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Jonathan Jacobs

@bioinformer.bsky.social
3K followers 1.1K following 671 posts

UofArizona #Aggie > UofMaryland PhD > NIH/NCI PostDoc > > > ATCC #Genomics, #Bioinformatics, Data Authenticity, #BioSecurity. 🎲♟️👾🎮 🎸 🧪 🧬 🖥 🦠🚀🏎️ he/him. bioinformer.substack.com

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Reposted by Jonathan Jacobs
Jonathan Jacobs @bioinformer.bsky.social · 24/09/2026
ATCC Genome Portal Q3 2026 Release out Monday! genomes.atcc.org previews... New genome assemblies: 207 bacterial, 24 fungal, 15 viral. Plus new RNAseq datasets for 51 human cell lines and organoids (255 total samples, typically N=5 per line) #genomics #bioinformatics #aixbio #referencedata #NGS
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Jonathan Jacobs @bioinformer.bsky.social · 29/09/2026
Well - at least we still have a edge for a little while longer...
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Jonathan Jacobs @bioinformer.bsky.social · 24/09/2026
ATCC Genome Portal Q3 2026 Release out Monday! genomes.atcc.org previews... New genome assemblies: 207 bacterial, 24 fungal, 15 viral. Plus new RNAseq datasets for 51 human cell lines and organoids (255 total samples, typically N=5 per line) #genomics #bioinformatics #aixbio #referencedata #NGS
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Magdalena Skipper @magdalenaskipper.bsky.social · 20/08/2026
Exclusive: NSF set to issue lowest number of new grants in four decades www.nature.com/articles/d41... 🧪 #AcademicSky @nature.com
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Jeff Dillon Fine Art @jeffdillonfineart.bsky.social · 07/07/2026
My name is Jeff Dillon and I'm a Canadian landscape painter. This is my art and I'd love to hear what you think. Jeff #art
My name is Jeff Dillon and I'm a Canadian landscape painter. This is my art and I'd love to hear what you think. 
Jeff
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Jonathan Jacobs @bioinformer.bsky.social · 12/06/2026
I can not believe this is a legitimate journal… And if you haven’t looked into the fast paced and growing field of necrobots… please do. And please stick to the PEER REVIEWED papers only.
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Jonathan Jacobs @bioinformer.bsky.social · 12/06/2026
Seems I’ve caught the writing bug. This is sort of follow up to my first SubStack post last week. Please take a look, repost and restack as well. Thank you!🙏 open.substack.com/pub/bioinfor...
open.substack.com
Reproducible Does Not Mean Correct
Reproducible Wrongness: When Genomics Gets the Same Answer for the Wrong Reason
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Jonathan Jacobs @bioinformer.bsky.social · 08/06/2026
I just started a Substack! If you're into #genomics #bioinformatics and #AIxBio topics - please subscribe. Especially if you want to follow topics around data quality, authenticity and traceability - which are my jam. 😊 bioinformer.substack.com?r=3xrm83&utm...
bioinformer.substack.com
Jonathan Jacobs | Substack
Authenticity and data provenance in #genomics & #bioinformatics. Also #scicom, #gaming #DnD #EDM #punk @ Home 🧘🏼‍♂️🐕🏕️🏃♟👾🎮 🎸he/him. Click to read Jonathan Jacobs on Substack. Launched 2 days ago.
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Jonathan Jacobs @bioinformer.bsky.social · 07/06/2026
If you’re attending #ASMicrobe today and the #metadata / #microbiome dark matter session - you may be interested in my recent Substack article and preprint on this broad issue across all of #genomics open.substack.com/pub/bioinfor... interested? Send me a DM and let’s chat!
open.substack.com
Metadata as Infrastructure
Genomics data provenance and quality are something we can't ignore anymore
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Reposted by Jonathan Jacobs
Jonathan Jacobs @bioinformer.bsky.social · 06/06/2026
Metadata as Infrastructure. I finally created a Substack! My first post is on a topic that I probably spend entirely too much time worrying about. 😊 please reshare with your #genomics and #bioinformatics peeps! 🙏 🧬🦠🔬📊🧫🚀 substack.com/home/post/p-... #ASMicrobe #digitalbiology #biotech #biopharma
substack.com
Metadata as Infrastructure
Genomics data provenance and quality are something we can't ignore anymore
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Jonathan Jacobs @bioinformer.bsky.social · 06/06/2026
Join ATCC’s Industry & Science Showcase today at the #ASMMicrobe conference and enjoy lunch on us while you learn. Discover how ATCC is supporting scientists in the fight against antimicrobial resistance with trusted strains and robust genomic resources. ow.ly/iv0950Z80wg
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Jonathan Jacobs @bioinformer.bsky.social · 06/06/2026
Metadata as Infrastructure. I finally created a Substack! My first post is on a topic that I probably spend entirely too much time worrying about. 😊 please reshare with your #genomics and #bioinformatics peeps! 🙏 🧬🦠🔬📊🧫🚀 substack.com/home/post/p-... #ASMicrobe #digitalbiology #biotech #biopharma
substack.com
Metadata as Infrastructure
Genomics data provenance and quality are something we can't ignore anymore
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Jonathan Jacobs @bioinformer.bsky.social · 06/06/2026
Hey #genomics and #bioinformatics community: I need an "endorsement" in order to submit a preprint to @arxiv.bsky.social 😭 I'm registered, but can't submit our preprint to q-bio\GN (Genomics) section until we get an endorsement from an existing arXiv author w/endorse privileges. that you? plz DM me🙏
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Kaz Windness she/her @kazwindness.bsky.social · 05/06/2026
Make art with your hands. It’s what humans do. #noAI #artistssupportingartists #humanart
A graphic by author illustrator Kaz Windness that says make art with your human hands. And shows colorful hand outlines pressed up against the wall with colorful splatters behind them, reminiscent of hands in caves.
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Jonathan Jacobs @bioinformer.bsky.social · 05/06/2026
“Every hour you spend confused is an hour spend building the infrastructure inside your own head that will eventually let you do original work,”… [by using AI tools]… “you haven’t saved time. You’ve forfeited the experience that the time was supposed to give you.” @minaskar.bsky.social
science.org
Amid a flood of AI advances, astrophysicists are questioning the soul of their field
Researchers see enormous power in new tools—but also the potential end of astrophysics as a human endeavor
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Jonathan Jacobs @bioinformer.bsky.social · 05/06/2026
This is a thought provoking metaphysical piece that pulls at the strings of why we care so much (or don’t) as to whether AI can be better at everything than we can be. Absolutely love this. Thanks @aaas.org @science.org 🥰
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Reposted by Jonathan Jacobs
Jonathan Jacobs @bioinformer.bsky.social · 21/06/2025
#ASMicrobe Gold. These are all great people.
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Scott V. Nguyen @scottnguyen.bsky.social · 05/06/2026
What if waste could become a resource? Join Dr. Ryan Bing as he explores how engineered microbes can transform waste feedstocks into valuable compounds. Looking forward to moderating this session! #ASMMicrobe @bioinformer.bsky.social
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Stephen Turner @stephenturner.us · 05/06/2026
Biodefense in the Intelligence Age: openai.com/index/biodef... PDF: cdn.openai.com/pdf/biodefen...
openai.com
Biodefense in the Intelligence Age
An action plan for AI-powered biological resilience
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Reposted by Jonathan Jacobs
Stephen Turner @stephenturner.us · 05/06/2026
Developing a standard definition for sequences of concern: www.frontiersin.org/journals/bio...
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Jonathan Jacobs @bioinformer.bsky.social · 05/06/2026
#ASMicrobe rumors: attendees climbed out the window of a rooftop bar to retrieve someone’s backpack that had fallen out the window onto a lower rooftop. @tallcuppajoe.bsky.social ?
static.klipy.com
Nick Fury: I Will Neither Confirm Nor Deny
ALT: Nick Fury: I Will Neither Confirm Nor Deny
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Jonathan Jacobs @bioinformer.bsky.social · 04/06/2026
#asmicrobe 🧐🤩
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Jonathan Jacobs @bioinformer.bsky.social · 04/06/2026
#ASMicrobe kicking off with the right message.
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Reposted by Jonathan Jacobs
Dr Jamie Gallagher @jamiebgall.co.uk · 02/06/2026
It’s Pride 🏳️‍🌈 Spare one repost for a small creator? 🥺 My science and sci fi pins raise money for homeless LGBTQ+ people. Just sent another £800 to @aktcharity.bsky.social bringing total to £47,521 New for Pride 2026: 🌈Scientist🌈 🏳️‍🌈🐥🦜🦅🏳️‍🌈 🌈pronouns🌈 www.jamiebgall.co.uk/shop
Pin badge “scientist” in rainbow motif Two bird pins. A series if birds sitting on a branch. Each bird is the colour of a stripe on the rainbow flag. Pronoun pins with rainbow motif:
She her 
He him 
She they 
He they 
They them An array of pride themed science and sci fi pins.
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Reposted by Jonathan Jacobs
Stephen Turner @stephenturner.us · 02/06/2026
Once upon a time I was falling in love, but now I'm only falling apart 🎵 The total eclipse of bioinformatics: From disruption to convention, and a gentle warning journals.plos.org/ploscompbiol...
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Jonathan Jacobs @bioinformer.bsky.social · 29/05/2026
I finally forked up the money to buy an original hardback version of S. Ohno’s infamous 1970 “Evolution by Gene Duplication” it’s wonderful. And I was super surprised and happy to find it had a page torn out of its book review in Science from 1972. 🤩
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Reposted by Jonathan Jacobs
Binning Singletons @binningsingletons.com · 28/05/2026
It’s exciting to go to @asm.org #ASMicrobe but it can be intimidating if it’s your first time or you are alone (and even if you’re not!). We help you have a great meeting through our grassroots peer mentoring program. Join today! 🔬 🧪 🦠 #MicroSky #AMR binningsingletons.com/singleton/bi...
Distracted girlfriend meme. She’s wearing a name tag that says “Hello my name is Solo and 1st time attendees.” She’s checking out Binning Singletons while her guy, wearing a tag that says “Attending ASMicrobe without binsing”, is upset
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Reposted by Jonathan Jacobs
Frank Figliuzzi @frankfigliuzzi.bsky.social · 23/05/2026
While we slept the DOJ deleted all press releases about charges against January 6 defendants: www.nbcnews.com/politics/jus...
nbcnews.com
Justice Department deletes press releases on charges against Jan. 6 rioters
The Justice Department confirmed that it had deleted the press releases as part of “stripping DOJ’s website of partisan propaganda.”
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James McInerney @jomcinerney.bsky.social · 11/05/2026
Paper: doi.org/10.64898/202... Code: github.com/mol-evol/pan... Pushback and alternative readings very welcome.
doi.org
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Ida Bae Wells @nhannahjones.bsky.social · 29/04/2026
None of us take pleasure in being right: But we are in the Second Nadir. www.nytimes.com/2025/06/27/m...
nytimes.com
How Trump Upended 60 Years of Civil Rights in Two Months
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J. Craig Venter Institute @jcvi.org · 30/04/2026
It is with great sadness that we announce J. Craig Venter has died. 🧪🧬 www.jcvi.org/media-center...
jcvi.org
J. Craig Venter, genomics pioneer and founder of JCVI and Diploid Genomics, Inc., dies at 79
La Jolla, California—April 29, 2026—The J. Craig Venter Institute (JCVI) announced that J. Craig Venter, Ph.D., the Institute’s founder, board...
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Jasmine 🌌🔭 @astrojaz.bsky.social · 27/04/2026
i feel like society moved on from these too quickly
A solar eclipse, captured from a camera mounted on one of the Orion spacecraft\u2019s solar array wings during the Artemis II crew\u2019s flyby of the Moon\u2019s far side. The Moon is dark, save for a bright halo of white light surrounding it. The Orion spacecraft is in the leftmost half of the image, mostly shadowed.The Moon and crescent Earth from Artemis IIA crescent Earth setting behind the Moon\u2019s horizon. Credit: NASAA full disk image of Earth, as seen from the Orion capsule. The planet is a pale blue, swirling with white clouds and glowing slightly lighter blue in place from reflected light. From about 8 to 9 o'clock, a large brown landmass is Africa, with the Iberian peninsula twinkling with lights just where the planet curves. At the 1 o'clock spot, aurora glow in a thin green glow, just barely separated from the planet's surface. Earth is set against the black of space. Credit: NASA/Reid Wiseman
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Kenneth Loi @kenjmloi.bsky.social · 27/04/2026
This work was co-led by myself and Peter Yoon. Structure was led by Peter, @terryzzy.bsky.social , and Trevor Docter. Many thanks to our intrepid collaborators and special thanks to Jennifer for supporting us through this project. www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...
biorxiv.org
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Jonathan Jacobs @bioinformer.bsky.social · 28/04/2026
When life imitates art
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Jonathan Jacobs @bioinformer.bsky.social · 27/04/2026
A “country of geniuses in a datacenter.” - @darioamodei.bsky.social (rereading this essay and it hits different even a few months later.. www.darioamodei.com/essay/the-ad... )
darioamodei.com
Dario Amodei — The Adolescence of Technology
Confronting and Overcoming the Risks of Powerful AI
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Jonathan Jacobs @bioinformer.bsky.social · 27/04/2026
internal discussion about the shoddy job most publications do in describing their bioinformatics methods... and one of my team members replied with this... LMAO.. (used with permission)... so true. 💀
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Jonathan Jacobs @bioinformer.bsky.social · 26/04/2026
Metadata as infrastructure Curation as design requirements not afterthoughts Reference materials as validation and benchmarking requirements This has to be the way moving forward
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Pat Schloss @patschloss.bsky.social · 26/04/2026
I never got to meet Woese, but Ford and Pace have been fantastic to me. Regardless of whether people agree with them, they are/were deep thinkers. No shade to anyone of my generation or the next, but I'm not sure who is similarly gifted.
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Jonathan Jacobs @bioinformer.bsky.social · 22/04/2026
About to submit a 10k word manuscript with ... zero figures. I'm pretty stoked about this body of work too. Several months of writing between everything else, but courtesy reviews by colleagues have been very positive despite my concerns about our attention span deficient era of social media.
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Jonathan Jacobs @bioinformer.bsky.social · 22/04/2026
Fun fact: “not a single person on the Wright Brothers team had a college education. They also had zero funding except their own money from their bicycle shop” They were OG hackers.
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Adam Phillippy @aphillippy.bsky.social · 20/04/2026
Friday was my last day at NHGRI. After 10 wonderful years, my lab is headed to Johns Hopkins University genomeinformatics.github.io/movingday/
genomeinformatics.github.io
We're moving!
Friday was my last day at NHGRI. After 10 wonderful years, my lab is headed one hour north on I-95 to set up shop at Johns Hopkins University. This is a very bittersweet move for me, as NHGRI has prov...
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Jo Rhodes @drjorhodes.com · 18/04/2026
Post the best photo you’ve ever taken of your pet
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Jonathan Jacobs @bioinformer.bsky.social · 18/04/2026
Post the best picture you have ever taken of of your pet
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Jonathan Jacobs @bioinformer.bsky.social · 13/04/2026
Scientific reproducibility, data provenance, metadata gaps are critical issues that are hampering AIxBIO advancements - especially in the ‘Omics space. If you missed my recent talk on this, plz check it out over @labroots.bsky.social www.labroots.com/webinar/repr... #genomics #bioinformatics
labroots.com
Reproducible Science in the Digital Age
Leveraging Authentic Data for Life Science Breakthroughs. Reproducibility is one of the most urgent challenges in life science research. Irreproducible results are often driven by unauthenti
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Jonathan Jacobs @bioinformer.bsky.social · 17/04/2026
I love this so much... and... it's things like this that make the voices in my head go "NERRRRDDDD!!!" 🤣 (for context - this is the W3C provenance model, PROV-DM. If you love this sort of thing... dive in! www.w3.org/TR/prov-dm/)
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Jonathan Jacobs @bioinformer.bsky.social · 16/04/2026
So i had a penchant for making 1 off limited run tshirts for “conference season”. It seems like each year things kind of get ratcheted up a notch too in terms of snark 🫣😂 So… question for the #microbiome #genomics #bioinformatics community… should I get these made? Would you want one?
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Elisabeth Bik @elisabethbik.bsky.social · 13/04/2026
I will be participating!
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Artologica aka Michele Banks @artologica.net · 13/04/2026
Here's another cool one for tree fans artologica.etsy.com/listing/4409... #sciart
Watercolor painting with blue and red dots arranged in a roughly circular pattern
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Artologica aka Michele Banks @artologica.net · 12/04/2026
Xylem Vessel, watercolor on cradled wood panel, ready to hang #sciart artologica.etsy.com/listing/4441...
Painting with blue and red blobsPainting with blue and red blobs seen from the side
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