Cryo-EM, topology mapping and genetic analyses reveal dynamic topological remodeling during assembly of the bacterial flagellar protein-export channel complex, providing a mechanistic framework for ex...

Author summary Bacterial pathogens often use specialized molecular syringes, known as type III secretion systems, to inject effector proteins directly into host cells and manipulate immune defenses. E...

Background: With antimicrobial resistance escalating globally, targeting virulence rather than viability offers a promising therapeutic strategy. The Type III S

The link between diet and overall human health is well established, with certain diets known to promote better health and be associated with a reduced risk of developing chronic diseases. Previous ...

Providencia alcalifaciens is a gram-negative, rod-shaped bacterium belonging to the family Morganellaceae and is commonly isolated from various environmental sources such as soil, water, sewage, meat,...

The link between diet and overall human health is well established, with certain diets known to promote better health and be associated with a reduced risk of developing chronic diseases. Previous ...

Bacterial flagella allow pathogens, such as Salmonella, to navigate complex environments and invade host cells. During flagellar assembly, the basal body must traverse the peptidoglycan layer, a step-...

Author summary Horizontal gene transfer allows bacteria to acquire new traits, including many of the genes that make pathogens harmful. However, newly acquired DNA can also disrupt normal cellular fun...

GpaR directly activates hrpG and hrpX, triggering the HrpG–HrpX cascade to promote virulence in rice and induce the hypersensitive response in nonhost plants, revealing a key upstream regulator of ty....

The type III secretion system (T3SS) is a virulence mechanism commonly used by Gram-negative bacterial pathogens to deliver virulence proteins, known as effectors, into infected cells. The T3SS secret...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Author summary Bacteria can acquire new genes from their environment in a process called horizontal gene transfer. While this enables bacteria to acquire new functions, including virulence genes requi...

Pathogens like Vibrio parahaemolyticus, a common cause of seafood-related gastroenteritis, use flagella to move and spread. Although the motilities help bacteria infect hosts, some V. parahaemolyticus...

Salmonella enterica serovar Typhimurium (STm) infection triggers robust intestinal inflammatory responses during host colonization. Although host i...

Author summary Pseudomonas aeruginosa is a leading cause of microbial keratitis, a sight-threatening infection characterised by rapid tissue destruction. A major contributor to disease severity is the...

Author summary Salmonella is a bacterium that causes a wide range of human diseases, from gastroenteritis to systemic infection. Blood stream infections are more common in young children or those who ...

Through low levels of extracellular ATP, EPEC induces small, rapid and coordinated Ca2+ responses in epithelial cells, a yet unreported pattern, that down-regulate inflammation at the onset of infecti...

In this Review, Vázquez-Torres discusses our current understanding of how the dynamic interplay between microbial competition, host defences and Salmonella enterica serovar Typhimurium countermeasures...

CryoEM analysis of the P-ring on polyrod gives insights into the self-assembly mechanism of the bacterial flagellar motor as to how the P-ring forms around the rod with tight attachment and then detac...

Many Gram-negative pathogens critically depend on the Type III secretion system (T3SS) to inject effector proteins into host cells for colonization. Because the channel of the T3SS is narrow (~2 nm),....

Xylophilus species include poorly characterized plant-associated bacteria, among them the grapevine pathogen Xylophilus ampelinus, yet their molecular mechanisms of host interaction have remained larg...

Diarrheal disease is a leading cause of child morbidity and mortality globally, largely resulting from contaminated food and water and exposure to enteric pathogens. Salmonella enterica serovar Typ...

Salmonella enterica serovar Typhimurium is a major bacterial pathogen that causes intestinal disease by invading host tissues and manipulating cellular functions. In this study, researchers investigat...

The pathogenic bacterium Salmonella survives and replicates in host cells within a Salmonella-containing vacuole (SCV), a membranous niche it actively remodels via secreted effectors. The phosphoinosi...

SyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchnera transmission.

Virulence genes in bacterial pathogens are often A/T-rich and horizontally acquired, yet they must be translated efficiently under stress and nutrient limitation encountered during infection. Here we ...

Human-restricted typhoidal Salmonella enterica serovars cause systemic infections known as enteric fever, whereas most non-typhoidal serovars cause self-limiting gastroenteritis. Both groups rely on f...

Bacterial type III secretion systems export proteins across the inner membrane using the proton-motive force (PMF), but how proton flow is coupled to opening of the export channel is unknown. Here we ...

Bacteria in the genus Yersinia use a type III secretion system to inject several effectors into host cells to disrupt multiple signaling processes. Two effectors disrupt host signaling by inactivating...

Type 3 secretion system (T3SS) injectisomes, the essential virulence factors of many bacterial pathogens, are thought to have evolved from the flagellar T3SS. Despite their high degree of structural s...

Recent advances in infection biology have increasingly underscored that mechanical forces and microenvironmental cues shape host-pathogen interactions…

The type VI secretion system (T6SS) is a widespread nanoweapon deployed by bacteria, but why is its deployment heterogeneous in many species? This study of T6SS in Escherichia coli shows that adopting...

Shigella spp. are the causative agents of bacillary dysentery, or shigellosis, a highly contagious diarrheal disease characterized by abdominal cramps, fever, severe diarrhea, and stools containing mu...

Flagellin is the structural protein of the bacterial flagellar filament, an extracellular propeller that rotates to drive swimming in many bacteria. The structure of flagellin allows for outer domain ...

Author summary To survive and cause disease within the host, enteric pathogens such as Salmonella sense and respond to changing environmental cues. One key strategy is quorum sensing, a cell–cell comm...

The prophage of a clinical Enterobacter isolate uses an RNA-guided transcription factor to alter flagellar composition, leading to enhanced bacterial motility and improved gut colonization in a mouse ...

Enterohemorrhagic Escherichia coli (EHEC) is a well-known foodborne pathogen that causes not only severe hemorrhagic diarrhea but also life-threatening complications such as hemolytic uremic syndrome ...

Living organisms are open systems in constant and selective exchange of matter, energy, and information with their surroundings. In diderm bacteria, the presence of a dual-membrane cell envelope impos...