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Silas Maniatis

@manimota.bsky.social
1.9K followers 4.4K following 189 posts

Father and scientist. Doing dad stuff in Brooklyn and science at New York Genome Center. 𝘈𝘴𝘴𝘰𝘤𝘪𝘢𝘵𝘦 𝘋𝘪𝘳𝘦𝘤𝘵𝘰𝘳, 𝘚𝘱𝘢𝘵𝘪𝘢𝘭 𝘎𝘦𝘯𝘰𝘮𝘪𝘤𝘴 𝘈𝘳𝘤𝘩𝘪𝘷𝘦 𝘰𝘧 𝘮𝘺 𝘵𝘪𝘮𝘦 𝘢𝘵 𝘵𝘩𝘦 𝘰𝘭𝘥 𝘱𝘭𝘢𝘤𝘦 @𝘮𝘢𝘯𝘪𝘮𝘰𝘵𝘢𝘴𝘰𝘭𝘥𝘴𝘵𝘶𝘧𝘧.𝘣𝘴𝘬𝘺.𝘴𝘰𝘤𝘪𝘢𝘭 @𝘮𝘢𝘯𝘪𝘮𝘰𝘵𝘢 𝘰𝘯 𝘮𝘰𝘴𝘵 𝘱𝘭𝘢𝘵𝘧𝘰𝘳𝘮𝘴

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Silas Maniatis @manimota.bsky.social · 28/09/2026
In 2022 we published an open-source hardware, software, and protocols ecosystem for repurposing sequencers as automated fluidics coupled imaging instruments. On Oct 13 @yougotkunal.bsky.social & @nygenome.org will host a workshop on current applications. Register here: regenseq.github.io/meeting/
regenseq.github.io
RegenSeq Community Meeting 2026
Bringing together the RegenSeq community across multiplexed imaging, spatial transcriptomics, and optical pooled screening.
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Silas Maniatis @manimota.bsky.social · 11/09/2026
25 years ago, hours after the towers fell, I decided to climb onto my roof and see what the clearing smoke and ash would reveal. When I reached the roof, it was covered in heavy ash and a ton of papers like these. If you weren’t old enough or don’t remember, Cantor Fitzgerald occupied…..
A photo of burned papers from the offices of Cantor Fitzgerald that were collected from a cobble hill Brooklyn rooftop on 9/11/2001
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Silas Maniatis @manimota.bsky.social · 10/09/2026
We spread love (and crafting supplies)
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Stephen Turner @stephenturner.us · 03/05/2026
Free and open-source images, icons, and tools for creating scientific illustrations doi.org/10.59350/5zt... 🧪
doi.org
Free and open-source images, icons, and tools for creating scientific illustrations
Phylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics
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Silas Maniatis @manimota.bsky.social · 17/07/2026
Ummmm…. Not good
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Silas Maniatis @manimota.bsky.social · 13/07/2026
Manhattanhenge Brooklyn golden hour remains undefeated
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Silas Maniatis @manimota.bsky.social · 05/07/2026
Brooklyn July 4th golden hour remains undefeated
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Silas Maniatis @manimota.bsky.social · 05/07/2026
Brooklyn July 4th golden hour remains undefeated
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Silas Maniatis @manimota.bsky.social · 12/06/2026
Starting now: @nygenome.org ‘s Satija Lab Single Cell Genomics Day! No better annual summation of advances in single cell and spatial genomics is available, and it’s free! Don’t miss it! www.youtube.com/live/ynO1PtN...
youtube.com
Single Cell Genomics Day 2026
YouTube video by Satija Lab
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Front Line Genomics @flgenomics.bsky.social · 01/05/2026
Ioannis Vlachos (Associate Professor of Pathology, Director of the Spatial Technologies Unit, Harvard Medical School) will be speaking at #FOGBoston! He’ll join a panel discussion on Spatial Technologies: What’s Real, What’s Hype, What’s Missing. More info: hubs.la/Q044gKQm0 @ioavlachos.bsky.social
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New York Genome Center @nygenome.org · 01/06/2026
Join us for the 3rd NYC Chromatin Club Symposium on July 21! Registration is completely free, but be sure to secure your spot before the deadline this Friday, June 5th. To register, please use this link. docs.google.com/forms/d/e/1F...
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Purchase with Purpose @purchase-w-purpose.bsky.social · 31/05/2026
🇪🇺 Meet EuroOffice, Europe’s bold alternative to Microsoft 365, promising sovereignty and control It is based on OnlyOffice and offers a near-like-for-like experience as Microsoft for free. Something for everyone to check out, not only Europeans.
windowscentral.com
EuroOffice emerges as Europe’s sovereignty‑focused alternative to Microsoft 365
Europe’s biggest tech players debut EuroOffice, a sovereign suite designed to challenge Microsoft 365’s dominance.
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Silas Maniatis @manimota.bsky.social · 29/05/2026
Today is one year since I had to say goodbye to my guy for the last time… man I miss my boy….
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Julia Lazzari-Dean @jlazzaridean.bsky.social · 12/05/2026
We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...
A cartoon overview of triplet tumbling microscopy, comparing data from bound and unbound samples.
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Silas Maniatis @manimota.bsky.social · 08/05/2026
Happy shared birthday to my biggest scientific heroes!
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Nature Reviews Clean Technology @natrevcleantech.nature.com · 29/04/2026
dlvr.it
Impacts of the Inflation Reduction Act and One Big Beautiful Bill Act on the US energy system
Nature Reviews Clean Technology, Published online: 29 April 2026; doi:10.1038/s44359-026-00168-zThe US Inflation Reduction Act aimed to enable clean energy development and reduce carbon emissions. This Review describes observed and projected impacts of this legislation and the potential impacts of the One Big Beautiful Bill Act.
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Nicolas Robine 🇪🇺🇫🇷🇺🇸 @nicorobine.bsky.social · 19/04/2026
Here it is: Atera: « High throughput. Whole transcriptome. Single cell sensitivity. » pages.10xgenomics.com/wbr-2026-02-... Thoughts?
pages.10xgenomics.com
10x Genomics
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Silas Maniatis @manimota.bsky.social · 31/03/2026
Brooklyn golden hour still undefeated
A picture of the Manhattan skyline silhouetted against the sunset, viewed from Brooklyn
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50501: The People’s Movement ❌👑 @50501movement.bsky.social · 28/03/2026
Holy New York.
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ACLU @aclu.org · 28/03/2026
If you're taking to the streets for No Kings protests today, know your rights. Find your nearest event at nokings.org/?SQF_SOURCE=aclu When using this link, Indivisible will know you came from us; their privacy policy applies.
Black graphic with text
"KNOW YOUR PROTEST RIGHTS

You don’t need a permit to protest in response to breaking news and you don’t need a permit to march in the streets or along sidewalks, as long as you’re not obstructing traffic or access to buildings.
When you are lawfully present in any public space, you have the right to photograph anything in plain view, including federal buildings and the police.
If you believe your rights have been violated, when you can, write down everything you remember, get contact information for witnesses, and take photographs of any injuries.
If you get stopped by the police, ask if you’re free to go. If they say yes, calmly walk away.
If you get arrested, you have a right to ask why. Otherwise, say you wish to remain silent and ask for a lawyer immediately. Don’t sign, say or agree to anything without a lawyer present.
If you get stopped by a member of the military or any law enforcement office at a protest, you have the right to remain silent or to tell them that you’ll only answer questions in the presence of an attorney — no matter your citizenship or immigration status."
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Silas Maniatis @manimota.bsky.social · 28/03/2026
Today’s official soundtrack: youtu.be/BlIREcAu0PI?...
youtu.be
YG - FDT ft. Nipsey Hussle (Official Audio)
YouTube video by YGVEVO
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Marco A. Maximo Prado @maximoprado.bsky.social · 27/03/2026
The @mind-western.bsky.social #fluorescencefriday entry focus on the hippocampus of an aggressive AD model Appnl-g-f with IBA1 (yellow) and abeta (magenta). thanks to @shahrzadbahrampour.bsky.social @nadiahaghbinphd.bsky.social and @kesummers.bsky.social
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Nicolas Robine 🇪🇺🇫🇷🇺🇸 @nicorobine.bsky.social · 14/03/2026
Despite the obvious superiority of fresh-frozen material for genomics, many samples are still stored in FFPE and remain challenging to characterize with Whole-genome sequencing. But here comes our solution:
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MwahahahahahadScientist @mads100tist.bsky.social · 12/03/2026
The ERC budget for 2026 is 2.7 billion euros 🧪
NYT headline: First 6  days of Iran War Cost US $11.3 billion, Pentagon says
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Páll Melsted @pmelsted.bsky.social · 06/03/2026
Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k... Figure 1 shows they key result
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Silas Maniatis @manimota.bsky.social · 04/03/2026
Khed… this fahkin guy bettah neva show his face neah Hahvahd again. Theyah’s gonna be like 20 doahds named Kennedy come outah Paddy’s Lunch ready foah him. Gonna be fahkin mint seein him have to drink a box o’ Joe to him self when they done with him. www.bostonglobe.com/2026/03/04/n...
bostonglobe.com
RFK Jr. wants Dunkin’ to prove drinking its iced coffee is safe - The Boston Globe
The warning comes as Kennedy is leaning heavily into his agenda to improve American diets.
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Drug Monkey @drugmonkey.bsky.social · 02/03/2026
$300 Million in jet planes lost to a fuckup. That’s 83 five year NIH R01 grants burned in minutes due to error, aka poor execution of this unnecessary war which serves only to make the world more dangerous.
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Silas Maniatis @manimota.bsky.social · 02/03/2026
As a federally funded researcher, every time I see the now customary start of war videos showing a BGM-109 TLAM launching from the bow magazine of a U.S. DDG at $2.5M a pop (FY 2023), I see a fully funded 5 year flagship NIH R01 biomedical research grant zooming off into oblivion.
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Marco A. Maximo Prado @maximoprado.bsky.social · 27/02/2026
#fluorescencefriday mapping the relationship between amyloid (green), microglia (magenta) and blood vessels (orange) in and aggressive model of AD. from @arashsalah.bsky.social @nadiahaghbinphd.bsky.social @shahrzadbahrampour.bsky.social @mind-western.bsky.social
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Rep. Judy Chu @chu.house.gov · 19/02/2026
On February 19, 1942, President Franklin D. Roosevelt signed E.O. 9066, authorizing the forced relocation & incarceration of more than 125,000 Japanese Americans, solely because of their heritage.
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Silas Maniatis @manimota.bsky.social · 13/02/2026
Nothing says ‘I’m a tough guy with the biggest baddest military in the world, and no one can mess with me if WWIII happens!’ Like scrubbing all mention of biodefense or pandemic preparedness does. www.nature.com/articles/d41...
nature.com
Exclusive: Key US infectious-diseases centre to drop pandemic preparation
Staff members have been instructed to scrub this topic and ‘biodefense’ from the agency’s website.
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eileen chengyin chow @chowleen.bsky.social · 30/01/2026
"It may take time to prove you're right, but you have to stick to it." - Fred Korematsu Jailed for refusing to abide by FDR's Exec Order 9066, he took his case against internment all the way to the Supreme Court - and lost. Remember him on Korematsu Day, January 30th. 1/
A young Fred KorematsuA photo of Fred Korematsu in his later years
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The Guardian @theguardian.com · 27/01/2026
10 of the greatest songs by Sly Dunbar – from reggae classics to Grace Jones and Bob Dylan
theguardian.com
10 of the greatest songs by Sly Dunbar – from reggae classics to Grace Jones and Bob Dylan
After his death aged 73, we look back at a selection of the hundreds of tracks the Sly and Robbie drummer had a hand in making
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Silas Maniatis @manimota.bsky.social · 27/01/2026
Just called both of my senators @schumer.senate.gov and @kirstengillibrand.bsky.social to let them know that appropriations for DHS are not compatible with a free society and that personnel shuffles do not matter. Even if my federal funding ends as a result, DHS must go and Holman Bondi et al too
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Kaitlyn Hajdarovic, Ph.D @khajdarovic.bsky.social · 25/01/2026
Fighting through snow so I can do my science. Animal care staff, building staff, clinical staff, nurses, doctors, veterinarians all work through these weather conditions to make the NIH run.
A snowy bus stop outside the NIH. Snow on the ground and sleeting down, everything is grey and white.
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David Ho @davidho.bsky.social · 20/01/2026
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...
This line graph illustrates the percentage change in agency staff levels from the previous year for nine major U.S. federal scientific and health organizations between the fiscal years 2016 and 2025. The agencies tracked include the CDC, Department of Energy, EPA, FDA, NASA, NIH, NIST, NOAA, and NSF. For the majority of the timeline between 2016 and 2023, the agencies show relatively stable fluctuations, generally staying within a range of +5% to -5% change per year. However, there is a dramatic and uniform plummet starting in the 2024–25 period. Every agency depicted shows a sharp downward trajectory, with staffing losses ranging from approximately -15% to over -25%. The Environmental Protection Agency (EPA) shows the most significant decline, dropping to roughly -26%, while the National Institute of Standards and Technology (NIST) shows the least severe but still substantial drop at approximately -15%.
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Silas Maniatis @manimota.bsky.social · 19/01/2026
Seems like voluntarily installing a secret police surveillance node at one’s own expense might be an action that one’s neighbors find upsetting. Would be weird and totally unrelated if all of a sudden lots of these went missing, or had sensors damaged with lasers etc techcrunch.com/2025/10/16/a...
techcrunch.com
Amazon's Ring to partner with Flock, a network of AI cameras used by ICE, feds, and police | TechCrunch
Agencies that use Flock can request that Ring doorbell users share footage to help with "evidence collection and investigative work."
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Nicole Foy @nicolefoy.bsky.social · 15/01/2026
I’m one of the ProPublica reporters who has been documenting the aggressive tactics federal agents are using against immigrants & U.S. citizens All eyes are on Minnesota right now, but I want to tell you about Arnoldo Bazan, a 16-YO citizen in Houston who was choked by immigration agents in October
A teenage boy with dark hair and a black and gold football jersey holds his helmet, standing on the side line of a green football field
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John Lukens @lukensjohnr.bsky.social · 13/01/2026
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis cell.com/cell/fulltex... cell.com/cell/fulltex... www.cell.com/cell/fulltex...
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Silas Maniatis @manimota.bsky.social · 13/01/2026
TDP43 dysfunction in ALS leads to transposon mayhem in the transcriptome. Nice work from @nygenome.org ‘s ALS consortium, lead by Hemali Phatnani, and @nyulangone.bsky.social ‘s @karthiknatarajan.bsky.social & @mollygale.bsky.social. Nice work guys! www.biorxiv.org/content/10.6...
biorxiv.org
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Boas Pucker @bpucker.bsky.social · 12/01/2026
“Analysis of Biological Data with Python” started today for biology bachelor students 🧬🐍 Want to learn Python for data analysis? Slides are freely available: github.com/bpucker/teac... #Python #DataAnalysis #Biology #OpenScience #BigData #Bioinformatics #DataScience @puckerlab.bsky.social
Figure illustrating some content of the Python course for biology students at UniBonn
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50501: The People’s Movement ❌👑 @50501movement.bsky.social · 11/01/2026
New York City turned OUT. @handsoffnyc.bsky.social ✊❤️
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The Tennessee Holler @thetnholler.bsky.social · 06/01/2026
Never forget. 🇺🇸
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Miser @misernyc.bsky.social · 06/01/2026
Zohran just went out and fixed the Williamsburg Bridge bike entrance. Just did it. No faffing, no nonsense. Bam. Fixed.
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Waggoner Lab @labwaggoner.bsky.social · 06/01/2026
A comprehensive spatial splicing analysis in the brain under normal and neoplastic conditions @natbiotech.nature.com @raulrabadan.bsky.social @columbiauniversity.bsky.social @davidaknowles.bsky.social @nygenome.org www.nature.com/articles/s41...
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Waggoner Lab @labwaggoner.bsky.social · 02/01/2026
SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...
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Kevin Dean @kevin-dean.bsky.social · 01/01/2026
20-plex volumetric super-resolution imaging of cellular ultrastructure. Preprint, led by @seweryn-galecki.bsky.social, dropping soon.
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Angus Johnston @angus.bsky.social · 01/01/2026
I was wondering what Mamdani's first executive order would be, and I'm not disappointed by this. He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
Mamdani's Executive Order Number 1, as described in the post.
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Silas Maniatis @manimota.bsky.social · 24/11/2025
It’s been amazing to watch the growth of the biomedical industry in NYC over the past decade. It’s also terrible watching it be destroyed by federal actions. To remain competitive with respect to national and global centers of biomedical research and industry, NY state must step in and invest!
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Denis Wirtz @deniswirtz.bsky.social · 20/11/2025
Still my favorite 3D reconstruction of a pancreatic tissue. Using the CODA workflow, we mapped a billion individual cells in 3D. Red: pre-cancer lesions Navy blue: ducts Light blue: islets of Langerhans Purple: acini Green: blood vessels Yellow: fat More here: www.nature.com/articles/s41...
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