Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of ...

Correctly assigning value to different options and leveraging this information to guide choice is a cornerstone of adaptive decision-making. Reinforcement learning (RL) has provided a computational fr...

PhD Position on “Mental disorders as harmful stable states” The departments Clinical Psychology and Methodology & Statistics, at the Institute of Psychology, Faculty of Social Sciences, Leiden Univers...

Flexible decision making depends on retrieving and recombining memories. Yet because this process unfolds covertly, its governing principles remain unknown. Here we use gaze reinstatement to uncover t...

Department SSD Institute for Mind and Biology: Staff and Temporary Employees About the Department The Eating Disorders Program in the Department of Psychiatry and Behavioral Neuroscience at the Univer...

Human curiosity is dynamic, however the principles governing its fluctuations remain debated. Here, we test two competing hypotheses about how past...

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Human exploration behaviour is studied using cognitive tasks where information seeking competes with reward seeking. Here the authors describe how humans discover the structure of new and uncertain en...

Strategic avoidance of uncertainty emerges under high cognitive demands, enabling faster decisions without impairing learning.

Nicholas and Mattar found that people use episodic memory to make decisions when it is unclear what will be needed in the future. These findings reveal how the rich representational capacity of episod...

Child & Adolescent Translational Science Lab at Northwestern University

Computational psychiatry is increasingly delivering causal evidence by focusing on interventions research and clinical trials. Causal evidence could improve patient outcomes through improved precision, repurposing, novel interventions, scaling of psychotherapy and better translation to the clinic.

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

In this trial involving participants with treatment-resistant depression, pramipexole augmentation of antidepressant treatment, at a target dose of 2·5 mg, demonstrated a reduction in symptoms relativ...

Reinforcement Learning Mechanisms of Pharmacological Treatments for Depression (RELMED)

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UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

At the end of a decision based on evidence accumulation, the neural representation of the accumulation is invariant across decisions. Zylberberg and Shadlen show, nonetheless, that accuracy can be dec...