the defense/intel world. I hated it. 1/
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Library Innovation Lab @harvardlil.bsky.social · 06/02/2025
We just launched a 16TB archive of every dataset that has been available on data.gov since November. This will be updated day by day as new datasets appear. It can be freely copied, and we're sharing the code behind it to help others make their own archives of data they depend on.
lil.law.harvard.edu
Announcing the Data.gov Archive | Library Innovation Lab
Today we released our archive of data.gov on Source Cooperative. The 16TB collection includes over 311,000 datasets harvested during 2024 and 2025, a complet...
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Howard Salis @hsalis.bsky.social · 05/02/2025
OMG the troll that demands that the U.S. stay out of world affairs now wants *us* to OWN the most controversial land in the world. NO NO NO NO NO NO NO NO NO NO. Sure looks like Trump is a Russian asset. Is it Stupidity or Treason? If you can't tell ...
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Andy Fraser @andyfraser.bsky.social · 04/02/2025
Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection: rdcu.be/d8xLv (1/6)
rdcu.be
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing
Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.
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Lauren Bauer @laurenhlb.bsky.social · 03/02/2025
New and important: we built a federal expenditure tracker. All expenditure line items that are available on the Daily Treasury Statement. USAID was zeroed out on 1/28 and has been at zero ever since. www.hamiltonproject.org/data/trackin... #EconSky
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Justin Brower @naturespoisons.bsky.social · 03/02/2025
I won't be around for ToxTueday, so you'll have to settle for ToxMonday, instead. Today, I'm posting an experiment I did about 5 years ago with my old lab for some "team building." So what did we do? Look for drugs on money, of course! What did we find? Lots, but you'll have to keep reading:
Just a photo of a one-dollar bill.
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Howard Salis @hsalis.bsky.social · 03/02/2025
Bernie's party-wide email! (One of the few I actually read)
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Waggoner Lab @labwaggoner.bsky.social · 31/01/2025
Ribosomes cooperate through transient collisions to ensure efficient translation www.cell.com/cell/fulltex... @cellcellpress.bsky.social @marvintanenbaum.bsky.social
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Nucleic Acids Research @narjournal.bsky.social · 31/01/2025
Hello Everyone! 👋 Nucleic Acids Research is excited to be on Bluesky! Please follow us for the latest #Research, #Breakthrough articles, journal issues and more. Also, please consider adding us to your starter packs!
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Howard Salis @hsalis.bsky.social · 29/01/2025
Does Trump have the legal right to pause or stop federal programs because he doesn’t like them? Short answer: no. Congress passed the Impoundment Control Act to prevent presidents from doing exactly this (especially Nixon). www.nytimes.com/2025/01/28/u...
nytimes.com
Does Trump Have the Power to Block Spending That Congress Has Authorized?
The White House’s temporary pause on trillions in federal spending could set up a court fight over executive authority and Congress’s control of the purse.
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Jeremy Yoder says no war @jbyoder.org · 29/01/2025
Deleted, reposting to clarify: the NSF statement does not define "DEIA", I haven't used that term in the proposal for my current NSF project. I could guess what it means, but that's not my job. I would need to know what specific activities I'm not allowed to do before I change any plans.
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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 29/01/2025
Leveraging AI for Systems & Synthetic Biology 🤔? Learn about the latest developments in the upcoming annual Colloquium of our Sys Bio Department this Feb 14. Starring @hsalis.bsky.social as opening speaker and featuring @alfonsovalencia.bsky.social along with other luminaries in the field 😱!
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Howard Salis @hsalis.bsky.social · 29/01/2025
Wait until they process a modification to your statement of work. (They will never do this). Until then, point to your approved statement of work.
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Angel Goñi-Moreno @angelgm.eurosky.social · 28/01/2025
Looking forward to this timely workshop on #AI in #Biology at @cnb-csic.bsky.social (Feb 14)! Excited to hear from experts like @hsalis.bsky.social , @alfonsovalencia.bsky.social , @noeliaferruz.bsky.social , @pablocarb.bsky.social , and others. (Note: Won’t be streamed.) 🧬🤖 #Science #synbio
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Chris Greening @greening.bsky.social · 27/01/2025
Extensive new preprint with Ying Teng's lab on how carbon monoxide affects soil communities and activities. Contrary to popular belief, CO at biologically relevant concentrations mainly stimulates rather than inhibits growth. Diverse bacteria grow and fix CO2 with it. www.biorxiv.org/content/10.1...
biorxiv.org
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Jodi Ettenberg @legalnomads.com · 25/01/2025
Given that there’s a pause on FDA comms right now, it may be useful for Americans to sign up for Canadian recalls, since many products are sold in both countries. Eg fellow celiacs, this may clue you into products to watch out for on the US side too: recalls-rappels.canada.ca/en/subscribe
This image is a screenshot from the subscribe page of the recalls newsletter, sign up form from Health Canada
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Clayton Flesher @claytonflesher.bsky.social · 25/01/2025
If you’re enjoying this, some of the best sci-fi I’ve ever experienced is being written by @mikeduncan.bsky.social over on the Revolutions podcast right now on the Martian revolution.
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noam @prywes.bsky.social · 22/01/2025
Fun to see it out in print! I was really lucky to have an amazing team to work with on this. If this sort of work seems interesting to you or someone you know, please feel free to reach out (planning to staff a lab later this year). www.nature.com/articles/s41...
nature.com
A map of the rubisco biochemical landscape - Nature
A massively parallel assay developed to map the essential photosynthetic enzyme rubisco showed that non-trivial biochemical changes and improvements in CO2 affinity are possible, signposting further e...
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Jeremy Berg @jeremymberg.bsky.social · 21/01/2025
Bluetorial-A dream and a bit of a nightmare Serving as Editor-in-Chief at Science was fascinating. I greatly enjoyed working with talented and committed editorial, news, graphics, and production staff. But the inside look into scientific publishing and AAAS was also deeply disillusioning.
media.tenor.com
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
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Howard Salis @hsalis.bsky.social · 21/01/2025
OK, so in honor of MLK jr, what are some modern ways to practice non-violent protest for the 21st century? I'll start: what happens if 20 million people stop paying federal income tax?
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Jonathan Eisen @phylogenomics.bsky.social · 20/01/2025
www.haaretz.com/israel-news/...
haaretz.com
Elon Musk appears to make fascist salute at Trump inauguration rally
***
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The Resister Linda Cardwell 🦋💙 @cardwell4u.bsky.social · 20/01/2025
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Howard Salis @hsalis.bsky.social · 18/01/2025
Q for all the genetic circuit engineers (SynBio peeps) out there: I'm looking for examples of genetic circuits with many layers. A layer here is where an "upstream" regulator regulates the expression of a "downstream" regulator. Could also be "longest path" from input to output. Ty in advance!
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Diego del Alamo @delalamo.xyz · 18/01/2025
FYI the designed esmGFP is 58% identical to the most similar extant GFP sequence - hence "500 million years of evolution" - but nearly half of the novelty (the 42% unaligned part of the seq) is derived from one other protein. Originally caught by @btnaughton.bsky.social, source link in alt text
Alignment showing how two extant sequences account for 74% of the sequence of esmGFP
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U.S. Consumer Product Safety Commission @cpsc.gov · 16/01/2025
If you've recently purchased a portable generator due to power outages caused by the LA fires, remember to keep it outdoors at least 20ft away from your home and make sure your carbon monoxide (CO) alarms are working. 1 generator can produce as much CO as hundreds of cars and CO can kill in minutes.
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Erik van Nimwegen @erikvannimwegen.bsky.social · 15/01/2025
What do bacterial cells do when they run out of nutrients? Although most bacterial studies focus on cells in exponentially growing states, in the wild bacteria likely spend most of their time slowly starving to death. 1/n www.biorxiv.org/content/10.1...
biorxiv.org
E. coli prepares for starvation by dramatically remodeling its proteome in the first hours after loss of nutrients
It is widely believed that due to nutrient limitations in natural environments, bacteria spend most of their life in non-growing states. However, very little is known about how bacteria change their p...
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Lingchong You @lingchongyou.bsky.social · 13/01/2025
1/ Hello BlueSky world -- my first post is about a new study from the lab, just published in @nchembio.bsky.social. We demonstrate how population-level gene regulation can be dynamically controlled and amplified using programmable gene transfer. Link to paper: doi.org/10.1038/s415...
doi.org
Population-level amplification of gene regulation by programmable gene transfer - Nature Chemical Biology
Gene regulation in engineered microbial populations is often tuned at individual cell levels. Now, a population-wide amplification system has been devised that expands the dynamic range of plasmid tra...
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Aditya Kunjapur @kunjapur.bsky.social · 09/01/2025
And the MASBN Symposium is now in full swing as Sherry Gao from UPenn kicks us off
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Aditya Kunjapur @kunjapur.bsky.social · 09/01/2025
In our New to the Mid Atlantic session, we're pleased to have Ophelia Venturelli tell us about multi-scale dynamics in gut microbial communities @oventurelli2.bsky.social #MASBN #synbio
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Aditya Kunjapur @kunjapur.bsky.social · 09/01/2025
Next up at MASBN is @victoriagmuir.bsky.social , my new colleague at @udelaware.bsky.social who is studying how cells navigate complex environments and host-pathogen interactions #MASBN #synbio
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Aditya Kunjapur @kunjapur.bsky.social · 09/01/2025
We're excited to hear about electromicrobiology from @electromicrobe.bsky.social who recently started his lab @princetonupress.bsky.social #MASBN #synbio
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Aditya Kunjapur @kunjapur.bsky.social · 09/01/2025
Our last speaker in the New to the Mid Atlantic session at this year's #MASBN symposium is @saramol.bsky.social who recently started her lab at U. Maryland. Cool results on asymmetric cell division for patterning #synbio
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Evgeny Kvon @evgenykvon.bsky.social · 03/01/2025
What’s currently the best computational tool for predicting mammalian promoters from DNA sequence alone?
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