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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 28/09/2026

Don't miss these two ORIVA workshops in October! Alternative Methodologies in Pharmaceutical Development 🔗 ntp.niehs.nih.gov/whatwestudy/... Recent Developments in Human-Based Models 🔗 ntp.niehs.nih.gov/whatwestudy/... ⌛ Register for in-person by Oct 13. 🖥️ Virtual registration is open too!

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 24/09/2026

OLAW is seeking input on annual reporting of vertebrate species covered by the PHS Policy but currently excluded from USDA annual reporting requirements (which as a reminder is 95-99% of the animals used). 📍 Stay tuned for more guidance on responding to this RFI, including key points to make.

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 24/09/2026

It was a big week for the movement for human-based science! 👏🎉 NIH & HHS unveiled new initiatives that expand investment in human-based science while addressing animal use across the biomedical research enterprise. Scroll down for key developments.

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 18/09/2026

"The same pharmaceutical agent can primarily boost circulation in dogs, alleviate constipation in horses and, in rodents, prevent the bulging of the eyes out of the sockets...

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 15/09/2026

This #PeerReviewWeek, we’re reminding you about the important role you play in preventing peer review bias, just by saying yes to review opportunities. 🧵 #peerreview #academicsky #phdsky

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 11/09/2026

🚨 Important paper alert! How do you transition an animal facility into a non-animal method lab? In this new paper, Clive Roper and Michael Coleman present what might be the first practical framework for doing this.

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 09/09/2026

📄 Has a reviewer ever told you to add an animal experiment to your study? 🐁 Has an advisor told you that you have to use animals to advance your career? 💸 Has a grant application of yours been rejected because it didn’t involve animals?

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 08/09/2026

For years, researchers developing non-animal methods could generate human-based data, publish it, and use it internally, but there was no clear pathway to share that evidence unless it was tied to a drug approval application. @ema.europa.eu's new pilot program is changing that. 🧵

A graphic with a laboratory photograph on the left showing people working at computers. Circular decorative graphics appear in the upper-right and lower-left corners, and the SAO icon appears in the lower-right. The slide text reads: “Non-animal methods news. Academics, method developers, and others can now share non-animal method data with the European Medicines Agency independent of drug marketing applications. Until now, non-animal method data rarely reached regulators, limiting opportunities for them to build confidence in the technologies. Learn more at ema.europa.eu/en/news.”

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 04/09/2026

📢 NIH is seeking reviewers for human-based science grant proposals! The U.S. National Institutes of Health is seeking scientists with expertise in human-based research approaches who may be interested in serving as grant reviewers and contributing to the NIH peer review process.

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 31/08/2026

“Animal models have only ever been a surrogate for the species whose biology we are actually trying to understand and improve ... there’s a really massive translational gap between existing preclinical models and clinical success.” - Nicole Kleinstreuer Nice piece by @jenabbasi.bsky.social!

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 31/08/2026

What hidden discoveries are waiting in biobanks? A study published in May provided strong genetic evidence for #PostpartumPsychosis. Using population-scale human datasets, researchers at Mount Sinai estimated that genetic factors account for roughly half of the risk.

Screenshot: Published: 14 May 2026; Genetic architecture of postpartum psychosis: from common to rare genetic variation
Seulgi Jung, Madison Caballero, Adrianna Kępińska, Shelby Smout, Trine Munk-Olsen, Thalia K. Robakis, Veerle Bergink & Behrang Mahjani
Molecular Psychiatry (2026); 6730 Accesses; 56 Altmetric

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 31/08/2026

NIH has added new Highlighted Topics* that include opportunities to address fundamental questions in human health using human-relevant, non-animal approaches, datasets, and technologies. grants.nih.gov/funding/find... #NIH #BiomedicalResearch #NIHFunding #Grant #NAMs

Graphic announcing “new nih highlighted topics for human-based methods.” It lists: “Research on the role of post-translational modifications in human health and disease”; “Advance the understanding of mechanisms regulating sex differences in response to exercise”; “Immune mechanisms for disease prevention”; “Environmental contributors to infertility”; and “Building health through multidomain resilience research from molecules to communities: mechanisms, measures, and biomarkers.” The graphic directs viewers to “find more at grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics”.

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 27/08/2026

NCATS and @utmbhealth.bsky.social scientists developed a 3D bioprinted human placenta barrier tissue model that recapitulates the “architecture and function of early- and late-stage human placenta, including barrier function, nutrient uptake, transporters activity and hormones secretion.”

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 24/08/2026

In a new paper, @nicodmueller.bsky.social argues that a core feature of modern #sciencepolicy stands in the way of reducing the use of animals in experimentation. Governments fund research and set ethical boundaries, but scientists largely decide which questions receive funding and attention.

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 24/08/2026

Scientific impact should be measured by rigor, transparency, and translatability. Last week, the COLAAB submitted comments to NIH's RFI on Measuring and Rewarding Scientific Impact. See what we recommended ⬇️ #SciencePolicy #PeerReview #ResearchAssessment #ScientificImpact #AnimalMethodsBias

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 24/08/2026

📣 New York! Next month there will be 2️⃣ opportunities to watch The New Gold Standard in theaters! I'll be joining the Albany screening virtually for the Q&A. Details and RSVP links in the 🧵 #animaltesting #animalresearch #NAMs

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 19/08/2026

How are non-animal methods helping advance research on brain aging, #Alzheimers, and related dementias? Join this #NIA virtual workshop to learn more! 📅 Sept 10-11 🕚 1:00–3:30 ET Register here: nih.zoomgov.com/webinar/regi... #alz #EndAlz #neuroskyence 🧪

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 17/08/2026

HIV researchers 🚨 Which human-based platforms will inform the next generation of #HIV science? Join this NIH Mini-Symposium Series to discuss non-animal preclinical advances, immune modeling, validation pathways, & more. Featuring @blishlab.bsky.social, @pompanolab.bsky.social, & more.

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 14/08/2026

This project. Y'all. 😭 Thank you to the writers, the artists, and Justify for bringing it all together. 🎨 @danaellyn.bsky.social @hannahwardstudio.bsky.social @katfarrell.bsky.social @janeoharaprojects.bsky.social & others www.justifyglobal.org/portraitsfro...

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 13/08/2026

Mitigating #AnimalMethodsBias is critical for creating viable pathways for scientists seeking to work in human-based science and broadening opportunities for researchers already working in the field. Read the testimonial: www.justifyglobal.org/desperately-... #ScienceCareers

justifyglobal.org

Desperately Trapped | Justify

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 13/08/2026

Animal methods bias often looks like peer reviewer pressure to use animals. But it can also come from supervisors or colleagues, with more damaging career consequences. 🧑‍🔬 From Justify's Portraits from the Lab series. 🧵 🧪 #PhDChat #PhDLife #PhDsky #AnimalMethodsBias

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Nico Müller @nicodmueller.bsky.social · 07/08/2026

🚨 New OA article 🚨 In which I argue that a gradual, controlled transition away from animal-reliant methods requires a break with laissez-faire science policy. #3Rs #animalexperimentation #animalresearch #animalethics doi.org/10.1017/pls....

Screenshot of title and abstract of Nico Müller's new article entitled "No transition without participation: Why moving beyond animal studies requires public input into the research agenda"

The abstract reads: "In many countries, a large portion of animal studies serve publicly funded research purposes, yet a transition beyond animal research is politically desired. This article argues that a gradual transition is obstructed by three commitments of traditional science policy: (1) the state should provide resources for research; (2) it should leave the direction of research to the scientific community; and (3) it should set side constraints for research. This framework severely restricts public influence on the amount and kind of animal research conducted with public funds. The public can allocate some extra resources to the innovation of alternatives to animal models or tighten legal side constraints, but neither approach is likely to significantly decrease
reliance on animal research overall. A gradual transition away from publicly funded animal research toward new approaches is feasible only if the second commitment is reconsidered, allowing the public greater
influence over the research agenda."

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 12/08/2026

🖥️ Join @jhucaat.bsky.social for this must-watch webinar. www.eventbrite.co.uk/e/the-scienc... 🌐 Featuring: Professor David Moher, internationally renowned expert in manuscript peer review, metascience, responsible research assessment, and research integrity 🎙️ Host: @kathrinherrmann.bsky.social

eventbrite.co.uk

The Science of Peer Review: Evidence, Challenges, and Improvements

The Science of Manuscript Peer Review: Evidence, Challenges, and Opportunities for Improvement

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 12/08/2026

📚 Peer review is a gatekeeper of scholarly publishing, but most scientists get no formal training in it, leaving gaps in quality and fairness. 🤔 Why we think you should join this webinar... 🧵 www.eventbrite.co.uk/e/the-scienc... #PeerReview #OpenScience #ScientificPublishing #MetaScience 🧪

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 11/08/2026

ICYMI 💡 NCI made two important, complementary announcements that point cancer research in the same direction. Let's take a look... 🧵 🧪 #oncsky #oncosky #cancer #scipol

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 05/08/2026

What is research assessment reform, and what does it have to do with animal experiments? 🔬 Expand this 🧵 to learn why the COLAAB has officially signed onto @dorassessment.bsky.social! ✒ #AnimalMethodsBias #ResearchAssessment #ResearchCulture #AcademicCommunity

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 05/08/2026

This narrow focus penalizes research that counters the status quo, including the animal experimentation paradigm that is upheld by decades of embedded preference, infrastructure, and culture, as well as entire industries with vested interests in maintaining it. 3/9

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 03/08/2026

🆕📌 77% of clinical drug failures are attributed to biological factors typically assessed in experiments on animals before human trials begin. After 60 years, "standardizing" or "improving" experiments on animals has not reduced clinical attrition. Research modernization is needed NOW.

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 22/07/2026

🐱 The COLAAB member spotlight series continues with @mikalahsinger.bsky.social! 🐱 Mikalah Singer, JD, LLM, is a science policy specialist with @pcrm.org and has been a member of the COLAAB Mitigation Working Group since 2024. She is based in Portland, Oregon. #SciPol

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 20/07/2026

"Medicine isn’t a fast-moving field, but it has always adapted when better technology arrived: the stethoscope gave way to the imaging scan; the scalpel to the laparoscope. Better tools for testing drugs are already here. It’s time we start using them." www.weforum.org/stories/emer...

weforum.org

Why it’s time to phase out animal testing in pharma

Primate testing is no longer the scientific gold standard. Here is why the pharmaceutical industry must commit to a human-first timeline by 2030.

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 16/07/2026

From @mayoclinic.org's Saranya Wyles, MD, PhD, on dermatological research: “Traditional approaches rely heavily on animal testing, but skin biology varies widely across species. Even commonly used preclinical models fall short when it comes to mimicking human skin conditions such as eczema.”

Photo from the article in Mayo Clinic's News Network, "3D-bioprinted human skin model expands options for preclinical research" by Marla Broadfoot, Ph.D., published May 5, 2026. The photo shows Aydin Tahmasebifar, Ph.D., M.S.; Saranya Wyles, M.D., Ph.D.; Rafa Mayumi Simoes Torigoe, REGS Ph.D. Candidate [Credit: Tom Matre]

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 15/07/2026

Another example of how non-animal methods are modeling complex, multi-organ diseases & uncovering the mechanisms underlying interdependent organ dysfunction: We know that communication between the heart & kidneys is essential for maintaining function, but how do these organs communicate? 🧵

A graphic with a dark purple background featuring a quote in white text: “By combining advanced stem cell-derived cardiac and kidney models, we can now start dissecting inter-organ communication mechanisms that were previously very difficult to study in human systems.” The quote is attributed to Viviana Meraviglia, PhD. A neon green quotation mark appears above the text. In the bottom right is a photo of a scientist working with cell culture in a laboratory hood, overlaid with a neon green eight-point star. A neon green banner at the bottom left reads “reNEW | May 28, 2026.”

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 14/07/2026

How is the media shaping public perceptions of #xenotransplantation? 🐷 A newly published study from NYU and collaborators analyzed 208 print media articles covering experimental pig-to-human transplants in the U.S. Some findings stood out: 🧵 #medialiteracy #transplant #bioethics

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 09/07/2026

Animal methods bias is showing up in more discussions about the barriers to reducing animal experimentation. In this 🧵, we discuss two recent pieces in @springernature.com's Journal of Translational Medicine. #AnimalMethodsBias #InstitutionalInertia 🧪

Animal methods bias is showing up in more discussions about the barriers to reducing the use of animals

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Coalition to Illuminate and Address Animal Methods Bias @thecolaab.bsky.social · 09/07/2026

Both publications point to the same constraint: Peer review expectations can undermine efforts to reduce animal use. Addressing animal methods bias is key to removing this barrier. #NAMs #NonAnimalMethods #ScientificParadigm

These publications point to the same constraint:
Peer review expectations can undermine efforts to reduce animal use, and addressing animal methods bias is key to removing this barrier.

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 08/07/2026

Which human kidney model is the best for your research question? With the recent boom in advanced human kidney models, @thecleverslab.bsky.social benchmarked these systems to help researchers choose the most appropriate model for their studies. 🧪 #Nephsky #RenalSky

Graphical abstract of linked paper by Pou Casellas et al. (2026) titled: “Single-cell transcriptomic comparison of tubular segment maturation in advanced human in vitro kidney models”

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 07/07/2026

Live animals are still used in some trauma surgery training, but advances like these from @ntunews.bsky.social demonstrate that realistic, clinically relevant training needs no animal use. The team developed lifelike torso models that ❤️ beat 🫁 breathe, & 🩸 bleed using synthetic blood.

An photograph of surgeons performing an operation on a fake body. From "Beating and bleeding dummy hearts to train surgeons for emergency trauma injuries" by Chris Birkle, published on 24 April 2026 by Nottingham Trent University. https://www.ntu.ac.uk/about-us/news/news-articles/2026/04/*-graphic-warning-*-beating-and-bleeding-dummy-hearts-to-train-surgeons-for-emergency-trauma-injuries

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 06/07/2026

Check out this incredible resource created through a large‑scale, team science effort! ~90 scientists from the @alleninstitute.org & UW worked together to map Alzheimer’s disease across the human brain at single‑cell resolution. 🗺️🧠 #neuroskyence #alzsky #brainmap #singlecell

Figures 1a-c from the linked paper. Multi-panel scientific figure summarizing brain region sampling, analytical approach, and cohort data. A shows simplified diagrams of postmortem human brain sections with highlighted regions across disease stages, including DFC, MFC, hippocampus, entorhinal cortex, STG, MTG, and primary visual cortex, with red and orange color overlays indicating regions associated with different Braak stages and Alzheimer’s disease spectrum cases. B presents a workflow diagram linking modalities—quantitative neuropathology, single-nucleus RNA sequencing, ATAC-seq, and genome sequencing—to analyses of pseudo-progression, differential cell-type abundance, and polygenic risk. C displays a large heatmap of SEA-AD cohort participants, organized by demographics and clinical staging. Rows include sex, age at death, postmortem interval, APOE genotype, AD neuropathological change, Braak stage, Thal phase, CERAD score, cognitive status, and comorbidities. Blue shading indicates demographic variation, red gradients indicate increasing Alzheimer’s disease severity, and gray/purple tones indicate co-morbid conditions such as LATE, Lewy body disease, arteriosclerosis, and atherosclerosis.

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 06/07/2026

New review from @wyssinstitute.bsky.social on #OrgansOnChips, including their use as preclinical tools, applications in drug discovery, how they compare with other preclinical models, and what's needed to make them even better. #OrganChip #OrganOnAChip #Preclinical #Pharmsky #NAMs 🧪 💊

Dark navy graphic featuring the following quote: "The pharmaceutical industry faces a critical attrition crisis, with ~90% of drug candidates failing in clinical trials largely due to the inability of conventional cell cultures and animal models to accurately predict human responses." A white laboratory mouse among glass ampoules is shown in the lower half. Attributed to Ryan Posey, Alican Özkan, & Donald E. Ingber (2026) from Advanced Drug Delivery Reviews.

Dark navy graphic with the following quote: "Organ Chips enable testing of therapeutics using clinically relevant pharmacokinetic profiles and administration routes, supporting more predictive preclinical assessment of drug efficacy, toxicity, and mechanisms of resistance across a broad range of organ systems and disease states." A researcher holding a capsule is shown in the lower portion. Attributed to Ryan Posey, Alican Özkan, & Donald E. Ingber (2026) from Advanced Drug Delivery Reviews.

Dark navy graphic with the following quote: "Integration of Organ Chips with high-throughput screening, functional genomic approaches, and artificial intelligence represents an emerging shift that enables rapid target identification, drug repurposing, and therapeutic discovery, while potentially reducing clinical failure rates." Two scientists working at a computer in a lab are shown in the upper half. Attributed to Ryan Posey, Alican Özkan, & Donald E. Ingber (2026) from Advanced Drug Delivery Reviews.

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Claudia Martins @claudia-martins.bsky.social · 01/10/2025

Out now in Advanced Drug Delivery Reviews: 🧠Our new review highlights in vitro models, from basic to advanced, that replicate the interplay between glioblastoma and the blood-brain barrier. These tools can support more efficient preclinical research. 🔗Link: www.sciencedirect.com/science/arti...

sciencedirect.com

Glioblastoma and blood-brain barrier cell interplay in vitro models for stratification of drug efficacy

Glioblastoma (GBM) is the most lethal brain cancer in adults, with a dismal prognosis and no curative therapies available. The treatment landscape rem…

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 06/07/2026

5️⃣ #funding opportunities are open through the NIH Common Fund's PRIMED‑AI program 🖥️👩‍⚕️🎯 Support is available for projects combining medical imaging with other health data to build clinical decision tools for patient care. Details: commonfund.nih.gov/primed-ai #NIHFunding #PrecisionMedicine 🧪

Informational graphic about NIH Funding Opportunities for the PRIMED-AI Program. The design features a light gray background with circuit board illustrations in the top corners and financial goal/checklist icons in the bottom-left. The header reads "NIH Funding Opportunities – PRIMED-AI Program" followed by a description of the program combining clinical imaging with multimodal health data to develop AI-powered clinical decision support tools. Five funding opportunity cards are displayed: Validation Center (RFA-RM-27-014), Logistics Center (RFA-RM-27-015), Model-to-Clinic (RFA-RM-27-013), Development and Testing of a Multi-use Frameworks Playbook (RFA-RM-27-011), and Data-to-Model: An Academic-Industrial Partnership (RFA-RM-27-012). The footer directs viewers to commonfund.nih.gov/primed-ai for more information

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 02/07/2026

Check out SAO's re-cap of #Shock2026! 🧪 Dr. Gabby Vidaurre presented her poster, "Modernizing Sepsis Research to Advance Human Health," heard updates from NIH on priorities for sepsis research, & caught up with investigators across the country doing excellent human-based research in this field.

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 01/07/2026

🥇 What do "gold standard," "fidelity," "transferability," & "sustainability" actually measure in #SurgicalSimulation? In this new blog, SAO's Donya Mand, MD draws from 2️⃣ recent conferences to examine curriculum, assessment, & the role of animal use in surgical education. ⬇️ Link #MedSky #SurgSky

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 30/06/2026

Laboratory animal personnel as secondary victims of animal experimentation In this new paper, Milford et al. use the "psychosocial hierarchy of controls" to show how the same practices that produce pain, suffering, and death in animals also harm the people who carry them out. 🧵 #bioethics

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 29/06/2026

It's incredible what we can learn when we use innovative tools to ask and answer direct, mechanistic questions about the human brain. 💫🧠💫 Jing Cai and colleagues at MGH recorded wide-scale, single-neuron activity in humans having real-time conversations. ️ 🧵 Coverage by @maxkozlov.bsky.social 👇

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 29/06/2026

🚨💰🔬 #NIDDK is seeking applications for the next phase of the @kpmproject.bsky.social, specifically to lead the project's Central Hub. ⌛ July 10 files.simpler.grants.gov/opportunitie... 🏷️ #liversky #nephsky #NIHFunding #NIHGrant #NIDDK #U24 #NOFO #ResearchFunding #KidneyResearch #PrecisionMedicine

Informational graphic announcing the NIDDK U24 Opportunity: Kidney Precision Medicine Project Central Hub (RFA-DK-27-303). Application closing date: July 10, 2026. The role provides strategic vision and leadership for a unified KPMP-wide effort to discover and define new disease pathways and subgroups that enable precision clinical trials, focusing on scientific discovery, communication and outreach, and project stewardship. The design features a light blue-gray background with decorative banking/goal-themed illustrations in the corners, a calendar icon, and a circular paint stroke accent.

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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 26/06/2026

📉 @gallup.com's annual moral acceptability poll has been conducted since 2001. 2026 marks the first year more Americans viewed medical testing on animals as morally wrong (48%) than morally acceptable (45%). Another 6% had no opinion or said it depends. news.gallup.com/poll/710981/... #morality

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