Release Notes Colored builds use far less memory at low and moderate thread counts. On 149,998 Salmonella assemblies at 16 threads, peak RSS falls from 22.4 GB to 8.9 GB (C++ Cuttlefish 3: 11.5 GB...

How to use dplyr-style slice operations on omics data objects in the tidyomics project.

Unmeasured confounding threatens causal inference and replicability in observational multi-omic studies across variable environments. Genetic instrumental variables (Mendelian randomization) and negat...

How functional protein sequences are distributed in sequence space is fundamentally important for evolutionary theory and protein design, particula...

Uzhhorod, 11 - 25 July 2026: the fourth edition

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

This release includes several security-oriented fixes, in addition to a couple quality of life improvements for multi-user and multi-session workspaces: The server now chooses its R session at too...

The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucl...

Silhouette score is unsuitable as a metric for single-cell data integration.

Nature Methods - EviAnn surpasses existing genome annotation methods by leveraging gene expression and protein sequence homology evidence to achieve higher accuracy and efficiency.

Type 2 diabetes (T2D) arises from genetic susceptibility and chronic metabolic stress, but whether these converge on shared molecular programs in human populations remains unclear. Here, we develop a ...

Air 0.10.0 is here! This release rounds up everything new since 0.8.2: a new `assignment-style` option, tighter Positron and RStudio integrations, installation via uv and friends, pre-commit support, ...

Unexpected shift in funds has meant sharp drop in grants this fiscal year

Long-read sequencing technologies can directly profile methylation modifications across the genome. In this Review, Fu et al. overview the long-read computational tools to identify and compare methyla...

Author summary Over 90% of human genetic variants associated with human traits and diseases lie in non-coding regions of the genome, making it difficult to interpret the mechanisms by which these vari...

Colocalisation is a powerful approach to assess if two genetic association signals are likely to share a causal variant. However, association analyses in large biobanks and molecular quantitative trai...

Long-read sequencing, paralog-aware variant calling, and telomere-to-telomere (T2T) human genome assemblies now enable the resolution of copy-, haplotype-, and nucleotide-level complexities in segment...

4.0.0 (2026-06-12) ⚠ BREAKING CHANGES Replace anyhow with typed thiserror errors (#674) Change Phase conversion methods to use TryFrom for better error handling (#625) for pairwise alignment, only...

A rust framework to make using alevin-fry even simpler - COMBINE-lab/simpleaf

More about what it does (maybe more than one line). Continuation lines should be indented.