Sign in

Fulya Alkan

@fulyaalkan.bsky.social
111 followers 400 following 20 posts

PhD in Neuroscience (hypothalamic regulation of satiety and hunger). Currently Postdoctoral Fellow in (Triple Negative) Breast Cancer, dormancy, tumor microenvironment , secondary organ metastasis. Flow Cytometry Geek.

PostsRepliesMedia
Fulya Alkan @fulyaalkan.bsky.social · 06/06/2025
#academia Hi! So question is When will I stop cleaning after my colleagues mess, fix their mistakes and re-do their job due to laziness in the #lab because I need that? not mentioning loss of time and effort which I have to spent for my work instead…
000
Reposted by Fulya Alkan
immunoboys @immunoboys.bsky.social · 26/04/2025
Jobin et al discover a second priming phase of CD8/DC interaction in the subfollicular LN area. CXCR3+ high-affinity CD8s can get IL-2 from "stop-and-go" moving CD4+ TCs, inducing affinity selection while Tregs mop up IL-2. in 🐭 @science.org 🧪⑂ 1/2 www.science.org/doi/10.1126/...
1104
Fulya Alkan @fulyaalkan.bsky.social · 29/04/2025
Cancel the poster session 🫠 #CanineSupport @theaacr.bsky.social #aacr2025
041
Fulya Alkan @fulyaalkan.bsky.social · 28/04/2025
2025 Next Gen Star Awarded Dr. Anniina Färkkilä on todays’s Major symposium about spatial mapping of #Tumor ecosystem before/after neoadjuvant treatment to be used in favor of anti-tumor immunity in #ovariancancer (in the future, other cancers!) #aacr2025 @theaacr.bsky.social @afarkkila.bsky.social
010
Fulya Alkan @fulyaalkan.bsky.social · 28/04/2025
Tonight at the #AACR2025 stage ! The Checkpoints! @patrickhwumd.bsky.social @jasonlukemd.bsky.social @theaacr.bsky.social
060
Fulya Alkan @fulyaalkan.bsky.social · 27/04/2025
@johannajoyce.bsky.social giving a wonderful presentation about she and her team’s successful discoveries on immunosuppressive myeloid cell infiltration and their contribution to recurrence and progression of brain tumors and at the #aacr2025 Plenary Session
1166
Fulya Alkan @fulyaalkan.bsky.social · 26/04/2025
Great speech by the Head of Breast Cancer Group , Dr. Giampaolo Bianchini from San Raffaele Scientific Institute,Milan, Italy on early TNBC biomarker detection! #aacr2025 #breastcancer #tnbc #earlydetection
000
Fulya Alkan @fulyaalkan.bsky.social · 26/04/2025
Can we track them back to the stemness in order to detect cancer in their “pre-cancerous” state? Dr. Ken Lau answers tese questions #Aacr2025 #cancer #detection #earlydetection
000
Fulya Alkan @fulyaalkan.bsky.social · 25/04/2025
Hall run officially started! Put your running shoes #aacr2025 @
000
Fulya Alkan @fulyaalkan.bsky.social · 25/04/2025
Ready for #AACR2025 This year, just 4 hours of driving : )
000
Reposted by Fulya Alkan
Journal of Experimental Medicine @jem.org · 24/04/2025
This review by @yibinkang.bsky.social et al. integrates key clinical, genetic, & pharmacologic data to suggest human disease settings where retinoic acid nuclear signaling plays a pathogenic role. rupress.org/jem/article/... 📘 In JEM #Cancer Collection rupress.org/jem/collecti... #AACR25
021
Fulya Alkan @fulyaalkan.bsky.social · 24/04/2025
Surprisingly, some LEP gene mutations tied to obesity may reduce body weight by enhancing leptin function. A reminder that biology is rarely black and white. www.nature.com/articles/s42...
nature.com
Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice - Nature Metabolism
In Drosophila and mouse models of cancer cachexia, Liu et al. show that tumour-derived cytokines induce hepatic gluconeogenesis, which in turn leads to dysregulation of metabolism and drives cancer cachexia.
000
Reposted by Fulya Alkan
Waggoner Lab @labwaggoner.bsky.social · 23/04/2025
OMIP-114: A 36-Color Spectral Flow Cytometry Panel for Detailed Analysis of T Cell Activation and Regulation in Small Human Blood Volumes onlinelibrary.wiley.com/doi/full/10....
0193
Reposted by Fulya Alkan
John Lukens @lukensjohnr.bsky.social · 09/04/2025
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease @nature.com www.nature.com/articles/s41...
0155
Fulya Alkan @fulyaalkan.bsky.social · 15/04/2025
🧠 Researchers created a single-cell atlas of brain metastases from various cancers, uncovering unique tumor-immune landscapes and microenvironmental niches. This comprehensive map offers insights for developing targeted treatments: www.cell.com/cancer-cell/... #CancerResearch #BrainMetastasis
cell.com
Pan-cancer human brain metastases atlas at single-cell resolution
Xing et al. construct a comprehensive pan-cancer human brain metastasis (BrM) atlas at single-cell resolution, uncovering five major BrM ecotypes associated with distinct phenotypic characteristics. T...
000
Fulya Alkan @fulyaalkan.bsky.social · 13/04/2025
CD8 T cell priming involves two phases: initial activation by dendritic cells, followed by a second phase where T cells re-cluster with DCs and receive IL-2 from CD4 T cells. This discovery could inform better immunotherapy strategies. www.science.org/doi/10.1126/... #Immunology #TCells
science.org
A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals
T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their diff...
021
Fulya Alkan @fulyaalkan.bsky.social · 12/04/2025
In #CancerCachexia, a brain-immune circuit in the area postrema links inflammation to apathy & low motivation. This explains how inflammation triggers loss of appetite & weight loss, pointing to possible new treatments. www.science.org/doi/10.1126/... #Neuroscience #Immunology
science.org
A neuroimmune circuit mediates cancer cachexia-associated apathy
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...
131
Fulya Alkan @fulyaalkan.bsky.social · 09/04/2025
Last day of bioinformatics workshop of @itcrtraining.bsky.social at @umich.edu Very informative for who wants to fill the gap between the connections of informatics and wet lab !
110
Reposted by Fulya Alkan
Waggoner Lab @labwaggoner.bsky.social · 08/04/2025
Retroelement-specific tissue resident T cells control tissue resilience and predisposition to inflammation papers.ssrn.com/sol3/papers.... @belkaidlab.bsky.social
0186
Fulya Alkan @fulyaalkan.bsky.social · 06/04/2025
Blockade of ARG2 in TAMs leading to decreased pro-tumor cytokine expression (e.g., IL10, CD274, TGFB1), shifting macrophage polarization away from the pro-tumor phenotype. #TME #TNBC #immunology #breastcancer www.sciencedirect.com/science/arti...
sciencedirect.com
Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion
Arginine metabolism reshapes the tumor microenvironment (TME) into a pro-tumor niche through complex metabolic cross-feeding among various cell types.…
000
Fulya Alkan @fulyaalkan.bsky.social · 04/04/2025
One of the most comprehensive review I’ve seen after a long time about IL1b driven inflammation in TME !
010
Reposted by Fulya Alkan
The French DC Society - Club Francophone des DC (CFCD) @frenchdcsociety.bsky.social · 04/04/2025
Cool paper by the group of @msmelanoma.bsky.social in @naturecancer.bsky.social showing that tumor secreted growth factor midkine rewires DCs toward a tolerogenic state and promotes tumor immune escape. www.nature.com/articles/s43...
nature.com
Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade - Nature Cancer
Catena et al. report that melanoma-secreted midkine impairs differentiation and function of dendritic cells, limiting antitumor immunity and response to immune checkpoint blockade.
0108
Reposted by Fulya Alkan
UT MD Anderson Cancer Center @mdanderson.bsky.social · 04/04/2025
Findings from a Phase I trial suggest natural killer cells pre-complexed with AFM13 has promise for specific patients with lymphoma and may be adapted for more cancer types in the future. Learn more: brnw.ch/21wRN45 #EndCancer
brnw.ch
NK cells complexed with bispecific antibody yield high response rates in patients with lymphoma
A novel cell therapy approach using cord blood-derived natural killer (NK) cells pre-complexed with AFM13, or acimtamig, a CD30/CD16A bispecific antibody, was safe and generated strong response rates ...
063
Reposted by Fulya Alkan
Audrey Drotos, PhD 🧠 🔬 @audreydrotos.bsky.social · 04/04/2025
Today we released our fourth article for @your.neighborhoodscientist.org! During this time when my future and the future of US science is uncertain, I’m finding a lot of comfort in my colleagues who continue to do beautiful work and Francesca’s words resonate deeply with me. Read & subscribe below:
084
Reposted by Fulya Alkan
UVA Immunology @uvaimmunology.bsky.social · 04/04/2025
Want to stay current with our members and affiliates? Check out the UVA immunology starter pack! If you're an immunologist at UVA and want to be added to the list, DM us! go.bsky.app/D6VcWYZ
042
Reposted by Fulya Alkan
Waggoner Lab @labwaggoner.bsky.social · 23/03/2025
CXCR3-mediated natural killer cell infiltration exacerbates white matter injury after intracerebral haemorrhage doi.org/10.1093/brai...
doi.org
CXCR3-mediated natural killer cell infiltration exacerbates white matter injury after intracerebral haemorrhage
Intracerebral haemorrhage is a subtype of stroke that is associated with poor outcomes. Ng et al. show in a preclinical study that CXC chemokine receptor 3
062
Fulya Alkan @fulyaalkan.bsky.social · 07/03/2025
This is nozzle! Filter your samples! #flowcytometry #facts
010
Reposted by Fulya Alkan
Christopher Michel @christophermichel.com · 03/03/2025
New Heroes: @deisseroth.bsky.social has to be one of the most interesting scientists on the planet. Find out why: glass.photo/cm/6S9GiVGAH... @nationalacademies.org
glass.photo
On September 20, 2022, I photographed Karl Deisseroth at his offices and laboratory at Stanford. He has a mop of dark hair, deep, thoughtful eyes, and…
Christopher Michel on Glass
0133
Reposted by Fulya Alkan
Waggoner Lab @labwaggoner.bsky.social · 06/03/2025
In extremely premature infants, immune cell trajectories are distinct from those of full-term infants over the first 60 days of life www.science.org/doi/10.1126/...
072
Reposted by Fulya Alkan
Eric Topol @erictopol.bsky.social · 23/02/2025
For decades, we underestimated the importance of our lymphatic vessels to suppress cancer and its spread. Here's a new, open-access, outstanding review rupress.org/jem/article/...
842699
Reposted by Fulya Alkan
Rita Strack @ritastrack.bsky.social · 30/01/2025
holy shit, nerds 😍
3325
Reposted by Fulya Alkan
Waggoner Lab @labwaggoner.bsky.social · 25/01/2025
IL-23 tunes inflammatory functions of human MAIT cells www.cell.com/iscience/ful... @laetitia-camard.bsky.social
0153
Reposted by Fulya Alkan
Waggoner Lab @labwaggoner.bsky.social · 14/01/2025
30-Color Longitudinal Full-Spectrum Immunophenotyping and Sorting of Human Circulating Immune Cell Subsets Implicated in Systemic Autoimmune Rheumatic Diseases doi.org/10.1101/2025... @montserrat-anguera.bsky.social
0216
Reposted by Fulya Alkan
Thiago Carvalho @cyrilpedia.bsky.social · 13/01/2025
"Our investigation into the effects of anti-CTLA-4 and anti-PD-1 on memory T cell formation in mice reveals that memory T cells generated by anti-CTLA-4 exhibit greater expansion, cytokine production, and antitumor activity than those from anti-PD-1." #Immunology #Immunotherapy
pnas.org
Anti-CTLA-4 generates greater memory response than anti-PD-1 via TCF-1 | PNAS
The effects of T cell differentiation arising from immune checkpoint inhibition targeting cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) and ...
094
Reposted by Fulya Alkan
Waggoner Lab @labwaggoner.bsky.social · 26/12/2024
Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses www.cell.com/cell-reports... @cellreports.bsky.social
0134
Reposted by Fulya Alkan
Mass Lab @masslab.bsky.social · 21/12/2024
Are you looking for a #PhD position in the interdisciplinary field of #immunology #development #cellbiology? Do you love #macrophages? #FOR5775 is hiring!! Find details here: macrophagenetwork.com/news-2/ Pls repost👇 #immunosky
macrophagenetwork.com
News – My WordPress
178
Fulya Alkan @fulyaalkan.bsky.social · 19/12/2024
CD177 expressing neutrophils in Nucleus Accumbens regulating brain immune imbalance and stress-related behaviors www.sciencedirect.com/science/arti...
sciencedirect.com
CD177 on neutrophils engages stress-related behavioral changes in male mice
Persistent psychological stress can affect immune homeostasis and is a key factor in the development of depression. Many efforts are focused on the id…
000
Reposted by Fulya Alkan
Johan Duchêne @johanduchene.bsky.social · 13/12/2024
Why do certain genetic mutations impact leukocyte production or function? With Bone Marrow Organoids (BMOs), we can now explore this question in vitro! BMOs, derived from human iPSCs, provide a tool to study hematopoiesis. Yellow: nuclei Blue: mesenchymal cells #fluorescencefriday #ImmunoSky 🧪
2301
Reposted by Fulya Alkan
Waggoner Lab @labwaggoner.bsky.social · 05/12/2024
The oestrous cycle stage affects mammary tumor sensitivity to chemotherapy www.nature.com/articles/s41... www.nature.com/articles/d41... www.nature.com/articles/d41...
153
Reposted by Fulya Alkan
simonyona @simonyona.bsky.social · 19/11/2024
✨This month - Human dendritic cells (DC)✨ using stable isotope labelling in healthy volunteers, we define the circulating lifespan of cDC subsets and explore their role in inflammation - huge thanks to the team and our amazing collaborators doi.org/10.1084/jem....
2369
Reposted by Fulya Alkan
IMP @impvienna.bsky.social · 19/11/2024
Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology? @IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-... Pls share!
04637
Fulya Alkan @fulyaalkan.bsky.social · 19/11/2024
Literally bleeding from flow.
000
Reposted by Fulya Alkan
Flow Cytometry @flowcytometry.bsky.social · 17/11/2024
Here is a list of online flow cytometry resources. Please feel free to add to the list! Online Communities: www.reddit.com/r/flowcytome... discord.gg/ySQFsz8gkB Podcasts: www.youtube.com/channel/UC_m... Blogs: www.colibri-cytometry.com Listserv: www.cyto.purdue.edu/content/cyto...
001
Reposted by Fulya Alkan
Denis Wirtz @deniswirtz.bsky.social · 19/11/2024
Check out our updated database of 189 PhD fellowships and funding opportunities. For each fellowship, we provide a description, $ amount, deadline, link to funder and eligibility criteria (such as citizenship). Good luck! Download freely here: research.jhu.edu/rdt/funding-...
1211125
Fulya Alkan @fulyaalkan.bsky.social · 19/11/2024
Thanksgiving is the deadline for submission. Flood of flow data to analyze including 2018 data with 0 knowledge of which antibody is which color. Squeeze 3 abstract submission and 1 poster in 2 days. Dishwasher is broken, don’t know when be fixed. After 2 years,Mom’s here for 2 weeks only. Oopsz.
000
Reposted by Fulya Alkan
Jlenia Guarnerio @jle84.bsky.social · 17/11/2024
www.science.org/doi/10.1126/...
science.org
In vivo dendritic cell reprogramming for cancer immunotherapy
Immunotherapy can lead to long-term survival for some cancer patients, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor ...
051
Reposted by Fulya Alkan
Razvan Borza @rborza.bsky.social · 17/11/2024
Cancer Immunology: bsky.app/starter-pack... A repertoire of immunologists II: bsky.app/starter-pack... Immunometabolism: bsky.app/starter-pack... Immunoengineering: bsky.app/starter-pack... A repertoire of immunologists: bsky.app/starter-pack...
24026
Reposted by Fulya Alkan
bioRxivpreprint @biorxivpreprint.bsky.social · 23/06/2024
Development of a Spectral Flow Cytometry Analysis Pipeline for High-Dimensional Immune Cell Characterization www.biorxiv.org/content/10.1101/202…
biorxiv.org
Development of a Spectral Flow Cytometry Analysis Pipeline for High-Dimensional Immune Cell Characterization https://www.biorxiv.org/content/10.1101/2024.06.19.599633v1
Flow cytometry is a widely used technique for immune cell analysis, offering insights into cell comp
021
Reposted by Fulya Alkan
Richard Sever @richardsever.bsky.social · 10/11/2024
Reminder for newcomers that bioRxiv has Bluesky accounts in every subject category - great way to keep up (please re-skeet) connect.biorxiv.org/news/2023/09...
connect.biorxiv.org
bioRxiv expands on Mastodon and Bluesky
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
6361286
Reposted by Fulya Alkan
Tara @taradeenihan.bsky.social · 15/11/2024
This is AMAZING. newsroom.clevelandclinic.org/2024/11/08/c...
newsroom.clevelandclinic.org
Cleveland Clinic Announces Updated Breast Cancer Vaccine Findings
Data presented at Society for Immunotherapy of Cancer Annual Meeting
1771968