iiinova — where your digital self keeps evolving

Uri Manor @manorlaboratory.bsky.social · 22/02/2026

I think this article is brilliantly written and made me laugh out loud a few times. The very real challenge of separating hype from reality exists on both ends of the dystopia-utopia spectrum. harpers.org/archive/2026...

harpers.org

Child’s Play, by Sam Kriss

Tech’s new generation and the end of thinking

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Uri Manor @manorlaboratory.bsky.social · 19/02/2026

A fun (AI-enhanced) image of 12187 ABR waveforms. We used these data from our own lab and several others to train ABRA (PMID: 38948763) and are still using it to train next-gen machine learning models for cochlear studies. Stay tuned (no pun intended) for more!

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Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 07/02/2026

Open-source, deep learning-based tool VASCilia enables rapid quantification & characterisation of stereocilia – advances capabilities in hearing research 📷 Yasmin M. Kassim et al @manorlaboratory.bsky.social @ucsandiego.bsky.social in @plosbiology.org ➡️ bpod.org.uk/archive/2026...

bpod.org.uk

BPoD | Seeing Sound Sensors

Seeing Sound Sensors - Biomedical pictures for February 2026.

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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 06/02/2026

As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway. 1/

simple diagram of the secretory pathway.

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Uri Manor @manorlaboratory.bsky.social · 30/01/2026

🚀 Registration is NOW OPEN for AIMS 2026! Join us at UC San Diego for the premier workshop on AI for Multimodal Science. Secure your spot (Deadline March 7): 👉 Register: tinyurl.com/AIMS2026 🔗 Website: aims-2026.vercel.app

tinyurl.com

AIMS 2026: AI for Multimodal Science Registration

Register for the AIMS 2026 workshop, sponsored by Schmidt Sciences, exploring the latest advancements in Artificial Intelligence for Multimodal Science. Time: June 23–25, 2026 Location: Seventh Colle...

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Uri Manor @manorlaboratory.bsky.social · 23/01/2026

Does anyone understand how the AC meeting is literally the day after Study Section? Don't they need summary statements for this? I have been refreshing my commons page every minute to see if there is a score/summary statement, but in reality this would be unprecedented speed? What am I missing?

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Uri Manor @manorlaboratory.bsky.social · 21/01/2026

So excited to see Yasmin’s beautiful paper is finally out! We hope this tool will be useful for everyone studying stereocilia bundles (including companies developing gene therapies). I fantasized about having an AI tool like this when I was a grad student. All the code and data is open source.

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PLOS Biology @plosbiology.org · 21/01/2026

Cochlear hair cell #stereocilia bundles are vital for hearing, but what is their 3D morphology? @manorlaboratory.bsky.social present VASCilia, a tool that automates analysis of 3D #ConfocalMicroscopy datasets of phalloidin-stained #CochlearHairCell bundles @plosbiology.org 🧪 plos.io/3NSHdYW

The algorithm successfully detects stereocilia bundles in 2D across successive frames, assigning unique IDs to each detected object within the 2D plane (left). The variation in IDs across frames reflects the independent detection process in each 2D frame. Subsequently, a multi-object assignment algorithm (middle) intervenes to reconcile these IDs, effectively re-assigning them to maintain consistency across frames. This step is crucial for reconstructing accurate 3D objects (right), ensuring that each bundle retains a consistent ID throughout all frames.

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Uri Manor @manorlaboratory.bsky.social · 16/01/2026

It took me >3 hours to update my @NIH ScienCV biosketch to meet new formatting requirements. These formats are often updated, forcing every one of ~45,000 NIH PI's to spend time on this. Assuming *minimum wage* ~$20/hour and my experience was average, this amounts to $3M/update.

media.tenor.com

a poster that says ' your tax dollars hard at work '

ALT: a poster that says ' your tax dollars hard at work '

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Jess Heebner @jessheebner.bsky.social · 09/01/2026

I'm so happy to have gotten the opportunity to work on this project and I'm SO excited that they selected our image for the cover!

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Uri Manor @manorlaboratory.bsky.social · 09/01/2026

The original proposal's critique scores. I don't know how we are supposed to succeed in such a capricious system.

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Peter O'Toole @yorkbioimaging.bsky.social · 09/01/2026

Emotional - Uri Manor @manorlaboratory.bsky.social was so wonderfully open & an inspiration to listen on #TheMicroscopists Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share Stream bit.ly/microscopist...

bit.ly

The Microscopists | Uri Manor (UC San Diego School of Biological Sciences)

In this episode of The Microscopists, Uri Manor, Assistant Professor of UCSD, opens up about growing up with profound hearing loss and how, despite wanting nothing to do with becoming a scientist, ...

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Uri Manor @manorlaboratory.bsky.social · 09/01/2026

Initial submission of a grant received a 15%-ile score. But we had to submit as new since the PAR expired. We submitted an even stronger, but just slightly modified version to address any/all weaknesses in the prior summary statement. Just found out it was "Not Discussed"😱

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Uri Manor @manorlaboratory.bsky.social · 09/12/2025

Can someone please connect me with someone at FDA CDER (or with expertise thereof) to discuss the pathway to approval for n-of-1 & n-of-many ASOs? I've got some pretty technical questions too involved to describe here.

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Wallace Marshall @wallaceucsf.bsky.social · 07/12/2025

Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 163 at CellBio2025 Sunday Dec 7, I present work by Hiro Ishikawa using a synthetic biology approach to test a length-sensing model based on diffusion of kinesin in flagella

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Wallace Marshall @wallaceucsf.bsky.social · 07/12/2025

Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 155 at the CellBio2025 meeting Sunday Dec 7, Ximena Garcia Arceo uses Lithium, which increases intraflagellar transport, as a tool to probe how length-altering mutants work.

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Uri Manor @manorlaboratory.bsky.social · 02/12/2025

Best email I ever got after a talk 🥹🥹🥹

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Uri Manor @manorlaboratory.bsky.social · 01/12/2025

My tenure talk is tomorrow 😅😅😅😅😅

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Uri Manor @manorlaboratory.bsky.social · 24/11/2025

Omg this is amazing. Fun fact: my original PhD goal was to study magnetoreception but no PIs were interested and someone suggested I study hair cells as an analogous system. Turns out they were even more analogous than we imagined!!! www.science.org/doi/10.1126/...

science.org

A global screen for magnetically induced neuronal activity in the pigeon brain

How animals detect the Earth’s magnetic field remains a mystery in sensory biology. Despite extensive behavioral evidence, the neural circuitry and molecular mechanisms responsible for magnetic sensin...

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Kyle M. Douglass @kmdouglass.bsky.social · 22/11/2025

A holiday demonstration of the different penetration depths of red and blue light into tissue. #optics

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Andy Moore @aaandmoore.bsky.social · 21/11/2025

Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.

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Jonathan Peelle @jpeelle.bsky.social · 21/11/2025

Important for reviewers and people interpreting reviews of their grants

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Uri Manor @manorlaboratory.bsky.social · 01/11/2025

As someone with Connexin-26 (GJB2) mutations, I've managed to so far study most forms of hearing loss that do NOT involve GJB2. As a cell biologist, I've managed to study ER-organelle related processes and disorders with minimal connection to hearing loss. Now this paper drops.

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Uri Manor @manorlaboratory.bsky.social · 16/10/2025

Looking forward to some "inner ear evangelism" in ~30 minutes (signup link in comments)

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Samara Reck-Peterson @samreckpeterson.bsky.social · 29/09/2025

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...

biochem.weill.cornell.edu

Join our Faculty | Department of Biochemistry & Biophysics

Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...

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Kurt Thorn @kurtthorn.bsky.social · 11/10/2025

Following this pattern I’ve been able to write a set of skills that turns Claude Code into a scientific literature searching tool, compiling lists of relevant papers. I’ll make it public after some more work.

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Anne Carpenter @drannecarpenter.bsky.social · 10/10/2025

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further

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Uri Manor @manorlaboratory.bsky.social · 10/10/2025

The things I’ve learned about drug development in the last few weeks are astounding. Our society & economy are centuries behind our science & it is devastating to think about all the parents and children who are held captive. www.statnews.com/2025/10/09/c...

statnews.com

Parents of children with rare diseases ask: How long until our CRISPR miracle?

How to better manage expectations around gene editing drugs for families of children with rare diseases.

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Carl Zimmer @carlzimmer.com · 09/10/2025

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

nyti.ms

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Uri Manor @manorlaboratory.bsky.social · 09/10/2025

I've once again found myself in the news for unfortunate reasons. I must be cursed, or perhaps the universe is just balanced and all the positive press I've gotten for our work just needs to counteracted with some negativity www.youtube.com/shorts/kkmYw...

youtube.com

Bear Mask donning man arrested for stabbing someone

YouTube video by ABC 10 News

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Kondadi Lab @kondadilab.bsky.social · 07/10/2025

For the attention of all the Organelle researchers in Germany, the Annual meeting of the @gbmev.bsky.social study section Cellular Organelles will be held in Düsseldorf …. Seats fast filling up … please submit your abstract … information below: gbm-online.de/de/tagungska...

gbm-online.de

2nd Meeting of the Study Group "Cellular Organelles" - Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V.

organized by Arun Kumar Kondadi and Andreas Reichert

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Robert Haase @haesleinhuepf.bsky.social · 01/10/2025

For academic purposes, I generated 100 UMAPs from the same tabular raw data, I sorted them and the result looks too funny to not share it with you 😃 haesleinhuepf.github.io/BioImageAnal...

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Uri Manor @manorlaboratory.bsky.social · 01/10/2025

The stories in this article are a huge part of what motivated me to start studying rare disease, which is actually one of the most common diseases (~10% of people have a rare disease) These Patients Got the Cure. Then It Went Away. www.nytimes.com/2025/09/22/h...

nytimes.com

These Patients Got the Cure. Then It Went Away.

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Uri Manor @manorlaboratory.bsky.social · 01/10/2025

Soooooo what happens to all the NIH study sections in October if the government shutdown lasts 30+ days like last time? 😬😬😬

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Rita Strack @ritastrack.bsky.social · 28/09/2025

#GEF25 the expansion microscopy community would benefit from high NA, long working distance water objectives. Who's working on these? What's out there?

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Uri Manor @manorlaboratory.bsky.social · 24/09/2025

I enjoyed doing this podcast interview which was just released but was actually recorded almost a year ago. A little sad to listen to it now knowing only in retrospect that my funding was about to get demolished 😅😭. But overall I still have the same hope and dreams. open.spotify.com/episode/1rjG...

open.spotify.com

From Hearing Loss to Superhuman AI: The Inspiring Journey of Dr. Uri Manor

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Uri Manor @manorlaboratory.bsky.social · 24/09/2025

open.spotify.com

From Hearing Loss to Superhuman AI: The Inspiring Journey of Dr. Uri Manor

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Paul Manis @auditoryneuro.bsky.social · 24/09/2025

I have recently used abranalysis (from the GitHub repo) for analysis of a couple of recent datasets and it does a very nice job once I account for the acoustic latency differences. I just had to put our data into the right intermediate format, which was a simple process. Very nice contribution!

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Uri Manor @manorlaboratory.bsky.social · 24/09/2025

2/2: ABRA, which can automatically analyze auditory brainstem response electrophysiology data from a broad range of mice with varying levels of hearing function/loss. New features in the open-source, free-to-use software (hosted on the San Diego Supercomputer Center!) increase usability and control.

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Uri Manor @manorlaboratory.bsky.social · 24/09/2025

Pleased to share updates for 2 deep learning papers: 1/2: VASCilia, which can automatically segment and analyze cochlear hair cell stereocilia bundles. We have added more features to the Napari plugin and some new data highlighting the power of our high-throughput automated 3D analysis approach.

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Uri Manor @manorlaboratory.bsky.social · 24/09/2025

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Uri Manor @manorlaboratory.bsky.social · 24/09/2025

Proud to announce that our superstar postdoc Yasmin Kassim was awarded a Schmidt AI in Science fellowship! Check out her recently updated VASCilia paper and then ponder the fact that this barely scratches the surface of what we’ve done and will be doing more of together 🙌🙌🙌

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Ewerslab @ewerslab.bsky.social · 13/09/2025

I love SciSky, great term.

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Peter Sobolewski @psobolewskiphd.bsky.social · 18/09/2025

Flying out of San Jose buzzing after @chanzuckerberg.bsky.social #ImagingTheFuture. Amazing to shake the hands of long time insprations: @andrewgyork.bsky.social @makertobey.bsky.social @manorlaboratory.bsky.social & new ones like Gustavo Menezes—plus catching up with friends & collaborators!

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Uri Manor @manorlaboratory.bsky.social · 13/09/2025

SciSky: what’s your favorite software or algorithm for designing siRNA? Bonus points if we can use it to add mismatches to improve allele specificity!

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Dr Zeinab Rekad 🔬🧬🧪 @zeinabrekad.bsky.social · 13/09/2025

DSIR A 2 decades old algorithm (Outch) co-developed by my ex-boss. More than 1 year and hundreds of sequences have been experimentally tested to valide the tool, which at the time was quite some work. biodev.cea.fr/DSIR/

biodev.cea.fr

DSIR Home page

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