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David G. Clark

@david-g-clark.bsky.social
612 followers 519 following 177 posts

Theoretical neuroscientist Group leader @ Flatiron Institute, Center for Computational Neuroscience dclark.io

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David G. Clark @david-g-clark.bsky.social · 01/10/2026
📣 Multiple Flatiron Research Fellow (FRF) postdoc positions are available in my @flatironinstitute.org group! We've never been better positioned to understand how high-dimensional nonlinear dynamical systems (neural circuits!) compute. If this is as exciting to you as it is to me, consider applying:
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Mitchell Ostrow @neurostrow.bsky.social · 21/09/2026
Very excited to announce our most recent paper! TL;DR we made our prior work on comparing dynamics (DSA) much faster and generalizable to diverse data domains and problem settings (1/)
biorxiv.org
A metric for comparing complex systems by their dynamics
Comparisons are fundamental to science: experiment against model, one organism against another, a system against itself across time. Because many systems, from brains to climate, are characterized by ...
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Ilenna Jones @ilennaj.bsky.social · 31/07/2026
What does synapse position buy a neuron? We trained a dendritic network to place its own synapses on a covariance task. It clustered correlated inputs onto shared branches, and shuffling that placement destroyed performance while every weight stayed intact. Preprint: arxiv.org/abs/2607.24503 🧵-->
arxiv.org
Synaptic clustering emerges from learning and supports covariance discrimination
Functional synapse clusters (FSCs) are synapses with correlated presynaptic activity that are colocalized on the same neuronal dendritic branch. FSCs have been observed after learning in cortical and ...
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David G. Clark @david-g-clark.bsky.social · 31/07/2026
This September, I will join the @flatironinstitute.org Center for Computational Neuroscience as a Group Leader, where I will launch the High-Dimensional Dynamics & Computation Group. Information for postdocs and grad students is forthcoming. I am grateful to my mentors who made this possible!
Exterior view of the Flatiron Institute in Manhattan
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 29/06/2026
Interpretable compositional computation with recurrent neural networks www.biorxiv.org/content/10.64898/20…
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David G. Clark @david-g-clark.bsky.social · 23/06/2026
Woooooo!!! 🔥🔥🔥
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Gaute Einevoll @gauteeinevoll.bsky.social · 23/05/2026
Episode #41 in #TheoreticalNeurosciencePodcast: On functional effects of neuronal heterogeneity – with David Dahmen theoreticalneuroscience.no/thn41 While network modelers often assume all neurons to be the same, biology says different. Can this hetereogeneity be a good thing?
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cogscikid.bsky.social @cogscikid.bsky.social · 07/05/2026
Do RL agents really need to replan from scratch for every new goal? Why do rodents "preplay" goals they haven't pursued? We think these questions share a candidate answer.
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David G. Clark @david-g-clark.bsky.social · 06/05/2026
Now in PRE: "Transient dynamics of associative memory models." I argue that the "blackout catastrophe" is not catastrophic when viewed from an out-of-equilibrium, dynamical perspective. Journal: journals.aps.org/pre/abstract/10.1103/42y2-bsh1 PDF: dclark.io/media/clark-...
journals.aps.org
Transient dynamics of associative memory models
Associative memory models such as the Hopfield network and its dense generalizations with higher-order interactions exhibit a ``blackout catastrophe''---a discontinuous transition where stable memory ...
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Kenji Lee @kenjilee.bsky.social · 27/04/2026
Super excited to (finally!) show our work on identifying cell types! Now in press www.nature.com/articles/s41.... We show how to identify cell types from ephys recordings *without* optotagging. This opens the study of not just individual cell types, but the interacting neural circuit during behavior
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Will Redman @wtredman.bsky.social · 28/04/2026
New preprint out 🚨 “Predictive pursuit emerges in high-dimensional recurrent neural networks”! This was an awesome collaboration with co-first author @fatihdinc.bsky.social , @andyalexander.bsky.social, @xiaoxiao-lin.bsky.social, and May Chen biorxiv.org/content/10.6... 1/
biorxiv.org
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David G. Clark @david-g-clark.bsky.social · 28/04/2026
New preprint: "Linear equivalence of nonlinear recurrent neural networks." For large nonlinear (potentially chaotic) RNNs with random connectivity, the full N×N covariance matrix takes the same form as that of a ~linear~ network with the same couplings, driven by independent noise.
arxiv.org
Linear equivalence of nonlinear recurrent neural networks
Large nonlinear recurrent neural networks with random couplings generate high-dimensional, potentially chaotic activity whose structure is of interest in neuroscience, machine learning, ecology, and o...
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Soledad Gonzalo Cogno @soledad-gcogno.bsky.social · 03/04/2026
📢🔥 My lab is recruiting a PhD student - join us! Apply before April 29 🧠💻🇳🇴 www.jobbnorge.no/en/available...
jobbnorge.no
PhD in Computational Neuroscience (298392) | NTNU - Norwegian University of Science and Technology
Job title: PhD in Computational Neuroscience (298392), Employer: NTNU - Norwegian University of Science and Technology, Deadline: Wednesday, April 29, 2026
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Pierre-Etienne Fiquet @pfiquet.bsky.social · 31/03/2026
Applications are open for the Junior Theoretical Neuroscientists Workshop which will take place July 21-24, 2026 at the Center for Computational Neuroscience, @flatironinstitute.org Travel, lodging, and meals will be covered for accepted participants. Application deadline: April 15, 2026
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Jasmine Stone @jasmine-stone.bsky.social · 25/03/2026
What do moonwalking flies teach us about fear, avoidance, and the brain? Come to my short talk and lab visit in #nyc @zuckermanbrain.bsky.social @columbiauniversity.bsky.social next Tues 7pm to find out! www.eventbrite.com/e/late-night...
eventbrite.com
Late Night Science: Moonwalking from Theory to Experiments and Back
Immerse yourself in the world of scientific research while learning about how the brain controls the body and tour a research lab!
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Alex Williams @itsneuronal.bsky.social · 19/03/2026
Cosyne invited me to give a long tutorial (4 hours!) on methods to quantify differences high-d neural recordings across animals, brain regions, deep neural nets, etc. The recording is up on youtube. I hope it inspires more research on this fundamental topic! www.youtube.com/watch?v=n44x...
youtube.com
Cosyne 2026 - Cosyne Tutorial: Comparative Analysis of Neural Population Codes
YouTube video by Cosyne Talks
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David G. Clark @david-g-clark.bsky.social · 12/03/2026
In Lisbon for @cosynemeeting.bsky.social 2026! ☀️☀️☀️☀️☀️ I'm very excited about the following posters, each associated with a preprint.
Sunny Lisbon.
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David G. Clark @david-g-clark.bsky.social · 12/03/2026
🔥
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Kim Stachenfeld, PhD @neurokim.bsky.social · 11/03/2026
I have just arrived at @cosynemeeting.bsky.social ! During my flight, as I thought about opening remarks (and had a glass of wine), I got to reflect on why I love neuroscience. Maybe other folks are doing the same and would like to read or add, so I thought I'd do something unusual and share!
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David G. Clark @david-g-clark.bsky.social · 11/03/2026
🤯
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Matt Perich @mattperich.bsky.social · 10/03/2026
New paper hot off the (pre-)press! We dig into the evolutionary origins of neural computations for behavioral control across mice, monkeys, and humans: www.biorxiv.org/content/10.6.... As our lab's first foray into comparative analysis of neural dynamics, I’m super excited about this work! 1/18
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David G. Clark @david-g-clark.bsky.social · 09/03/2026
Very clear & interesting blog post from @annhuang42.bsky.social and @kanakarajanphd.bsky.social on their paper!
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Louis Pezon @lpezon.bsky.social · 06/03/2026
Excited to share our new paper to be published in Neuron! With Valentin Schmutz @bio-emergent.bsky.social and Wulfram Gerstner @gerstnerlab.bsky.social, we explore how circuit structure in RNNs shapes network computation and single-neuron responses. www.sciencedirect.com/science/arti...
sciencedirect.com
Linking neural manifolds to circuit structure in recurrent networks
Dimensionality reduction methods are widely used in neuroscience to investigate two complementary aspects of neural activity: the distribution of sing…
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Kempner Institute at Harvard University @kempnerinstitute.bsky.social · 04/03/2026
NEW: #Kempner researchers develop a mean-field theory of task-trained RNNs that bridges random and learned connectivity—and find macaque motor cortex is best captured by an intermediate, task-specific recurrent structure. Read the blog post 👇 🔗 bit.ly/47f3Ldl
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David G. Clark @david-g-clark.bsky.social · 04/03/2026
I am totally pumped about this new work . "Task-trained RNNs" are a powerful and influential framework in neuroscience, but have lacked a firm theoretical footing. This work provides one, and makes direct contact with the classical theory of random RNNs: www.biorxiv.org/content/10.6...
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Dan Levenstein @dlevenstein.bsky.social · 18/02/2026
With this one in print, I think I finally earned that PhD... 😅 Presented for the first time at the cosyne when the world ended (March 2020). I'll bring over a summary thread from twitter when it was still twitter... www.sciencedirect.com/science/arti...
sciencedirect.com
Neuronal spiking in the mammalian forebrain is dominated by a heterogeneous ground state
Neuronal firing patterns have significant spatiotemporal variability with no agreed-upon theoretical framework. Using a combined experimental and mode…
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Colton Casto @coltoncasto.bsky.social · 22/01/2026
The cerebellum supports high-level language?? Now out in @cp-neuron.bsky.social, we systematically examined language-responsive areas of the cerebellum using precision fMRI and identified a *cerebellar satellite* of the neocortical language network! authors.elsevier.com/a/1mUU83BtfH... 1/n 🧵👇
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Jeff Johnston @wjj.bsky.social · 09/01/2026
By the way, if you’re interested in working together on problems like this, I’m starting my lab at UCSF this summer. Get in touch if you’re interested in doing a postdoc! More info here: wj2.github.io/postdoc_ad (7/7)
wj2.github.io
W. Jeffrey Johnston - Postdoctoral position ad
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David G. Clark @david-g-clark.bsky.social · 10/01/2026
Excited to be giving the van Vreeswijk Theoretical Neuroscience Seminar this Wednesday, Jan 14, where I'll talk about "Computation Through Neuronal-Synaptic Dynamics"! www.wwtns.online
wwtns.online
Home | Neuroscience | World Wide Theoretical Neuroscience Seminar
WWTNS is a weekly digital seminar on Zoom targeting the theoretical neuroscience community. Its aim is to be a platform to exchange ideas among theoreticians.
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Portugues Lab @portugueslab.bsky.social · 02/01/2026
1/n: A new collaborative preprint from the lab to start the year: "A multi-ring shifter network computes head direction in zebrafish" together with Siyuan Mei, Martin Stemmler and Andreas Herz from the LMU, Munich.
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David G. Clark @david-g-clark.bsky.social · 19/12/2025
Excited and honored to be speaking at this ICLR workshop on associative memory in Rio!
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Jonathan Pillow @jpillowtime.bsky.social · 17/12/2025
Bichan Wu (@bichanw.bsky.social) & I wrote a tutorial paper on Reduced Rank Regression (RRR) — the statistical method underlying "communication subspaces" from Semedo et al 2019 — aimed at neuroscientists. arxiv.org/abs/2512.12467
arxiv.org
Reduced rank regression for neural communication: a tutorial for neuroscientists
Reduced rank regression (RRR) is a statistical method for finding a low-dimensional linear mapping between a set of high-dimensional inputs and outputs. In recent years, RRR has found numerous applica...
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David G. Clark @david-g-clark.bsky.social · 15/12/2025
Very excited about this new work from the omnipotent Owen, with me and Ashok Litwin-Kumar! Can we reconcile low- and high-dimensional activity in neural circuits by recognizing that these circuits ~multitask~? (Plausibly, yes 😊)
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Ann Huang @annhuang42.bsky.social · 24/11/2025
📍Excited to share that our paper was selected as a Spotlight at #NeurIPS2025! arxiv.org/pdf/2410.03972 It started from a question I kept running into: When do RNNs trained on the same task converge/diverge in their solutions? 🧵⬇️
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Machine Learning in Science @mackelab.bsky.social · 13/11/2025
Our work on training biophysical models with Jaxley is now out in @natmethods.nature.com. Led by @deismic.bsky.social, with @philipp.hertie.ai, @ppjgoncalves.bsky.social & @jakhmack.bsky.social et al. Paper: www.nature.com/articles/s41...
nature.com
Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods
Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...
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David G. Clark @david-g-clark.bsky.social · 10/11/2025
🆒
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Quanta Magazine @quantamagazine.org · 08/11/2025
The term “manifold” comes from “Mannigfaltigkeit,” which is German for “variety” or “multiplicity.” www.quantamagazine.org/what-is-a-ma...
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Alexander van Meegen @avm.bsky.social · 05/11/2025
This was a lot of fun! From my side, it started with a technical Q: what's the relation between two-side cavity and path integrals? Turns out it's a fluctuation correction - and amazingly, this also enable the "O(N) rank" theory by @david-g-clark.bsky.social and @omarschall.bsky.social. 🤯
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Owen Marschall @omarschall.bsky.social · 04/11/2025
Can confirm this was a fun project! My favorite takeaway is that the (low-but-extensive) rank of a network can be used as a knob for controlling dimensionality while leaving single-neuron properties unchanged.
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 03/11/2025
Simultaneous detection and estimation in olfactory sensing www.biorxiv.org/content/10.1101/202…
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David G. Clark @david-g-clark.bsky.social · 03/11/2025
Now in PRX: Theory linking connectivity structure to collective activity in nonlinear RNNs! For neuro fans: conn. structure can be invisible in single neurons but shape pop. activity For low-rank RNN fans: a theory of rank=O(N) For physics fans: fluctuations around DMFT saddle⇒dimension of activity
journals.aps.org
Connectivity Structure and Dynamics of Nonlinear Recurrent Neural Networks
The structure of brain connectivity predicts collective neural activity, with a small number of connectivity features determining activity dimensionality, linking circuit architecture to network-level...
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David G. Clark @david-g-clark.bsky.social · 27/10/2025
scipost.org/SciPostPhysL...
scipost.org
SciPost: SciPost Phys. Lect. Notes 105 (2025) - Simplified derivations for high-dimensional convex learning problems
SciPost Journals Publication Detail SciPost Phys. Lect. Notes 105 (2025) Simplified derivations for high-dimensional convex learning problems
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Naomi Saphra @nsaphra.bsky.social · 24/09/2025
I did a QA with Quanta about interpretability and training dynamics! I got to talk about a bunch of research hobby horses and how I got into them.
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Kris Jensen @kristorpjensen.bsky.social · 24/09/2025
I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time! www.biorxiv.org/content/10.1...
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Valentin Schmutz @bio-emergent.bsky.social · 19/09/2025
🎉 "High-dimensional neuronal activity from low-dimensional latent dynamics: a solvable model" will be presented as an oral at #NeurIPS2025 🎉 Feeling very grateful that reviewers and chairs appreciated concise mathematical explanations, in this age of big models. www.biorxiv.org/content/10.1... 1/2
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David G. Clark @david-g-clark.bsky.social · 15/09/2025
A great reading list for historical+recent RNN theory
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David G. Clark @david-g-clark.bsky.social · 08/09/2025
One for the books
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Sreejan Kumar @sreejan.bsky.social · 06/09/2025
I'm excited to share that my new postdoctoral position is going so well that I submitted a new paper at the end of my first week! www.biorxiv.org/content/10.1... A thread below
biorxiv.org
Sensory Compression as a Unifying Principle for Action Chunking and Time Coding in the Brain
The brain seamlessly transforms sensory information into precisely-timed movements, enabling us to type familiar words, play musical instruments, or perform complex motor routines with millisecond pre...
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David G. Clark @david-g-clark.bsky.social · 25/08/2025
(1/26) Excited to share a new preprint led by grad student Albert Wakhloo, with me and Larry Abbott: "Associative synaptic plasticity creates dynamic persistent activity." www.biorxiv.org/content/10.1...
biorxiv.org
Associative synaptic plasticity creates dynamic persistent activity
In biological neural circuits, the dynamics of neurons and synapses are tightly coupled. We study the consequences of this coupling and show that it enables a novel form of working memory. In recurren...
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David G. Clark @david-g-clark.bsky.social · 19/08/2025
Wanted to share a new version (much cleaner!) of a preprint on how connectivity structure shapes collective dynamics in nonlinear RNNs. Neural circuits have highly non-iid connectivity (e.g., rapidly decaying singular values, structured singular-vector overlaps), unlike classical random RNN models.
arxiv.org
Connectivity structure and dynamics of nonlinear recurrent neural networks
Studies of the dynamics of nonlinear recurrent neural networks often assume independent and identically distributed couplings, but large-scale connectomics data indicate that biological neural circuit...
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