Fulya Alkan @fulyaalkan.bsky.social · 06/06/2025#academia Hi! So question is When will I stop cleaning after my colleagues mess, fix their mistakes and re-do their job due to laziness in the #lab because I need that? not mentioning loss of time and effort which I have to spent for my work instead… 000
Reposted by Fulya Alkanimmunoboys @immunoboys.bsky.social · 26/04/2025Jobin et al discover a second priming phase of CD8/DC interaction in the subfollicular LN area. CXCR3+ high-affinity CD8s can get IL-2 from "stop-and-go" moving CD4+ TCs, inducing affinity selection while Tregs mop up IL-2. in 🐭 @science.org 🧪⑂ 1/2 www.science.org/doi/10.1126/... 1104
Fulya Alkan @fulyaalkan.bsky.social · 29/04/2025Cancel the poster session 🫠 #CanineSupport @theaacr.bsky.social #aacr2025 041
Fulya Alkan @fulyaalkan.bsky.social · 28/04/20252025 Next Gen Star Awarded Dr. Anniina Färkkilä on todays’s Major symposium about spatial mapping of #Tumor ecosystem before/after neoadjuvant treatment to be used in favor of anti-tumor immunity in #ovariancancer (in the future, other cancers!) #aacr2025 @theaacr.bsky.social @afarkkila.bsky.social 010
Fulya Alkan @fulyaalkan.bsky.social · 28/04/2025Tonight at the #AACR2025 stage ! The Checkpoints! @patrickhwumd.bsky.social @jasonlukemd.bsky.social @theaacr.bsky.social 060
Fulya Alkan @fulyaalkan.bsky.social · 27/04/2025@johannajoyce.bsky.social giving a wonderful presentation about she and her team’s successful discoveries on immunosuppressive myeloid cell infiltration and their contribution to recurrence and progression of brain tumors and at the #aacr2025 Plenary Session 1166
Fulya Alkan @fulyaalkan.bsky.social · 26/04/2025Great speech by the Head of Breast Cancer Group , Dr. Giampaolo Bianchini from San Raffaele Scientific Institute,Milan, Italy on early TNBC biomarker detection! #aacr2025 #breastcancer #tnbc #earlydetection 000
Fulya Alkan @fulyaalkan.bsky.social · 26/04/2025Can we track them back to the stemness in order to detect cancer in their “pre-cancerous” state? Dr. Ken Lau answers tese questions #Aacr2025 #cancer #detection #earlydetection 000
Fulya Alkan @fulyaalkan.bsky.social · 25/04/2025Hall run officially started! Put your running shoes #aacr2025 @ 000
Fulya Alkan @fulyaalkan.bsky.social · 25/04/2025Ready for #AACR2025 This year, just 4 hours of driving : ) 000
Reposted by Fulya AlkanJournal of Experimental Medicine @jem.org · 24/04/2025This review by @yibinkang.bsky.social et al. integrates key clinical, genetic, & pharmacologic data to suggest human disease settings where retinoic acid nuclear signaling plays a pathogenic role. rupress.org/jem/article/... 📘 In JEM #Cancer Collection rupress.org/jem/collecti... #AACR25 021
Fulya Alkan @fulyaalkan.bsky.social · 24/04/2025Surprisingly, some LEP gene mutations tied to obesity may reduce body weight by enhancing leptin function. A reminder that biology is rarely black and white. www.nature.com/articles/s42...nature.comHepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice - Nature MetabolismIn Drosophila and mouse models of cancer cachexia, Liu et al. show that tumour-derived cytokines induce hepatic gluconeogenesis, which in turn leads to dysregulation of metabolism and drives cancer cachexia. 000
Reposted by Fulya AlkanWaggoner Lab @labwaggoner.bsky.social · 23/04/2025OMIP-114: A 36-Color Spectral Flow Cytometry Panel for Detailed Analysis of T Cell Activation and Regulation in Small Human Blood Volumes onlinelibrary.wiley.com/doi/full/10.... 0193
Reposted by Fulya AlkanJohn Lukens @lukensjohnr.bsky.social · 09/04/2025Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease @nature.com www.nature.com/articles/s41... 0155
Fulya Alkan @fulyaalkan.bsky.social · 15/04/2025🧠 Researchers created a single-cell atlas of brain metastases from various cancers, uncovering unique tumor-immune landscapes and microenvironmental niches. This comprehensive map offers insights for developing targeted treatments: www.cell.com/cancer-cell/... #CancerResearch #BrainMetastasiscell.comPan-cancer human brain metastases atlas at single-cell resolutionXing et al. construct a comprehensive pan-cancer human brain metastasis (BrM) atlas at single-cell resolution, uncovering five major BrM ecotypes associated with distinct phenotypic characteristics. T... 000
Fulya Alkan @fulyaalkan.bsky.social · 13/04/2025CD8 T cell priming involves two phases: initial activation by dendritic cells, followed by a second phase where T cells re-cluster with DCs and receive IL-2 from CD4 T cells. This discovery could inform better immunotherapy strategies. www.science.org/doi/10.1126/... #Immunology #TCellsscience.orgA distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signalsT cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their diff... 021
Fulya Alkan @fulyaalkan.bsky.social · 12/04/2025In #CancerCachexia, a brain-immune circuit in the area postrema links inflammation to apathy & low motivation. This explains how inflammation triggers loss of appetite & weight loss, pointing to possible new treatments. www.science.org/doi/10.1126/... #Neuroscience #Immunologyscience.orgA neuroimmune circuit mediates cancer cachexia-associated apathyCachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres... 131
Fulya Alkan @fulyaalkan.bsky.social · 09/04/2025Last day of bioinformatics workshop of @itcrtraining.bsky.social at @umich.edu Very informative for who wants to fill the gap between the connections of informatics and wet lab ! 110
Reposted by Fulya AlkanWaggoner Lab @labwaggoner.bsky.social · 08/04/2025Retroelement-specific tissue resident T cells control tissue resilience and predisposition to inflammation papers.ssrn.com/sol3/papers.... @belkaidlab.bsky.social 0186
Fulya Alkan @fulyaalkan.bsky.social · 06/04/2025Blockade of ARG2 in TAMs leading to decreased pro-tumor cytokine expression (e.g., IL10, CD274, TGFB1), shifting macrophage polarization away from the pro-tumor phenotype. #TME #TNBC #immunology #breastcancer www.sciencedirect.com/science/arti...sciencedirect.comCancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasionArginine metabolism reshapes the tumor microenvironment (TME) into a pro-tumor niche through complex metabolic cross-feeding among various cell types.… 000
Fulya Alkan @fulyaalkan.bsky.social · 04/04/2025One of the most comprehensive review I’ve seen after a long time about IL1b driven inflammation in TME ! 010
Reposted by Fulya AlkanThe French DC Society - Club Francophone des DC (CFCD) @frenchdcsociety.bsky.social · 04/04/2025Cool paper by the group of @msmelanoma.bsky.social in @naturecancer.bsky.social showing that tumor secreted growth factor midkine rewires DCs toward a tolerogenic state and promotes tumor immune escape. www.nature.com/articles/s43...nature.comSystemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade - Nature CancerCatena et al. report that melanoma-secreted midkine impairs differentiation and function of dendritic cells, limiting antitumor immunity and response to immune checkpoint blockade. 0108
Reposted by Fulya AlkanUT MD Anderson Cancer Center @mdanderson.bsky.social · 04/04/2025Findings from a Phase I trial suggest natural killer cells pre-complexed with AFM13 has promise for specific patients with lymphoma and may be adapted for more cancer types in the future. Learn more: brnw.ch/21wRN45 #EndCancerbrnw.chNK cells complexed with bispecific antibody yield high response rates in patients with lymphomaA novel cell therapy approach using cord blood-derived natural killer (NK) cells pre-complexed with AFM13, or acimtamig, a CD30/CD16A bispecific antibody, was safe and generated strong response rates ... 063
Reposted by Fulya AlkanAudrey Drotos, PhD 🧠 🔬 @audreydrotos.bsky.social · 04/04/2025Today we released our fourth article for @your.neighborhoodscientist.org! During this time when my future and the future of US science is uncertain, I’m finding a lot of comfort in my colleagues who continue to do beautiful work and Francesca’s words resonate deeply with me. Read & subscribe below: 084
Reposted by Fulya AlkanUVA Immunology @uvaimmunology.bsky.social · 04/04/2025Want to stay current with our members and affiliates? Check out the UVA immunology starter pack! If you're an immunologist at UVA and want to be added to the list, DM us! go.bsky.app/D6VcWYZ 042
Reposted by Fulya AlkanWaggoner Lab @labwaggoner.bsky.social · 23/03/2025CXCR3-mediated natural killer cell infiltration exacerbates white matter injury after intracerebral haemorrhage doi.org/10.1093/brai...doi.orgCXCR3-mediated natural killer cell infiltration exacerbates white matter injury after intracerebral haemorrhageIntracerebral haemorrhage is a subtype of stroke that is associated with poor outcomes. Ng et al. show in a preclinical study that CXC chemokine receptor 3 062
Fulya Alkan @fulyaalkan.bsky.social · 07/03/2025This is nozzle! Filter your samples! #flowcytometry #facts 010
Reposted by Fulya AlkanChristopher Michel @christophermichel.com · 03/03/2025New Heroes: @deisseroth.bsky.social has to be one of the most interesting scientists on the planet. Find out why: glass.photo/cm/6S9GiVGAH... @nationalacademies.orgglass.photoOn September 20, 2022, I photographed Karl Deisseroth at his offices and laboratory at Stanford. He has a mop of dark hair, deep, thoughtful eyes, and…Christopher Michel on Glass 0133
Reposted by Fulya AlkanWaggoner Lab @labwaggoner.bsky.social · 06/03/2025In extremely premature infants, immune cell trajectories are distinct from those of full-term infants over the first 60 days of life www.science.org/doi/10.1126/... 072
Reposted by Fulya AlkanEric Topol @erictopol.bsky.social · 23/02/2025For decades, we underestimated the importance of our lymphatic vessels to suppress cancer and its spread. Here's a new, open-access, outstanding review rupress.org/jem/article/... 842699
Reposted by Fulya AlkanWaggoner Lab @labwaggoner.bsky.social · 25/01/2025IL-23 tunes inflammatory functions of human MAIT cells www.cell.com/iscience/ful... @laetitia-camard.bsky.social 0153
Reposted by Fulya AlkanWaggoner Lab @labwaggoner.bsky.social · 14/01/202530-Color Longitudinal Full-Spectrum Immunophenotyping and Sorting of Human Circulating Immune Cell Subsets Implicated in Systemic Autoimmune Rheumatic Diseases doi.org/10.1101/2025... @montserrat-anguera.bsky.social 0216
Reposted by Fulya AlkanThiago Carvalho @cyrilpedia.bsky.social · 13/01/2025"Our investigation into the effects of anti-CTLA-4 and anti-PD-1 on memory T cell formation in mice reveals that memory T cells generated by anti-CTLA-4 exhibit greater expansion, cytokine production, and antitumor activity than those from anti-PD-1." #Immunology #Immunotherapypnas.orgAnti-CTLA-4 generates greater memory response than anti-PD-1 via TCF-1 | PNASThe effects of T cell differentiation arising from immune checkpoint inhibition targeting cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) and ... 094
Reposted by Fulya AlkanWaggoner Lab @labwaggoner.bsky.social · 26/12/2024Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses www.cell.com/cell-reports... @cellreports.bsky.social 0134
Reposted by Fulya AlkanMass Lab @masslab.bsky.social · 21/12/2024Are you looking for a #PhD position in the interdisciplinary field of #immunology #development #cellbiology? Do you love #macrophages? #FOR5775 is hiring!! Find details here: macrophagenetwork.com/news-2/ Pls repost👇 #immunoskymacrophagenetwork.comNews – My WordPress 178
Fulya Alkan @fulyaalkan.bsky.social · 19/12/2024CD177 expressing neutrophils in Nucleus Accumbens regulating brain immune imbalance and stress-related behaviors www.sciencedirect.com/science/arti...sciencedirect.comCD177 on neutrophils engages stress-related behavioral changes in male micePersistent psychological stress can affect immune homeostasis and is a key factor in the development of depression. Many efforts are focused on the id… 000
Reposted by Fulya AlkanJohan Duchêne @johanduchene.bsky.social · 13/12/2024Why do certain genetic mutations impact leukocyte production or function? With Bone Marrow Organoids (BMOs), we can now explore this question in vitro! BMOs, derived from human iPSCs, provide a tool to study hematopoiesis. Yellow: nuclei Blue: mesenchymal cells #fluorescencefriday #ImmunoSky 🧪 2301
Reposted by Fulya AlkanWaggoner Lab @labwaggoner.bsky.social · 05/12/2024The oestrous cycle stage affects mammary tumor sensitivity to chemotherapy www.nature.com/articles/s41... www.nature.com/articles/d41... www.nature.com/articles/d41... 153
Reposted by Fulya Alkansimonyona @simonyona.bsky.social · 19/11/2024✨This month - Human dendritic cells (DC)✨ using stable isotope labelling in healthy volunteers, we define the circulating lifespan of cDC subsets and explore their role in inflammation - huge thanks to the team and our amazing collaborators doi.org/10.1084/jem.... 2369
Reposted by Fulya AlkanIMP @impvienna.bsky.social · 19/11/2024Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology? @IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-... Pls share! 04637
Reposted by Fulya AlkanFlow Cytometry @flowcytometry.bsky.social · 17/11/2024Here is a list of online flow cytometry resources. Please feel free to add to the list! Online Communities: www.reddit.com/r/flowcytome... discord.gg/ySQFsz8gkB Podcasts: www.youtube.com/channel/UC_m... Blogs: www.colibri-cytometry.com Listserv: www.cyto.purdue.edu/content/cyto... 001
Reposted by Fulya AlkanDenis Wirtz @deniswirtz.bsky.social · 19/11/2024Check out our updated database of 189 PhD fellowships and funding opportunities. For each fellowship, we provide a description, $ amount, deadline, link to funder and eligibility criteria (such as citizenship). Good luck! Download freely here: research.jhu.edu/rdt/funding-... 1211125
Fulya Alkan @fulyaalkan.bsky.social · 19/11/2024Thanksgiving is the deadline for submission. Flood of flow data to analyze including 2018 data with 0 knowledge of which antibody is which color. Squeeze 3 abstract submission and 1 poster in 2 days. Dishwasher is broken, don’t know when be fixed. After 2 years,Mom’s here for 2 weeks only. Oopsz. 000
Reposted by Fulya AlkanJlenia Guarnerio @jle84.bsky.social · 17/11/2024www.science.org/doi/10.1126/...science.orgIn vivo dendritic cell reprogramming for cancer immunotherapyImmunotherapy can lead to long-term survival for some cancer patients, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor ... 051
Reposted by Fulya AlkanRazvan Borza @rborza.bsky.social · 17/11/2024Cancer Immunology: bsky.app/starter-pack... A repertoire of immunologists II: bsky.app/starter-pack... Immunometabolism: bsky.app/starter-pack... Immunoengineering: bsky.app/starter-pack... A repertoire of immunologists: bsky.app/starter-pack... 24026
Reposted by Fulya AlkanbioRxivpreprint @biorxivpreprint.bsky.social · 23/06/2024Development of a Spectral Flow Cytometry Analysis Pipeline for High-Dimensional Immune Cell Characterization www.biorxiv.org/content/10.1101/202… biorxiv.orgDevelopment of a Spectral Flow Cytometry Analysis Pipeline for High-Dimensional Immune Cell Characterization https://www.biorxiv.org/content/10.1101/2024.06.19.599633v1 Flow cytometry is a widely used technique for immune cell analysis, offering insights into cell comp 021
Reposted by Fulya AlkanRichard Sever @richardsever.bsky.social · 10/11/2024Reminder for newcomers that bioRxiv has Bluesky accounts in every subject category - great way to keep up (please re-skeet) connect.biorxiv.org/news/2023/09...connect.biorxiv.orgbioRxiv expands on Mastodon and BlueskybioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution 6361286
Reposted by Fulya AlkanTara @taradeenihan.bsky.social · 15/11/2024This is AMAZING. newsroom.clevelandclinic.org/2024/11/08/c...newsroom.clevelandclinic.orgCleveland Clinic Announces Updated Breast Cancer Vaccine FindingsData presented at Society for Immunotherapy of Cancer Annual Meeting 1771968