Behaviour of human participants in a prey-pursuit task reflects dynamic blending of goal-specific control policies, with hippocampus estimating latent states, anterior cingulate cortex orchestrating p...

This randomized clinical trial estimates the effect size of connectivity- vs scalp-based targeting of accelerated transcranial magnetic stimulation for treatment-resistant depression.

Busch et al. use nonlinear neural manifolds to help humans gain rapid control over a noninvasive brain–computer interface, allowing them to learn how to play a video game with real-time fMRI neurofeed...

How humans process competing information when making multi-alternative decisions remains unclear. Here, the authors show that the brain resolves the trade-off between “evaluating within” and “comparin...

Now hiring a postdoc and a research technician with an interest in neuroeconomics or computational psychiatry.

A pipeline for processing and analyzing human single-neuron data.

Human curiosity is dynamic, however the principles governing its fluctuations remain debated. Here, we test two competing hypotheses about how past...

Nature Reviews Neuroscience - Appeals to representation are widespread, despite neuroscientists’ uncertainty about what kind of findings count as evidence for such claims. In this...

DeepCor is a deep-learning-based denoising approach for task-based and resting-state fMRI data that can be used even for single participants.

The neuroscience of planning has long been analogized to search algorithms in artificial intelligence (AI), which simulate future actions to guide immediate choices. We argue that advances in both neu...

New Haven, USA (July 14-16, 2026)

The Computational Psychiatry Pre-Conference is a one-day workshop and symposium (approximately 10:00 AM–6:30 PM) designed to prepare early-career researchers for the main conference while fostering collaboration and skill-building.

This study investigated the computational mechanisms linking momentary craving and decision-making in people with moderate to high addiction risk levels for alcohol or cannabis use, uncovering differe...

This narrative review explores the idea of understanding mental disorders according to homeostatic property clusters rather than through typical classification systems.

The rapidly evolving field of computational psychiatry enables quantification of specific cognitive processes, and their underlying mechanisms, in a translational and potentially scalable manner, usin...

Reward predictions not only promote reward pursuit, they also shape how reward is pursed. Such predictions are supported by environmental cues that signal reward availability and probability. Such cue...

Cue–reward learning rate scales proportionally with the time between rewards. Consequently, learning over a fixed duration is independent of the number of trials. This challenges trial-based dopamine ...

Value-guided decisions are a cornerstone of cognition, yet the underlying circuit-level mechanisms remain elusive. We used reinforcement learning to t…

Nature - The brain can flexibly perform multiple tasks by compositionally combining task-relevant neural representations.

In the centuries-long history of decision-making research, emotion’s role in choice has only been investigated relatively recently. Early theories of decision-making, which conceived of emotions...

Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion — without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)

Calcium imaging of mouse hippocampal neurons while mice learn a reward-based task over several weeks provides insight into the evolution of the hippocampal reward representation during extended period...

Nature Neuroscience - Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas...

Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for ...

Here, the authors develop novel dynamical methods to model brain regions’ intrinsic neural timescales (INTs) from data, and find that they couple whole-brain structural connectivity to dynamic switchi...