How cells sense and respond to splicing aberrations remains elusive. Yang et al. find that spliceosome inhibition causes the accumulation of mis-spliced transcripts that produce Z-form dsRNA (Z-RNA), ...

Srivastava et al. present the cryo-EM structure of the anti-apoptotic MCL-1:BAK complex assembled from full-length globular domains to reveal the sequestration mechanism and a dynamic BAK conformation...

MLKL mediates plasma membrane permeabilization in necroptosis. Ros et al. show that alternative splicing inserting short sequences in the C-terminal α-helix (Hc) abolishes its killing activity, genera...

Song et al. demonstrated that the cytosolic CYCS-INPP4A complex inhibits ferroptosis by promoting phosphatidylinositol-3-phosphate synthesis and preventing phospholipid peroxidation. The small molecul...

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