This cross-sectional study evaluates the prevalence of glucagon-like peptide-1 (GLP-1) receptor agonist use and misuse among people with eating disorders in the US.

This Special Communication reviews the US Food and Drug Administration evaluation of 1 investigational drug (gepirone extended release) for major depressive disorder with conflicting evidence of benefit.

This proof-of-concept randomized clinical trial identifies likely treatment-sensitive outcomes and effect size for systemic interleukin 6 inhibition in patients with difficult-to-treat depression

This case-control study analyzes the mediating effects of brain morphology on the association of childhood trauma with bipolar disorder.

This case-control study evaluates the association between electroencephalography microstates and risk of psychosis and other clinical outcomes.

This genetic association study evaluates the association of recurrent copy number variants and polygenic scores with genetic risk factors for psychiatric disorders in the population.

This cohort study evaluates the structure of genetic risk factors associated with 18 diverse psychiatric and substance use disorders.

This randomized clinical trial estimates the effect size of connectivity- vs scalp-based targeting of accelerated transcranial magnetic stimulation for treatment-resistant depression.

This randomized clinical trial estimates the effect size of connectivity- vs scalp-based targeting of accelerated transcranial magnetic stimulation for treatment-resistant depression.

This study investigates individual differences in the effect of social media likes on posting behavior and their association with and specificity to depressive psychopathology.

This study investigates individual differences in the effect of social media likes on posting behavior and their association with and specificity to depressive psychopathology.

This meta-analysis of 12 randomized controlled trials evaluates the treatment effect of pharmacological interventions tested for stimulant use disorder, comparing reduced use to total abstinence.

This cohort study examines sex and age patterns of disease development for 7 major groups of mental disorders.

Over the past century, advances in neuroimaging and cognitive neuroscience reshaped how we understand psychiatric disorders, expanding the portfolio of evidence-based treatments while routine clinical practice has mostly relied on trial and error. Precision medicine has steadily extended to...

In recent years, there have been extensive efforts in schizophrenia research to identify individuals at clinical high risk of psychosis (CHR-P) based on self-reported clinical symptoms with the goal to enable early detection and intervention. However, the CHR-P phenotype is characterized by...

This proof-of-concept randomized clinical trial identifies likely treatment-sensitive outcomes and effect size for systemic interleukin 6 inhibition in patients with difficult-to-treat depression

This case-control study analyzes the mediating effects of brain morphology on the association of childhood trauma with bipolar disorder.

This case-control study evaluates the association between electroencephalography microstates and risk of psychosis and other clinical outcomes.

This genetic association study evaluates the association of recurrent copy number variants and polygenic scores with genetic risk factors for psychiatric disorders in the population.

This article explores the therapeutic potential of low-intensity focused ultrasound to modulate focal brain regions for noninvasive and reversible deep brain stimulation.

This randomized clinical trial estimates the effect size of connectivity- vs scalp-based targeting of accelerated transcranial magnetic stimulation for treatment-resistant depression.