Reposted by Jose BengoecheaJackie Knee @jackieknee.bsky.social · 12/08/2026Job alert! Join our fantastic cholera research team & work with colleagues at LSHTM, University of Geneva, & DRC. Closing August 30. Details and application here: jobs.lshtm.ac.uk/vacancy.aspx... @lshtm-ehg.bsky.social @gddynamics.bsky.social @lshtm.bsky.social @lshtmamrcentre.bsky.socialjobs.lshtm.ac.ukJob Opportunity at LSHTM: Research FellowThe London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i... 022
Reposted by Jose BengoecheaAlan McNally @alanmcn1.bsky.social · 28/07/2026Peer review as it should be. From an ASM journal. Fine maybe the decision makes you go “ugh” but brilliantly inciteful and constructive review comments that undoubtedly make the paper better. 1172
Jose Bengoechea @josebengoechea.bsky.social · 21/07/2026Delighted to share our last Kleb work. From developing a platform to asses in real time bugs effect on vessels to nail down the role of the T6SS and the CPS including in vvo work. Superb collaboration and hard work of PhD student @safimicro.bsky.social 0194
Jose Bengoechea @josebengoechea.bsky.social · 16/07/2026Delighted with the publication in @cp-trendsmicrobiol.bsky.social of a concept note where we propose a new framework to capture the complexity of infections in vivo: metapopulation infection biology. Supported by Klebsiella and Cryptococcus research among other pathogens www.cell.com/trends/micro...cell.comBeyond intracellular–extracellular divide toward metapopulation infection biologyThe binary classification of pathogens as intracellular or extracellular fails to capture the complexity of infections in vivo. We propose the metapopulation infection biology framework, in which infe... 083
Reposted by Jose BengoecheaLondon School of Hygiene & Tropical Medicine @lshtm.bsky.social · 09/07/2026Meet the ‘princess’ mosquito 👑 🦟 LSHTM establishes UK’s first laboratory colony of Aedes vexans, a mosquito that's very 'high maintenance' Find out how this pioneering research is helping to protect the UK from disease threats as our climate changes 👉 www.lshtm.ac.uk/newsevents/n... 11813
Jose Bengoechea @josebengoechea.bsky.social · 26/06/2026Recruiting a postdoc to join my lab at @lshtm.bsky.social to work in an MRC porgramme grant funded project to dissect the gut colonziation by Klebsiella. In vivo and in vitro models, and new approaches to identify Klebsiella factors involved. jobs.lshtm.ac.uk/vacancy.aspx...jobs.lshtm.ac.ukJob Opportunity at LSHTM: Research FellowThe London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i... 02327
Reposted by Jose BengoecheaMicrobiology Society @microbiologysociety.org · 18/06/2026We asked the Editor-in-Chief of Microbiology Horizons, Tania Dottorini, what our new and exciting multidisciplinary journal can offer the community. To join Tania's passion and excitement for Microbiology Horizons, follow the link to find out more: microb.io/4ttwnbm 012
Reposted by Jose BengoecheaLondon School of Hygiene & Tropical Medicine @lshtm.bsky.social · 16/06/2026📝 LSHTM & @ukhsa.bsky.social have renewed & expanded #UKPHRST academic partnership. 🤝LSHTM will lead a consortium from UK & 6 countries across Africa & SE Asia to co-produce research to protect global health security. Funding: DHSC with UK ODA & NIHR 👉 www.lshtm.ac.uk/newsevents/n...lshtm.ac.ukLSHTM to lead research partnership in £18m outbreak response initiative | LSHTMThe London School of Hygiene & Tropical Medicine (LSHTM) has been selected to lead the research arm of the UK Public Health Rapid Support Team (UK-PHRST) in an £18m initiative to continue to help 1156
Reposted by Jose BengoecheaPLOS Biology @plosbiology.org · 05/06/2026The T6SS is a widespread nanoweapon deployed by #bacteria, but why is it deployed heterogeneously? @cascaleslab.bsky.social &co show that #Ecoli adopt distinct #T6SS attacker "ON" & defender "OFF" roles to optimize survival, a key strategy in microbial warfare @plosbiology.org 🧪 plos.io/3S5dL45 1269
Reposted by Jose BengoecheaLondon School of Hygiene & Tropical Medicine @lshtm.bsky.social · 27/05/2026Want to learn more about LSHTM's #MRes in Infectious & Tropical Diseases? 😃 Join our online information webinar on Thursday 28 May 2026 (14:00-15:00 UK time) to learn more about our exciting new programme. Book your place 👉 lshtm.zoom.us/webinar/regi... #PublicHealth 166
Reposted by Jose BengoecheaDaniel L. Barber, PhD @danbarberphd.bsky.social · 29/04/2026So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB #tuberculosis #immunologyrdcu.beIFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial controlNature Communications - Here, the authors show that IFNγ blockade does not impair resistance to Mycobacterium tuberculosis infection in macaques, opposed to what has been observed in mice, due... 24222
Reposted by Jose BengoecheaChristian Lentz @christianslentz.bsky.social · 13/04/2026Come join us! 4 year PhD position in infection biology/microbiology available associated to our newly funded Clinical Academic Group “Patient-tailored management of bacterial infections in the age of antimicrobial resistance”. Applications via: www.jobbnorge.no/en/available.... @cansuit.bsky.socialjobbnorge.noPhD fellow in infection biology/microbiology (297648) | UiT The Arctic University of NorwayJob title: PhD fellow in infection biology/microbiology (297648), Employer: UiT The Arctic University of Norway, Deadline: Tuesday, April 28, 2026 034
Reposted by Jose BengoecheaLondon School of Hygiene & Tropical Medicine @lshtm.bsky.social · 07/04/2026LSHTM: where your 'what ifs' become your reason why... This #WorldHealthDay find out how you could become part of our community, tackling the complex challenges of global & #PublicHeath with clarity, compassion and conviction. Join us: explore our programmes: www.lshtm.ac.uk/study?utm_so... 0119
Reposted by Jose BengoecheaJosé R Penadés @jrpenades.bsky.social · 05/04/2026Latest from the lab! Between clinical S. aureus, most gene transfer mechanisms are blocked, yet lateral transduction remains highly efficient. Restriction modification-defective strains act as gateways for horizontal gene transfer, enabling DNA flow across populations. rdcu.be/fbNQKrdcu.beImmune-deficient bacteria serve as gateways to genetic exchange and microbial evolutionNature Communications - The efficiency of horizontal gene transfer between different bacterial lineages is often unclear. Here, Figueroa et al. show that lateral transduction is the primary driver... 03118
Reposted by Jose BengoecheaPatrick Moynihan @pmoyniha.bsky.social · 27/03/2026We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...biorxiv.org 44826
Reposted by Jose BengoecheaLondon School of Hygiene & Tropical Medicine @lshtm.bsky.social · 26/03/2026Introducing the #MRes in Infectious & Tropical Diseases LSHTM’s exciting new #postgraduate degree putting you at the heart of our world-leading research: → Learn from the experts → Build your network → Study in a unique environment Applications now open 👉 www.lshtm.ac.uk/study/course... 11815
Jose Bengoechea @josebengoechea.bsky.social · 24/03/2026@lshtm.bsky.social launches its new MRes in Infectious & Tropical Diseases, a research-focused Master’s. It is based within LSHTM’s Faculty of Infectious & Tropical Disease. Strong option for intercaled students. More details here: www.lshtm.ac.uk/study/course...lshtm.ac.ukMRes Infectious & Tropical Diseases | LSHTM 087
Reposted by Jose BengoecheaLondon School of Hygiene & Tropical Medicine @lshtm.bsky.social · 17/03/2026BREAKING NEWS: Deadly outbreak of #meningitis B in UK LSHTM experts discuss latest situation, including access to #MenB #vaccines More: www.lshtm.ac.uk/newsevents/n... #PublicHealth 12419
Reposted by Jose BengoecheaLondon School of Hygiene & Tropical Medicine @lshtm.bsky.social · 12/03/2026👋We welcomed Director-General of @who.int & LSHTM alumnus @drtedros.who.int who returned to LSHTM this week to discuss how we can strengthen collaborations to tackle major #GlobalHealth challenges.🌍 👉 www.lshtm.ac.uk/research/cen... 1177
Reposted by Jose BengoecheaWillem van Schaik @wvschaik.bsky.social · 03/03/2026Great @imibirmingham.bsky.social seminar by the brilliant @josebengoechea.bsky.social who has uncovered another cool and important mechanisms in Klebsiella pneumoniae virulence (no spoilers because unpublished data) 1112
Reposted by Jose BengoecheaSFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 27/02/2026🔬 New work from the Mazel Lab engineers programmable conjugative plasmids to selectively target MDR bacteria and the resistance plasmid pOXA-48, blocking its spread in complex communities. ✍️ @amazeld.bsky.social & coll. @pasteur.fr 📖 shorturl.at/GZdJu #MicroSky #AntibioticResistance #Conjugation 01911
Reposted by Jose BengoecheaMatthias Trost @mtrost.bsky.social · 26/02/2026I am rather worried that this government not only will actively fail UK universities but also screw over one of the gems of UK economy - science and life science, particularly. Will UKRI's funding buckets shore up UK research? share.google/B92vQ7E6nEOK...share.googleWill UKRI’s funding buckets shore up UK research’s sandcastle?Academics’ concerns are mounting as news drips out of the research councils about cuts and freezes ahead of a major funding restructuring intended to promote interdisciplinarity and transparency. But ... 042
Reposted by Jose BengoecheaLondon School of Hygiene & Tropical Medicine @lshtm.bsky.social · 24/02/2026👋LSHTM offers #scholarships to tackle barriers to education for students from all backgrounds. Check out our First and Next Generation Scholarships for home fee students & those interested in distance learning MSc programmes. Apply by 27 March 2026👉 www.lshtm.ac.uk/study/fees-a... 088
Reposted by Jose BengoecheaMicrobiology Society @microbiologysociety.org · 23/02/2026Join us this Thursday for our online seminar series, Safe Microbiome Perturbations. Featuring a live discussion on 'Gut Microbiome and Probiotics.' Register now: microb.io/3OBhVPs #GutMicrobiome #WebinarSeries 134
Reposted by Jose BengoecheaRoss Fitzgerald @jrossfitz.bsky.social · 18/02/2026Insights into how #Staph aureus adapts to the bovine host by unlocking nutrients from the dairy niche. Great work by Amy Pickering, Jamie Gorzynski and others in the group. Bacterial metabolic remodeling by convergent evolution after a host switch.|Science Advances www.science.org/doi/10.1126/...science.orgBacterial metabolic remodeling by convergent evolution unlocks nutrient availability after a host switchStaphylococcus aureus has undergone metabolic remodeling to adapt to the dairy niche. 02915
Reposted by Jose BengoecheaCraig Winstanley @cwinstan.bsky.social · 02/02/2026On this plus side, the number of billionaires in the UK rose from 15 in 1990 to 165 in 2024. Huzzah! 002
Reposted by Jose BengoecheaIvan Zanoni @lozanzi.bsky.social · 18/01/2026#WeekendRead #MicrobiotaPower! Tsai, @diehllab.bsky.social &co show @ Science Immunology that E. coli flagellin is recognized by TLR5 on intestinal epithelial stem cells to recruit gut protective CCR2+ monocyte-derived macrophages, decreasing colitis! #IBDs doi.org/10.1126/sciimmunol.adr4057doi.orgIntestinal epithelial TLR5 signaling promotes barrier-supportive macrophagesColonic stem cell TLR5 sensing of microbes promotes macrophage recruitment and maturation to support intestinal barrier repair. 081
Jose Bengoechea @josebengoechea.bsky.social · 15/12/2025Milestone of the lab...10000 strains in our collection! 0110
Reposted by Jose BengoecheaLondon School of Hygiene & Tropical Medicine @lshtm.bsky.social · 20/11/2025#Klebsiella infections are a serious & growing #PublicHealth threat For #AntimicrobialAwarenessWeek, @josebengoechea.bsky.social discusses the dangers of bacterial infections, antimicrobial resistance & the global efforts to tackle it. @lshtmamrcentre.bsky.social www.lshtm.ac.uk/newsevents/e... 088
Jose Bengoechea @josebengoechea.bsky.social · 10/11/2025For anyone interested in doing a PhD at the interface of microbiology and immunology focusing on how AMR pathogens subvert host defenses...you may consider applying to our MRC LID DTP project in which we will explore how Klebsiella hijacks the immune checkpoint PD-L1 mrc-lid.lshtm.ac.uk/apply/mrc-lid.lshtm.ac.ukHow to Apply - MRC London Intercollegiate Doctoral Training Partnership StudentshipsMRC LID is open for application for 2026-27 PRE-APPLICATION STEPS 1. Find out more about... 053
Reposted by Jose BengoecheaConnor Sharp @magicmicrobe.bsky.social · 05/11/2025So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae. www.nature.com/articles/s41...nature.comBacterial warfare is associated with virulence and antimicrobial resistance - Nature CommunicationsBacteria employ a range of competition systems that deliver toxins to inhibit competing strains. This study shows that these systems are particularly important for the ecology of virulent and antibiot... 17840
Reposted by Jose BengoecheaHetan Shah @hetanshah.bsky.social · 30/10/2025Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term www.gov.uk/government/p...gov.ukThe value of public R&D 8628353
Reposted by Jose BengoecheaBibiana Rojas @biobiiana.bsky.social · 23/10/2025What makes PhD students happy? Good supervision www.nature.com/articles/d41...nature.comWhat makes PhD students happy? Good supervisionSupervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research. 14420
Reposted by Jose BengoecheaPLOS Biology @plosbiology.org · 23/10/2025Intrinsic resistance pathways & #ResistanceBreaking. Study shows that inhibiting efflux pumps & cell envelope biogenesis sensitizes #bacteria to #antibiotics, but rapid evolutionary recovery may limit long-term effectiveness of resistance-breaking strategies #AMR @plosbiology.org 🧪 plos.io/4huAtvo 2117
Reposted by Jose BengoecheaSerge Mostowy @sergemostowylab.bsky.social · 13/10/2025Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei @sydneylmiles.bsky.social @katholt.bsky.social 🙏to transformative collaborative effort www.nature.com/articles/s41... 12314
Reposted by Jose BengoecheaAlvaro San Millan @sanmillan.bsky.social · 22/10/2025New paper with my (amazing) friend and mentor @jrpenades.bsky.social Really looking forward to see what plasmid aficionados think of this one!! With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others www.cell.com/cell-reports...cell.comNon-conjugative plasmids limit their mobility to persist in natureSabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it... 17742
Reposted by Jose BengoecheaLondon School of Hygiene & Tropical Medicine @lshtm.bsky.social · 20/10/2025#WHO report shows rising #antibiotic resistance in common bacteria @katholt.bsky.social & @josebengoechea.bsky.social explain resistance worryingly high in #Klebsiella & E.coli as 1 in 6 lab-confirmed #bacterial infections in 2023 shown resistant to antibiotics. www.lshtm.ac.uk/newsevents/n... 23411
Reposted by Jose BengoecheaIlyas Alav @ilyasalav.bsky.social · 22/09/2025My nose must be riddled with S. aureus then 🫠 062
Reposted by Jose BengoecheaᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 21/09/2025𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢 𝘱𝘯𝘦𝘶𝘮𝘰𝘯𝘪𝘢𝘦 is a Gram-negative, non-motile, straight rod-shaped bacterium that can divide rapidly, with some strains having a median doubling time of < 30 min, forming biofilms that interfere with both antibiotic and immune clearance 5365
Reposted by Jose BengoecheaOlaya Rendueles @olayarendueles.bsky.social · 12/09/2025What an incredible week for @julielebris.bsky.social with one published ms in @asm.org #mBio on #capsule phenotypic heterogeneity & a preprint on the modular evolution of a highly exchangeable locus ⏩️capsule 😅 All her hard work is paying off! #ProudPI #microsky @klebclub.bsky.social Check her 🧵👇🏻 091
Reposted by Jose BengoecheaNature Microbiology @natmicrobiol.nature.com · 08/09/2025#NewResearch This study uses Salmonella strains genetically engineered to express minimal effector subsets and mass cytometry to characterise infection of the spleen, revealing bottlenecks overcome by these effectors #MicroSky www.nature.com/articles/s41...nature.comSingle-cell analysis of genetically minimized Salmonella reveals effector gene cooperation in vivo - Nature MicrobiologyA minimal effector subset enables Salmonella Typhimurium to overcome bottlenecks regulated by the early innate immune response and establish infection within a CD62L+ monocyte niche in the spleen. 065
Reposted by Jose BengoecheaJessica Blair @jessicamablair.bsky.social · 01/09/2025A good way to think about institutional research culture! 2289
Jose Bengoechea @josebengoechea.bsky.social · 26/08/2025Good opportunity here to work with a super talented new PI. 112
Reposted by Jose BengoecheaWillem van Schaik @wvschaik.bsky.social · 20/08/2025Maybe I am being grumpy, but can people please stop using poorly curated databases of antibiotic resistance genes (I am looking at you, DeepARG) on shotgun metagenomic data and then present these results without any reflection on their validity, or shortcomings of databases? 45410
Reposted by Jose BengoecheaASM @asm.org · 29/07/2025New in #JClinMicro! An optimized, streamlined nanopore-only workflow for epidemiologic analysis of bacterial pathogens, enabling outbreak analysis with performance comparable to that of Illumina short-read sequencing. Get the details: asm.social/2wd 189
Reposted by Jose BengoecheaAsaf Levy @asaflevylab.bsky.social · 22/10/2024Several years of work with several great collaborators, that combined computational biology, molecular microbiology, biochemistry, structural biology and mycology assay culminated in today's publication on discovery of novel bacterial toxins: www.nature.com/articles/s41...nature.comSystematic discovery of antibacterial and antifungal bacterial toxins - Nature MicrobiologyGenome sequence mining and computational analyses lead to the discovery and functional characterization of conserved bacterial toxins with activity against bacteria and fungi. 05729