Reposted by Oded MayselessAlex Schier @schierlab.bsky.social · 08/09/2026The first Danionella paper from the lab. Danionella cerebrum is transparent, so you can see all of the internal organs. But what sensory information are the organs sending to the brain? In our new preprint, Emily Bayer wanted to find out. 1/4 www.biorxiv.org/content/10.6... 18135
Reposted by Oded MayselessRainer Friedrich @rainerfriedrichlab.bsky.social · 08/09/2026Ultrastructural reconstruction of hundreds of neurons by volume EM revealed cell types and a precise glomerular organization in the zebrafish olfactory bulb. A heroic effort by Nila! Special thanks to Nila @michalwj.bsky.social and the whole team! www.biorxiv.org/content/10.6...biorxiv.orgDeep anatomical and ultrastructural classification of neurons in the zebrafish olfactory bulbNeuronal circuits in the olfactory bulb (OB) perform computations fundamental to pattern classification including a decorrelation and normalization of odor-evoked activity. These computations are medi... 0125
Reposted by Oded MayselessRainer Friedrich @rainerfriedrichlab.bsky.social · 08/09/2026Imaging of activity in the telencephalon of adult zebrafish moving through a virtual reality revealed amazingly precise, structured internal representations of spatial environments. And they get better over time! Great work by Kim! Thanks also to Sriram and Jan. www.biorxiv.org/content/10.6...biorxiv.orgDynamic cognitive representations in the dorsal pallium of adult zebrafishBrains rely on internal models of the world to interpret sensory input and to simulate the future. In the mammalian hippocampal-entorhinal network, environments are represented by cognitive maps that ... 1299
Reposted by Oded MayselessRainer Friedrich @rainerfriedrichlab.bsky.social · 08/09/2026New preprint by Tommaso: olfactory cortex (of zebrafish) represents not only odor information but also temporal context, and these multimodal representations are sharpened after learning. And check out Tommaso's new method for 2P imaging in awake adult zebrafish! www.biorxiv.org/content/10.6...biorxiv.orgJoint experience-dependent representations of odors and temporal context in the zebrafish homolog of piriform cortexIntelligent behavior requires experience-dependent internal representations of relevant information. We examined representational learning in telencephalic area pDp of adult zebrafish, the homolog of ... 12712
Reposted by Oded MayselessMwahahahahahadScientist @mads100tist.bsky.social · 29/08/2026Do you work with microscopy images and segment to quantify or track? Do you study cell biology? development? Gather round! Let me tell you about FOCUS-3D, a segmentation algorithm that is fast, accurate and can be used on any model. We used it here to study zebrafish development. 🧪 (thread)biorxiv.orgFOCUS‑3D: Robust, generalizable volumetric cell segmentation for three‑dimensional fluorescence microscopyUnderstanding how cells establish spatial organization within tissues is a fundamental question in life sciences. While modern three-dimensional fluorescence microscopy captures large-volume tissue ar... 1525184
Oded Mayseless @mayseless.bsky.social · 19/08/2026Congratulations 🎉💐🎉 to everyone for the herculian and most amazing work! 000
Reposted by Oded MayselessAlex Schier @schierlab.bsky.social · 19/08/2026What regulates the urge to sleep? William Joo and colleagues identified brain regions that reflect how long mice have been awake. Strikingly, inhibiting one of these regions reduces sleep by 70%, without the major behavioral deficits associated with sleep deprivation. www.nature.com/articles/s41...nature.comWake-activated neuronal populations that regulate sleep drive - NatureWhole-brain activity mapping, targeted cell manipulations and electrophysiology in mice identify wake-activated neuronal populations that are crucial for sleep drive and can persistently red... 48632
Reposted by Oded MayselessHarmit Singh Malik @harmitmalik.bsky.social · 06/08/2026Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline. 2163152
Reposted by Oded MayselessBahl Lab @bahllab.bsky.social · 03/08/2026🚨New preprint doi.org/10.64898/2026.06.07.730682. We show that zebrafish larvae exhibit complex, internally generated, spontaneous behavioral patterns in the absence of stimuli. These dynamics can be described by a simple Markov process with transition probabilities that change over time. 6197
Reposted by Oded MayselessShawn Burgess @burgesslab.bsky.social · 30/07/2026Yet another #zebrafish genome update: We just updated our ZebrafishGenomics public datahub for the UCSC browser (available all the way at the bottom here: genome.ucsc.edu/cgi-bin/hgHu...). We added several useful tracks including:genome.ucsc.edu 11410
Reposted by Oded MayselessJohannes Felsenberg @felsenberg.bsky.social · 31/07/2026Finally out in @natneuro.nature.com! A forgotten memory isn't always gone. We show that forgotten memories persist as silent memory traces, can be recovered by reminders, and can even be reconstructed into false memories. Excited to finally share this work! www.nature.com/articles/s41...nature.comCreating true and false memories from forgotten information in Drosophila - Nature NeuroscienceForgotten memories in Drosophila persist as silent memory traces and can be recovered by reminder cues. Manipulating reminders can create false memories, showing that memory reconstruction flexibly in... 1214154
Reposted by Oded MayselessEmre Yaksi @emreyaksi.bsky.social · 17/07/2026🧠 A new paper from our lab is out! In this study, we explore how dorsal raphe nucleus (DRN) circuits modulate forebrain activity and behavior. www.nature.com/articles/s41...nature.comTopographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors - Nature CommunicationsFunctional heterogeneity of dorsal raphe nucleus is not fully understood. Here authors show topographically organized sensory and locomotor responses from the zebrafish dorsal raphe and its forebrain ... 26621
Reposted by Oded MayselessAustin Seroka @austinseroka1.bsky.social · 06/07/2026We're excited to present a single-cell atlas of vertebrate cranial motor neuron development, the first story from my postdoctoral work in the Moens lab, up now on bioRxiv! 53116
Reposted by Oded MayselessTakashi Fukaya @fukayalab.bsky.social · 06/07/2026We have an open professor position at my institute, the Institute for Quantitative Biosciences, The University of Tokyo! www.iqb.u-tokyo.ac.jp/recruiting/2...iqb.u-tokyo.ac.jp 02522
Reposted by Oded Mayselessvoigtvision.bsky.social @voigtvision.bsky.social · 06/07/2026🚨 New Preprint! 🚨: A new method for quantifying #tissue #clearing and a next-get #lightsheet #Microscope - the #mesoSPIM ultra by Marko Pende, @jcregg.bsky.social, @murawalalab.bsky.social @mdibl.org & many more! Preprint: www.biorxiv.org/content/10.6... Github: github.com/mesoSPIM/mes... 32710
Reposted by Oded MayselessBahl Lab @bahllab.bsky.social · 05/07/2026We are excited to share our collaboration with @pheereynolds.bsky.social, Robert Hindges & team on retinal plasticity, now out in Neuron! This work shows how visual experience during early development changes the anatomical and functional properties of amacrine cells and ultimately behavior!cell.comEarly visual experience elicits cellular and functional plasticity in the retina and alters behaviorThe understanding of experience-dependent plasticity in the vertebrate retina is largely incomplete. Reynolds et al. discovered that raising animals in differently patterned visual environments change... 34120
Oded Mayseless @mayseless.bsky.social · 02/07/2026Wow! Congratulations Emre! Exciting paper. Can't wait to dig in and see where you take this in the future. 010
Reposted by Oded MayselessEmre Yaksi @emreyaksi.bsky.social · 02/07/2026I am excited to announce the latest paper from our lab, published in Science ! In this study, we show that thalamocortical-like circuits in the zebrafish brain process sensory information hierarchically across topographically organized forebrain circuits.science.orgHierarchical sensory processing in zebrafish thalamocortical-like circuitsThalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in non-mammalian... 1311837
Reposted by Oded MayselessFumi Kubo @fumikubo.bsky.social · 01/07/2026Happy to share our new paper published in @currentbiology.bsky.social! Using in vivo imaging of genetically defined zebrafish retinal ganglion cells (RGCs), we show that while some Satb2+ RGCs maintain stable functional identities during development, others undergo functional changes. 3132
Reposted by Oded MayselessJohn Tuthill @tuthill.bsky.social · 30/06/2026My department, Neurobiology and Biophysics at the University of Washington (nbio.uw.edu), is hiring a new tenure-track Assistant Professor, application deadline 09/30/26. It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome. apply.interfolio.com/187735 110789
Reposted by Oded MayselessLoïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · 29/06/20261/ 🧬🔬 How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇 www.kaggle.com/competitions... @biohub.org 17941
Reposted by Oded Mayselesstahneema.bsky.social @tahneema.bsky.social · 28/06/2026Very excited to finally share my PhD! 🎉 Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances. Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social! 📄 www.science.org/doi/10.1126/...science.orgNeuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafishLoss of the conserved splicing factor for neuronal microexons disrupts neuromodulatory signaling and drives hyperarousal. 085
Reposted by Oded MayselessMarc Dionne @marcsdionne.bsky.social · 25/06/2026We're hiring! The Department of Life Sciences at Imperial College London is seeking a new Assistant Professor in ecology, evolution, or environmental science. It's a great department with great students at a great university. www.imperial.ac.uk/jobs/search-...imperial.ac.ukDescriptionPlease note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment... 0712
Reposted by Oded MayselessPhoebe Reynolds @pheereynolds.bsky.social · 23/06/2026I’m very excited to share that our paper is now out in Neuron! 🎉 34114
Reposted by Oded MayselessBahl Lab @bahllab.bsky.social · 22/06/2026New paper out: www.cell.com/iscience/ful... Congratulations to our former PhD student @maxcapelle.bsky.social whose work reveals that the switch in light preference across zebrafish development is driven by a reweighting of three parallel visual processing pathways. Check out a short summary below! 13212
Reposted by Oded MayselessAlex Schier @schierlab.bsky.social · 17/06/2026Might cerebellar disinhibition underlie Restless Legs Syndrome symptoms? Will Joo found that loss of the RLS-associated gene meis1b perturbs locomotion in zebrafish by disinhibiting cerebellar output. www.sciencedirect.com/science/arti... 23410
Reposted by Oded MayselessLukas Anneser @lukas-anneser.bsky.social · 17/06/2026Congratulations! This was long in the making and the resulting data is quite beautiful. Definitely worth a read! 172
Reposted by Oded MayselessZebrafish Rock! @zebrafishrock.bsky.social · 17/06/2026🔗 to paper: www.biorxiv.org/content/10.6... 041
Reposted by Oded MayselessMwahahahahahadScientist @mads100tist.bsky.social · 16/06/2026Happy to have contributed to this mastodon of a paper about how the nose knows 🧪🐟 2162
Oded Mayseless @mayseless.bsky.social · 16/06/2026@mads100tist.bsky.socialstatic.klipy.comFresh Prince: Yo, Holmes, Smell Ya Later!ALT: Fresh Prince: Yo, Holmes, Smell Ya Later! 040
Oded Mayseless @mayseless.bsky.social · 16/06/2026couldn't have done it without my main colluding partner 🫶 110
Oded Mayseless @mayseless.bsky.social · 16/06/2026This project was made possible by many generous people sharing their time, expertise, ideas, and belief in the work. 220
Oded Mayseless @mayseless.bsky.social · 16/06/2026Special thanks to @frankfishlab.bsky.social, Bethan Jenkins, @johanneskappel.bsky.social, @lukas-anneser.bsky.social, Ruth Montano, and the Biozentrum core facilities; Research IT, IMCF, FACS, Genomics, and Workshop teams. 220
Oded Mayseless @mayseless.bsky.social · 16/06/2026Science is never done alone. Huge thanks to the Schier and Friedrich lab for the discussions, support, criticism, encouragement, and community that shaped this work. 110
Oded Mayseless @mayseless.bsky.social · 16/06/202611/11 Big picture: the larval zebrafish olfactory bulb is organized spatially, transcriptionally, and functionally in ways that reflect behavioral preference. Paper: www.biorxiv.org/content/10.6... 131
Oded Mayseless @mayseless.bsky.social · 16/06/202610/11 Attractive and aversive odorants recruited separable neuronal populations! Attractive odorants preferentially recruited a dopaminergic short-axon-like interneuron population. Two-photon ablation of TH⁺ interneurons selectively impaired attraction while sparing aversion. 111
Oded Mayseless @mayseless.bsky.social · 16/06/20269/11 Next we asked which subtypes are recruited by different odorants. @mads100tist.bsky.social and the Picelli lab adapted Flash-seq for low-input zebrafish neurons, combining CaMPARI labeling, sorting, and deep sequencing. 110
Oded Mayseless @mayseless.bsky.social · 16/06/2026Mapping these genes in single brains let us impute our scRNA-seq atlas into space with Tangram. This revealed cohesive OB domains: projection neurons tile the outer layer, while interneurons form partially nested inner domains. Not a uniform mosaic: a domain architecture. 110
Oded Mayseless @mayseless.bsky.social · 16/06/20267/11 Luckily, @yinanwan.bsky.social and Jakob developed a powerful approach for multiplexed whole-mount gene-expression mapping. Sequentially imaging 68 genes in intact larval brains, defined anatomical and transcriptional boundaries of the olfactory bulb at cellular resolution. 121
Oded Mayseless @mayseless.bsky.social · 16/06/20266/11 But which neurons make up these domains? We profiled the larval telencephalon by scRNA-seq, but many markers were shared between olfactory bulb and pallial regions. Reliable subtype identification required combinatorial information from 32 genes and spatial context. 120
Oded Mayseless @mayseless.bsky.social · 16/06/20265/11 This OB-level preference structure was reinforced by a companion brain-wide Ca²⁺ imaging study from the @frankfishlab.bsky.social. Comparing the datasets showed that preference-associated OB patterns were partially reproducible across independent experiments and imaging modalities. 110
Oded Mayseless @mayseless.bsky.social · 16/06/20264/11 Clustering 3D activity maps revealed spatial response patterns. Two were biased by preference: one enriched for aversive odorants, one for attractive odorants, despite chemically diverse members. This suggests bulb activity reflects behavioral preference as well as chemistry 111
Oded Mayseless @mayseless.bsky.social · 16/06/20263/11 Early olfactory circuits may organize odor information along behaviorally relevant dimensions. To test this in zebrafish larvae, we used pan-neuronal CaMPARI2 to map odorant-evoked activity in freely swimming larvae across a broad spectrum of odorants. 153