In a phase 1 trial, treatment with the antibody−drug conjugate DYP688, targeting PMEL and delivering a Gq/11 inhibitor, in patients with GNAQ/GNA11-mutant metastatic uveal melanoma or other GNAQ/GNA11...

Background Cancer progression involves not only uncontrolled proliferation but also the strategic entry of tumour cells into reversible (quiescent) or irreversible (senescent) states of cell cycle arr...

CAR T cell therapy remains largely ineffective in solid tumors, where quiescent cancer cells contribute to treatment resistance. Here, the authors identify a population of quiescent pancreatic cancer ...

IntroductionImmune responses in cancer arise from dynamic interactions across biological scales, linking intracellular signaling, cellular phenotypic plastic...

Cancer Dormancy Institute, Montefiore Einstein Comprehensive Cancer Center (MECCC). Non-institutional website for the laboratory headed by Dr. Samarth Hegde, Department of Developmental and Molecular ...

Geng et al. report that quiescent persister tumor cells persisting after neoadjuvant chemotherapy can restrain CD8+ T cell-mediated cytotoxicity via CD96, thereby contributing to colorectal cancer rec...

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...

Historically, eligibility for receiving human epidermal growth factor receptor 2 (HER2)-targeted therapies was limited to HER2-positive tumors (immunohistochemistry 3+ or in situ hybridization amplifi...

Investigating how aging predisposes individuals to a higher metastatic risk, the authors identify that extracellular vesicles secreted by senescent hepatocytes carry miRNAs that enhance metastatic pot...

Gastrointestinal stromal tumors (GISTs), the most common mesenchymal neoplasms of the digestive tract, are primarily driven by mutations in KIT/PDGFRA…

This cohort study assessess whether adjuvant chemotherapy is associated with breast cancer mortality among women 70 years or older with nonmetastatic triple-negative breast cancer.

PRRX1 is an epithelial– mesenchymal transition-linked transcription factor. Here, the authors discover that intermediate PRRX1 levels primes cancer cell for high invasion and metastatic fitness, where...

Cancer now ‘fightable’ with a jab?  mRNA-based cancer vaccine human trials on

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

Cancer can recur when a subset of tumor cells, termed persister cells, survive therapy and re-enter the cell cycle. Through single-nucleus multi-omic …

Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remode...

The MRS is excited to announce the awardees for the 2026 MRS Awards. Congratulations to all of the awardees! 🏆 Paget-Ewing Award (Honoring scientific excellence and substantial contributions to the ...