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Hauke Drechsler

@hd-sci.bsky.social
123 followers 231 following 34 posts

Biochemist/Molecular Biologist studying the Biophysics of the human cytoskeleton in a plant institute @unituebingen using Cell Biology and in vitro reconstitution approaches - is interdisciplinarity still a thing? Mastodon: @HD_sci@biologists.social

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Reposted by Hauke Drechsler
Universität Tübingen @unituebingen.bsky.social · 10h
Die Universität Tübingen feiert ihr 550-jähriges Bestehen und die #SIDays26 feiern mit! 🎉 Unter dem Motto „Vom Wert der Wissenschaft“ lädt das große Tübinger #Wissenschaftsfestival am 6. und 7. November 2026 zu einem vielseitigen Programm ein 👉 www.sidays.com
Veranstaltungsplakat der „Science & Innovation Days 2026“ in Tübingen. Dunkelblauer Hintergrund, mit Schriftzug "Vom Wert der Wissenschaft", dem Datum 6.–7. November und dem Text "Das große Tübinger Wissenschaftsfestival für alle - jetzt Programm entdecken! Am unteren Rand sind gelbgrüne grafische Linien.
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Reposted by Hauke Drechsler
Maiato Lab @mitosisrocks.bsky.social · 09/09/2026
A long time in the making, now finally out.💥 Our new study shows that division stays on time when kinetochore–microtubule attachments form efficiently. When the process drags, that delay is remembered, limiting future cell proliferation. www.nature.com/articles/s41... #mitosis #biology #microscopy
nature.com
Low kinetochore-microtubule occupancy leaves a mitotic memory by delaying checkpoint silencing - Nature Communications
How do cells faithfully segregate chromosomes within an optimal time? Using naturally “super-resolved” kinetochores, the authors show that maximal microtubule occupancy prevents bad mitotic memories t...
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Maiato Lab @mitosisrocks.bsky.social · 03/09/2026
What is the sequence of events at the kinetochore? Our Spotlight article highlighting a beautiful study by Conway et al. is out now in Trends in Cell Biology! Click here for download: sl1nk.com/euzlpiq A temporal framework for error-free mitosis: Trends in Cell Biology www.cell.com/trends/cell-...
cell.com
A temporal framework for error-free mitosis
The spindle assembly checkpoint (SAC) promotes mitotic fidelity by delaying anaphase until all kinetochores are stably attached to spindle microtubules. SAC silencing is increasingly recognised as a d...
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Reposted by Hauke Drechsler
Katrina Velle @katrinavelle.bsky.social · 03/09/2026
Teaching advanced cell bio this morning and including a cautionary note about using AI. So I asked AI to draw a microtubule, thinking it would have subtle but important errors. But wow. I think dissecting everything wrong here could take all semester! Maybe a fun exam question?
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Reposted by Hauke Drechsler
Joachim Goedhart @joachimgoedhart.bsky.social · 01/09/2026
grafify online: A web app for graphing and statistical analysis dx.plos.org/10.1371/jour... grafifyonline.shinyapps.io/grafify/
dx.plos.org
grafify online: A web app for graphing and statistical analysis
Creating accurate graphs and performing statistical analyses can be challenging for those who lack coding experience. This Community Page introduces grafify online, a free, browser-based app for generating publication-quality graphs and performing statistical tests and post-hoc comparisons.
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Reposted by Hauke Drechsler
Cytoskeleton Journal @cytoskeljournal.bsky.social · 31/08/2026
#Microtubule nucleation is the critical first step in building microtubule networks. This #FREE access #review in #CYTOSKELETON explores how noncentrosomal MTOCs control nucleation, cell polarity, morphology & cell division. onlinelibrary.wiley.com/doi/10.1002/...
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Hauke Drechsler @hd-sci.bsky.social · 28/08/2026
Free unasked advice: If you want to illustrate your paper but you cannot make polished illustrations yourself - it's ok to go with basic illustrations made in power point or to get a professional illustrator/artist to do these things for you. Using AI, however, to look bold and deliver this slop: /1
AI-generated scheme showing a kinesin motor melting into a microtubule
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Cytoskeleton Journal @cytoskeljournal.bsky.social · 26/08/2026
In a new #openaccess PERSPECTIVE in #CYTOSKELETON, Ron Vale reflects on 40 years of #kinesin, from its serendipitous discovery to how this microscopic motor drove a revolution in single-molecule imaging. Read "Captivated by Kinesin" here: onlinelibrary.wiley.com/doi/full/10....
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Cytoskeleton Journal @cytoskeljournal.bsky.social · 19/08/2026
The new issue of #CYTOSKELETON is out! #SpecialIssue: #Microtubule‐Based Structures in #Health and #Disease. Check it out here: onlinelibrary.wiley.com/toc/19493592...
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Cytoskeleton Journal @cytoskeljournal.bsky.social · 14/08/2026
Check out this #new #openaccess mini #review in #CYTOSKELETON. Cytoskeleton–Membrane Uncoupling in Duchenne #Muscular #Dystrophy: Implications for Newborn #Screening and Early Protection. onlinelibrary.wiley.com/doi/10.1002/...
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Reposted by Hauke Drechsler
Maiato Lab @mitosisrocks.bsky.social · 11/08/2026
Learn more about the clinical relevance of the tubulin code in our comprehensive review, recently published in Cancer and Metastasis Reviews. #Cancer #Tubulin link.springer.com/article/10.1...
link.springer.com
Prognostic, diagnostic and therapeutic value of the cancer tubulin code - Cancer and Metastasis Reviews
Microtubules are essential cytoskeleton polymers composed of α/β-tubulin heterodimers that play a central role in the regulation of various cellular processes, including cell division, cell shape, cel...
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Reposted by Hauke Drechsler
Erik Schäffer Lab @schaefferlab.bsky.social · 24/07/2026
Where biology, chemistry, and physics meet! 🧬🧪⚛️ Explore our Bachelor's and Master's programmes in Nano-Science at the University of Tübingen and shape the future of science. 🔗 Learn more: www.nano-science.uni-tuebingen.de #NanoScience #UniTuebingen #StudyScience #Interdisciplinary #Biophysics
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Luiselotte Rausch @luiselotterausch.bsky.social · 22/07/2026
Now in @jxbotany.bsky.social ! Check out our opinion piece on Atomic Force Microscopy #afm in Plant Biomechanic Research: A powerful tool that needs careful handling, interpretation & more research! @Klaus Harter, @moscabiomeclab.bsky.social at @zmbp-tuebingen.bsky.social doi.org/10.1093/jxb/...
doi.org
Validate User
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Nogales Lab @nogaleslab.bsky.social · 20/07/2026
Thrilled to share our collab led by Grace Hibshman with the Shipman lab! Type IX retron-Kva2 structure reveals phage detection via an HTH fold, not a primary sequence. We computationally designed triggers that program bacteria cell death, pointing toward designer antimicrobials.
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Diez Lab @ TU Dresden @stefandiezlab.bsky.social · 19/07/2026
🔬 #JobAlert Interested in doing a PhD with us in #SyntheticBiology on the Reconstitution of Oscillatory Microtubule-Motor Systems? Check shorturl.at/wis5P (note the eligibility criteria) or/and get in touch with us shorturl.at/WmgOD. Deadline: 31 July 2026 #WeAreHiring #AcademicJobs #ScienceJobs
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rob.mechanochemistry.org @rob.mechanochemistry.org · 11/07/2026
In www.biorxiv.org/content/10.6... Yean Ming Chew & I show that mutating the interPF interface in human MTs can allow them to assemble in GDP. We propose that tubulin molecules are captured indiscriminately at MT tips but then retained only if they can bind stably to a lateral nearest-neighbour.
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Hauke Drechsler @hd-sci.bsky.social · 09/07/2026
Now online as an "accepted manuscript" @jxbotany.bsky.social : Our attempt on summarising our current biophysical knowledge of plant kinesins - including look-up tables for all published motor parameters and where to find them academic.oup.com/jxb/advance-...
academic.oup.com
Plant kinesins: a bottom-up approach – from single molecules to function
Abstract. During land colonisation, plants evolved new microtubule structures that have no functional analogues in opisthokonts, namely animals and fungi.
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Felipe Opazo @opazo.bsky.social · 02/07/2026
New paper! 🚀 A high-affinity anti- #mNeonGreen #nanobody turns #mNG into a #multifunctional Tag. @nanotag.bsky.social decided to openly share the #nanobody for research use. Not common, but we strongly believe well-defined reagents are key for reproducible science. We hope you find it useful! 💚
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Joachim Goedhart @joachimgoedhart.bsky.social · 01/07/2026
A High-Affinity Nanobody Recognizing mNeonGreen Enables Versatile Biochemical, Cellular, and in vivo Applications. by Steffen Frey and team: www.biorxiv.org/content/10.6...
mNeonGreen Selector: a pulldown resin for mNeonGreen-fusion proteins. (A) Sketch of mNG
Selector binding mNG fusion proteins. (B, C) Immunoprecipitation from E.coli lysate in the presence (B) or
absence (C) of target protein (mNG-Halo fusion, arrowhead). Proteins were eluted in boiling SDS sample
buffer. mNG Selector enables highly specific one-step capture of mNG-tagged proteins. (D) Binding assay to
evaluate the cross-reactivity of the mNG Selector to other recombinant fluorescent proteins. Shown is a figure
of the equilibrium bound fraction of each indicated fluorescent protein prior to buffer washing. (E)
Compatibility of mNG Selector to various reagents applied during binding (top panel) or during washing steps
(lower panel). mNG fluorescence is lost in the presence of 2 M Gua-HCl. The symbols below each row indicate
binding efficiency: ++: strong binding, + binding, -: no binding
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 16/06/2026
With a motivating push from @christlet.bsky.social I made a new Fiji plugin, CurveMorph. The idea was to create a tool for kymograph generation along the dynamic (bending/shaking) filament shapes (microtubules, cilia, neurites, etc). The logo was made using the plugin. github.com/UU-cellbiolo...
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Ali Twelvetrees @dozenoaks.bsky.social · 16/06/2026
Our latest review is out. We take a deep dive into the human mutations in microtubule motors that drive devastating neurodevelopmental and neurodegenerative diseases. Taking in motor protein biophysics, animal models of disease as well as patient phenotypes. onlinelibrary.wiley.com/doi/full/10....
Graphical abstract summarising the impact of defective microtubule motors on axonal transport. Kinesins (green) and dyneins (magenta) maintain balance along the length of the axon. When disease causing mutations cause either hyper or hypo activity, the loss of balance results in axon dieback.
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Thomas Ott @ottlab.bsky.social · 12/06/2026
Happy to share our newest preprint. We developed guidelines and analysis workflows for FLIM Imaging in plants. Multiplexing with spectrally overlapping fluorophores in plants is now possible. Have a look. Any feedback is more than welcome. www.biorxiv.org/content/10.6...
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Hauke Drechsler @hd-sci.bsky.social · 02/06/2026
Wormholes do exist....👽
Micrograph showing an expanded RPE1 cell stained for DNA (orange), microtubules (magenta) and the kinesin KIF11 (blue)
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Reposted by Hauke Drechsler
Journal of Cell Biology @jcb.org · 26/05/2026
Saishree S. Iyer and Anna Akhmanova @utrechtuniversity.bsky.social review the mechanisms controlling plus-end elongation of centriolar and ciliary #microtubules, revealing shared principles. rupress.org/jcb/article/... #Centrioles #Cilia #Cytoskeleton
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Simon Bullock @simonbullock11.bsky.social · 05/05/2026
Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4). www.nature.com/articles/s41...
nature.com
Structural basis for recognition of diverse localizing mRNAs by Egl–BicD - Nature Structural & Molecular Biology
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
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Physics of Life Dresden @poldresden.bsky.social · 04/05/2026
👩‍🔬Calling all researchers! Are you interested in working on a project at Physics of Life? 🔬Our new Visitors Program will allow scientists to visit PoL for up to 6 months to pursue an interdisciplinary project, with their travel and accommodation covered. Learn more here and apply: tud.link/nasaw5
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British Society for Cell Biology @bscb-official.bsky.social · 23/04/2026
Rob Cross @mechanochemistry.org shares his insights on kinesin and microtubule nanomechanics at #DynamicCellVI Rob is the recipient of the @biochemsoc.bsky.social Award for Sustained Excellence 2025. Congratulations!
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Diez Lab @ TU Dresden @stefandiezlab.bsky.social · 23/04/2026
Come and join us at B CUBE (TU Dresden) as group leader - great environment, lots of Molecular Bioengineering from biochemistry to biophysics around and looking forward to support you in setting up your own research team. Details 👇 datashare.tu-dresden.de/s/XtAFtSy25H.... Deadline 21 May 2026.
datashare.tu-dresden.de
B_CUBE_GL_Ad.pdf
Datashare - Provided by ZIH
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Cytoskeleton Journal @cytoskeljournal.bsky.social · 22/04/2026
Attention #MICROTUBULE fans!! A new TECHNIQUES AND PROCEDURES paper is out at #CYTOSKELETON. Visualizing Specific #Tubulin Isotypes and #Pathogenic Variants in #Cellular Microtubule Arrays. Check out the paper here: onlinelibrary.wiley.com/doi/10.1002/...
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Felix Mikus @fmikus.bsky.social · 21/04/2026
Our ExM Atlas of eukaryotes is moving along with more and more images coming in - some featured in nature last month! Culture we’re provided by @ccapoban.bsky.social & Julius Lukeš during visits last year www.nature.com/immersive/d4...
nature.com
See the intricate worlds of parasites and algae — March’s best science images
The month’s sharpest science shots, selected by Nature’s photo team.
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Sophien Kamoun @kamounlab.bsky.social · 15/04/2026
I just published: TSL Alumnus wins Biochemical Society Award Mauricio Contreras has been recognised as an exceptional Early Career Researcher by the Biochemical Society. #CelebratingAlumni medium.com/p/tsl-alumnu...
medium.com
TSL Alumnus wins Biochemical Society Award
FIRST PUBLISHED: 14.04.26 | THE SAINSBURY LABORATORY
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Christophe 🔬 Leterrier @christlet.bsky.social · 13/04/2026
Make your own PDMS+micromirror device for single-objective light-sheet SMLM: www.biorxiv.org/content/10.6...
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Katherine Brown @katherine-brown.bsky.social · 01/04/2026
"Why is publishing so expensive?" It's a question I hear all the time, so we at @biologists.bsky.social thought we'd try to dispel some of the myths around publishing economics & provide transparency around our costs. Today, we publish editorials in all 5 of our journals - links in the thread below.
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Anne Straube @anne.mechanochemistry.org · 31/03/2026
Registration deadline for our motors and filaments meeting is tomorrow - not a 1st April joke! Thanks to our generous sponsors supporting sustainable scientific conference organisation @embo.org @biologists.bsky.social we also offer registration for a free livestream, supported by bsky discussions!
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Stephen Royle @steveroyle.bsky.social · 30/03/2026
A unique opportunity to lead the most wonderful company in scientific publishing (I might be slightly biased here). The Company of Biologists are searching for a CEO. www.inspiredselection.com/jobs/jo00000...
inspiredselection.com
Chief Executive Officer | Inspired Selection
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Journal of Cell Biology @jcb.org · 30/03/2026
#Neurons rely on molecular motors to deliver proteins to precise locations. Jiang, Ichinose, Hirokawa et al. show that #kinesin-2 motors form heterogeneous assemblies with distinct cargo preferences: A KIF3B-enriched assembly preferentially associates with TRIM46 rupress.org/jcb/article/...
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DGZ.bsky.social @dgz.bsky.social · 28/03/2026
Join us for the next DGZ Focus Workshop, next week Tuesday, organized by Franziska Lautenschläger & Anne Straube, featuring topics around #cytoskeleton and #molecularmotors. Talks by @lilianpaty.bsky.social , Rhoda Hawkins, Roman Podhajecky & Kanako Iwasaki
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Kelly Nguyen @kellythd-nguyen.bsky.social · 26/03/2026
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...
youtube.com
Cryo-EM structure of yeast telomerase
YouTube video by MRC Laboratory of Molecular Biology
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Deutsche Forschungsgemeinschaft @dfg.de · 26/03/2026
Deutschland beteiligt sich an "Open Research Europe" #ORE. Über die Plattform können Wissenschaftler*innen aller deutschen Forschungseinrichtungen ihre Ergebnisse künftig kostenfrei veröffentlichen u. im offenen Verfahren begutachten lassen. Die DFG ist mit der Durchführung beauftragt: sohub.io/rqll
Logo Weiß auf Blau mit Schriftzug:
open
research
europe
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Hauke Drechsler @hd-sci.bsky.social · 25/03/2026
#ServiceNotification SiR-DNA completely blocks Anaphase of hTERT-RPE1 cells during time lapse recordings (every 3min) for mitotic progression analyses at concentrations >/= 5nM (@1h preincubation). No DNA staining with 1nM. Visible staining AND progression beyond Anaphase with 3nM SiR-DNA only.
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Vladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · 20/03/2026
Happy to see the first paper from the lab published in the EMBO J today: link.springer.com/article/10.1... In it, we reconstitute self-assembling cooperative oligomers of human Ndc80 and Ska kinetochore complexes that stabilise microtubule ends, and study these samples using cryoET and TIRF
link.springer.com
Microtubule end stabilisation by cooperative oligomers of Ska and Ndc80 complexes - The EMBO Journal
During mitosis, properly aligned chromosomes stabilise microtubule ends with the help of kinetochores to ensure timely segregation of chromosomes. Microtubule-binding components of the human outer kin...
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Sebi @sebi06.bsky.social · 19/03/2026
Hi all fans of #smart #microscopy, we from @zeiss-microscopy.bsky.social have just published a new application note: "Study Mitotic Progression with Guided Acquisition – Rare Event Detection" go2.zeiss.com/ODk2LVhNUy03... For more details: forum.image.sc/t/applicatio...
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Journal of Cell Science @jcellsci.bsky.social · 19/03/2026
Cordula Reuther, Paula Santos-Otte, Stefan Diez and colleagues find that microtubule lattice defects facilitate spastin-mediated severing. journals.biologists.com/jcs/article/... #OpenAccess #ReadandPublish
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 11/03/2026
Neat paper from Schwille lab. They demonstrate constriction of synthetic vesicles using important components of the bacterial cell division machinery, FtsZ and FtsN. They induce strong constriction of Z-rings in vesicles just by adding the cytoplasmic domain of FtsN www.nature.com/articles/s41...
nature.com
Optimizing spatial organization of FtsZ rings for large-scale constriction in synthetic cells - Nature Communications
Spatially regulated membrane constriction is an important milestone in reconstituting minimal cell division. Here the authors engineer a truncated system where the cytosolic domain of FtsN forms large...
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Universität Tübingen @unituebingen.bsky.social · 11/03/2026
Die Universität Tübingen bleibt Exzellenzuniversität! 🎉 Dies hat eine Kommission aus Wissenschaftlerinnen und Wissenschaftlern sowie Vertreterinnen und Vertretern von Bund und Ländern am Abend bekannt gegeben: 👉 uni-tuebingen.de/universitaet/… #ExStra #Forschung #UniTübingen #Exzellenzstrategie
Grafik mit goldenem, geschwungenem Weg und Bäumen, Text: „Excellent – today and in the future. University of Excellence 2027–2033“.Grafik mit Text vor grünem Hintergrund: 

Fünf Ziele in der neuen Förderphase

Die in der vergangenen Förderphase begonnenen Projekte werden fortgeführt beziehungsweise weiterentwickelt. Dabei wird die Universität Tübingen mit den Mitteln aus der künftigen Exzellenzförderung fünf Ziele verfolgen:

Exzellenz in Forschung und Lehre
Aufbau eines integrativen und kooperativen Universitätsumfelds
Flexibilität und Anpassungsfähigkeit in einer sich schnell verändernden Welt
Globales Bewusstsein und internationale Vernetzung
Gesellschaftliches Engagement, Innovation und Ko-KreationLogowand: Exzellenzstrategie, Wissenschaftsrat, DFG sowie Förderhinweis mit Logos von Bundesministerium für Forschung, Technologie und Raumfahrt und Baden-Württembergischem Wissenschaftsministerium.
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Hauke Drechsler @hd-sci.bsky.social · 10/03/2026
Given that the last proper position paper on the classification and nomenclature of kinesins is more than 20 years old and our knowledge of kinesins has vastly expanded during this time, but people in the field are still using 3+ different names for the same kinesin and ... 1/2
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Calin Plesa @calin.bsky.social · 03/03/2026
To enable reuse by the research community we're making the two parental FPBase libraries available on @addgene.bsky.social as pooled plasmid libraries (Addgene #245482 #245483). Use them. Shuffle them. Train on them! addgene.org/Calin_Plesa/ 12/n
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Dolf Weijers @dolfweijers.bsky.social · 03/03/2026
We are very excited to share a new resource from our team: spatial subcellular proteome maps in plants! We developed an MS-based method that registers localizations of about 8000 proteins in Arabidopsis roots in a single experiment. (1/9) www.biorxiv.org/cgi/content/...
biorxiv.org
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