Karl Deisseroth, Peter Hegemann and George Nagel receive the prize for their work on light-gated ion channels and optogenetics

Karl Deisseroth, Peter Hegemann and Georg Nagel were recognized for their work on light-gated ion channels and optogenetics, a technique that uses tiny lights to activate neurons in the brain.

The photobiologist explains how careful manipulation of light has revealed a path to better understand how the brain works

Cell Press article: mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity

The CD1 system responds to lipids, not proteins, driving reactions to bee stings, bacteria, and possibly poison ivy

Nature - There is growing concern that AI can blunt memory and reasoning. But science shows ways to keep the brain sharp.

Nature - AI predictions could help with pandemic preparedness, but they will need experimental confirmation.

Use of e-cigarettes makes it more likely that young people will experience mental-health disorders and take up smoking. Governments must act.

ZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and its deletion boosts effector-like states and markedly enhances antiviral and antitumour immunity.

Researchers are trying everything they can to help coral reefs to survive severe heat stress from climate change, including playing sounds underwater.

Metastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this amino acid, thus promoting tumour growth and survival.

Analysis of cancer growing adjacent to the brain reveals that bone-eroding cells interfere with lymphatic drainage vessels and hinder anti-tumour immune responses.

Ageing reflects progressive decanalization of mammalian cell identity, driven by erosion of a regulatory grammar written during development.

Tissue-resident γδ T cells mount rapid, innate-like stress responses that require γδ T cell receptor signalling, revealing lineage-specific receptor dependence that underpins their conserved roles in immunosurveillance and informs therapeutic deployment.

‘Agentic’, ‘prompt engineering’ and other technical terms are among the 1,400 entries added to Merriam-Webster’s online catalogue.

Osteoclast-derived angiopoietin-2 in the dura mater impairs lymphatic vessel function and weakens anti-tumour immunity against dural metastases, which offers new therapeutic approaches to restore meningeal lymphatic function through selective osteoclast targeting.

In Nature, Desharnais et al. show that in diverse mouse models, anti-PD-1 sensitivity is more closely linked to diet-microbiome-metabolite ecosystem than to obesity-associated metabolic dysfunction. Their findings reinforce body mass index (BMI) as an incomplete proxy for host biology and suggest strategies to improve anti-PD-1 efficacy without inducing obesity.

Take Nature’s quiz on female Nobel laureates in physics, chemistry or physiology or medicine.

T cell receptor (TCR) engagement stimulates formation of a biomolecular condensate, including the scaffold protein linker of activated T cells (LAT). We investigated whether the immune-inhibitory rece...

ALT: Pinocchio's Nose Grows After a Lie

Nature Reviews Cancer, Published online: 02 October 2026; doi:10.1038/s41568-026-00987-zIn a recent study, Chramiec, Baldassarri, Öztürk et al. develop a vascularized human multi-tissue platform that captures organ-specific metastatic colonization, microenvironmental remodelling and tumour-cell adaptation, offering a configurable system for modelling metastatic progression.

Currently, this book is exclusive to Kindle Unlimited and available in ebook on Amazon. The paperback is available at your favorite bookstore.    Amazon E-Book Audiobook Audible Audiobook All Retailer...

The dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selec...

Nature Structural & Molecular Biology, Published online: 30 September 2026; doi:10.1038/s41594-026-01877-6Koenig et al. present a phosphoproteome atlas of 33 human cell lines covering >200,000 phosphosites, advancing cellular kinase activity scoring and drug sensitivity prediction, providing a resource for cell signaling insights and precision oncology.

npj Quantum Information - Practical blueprint for low-depth photonic quantum computing with quantum dots

ALT: Slap In The Face Scene

Winning Nia by Morgana Bevan — He’s a second chance wrapped in muscle and black ink — too bad I’ve never believed in second chances. Second Chance, Exes…

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This materials scientist creates garments that can change color, filter pollutants, or detect explosives

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Mechanisms by which primary tumor cells acquire metastatic capability through metabolic and signaling adaptations are currently poorly understood. We demonstrate that tumor-intrinsic ceramide metaboli...

Metastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this amino acid, thus promoting tumour growth a...