iiinova — where your digital self keeps evolving

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 02/10/2026

Great intro! You also got me excited about cell blebbing—just watched your full talk and can confirm, it’s 100% worth the watch! 👏🔬

110

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 01/10/2026

True for confocal z-slicing, but here, even when the focal plane stays stable -purple blobs don't shift- individual blobs pop out (see GIF below). That local inconsistency further suggests AI interpolation over optical drift, on top of your points. Full video for context: youtu.be/t1hlHFyNfI4

110

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 27/09/2026

Regarding the Nikon Small World controversy, I made a short explaining our concerns to the public—and why data integrity in microscopy matters: youtube.com/shorts/t1hlH... And just now seeing the LinkedIn breakdown showing Gemini generative AI altered the entry makes the whole outcome even sadder.

0225

Reposted by Sasha | Kai Dao 🔬

Institut Necker Enfants Malades @inem-necker.bsky.social · 07/09/2026

🔬 New publication, now out in #ScienceImmunology led by Mathieu Deygas in Pablo Vargas team, shows that Adaptive motility enables neutrophils to rapidly navigate confined capillaries 📰 To read the article: tinyurl.com/52vxuhmp

33316

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 21/08/2026

What happens when you make an organism transparent & use AI to map every cell? 🔬 An incredible @nature.com paper by @dorie00.bsky.social & @erturklab.bsky.social mapped metabolic stress—revealing damage far beyond the usual suspects. Watch: youtu.be/RfNoEu9_VJ8 #FluorescenceFriday #Microscopy

1187

Reposted by Sasha | Kai Dao 🔬

Zebrafish Rock! 🎃 @zebrafishrock.bsky.social · 16/08/2026

Time-lapse video of vascular development in a transgenic #zebrafish embryo. Credit to @kuglerelisabeth.bsky.social. #ZebrafishZunday

15614

Reposted by Sasha | Kai Dao 🔬

Zebrafish Rock! 🎃 @zebrafishrock.bsky.social · 09/08/2026

Light sheet fluorescence microscopy (LSFM) movie of axon branching during #zebrafish development in a neurodegenerative disease gene (KLC4) mutant. Credit to @drlizhaynes.bsky.social. #ZebrafishZunday

16517

Reposted by Sasha | Kai Dao 🔬

Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 24/07/2026

Happy #FluorescenceFriday. Its always exciting when i get to test out new constructs in my cells. It's not common that I get to see the ER network in an immune cell. This construct is not strictly ER but it's so overly expressed that it labels the ER in an embryonic macrophage in 🐸. How cool?

1345

Reposted by Sasha | Kai Dao 🔬

Marco A. Maximo Prado @maximoprado.bsky.social · 24/07/2026

#fluoroscencefriday It is all about blood vessels and plaques by the @mind-western.bsky.social

0205

Reposted by Sasha | Kai Dao 🔬

AIC at Janelia @aicjanelia.bsky.social · 23/07/2026

This afternoon's imaging lab at #IALSJanelia is all about subcellular structures, highlighted here by myosin (white) and actin (orange). These membrane ruffles were captured on our lattice light-sheet microscope by @cmhobson.bsky.social

05218

Reposted by Sasha | Kai Dao 🔬

Journal of Cell Biology @jcb.org · 23/07/2026

Excitable RhoA dynamics drive pulsed contractions in the early #Celegans embryo. From Jonathan B. Michaux, François B. Robin, William M. McFadden, and Edwin M. Munro: rupress.org/jcb/article/... 📕 Part of "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

092

Reposted by Sasha | Kai Dao 🔬

Kirsty Wan @micromotility.bsky.social · 21/07/2026

Do #tintinnids dream of electric sheep? 🤯 Here is a single cell capable of building a lorica and living inside it for protection... it also swims, feeds, hunts Can even detect and habituate to mechanical cues! #celllearning #protistsonsky #cilia Read more in our preprint doi.org/10.64898/202...

412537

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 13/07/2026

This video is incredible, Danielle! I'm a cell biologist/sci-comm creator and I’m currently putting together a microscopy storytelling video about your MouseMapper paper. I would love to feature the first part with the transparent mouse in it! What would be the best way to connect to chat about it?

010

Reposted by Sasha | Kai Dao 🔬

Ulrike Boehm @ulrikeboehm.bsky.social · 02/04/2026

I'm happy to share a recent study by @cathygalbraith.bsky.social & James Galbraith, along with @sciencethecat.bsky.social & myself. It challenges existing views on intracellular transportation… 🔗 www.nature.com/articles/s41...

0158

Reposted by Sasha | Kai Dao 🔬

Danielle Beckman @daniellebeckman.bsky.social · 10/07/2026

An intact human heart, rendered transparent. Because disease doesn't happen in 2D. Whole-organ tissue clearing and light-sheet microscopy reveal coronary vessels (magenta) and atherosclerotic plaques (gold) across the intact organ. More at: shorturl.at/iqTBh 🫀🔬 #FluorescenceFriday!

29922

Reposted by Sasha | Kai Dao 🔬

Dylan Burnette @mag2art.bsky.social · 09/07/2026

Two cells videoed through a microscope. One has big membrane blebs (right) and one has little membrane blebs (left). What do they have in common. They will be dead soon...... #CellBiology #Apoptosis

091

Reposted by Sasha | Kai Dao 🔬

Anders Sejr Hansen @andersshansen.bsky.social · 22/06/2026

(3/n) We engineering a synthetic 339 kb E-P pair in 'vacant' region - Vary E-P dist - +/- CTCF at E and P - See nice dot in RCMC maps - Can track E-P 3D distance and nascent RNA from 2Hz to 6+ hours using Super-Res Live Cell Imaging - Txn strictly dependent on E. - New DNA fluor label: synBsr1 (!)

1113

Reposted by Sasha | Kai Dao 🔬

Danielle Beckman @daniellebeckman.bsky.social · 04/07/2026

I had fun editing these videos 😎 Whole-body imaging is really opening new possibilities for biology. Seeing the whole picture changes the questions we can ask, and ultimately the discoveries we can make. Read more: 🔬 DISCO-seq www.biorxiv.org/content/10.6... 🚀 LipiGo www.biorxiv.org/content/10.1...

27116

Reposted by Sasha | Kai Dao 🔬

Matyas Bubna-Litic @matyasbl.bsky.social · 03/07/2026

Happy #FluorescenceFriday! Eye of a zebrafish embryo🐟

16515

Reposted by Sasha | Kai Dao 🔬

Zebrafish Rock! 🎃 @zebrafishrock.bsky.social · 05/07/2026

Rhythmic beating of a transgenic zebrafish embryo’s heart. Credit to @helenevignes.bsky.social, @cvagenapantoula.bsky.social & @vermotlab.bsky.social. #ZebrafishZunday 🧪

38319

Reposted by Sasha | Kai Dao 🔬

epithelial mechanics fan club @epimechfc.bsky.social · 05/07/2026

From single-celled organisms to ciliated epithelia in metazoans, precise positioning of basal bodies (BBs), which anchor motile cilia, is essential for generating fluid flows. Here, I, @raghavan-thiaga.bsky.social, will take you on a brief tour of how cells build this spatial organization.

24112

Reposted by Sasha | Kai Dao 🔬

Evelyn Strickland @strickland-evelyn.bsky.social · 20/04/2026

What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~ www.biorxiv.org/content/10.6...

315443

Reposted by Sasha | Kai Dao 🔬

Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 03/07/2026

Not many people know this but 🐸 embryos make an amazing system to study immune cells. If 🐟 embryos become less transparent as they grow, 🐸 embryos do the reverse, becoming progressively transparent. Their immune cells are very similar to 🐟 and 🚶‍♂️. Here are some 🐸 macrophages (🔴): #FluorescenceFriday

2477

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 03/07/2026

Far from a static structure, the ER actively shapes its environment. See how its motility allows it to physically shape the cellular environment in this microscopy footage from Dong Li (CAS) & Andy Moore (Janelia): youtu.be/DnOYwPLhq60 doi.org/10.1016/j.ce... #FluorescenceFriday #Microscopy

0258

Reposted by Sasha | Kai Dao 🔬

Phil Abitua @ohnolog.bsky.social · 30/06/2026

Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil

720357

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 27/06/2026

Great paper, Javier! What tunes the varying H2O2 sensitivities across these 24 neuron classes? Could neural C. elegans globins act as localized competitive sinks? Could a membrane-bound globin scavenge low-level H2O2 as a filter, preventing minor metabolic noise from tripping the PRDX-2 switch?

210

Reposted by Sasha | Kai Dao 🔬

Scott Coyle @cellraiser.bsky.social · 16/06/2026

Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...

24323

Reposted by Sasha | Kai Dao 🔬

Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 26/06/2026

Working with complex systems makes even the most mundane thing fascinating. This is cortical reaction in 🐸 embryos. Upon fertilisation, ions are released and draw water in thru osmosis, making zygotes float and orient according to gravity. Do you see the waves?👀 not quite #fluorescencefriday #devbio

15511

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 26/06/2026

Fruit fly embryo development is wild! 1 nucleus clones into 6,000+ copies in just 2 hours. Perfectly synchronized. With built-in bumper system. And absolutely mesmerizing. I visualized the science behind it in a microscopy story 🔬👇 youtu.be/xyV9BhIVRjM #FluorescenceFriday #Microscopy #Drosophila

0389

Reposted by Sasha | Kai Dao 🔬

Physics of Life Dresden @poldresden.bsky.social · 24/06/2026

🤔How much energy do cellular processes cost, and how does this affect self-organization of living systems? 🔬The Yang group at PoL develops methods to map energy fluxes in cells with subcellular resolution, uncovering the energetic costs/constraints that shape life YouTube video👉 y2u.be/HDA6_58t0Jw

172

Reposted by Sasha | Kai Dao 🔬

Pablo J. Sáez @pjsaez.bsky.social · 16/03/2026

This is why we love #CalciumSignaling Look how mechanical damage triggers long range Ca2+ waves in this plant !! By @annalisabellandi.bsky.social, who is now around here ;) Full www.science.org/doi/10.1126/... @science.org #microscopy #cell #mechanobiology 🧪🔬

319860

Reposted by Sasha | Kai Dao 🔬

Chad Hobson @cmhobson.bsky.social · 24/04/2026

Happy #FluorescenceFriday! Just some random data I collected from a while back, actin and myosin in a U2OS cell imaged on our lattice light sheet microscope.

19316

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 21/06/2026

Yes, exactly! The fin that provided the wound-healing cells goes through a proliferation burst of its own skin cells afterwards. It's a really clever solution.

010

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 20/06/2026

I couldn't agree more, it's so mesmerizing! And if you want to check out the original paper from Chen-Hui Chen's team and Fiorency Santoso, you can find it here: www.cell.com/current-biol...

cell.com

210

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 20/06/2026

So happy to see this story getting so much love! 🐟✨ Huge thanks to Chen-Hui Chen and Fiorency Santoso for sharing their original material with me and trusting me to bring their amazing work to a wider audience. 🔬 Check out their full paper: www.cell.com/current-biol...

cell.com

Appendage-resident epithelial cells expedite wound healing response in adult zebrafish

Santoso et al. report an unexpected role of adult zebrafish fins in accelerating re-epithelialization. They find that fin-resident epithelial cells are highly mobile, migrating to cover nearby millime...

084

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 20/06/2026

Absolutely beautiful work, agreed! The moment I read their paper, I knew I had to make a story about it. So grateful to Fiorency Santoso and Chen-Hui Chen that they shared their original material for this.

010

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 19/06/2026

8 hours. That’s all fish need to heal wounds 🐟⏱️ Why are they so fast compared to humans? I break down the science of rapid regeneration in a microscopy story 🔬 Watch here: youtu.be/Mt9f61adaP0 #FluorescenceFriday #Microscopy

621571

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 29/05/2026

Ever seen mitochondria fly around like little rockets? 🚀 When cells divide, they don't just split DNA. I made a YouTube story based on a major Nature paper, showing how cells use actin waves to shuffle their powerhouses! 🔬 Watch the video here: youtu.be/udrVh_p7kCg #FluorescenceFriday #Microscopy

0115

Reposted by Sasha | Kai Dao 🔬

Society for Developmental Biology @socdevbio.bsky.social · 22/05/2026

✨ Serving egg-cellent organization and fluorescent elegance 🥚 Partial Drosophila 🪰 ovariole with WGA staining of nuclear envelopes 🔬 📸 Image by Michelle Giedt #FluorescenceFriday 🐣

2279

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 27/05/2026

Absolutely gorgeous! The development of the Drosophila ovariole and embryo are so incredibly fascinating - it actually drove me to make a video about it because they are just that cool! 🪰✨ Thanks for sharing this beautiful image!

000

Reposted by Sasha | Kai Dao 🔬

Kevin Terretaz @kwolbachia.bsky.social · 22/05/2026

Have a nice #FluorescenceFriday This is an insect larvae with endosymbiotic bacteria enverywhere! (in orange) #Microscopy #Sciart

2245

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 26/05/2026

That's an amazing picture, and it raises so many questions! What are the different population's roles, how did they get there, how are they symbiotic and not parasitic... You opened a world for me here, thanks for sharing!

120

Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 25/05/2026

Captivated by the earliest stage of a fruit fly's life—which completely defies textbook biology—I reached out to the people behind groundbreaking papers. I wove their breathtaking live-cell imaging into a story of self-organization. Super fascinating! youtu.be/xyV9BhIVRjM #Microscopy #CellBiology

youtu.be

Why Nature Ditched the Rules

YouTube video by Kai Dao

050