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Jose Bengoechea

@josebengoechea.bsky.social
1K followers 549 following 74 posts

Working on innate immunity & host-pathogen interactions. Finding new ways to treat infections by antibiotic resistant bacteria. All views are my own.

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Jose Bengoechea @josebengoechea.bsky.social · 19/08/2026
Exciting story!
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Jose Bengoechea @josebengoechea.bsky.social · 18/08/2026
Strongly recommend this one....
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Jackie Knee @jackieknee.bsky.social · 12/08/2026
Job alert! Join our fantastic cholera research team & work with colleagues at LSHTM, University of Geneva, & DRC. Closing August 30. Details and application here: jobs.lshtm.ac.uk/vacancy.aspx... @lshtm-ehg.bsky.social @gddynamics.bsky.social @lshtm.bsky.social @lshtmamrcentre.bsky.social
jobs.lshtm.ac.uk
Job Opportunity at LSHTM: Research Fellow
The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i...
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Alan McNally @alanmcn1.bsky.social · 28/07/2026
Peer review as it should be. From an ASM journal. Fine maybe the decision makes you go “ugh” but brilliantly inciteful and constructive review comments that undoubtedly make the paper better.
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Jose Bengoechea @josebengoechea.bsky.social · 21/07/2026
Delighted to share our last Kleb work. From developing a platform to asses in real time bugs effect on vessels to nail down the role of the T6SS and the CPS including in vvo work. Superb collaboration and hard work of PhD student @safimicro.bsky.social
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Jose Bengoechea @josebengoechea.bsky.social · 16/07/2026
Delighted with the publication in @cp-trendsmicrobiol.bsky.social of a concept note where we propose a new framework to capture the complexity of infections in vivo: metapopulation infection biology. Supported by Klebsiella and Cryptococcus research among other pathogens www.cell.com/trends/micro...
cell.com
Beyond intracellular–extracellular divide toward metapopulation infection biology
The binary classification of pathogens as intracellular or extracellular fails to capture the complexity of infections in vivo. We propose the metapopulation infection biology framework, in which infe...
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 09/07/2026
Meet the ‘princess’ mosquito 👑 🦟 LSHTM establishes UK’s first laboratory colony of Aedes vexans, a mosquito that's very 'high maintenance' Find out how this pioneering research is helping to protect the UK from disease threats as our climate changes 👉 www.lshtm.ac.uk/newsevents/n...
Photo of Mocja Kristan, wearing glasses and a dark top, leant over a bowl labelled 'Ae vexans' while transferring mosquito larvae in a white laboratory environment.
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Jose Bengoechea @josebengoechea.bsky.social · 26/06/2026
Recruiting a postdoc to join my lab at @lshtm.bsky.social to work in an MRC porgramme grant funded project to dissect the gut colonziation by Klebsiella. In vivo and in vitro models, and new approaches to identify Klebsiella factors involved. jobs.lshtm.ac.uk/vacancy.aspx...
jobs.lshtm.ac.uk
Job Opportunity at LSHTM: Research Fellow
The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i...
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Microbiology Society @microbiologysociety.org · 18/06/2026
We asked the Editor-in-Chief of Microbiology Horizons, Tania Dottorini, what our new and exciting multidisciplinary journal can offer the community. To join Tania's passion and excitement for Microbiology Horizons, follow the link to find out more: microb.io/4ttwnbm
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 16/06/2026
📝 LSHTM & @ukhsa.bsky.social have renewed & expanded #UKPHRST academic partnership. 🤝LSHTM will lead a consortium from UK & 6 countries across Africa & SE Asia to co-produce research to protect global health security. Funding: DHSC with UK ODA & NIHR 👉 www.lshtm.ac.uk/newsevents/n...
lshtm.ac.uk
LSHTM to lead research partnership in £18m outbreak response initiative | LSHTM
The London School of Hygiene & Tropical Medicine (LSHTM) has been selected to lead the research arm of the UK Public Health Rapid Support Team (UK-PHRST) in an £18m initiative to continue to help
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PLOS Biology @plosbiology.org · 05/06/2026
The T6SS is a widespread nanoweapon deployed by #bacteria, but why is it deployed heterogeneously? @cascaleslab.bsky.social &co show that #Ecoli adopt distinct #T6SS attacker "ON" & defender "OFF" roles to optimize survival, a key strategy in microbial warfare @plosbiology.org 🧪 plos.io/3S5dL45
Top: Representative confocal fields of the 3 types of TssC-GFP-TssK microcolonies (homogeneous ON, heterogeneous, homogeneous OFF). Scale bars, 10 μm. Bottom:  Model for the role of T6SS phenotypic heterogeneity in EAEC. Top: The Psci1 promoter integrates Fur- and Dam-dependent regulation, generating ON (T6SS⁺, yellow) and OFF (T6SS⁻, blue) subpopulations at a reversible equilibrium. Bottom left: OFF (blue) cells, which do not express T6SS, do not kill competitors but avoid triggering such defences (1). Due to the absence of killing activity, OFF cells are unable to colonize the niche (2). Bottom centre: While ON (yellow) cells assemble and deploy functional T6SS (1) and kill susceptible competitors (2), they provoke retaliatory attacks from defensive T6SS⁺ species (gray) and are eliminated and fail to colonize the niche (3). Bottom right: Heterogeneous ON/OFF population (1) optimizes colonization by killing neighboring cells (2). While ON (yellow) cells are eliminated by counterattacks by defensive T6SS+ species (gray), OFF (blue) cells resist (3) and can ensure a continuous supply of ON cells (4-5) while limiting population-wide exposure to retaliation.
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 27/05/2026
Want to learn more about LSHTM's #MRes in Infectious & Tropical Diseases? 😃 Join our online information webinar on Thursday 28 May 2026 (14:00-15:00 UK time) to learn more about our exciting new programme. Book your place 👉 lshtm.zoom.us/webinar/regi... #PublicHealth
Graphic with white text on a blue background reading: MRes Information Webinar Thursday 28 May 2026 14:00-15:00 (UK time) Online with an inset image of two women in white lab coats and purple gloves handling specimen vials.
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Daniel L. Barber, PhD @danbarberphd.bsky.social · 29/04/2026
So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB #tuberculosis #immunology
rdcu.be
IFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial control
Nature Communications - Here, the authors show that IFNγ blockade does not impair resistance to Mycobacterium tuberculosis infection in macaques, opposed to what has been observed in mice, due...
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Christian Lentz @christianslentz.bsky.social · 13/04/2026
Come join us! 4 year PhD position in infection biology/microbiology available associated to our newly funded Clinical Academic Group “Patient-tailored management of bacterial infections in the age of antimicrobial resistance”. Applications via: www.jobbnorge.no/en/available.... @cansuit.bsky.social
jobbnorge.no
PhD fellow in infection biology/microbiology (297648) | UiT The Arctic University of Norway
Job title: PhD fellow in infection biology/microbiology (297648), Employer: UiT The Arctic University of Norway, Deadline: Tuesday, April 28, 2026
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 07/04/2026
LSHTM: where your 'what ifs' become your reason why... This #WorldHealthDay find out how you could become part of our community, tackling the complex challenges of global & #PublicHeath with clarity, compassion and conviction. Join us: explore our programmes: www.lshtm.ac.uk/study?utm_so...
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José R Penadés @jrpenades.bsky.social · 05/04/2026
Latest from the lab! Between clinical S. aureus, most gene transfer mechanisms are blocked, yet lateral transduction remains highly efficient. Restriction modification-defective strains act as gateways for horizontal gene transfer, enabling DNA flow across populations. rdcu.be/fbNQK
rdcu.be
Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution
Nature Communications - The efficiency of horizontal gene transfer between different bacterial lineages is often unclear. Here, Figueroa et al. show that lateral transduction is the primary driver...
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Patrick Moynihan @pmoyniha.bsky.social · 27/03/2026
We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 26/03/2026
Introducing the #MRes in Infectious & Tropical Diseases LSHTM’s exciting new #postgraduate degree putting you at the heart of our world-leading research: → Learn from the experts → Build your network → Study in a unique environment Applications now open 👉 www.lshtm.ac.uk/study/course...
Graphic with white text reading: New programme, MRes Infectious & Tropical Diseases on a royal blue background. An inset image shows two female researchers in white coats and purple gloves standing in a laboratory placing specimen vials into a machine.
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Jose Bengoechea @josebengoechea.bsky.social · 24/03/2026
@lshtm.bsky.social launches its new MRes in Infectious & Tropical Diseases, a research-focused Master’s. It is based within LSHTM’s Faculty of Infectious & Tropical Disease. Strong option for intercaled students. More details here: www.lshtm.ac.uk/study/course...
lshtm.ac.uk
MRes Infectious & Tropical Diseases | LSHTM
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 17/03/2026
BREAKING NEWS: Deadly outbreak of #meningitis B in UK LSHTM experts discuss latest situation, including access to #MenB #vaccines More: www.lshtm.ac.uk/newsevents/n... #PublicHealth
Light blue graphic with black text reading: "Meningitis is now very rare in the UK in the era of vaccination but there are still cases every year." Eliza Gil, Clinical Lecturer, LSHTM
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Jose Bengoechea @josebengoechea.bsky.social · 16/03/2026
Indeed!
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 12/03/2026
👋We welcomed Director-General of @who.int & LSHTM alumnus @drtedros.who.int who returned to LSHTM this week to discuss how we can strengthen collaborations to tackle major #GlobalHealth challenges.🌍 👉 www.lshtm.ac.uk/research/cen...
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Willem van Schaik @wvschaik.bsky.social · 03/03/2026
Great @imibirmingham.bsky.social seminar by the brilliant @josebengoechea.bsky.social who has uncovered another cool and important mechanisms in Klebsiella pneumoniae virulence (no spoilers because unpublished data)
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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 27/02/2026
🔬 New work from the Mazel Lab engineers programmable conjugative plasmids to selectively target MDR bacteria and the resistance plasmid pOXA-48, blocking its spread in complex communities. ✍️ @amazeld.bsky.social & coll. @pasteur.fr 📖 shorturl.at/GZdJu #MicroSky #AntibioticResistance #Conjugation
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Matthias Trost @mtrost.bsky.social · 26/02/2026
I am rather worried that this government not only will actively fail UK universities but also screw over one of the gems of UK economy - science and life science, particularly. Will UKRI's funding buckets shore up UK research? share.google/B92vQ7E6nEOK...
share.google
Will UKRI’s funding buckets shore up UK research’s sandcastle?
Academics’ concerns are mounting as news drips out of the research councils about cuts and freezes ahead of a major funding restructuring intended to promote interdisciplinarity and transparency. But ...
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 24/02/2026
👋LSHTM offers #scholarships to tackle barriers to education for students from all backgrounds. Check out our First and Next Generation Scholarships for home fee students & those interested in distance learning MSc programmes. Apply by 27 March 2026👉 www.lshtm.ac.uk/study/fees-a...
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Microbiology Society @microbiologysociety.org · 23/02/2026
Join us this Thursday for our online seminar series, Safe Microbiome Perturbations. Featuring a live discussion on 'Gut Microbiome and Probiotics.' Register now: microb.io/3OBhVPs #GutMicrobiome #WebinarSeries
Virtual webinar on safe microbiome perturbations focusing on gut microbiome and probiotics, scheduled for 26 February 2026.
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Ross Fitzgerald @jrossfitz.bsky.social · 18/02/2026
Insights into how #Staph aureus adapts to the bovine host by unlocking nutrients from the dairy niche. Great work by Amy Pickering, Jamie Gorzynski and others in the group. Bacterial metabolic remodeling by convergent evolution after a host switch.|Science Advances www.science.org/doi/10.1126/...
science.org
Bacterial metabolic remodeling by convergent evolution unlocks nutrient availability after a host switch
Staphylococcus aureus has undergone metabolic remodeling to adapt to the dairy niche.
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Craig Winstanley @cwinstan.bsky.social · 02/02/2026
On this plus side, the number of billionaires in the UK rose from 15 in 1990 to 165 in 2024. Huzzah!
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Ivan Zanoni @lozanzi.bsky.social · 18/01/2026
#WeekendRead #MicrobiotaPower! Tsai, @diehllab.bsky.social &co show @ Science Immunology that E. coli flagellin is recognized by TLR5 on intestinal epithelial stem cells to recruit gut protective CCR2+ monocyte-derived macrophages, decreasing colitis! #IBDs doi.org/10.1126/sciimmunol.adr4057
doi.org
Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages
Colonic stem cell TLR5 sensing of microbes promotes macrophage recruitment and maturation to support intestinal barrier repair.
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Jose Bengoechea @josebengoechea.bsky.social · 15/12/2025
Milestone of the lab...10000 strains in our collection!
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 20/11/2025
#Klebsiella infections are a serious & growing #PublicHealth threat For #AntimicrobialAwarenessWeek, @josebengoechea.bsky.social discusses the dangers of bacterial infections, antimicrobial resistance & the global efforts to tackle it. @lshtmamrcentre.bsky.social www.lshtm.ac.uk/newsevents/e...
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Jose Bengoechea @josebengoechea.bsky.social · 10/11/2025
For anyone interested in doing a PhD at the interface of microbiology and immunology focusing on how AMR pathogens subvert host defenses...you may consider applying to our MRC LID DTP project in which we will explore how Klebsiella hijacks the immune checkpoint PD-L1 mrc-lid.lshtm.ac.uk/apply/
mrc-lid.lshtm.ac.uk
How to Apply - MRC London Intercollegiate Doctoral Training Partnership Studentships
MRC LID is open for application for 2026-27 PRE-APPLICATION STEPS 1. Find out more about...
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Connor Sharp @magicmicrobe.bsky.social · 05/11/2025
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae. www.nature.com/articles/s41...
nature.com
Bacterial warfare is associated with virulence and antimicrobial resistance - Nature Communications
Bacteria employ a range of competition systems that deliver toxins to inhibit competing strains. This study shows that these systems are particularly important for the ecology of virulent and antibiot...
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Hetan Shah @hetanshah.bsky.social · 30/10/2025
Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term www.gov.uk/government/p...
gov.uk
The value of public R&D
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Bibiana Rojas @biobiiana.bsky.social · 23/10/2025
What makes PhD students happy? Good supervision www.nature.com/articles/d41...
nature.com
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
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PLOS Biology @plosbiology.org · 23/10/2025
Intrinsic resistance pathways & #ResistanceBreaking. Study shows that inhibiting efflux pumps & cell envelope biogenesis sensitizes #bacteria to #antibiotics, but rapid evolutionary recovery may limit long-term effectiveness of resistance-breaking strategies #AMR @plosbiology.org 🧪 plos.io/4huAtvo
Genome-wide screen to identify Escherichia coli gene knockouts hypersensitive to trimethoprim and chloramphenicol. Top left: Schematic showing the screening strategy for identifying hypersensitive gene knockouts from the Keio mutant library. All mutants were cultured in LB and LB supplemented with trimethoprim (TMP) and chloramphenicol (CMP) at their respective IC50s. Top right: Distribution of drug-susceptibilities of Keio mutants grown in indicated growth media obtained after normalizing the growth of each mutant to wild type (set to 1). Mean ± S.D. derived after fitting each distribution to a Gaussian function are shown. Bottom left: Analysis of gene functional categories for hypersensitive mutants compared with the frequency of genes in each category encoded by E. coli K-12 MG1655. Percentage of the total in each case is provided above each bar. Bottom right: Comparison of hypersensitive mutants identified in the trimethoprim and chloramphenicol screens shown as a Venn diagram. Representative genes from each set are named and gene names are colored by functional categories.
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Serge Mostowy @sergemostowylab.bsky.social · 13/10/2025
Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei @sydneylmiles.bsky.social @katholt.bsky.social 🙏to transformative collaborative effort www.nature.com/articles/s41...
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Alvaro San Millan @sanmillan.bsky.social · 22/10/2025
New paper with my (amazing) friend and mentor @jrpenades.bsky.social Really looking forward to see what plasmid aficionados think of this one!! With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others www.cell.com/cell-reports...
cell.com
Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 20/10/2025
#WHO report shows rising #antibiotic resistance in common bacteria @katholt.bsky.social & @josebengoechea.bsky.social explain resistance worryingly high in #Klebsiella & E.coli as 1 in 6 lab-confirmed #bacterial infections in 2023 shown resistant to antibiotics. www.lshtm.ac.uk/newsevents/n...
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Ilyas Alav @ilyasalav.bsky.social · 22/09/2025
My nose must be riddled with S. aureus then 🫠
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 21/09/2025
𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢 𝘱𝘯𝘦𝘶𝘮𝘰𝘯𝘪𝘢𝘦 is a Gram-negative, non-motile, straight rod-shaped bacterium that can divide rapidly, with some strains having a median doubling time of < 30 min, forming biofilms that interfere with both antibiotic and immune clearance
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Olaya Rendueles @olayarendueles.bsky.social · 12/09/2025
What an incredible week for @julielebris.bsky.social with one published ms in @asm.org #mBio on #capsule phenotypic heterogeneity & a preprint on the modular evolution of a highly exchangeable locus ⏩️capsule 😅 All her hard work is paying off! #ProudPI #microsky @klebclub.bsky.social Check her 🧵👇🏻
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Jose Bengoechea @josebengoechea.bsky.social · 11/09/2025
Cool work Lindsay, congrats.
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Nature Microbiology @natmicrobiol.nature.com · 08/09/2025
#NewResearch This study uses Salmonella strains genetically engineered to express minimal effector subsets and mass cytometry to characterise infection of the spleen, revealing bottlenecks overcome by these effectors #MicroSky www.nature.com/articles/s41...
nature.com
Single-cell analysis of genetically minimized Salmonella reveals effector gene cooperation in vivo - Nature Microbiology
A minimal effector subset enables Salmonella Typhimurium to overcome bottlenecks regulated by the early innate immune response and establish infection within a CD62L+ monocyte niche in the spleen.
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Jessica Blair @jessicamablair.bsky.social · 01/09/2025
A good way to think about institutional research culture!
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Jose Bengoechea @josebengoechea.bsky.social · 26/08/2025
Good opportunity here to work with a super talented new PI.
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Willem van Schaik @wvschaik.bsky.social · 20/08/2025
Maybe I am being grumpy, but can people please stop using poorly curated databases of antibiotic resistance genes (I am looking at you, DeepARG) on shotgun metagenomic data and then present these results without any reflection on their validity, or shortcomings of databases?
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ASM @asm.org · 29/07/2025
New in #JClinMicro! An optimized, streamlined nanopore-only workflow for epidemiologic analysis of bacterial pathogens, enabling outbreak analysis with performance comparable to that of Illumina short-read sequencing. Get the details: asm.social/2wd
Schematic overview of benchmarking approach, highlighting the optimized pipeline.
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Asaf Levy @asaflevylab.bsky.social · 22/10/2024
Several years of work with several great collaborators, that combined computational biology, molecular microbiology, biochemistry, structural biology and mycology assay culminated in today's publication on discovery of novel bacterial toxins: www.nature.com/articles/s41...
nature.com
Systematic discovery of antibacterial and antifungal bacterial toxins - Nature Microbiology
Genome sequence mining and computational analyses lead to the discovery and functional characterization of conserved bacterial toxins with activity against bacteria and fungi.
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