iiinova — where your digital self keeps evolving

ttsukaza @ttsukaza.bsky.social · 01/10/2026

Crystal structure of YidC in complex with YibN Takahashi et al., BBRC, 2026 EcYidC TM1 was disordered in previous structures, and its role unclear. Crystal structure reveals its interaction with YibN. 50days' free access kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... DOI doi.org/10.1016/j.bb...

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ttsukaza @ttsukaza.bsky.social · 04/09/2026

New Publication: Miyazaki et al., Nature Communications (2026) Our structural and functional analyses of the SurA–BAM complex reveal how SurA and BAM cooperate during outer membrane protein assembly. [Paper URL] www.nature.com/articles/s41...

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ttsukaza @ttsukaza.bsky.social · 12/11/2025

Using multiple cryo-EM structures, we revealed how the periplasmic chaperone SurA dynamically changes its conformation to deliver substrates to the BAM complex. Miyazaki et al., 2025, bioRxiv t.co/g7zkwqiwhz

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ttsukaza @ttsukaza.bsky.social · 16/10/2025

細菌に必須の膜タンパク質 MurJ と、それを阻害するファージペプチドとの構造解析・第２弾！ファージ由来の SglPP7 と LysM は、同じ Lipid II フリッパーゼ MurJ を標的にするが、結合様式は異なる。収斂進化のようだ。 Hosoda et al., bioRxiv (2025) t.co/IcDlImMS2F

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ttsukaza @ttsukaza.bsky.social · 16/10/2025

The complex between a bacteriophage peptide and the essential membrane protein MurJ — Part II Both SglPP7 and LysM inhibit MurJ, but through distinct binding modes — a striking case of convergent evolution. Hosoda et al., bioRxiv (2025) t.co/IcDlImMkd7

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ttsukaza @ttsukaza.bsky.social · 09/10/2025

Happy to share our 2025 “Open CNS” achievement! 🎉 Many thanks to my students and collaborators 🙏 Cell Reports: doi.org/10.1016/j.ce... Nat Commun: doi.org/10.1038/s414... Sci Adv: doi.org/10.1126/scia...

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ttsukaza @ttsukaza.bsky.social · 08/10/2025

クテリオファージ由来の小型タンパク質LysMが、Lipid II フリッパーゼMurJの機能を阻害する様子をクライオ電子顕微鏡解析で明らかにしました。 Kohga et al., Sci. Adv. (2025) t.co/u5ZibBF0kA

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ttsukaza @ttsukaza.bsky.social · 08/10/2025

Our MurJ/LysM paper has been published in Science Advances. Kohga et al., Sci. Adv. (2025). This study elucidates, through cryo-electron microscopy, the mechanism by which the small bacteriophage-derived protein LysM inhibits the lipid II flippase MurJ. t.co/u5ZibBF0kA

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ttsukaza @ttsukaza.bsky.social · 16/07/2025

We revealed, through cryo-EM and functional analyses, that the small lipoprotein LptM stabilizes LptD at a late stage of LptDE complex maturation in the outer membrane. Miyazaki et al., Cell Reports (2025) www.cell.com/cell-reports...

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ttsukaza @ttsukaza.bsky.social · 27/04/2025

Just posted on bioRxiv! We reveal the structure of the MurJ/LysM (JM) complex. A small phage protein, LysM (37 residues), binds to MurJ like a wedge and freezes its motion. www.biorxiv.org/content/10.1...

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Reposted by ttsukaza

bioRxivpreprint @biorxivpreprint.bsky.social · 04/04/2025

Structural basis of a phosphotransferase system xylose transporter www.biorxiv.org/content/10.1101/202…

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Reposted by ttsukaza

Azusa Kage @azusakage.bsky.social · 05/12/2024

I made a (quite incomplete) starter pack of Japanese or in-Japan researchers. Self-identify, and I will add you! 日本人/日本にいる研究者のスターターパックを作りました。リプしていただければ追加します！ go.bsky.app/7kMz86x

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ttsukaza @ttsukaza.bsky.social · 08/01/2025

We captured the process of a substrate protein through a membrane using HS-AFM. A string-like protein (peptide) is being translocated by a single SecYEG-SecA. Kanaoka et al., Nature communications (2025) www.nature.com/articles/s41...

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ttsukaza @ttsukaza.bsky.social · 08/01/2025

タンパク質が膜透過する様子を高速AFMで捉えました１ユニットのSecYEG-SecAを、紐状のタンパク質（ペプチド）が通過しています名古屋大学内橋研、東京理科大学森研との共同研究です。 Kanaoka et al., Nature communications (2025) www.nature.com/articles/s41...

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Reposted by ttsukaza

bioRxivpreprint @biorxivpreprint.bsky.social · 04/01/2025

Structural basis of lipopolysaccharide translocon assembly mediated by the small lipoprotein LptM www.biorxiv.org/content/10.1101/202…

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Reposted by ttsukaza

bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 04/01/2025

Structural basis of lipopolysaccharide translocon assembly mediated by the small lipoprotein LptM www.biorxiv.org/content/10.1101/202…

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ttsukaza @ttsukaza.bsky.social · 05/01/2025

doi.org/10.1101/2025... LptM の機能とLptDEM複合体の構造解析です bioRxiv にポストしました

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