Sign in

Brian English

@sciencethecat.bsky.social
2.5K followers 2.4K following 48 posts

senior scientist at Janelia | single particle tracking & #microscopy 🔬 | PhD on single-molecule enzymatic dynamics | my path: 🇩🇪→🇺🇸→🇸🇪→🇺🇸 | scholar.google.com/citations?user=U…

PostsRepliesMedia
Brian English @sciencethecat.bsky.social · 28/09/2026
... 10 years ago today (and 4 years later) #Nobel @ritastrack.bsky.social #JenniferDoudna #EmmanuelleCharpentier
130
Brian English @sciencethecat.bsky.social · 15/09/2026
Heloisa and I just got the next-gen Moderna covid shot mNEXSPIKE at Costco. mNEXSPIKE is a lower-dose (10 vs 50 mcg mRNA), more targeted option than the standard Spikevax. It may also produce a stronger immune response, so get this one if you can! @heloisarts.bsky.social #covid #moderna
130
Brian English @sciencethecat.bsky.social · 13/09/2026
Golazos for both us and Elversberg and an exciting match and win #miasanmia🔴⚪️ #washingtondc @fcbayernmunich.bsky.social @sv07elversberg.bsky.social
032
Reposted by Brian English
Michael DeVries @michaeldevries.bsky.social · 01/09/2026
Absolutely well worth the read. As a long time adjunct, the struggle is definitely real.
032
Brian English @sciencethecat.bsky.social · 28/08/2026
with @heloisarts.bsky.social from our balcony in Crystal City, lots of clouds but we got a little lucky
050
Reposted by Brian English
Rita Strack @ritastrack.bsky.social · 26/08/2026
It was a busy day But I still found time To be sad about Dolly Parton
0683
Brian English @sciencethecat.bsky.social · 26/08/2026
Heloisa in art handling action! Opening this Friday, Ebenezer Nketsiah Mensah: Mining Memory, at VisArts in Rockville @heloisarts.bsky.social #VisArts
030
Reposted by Brian English
jimgalbraith27.bsky.social @jimgalbraith27.bsky.social · 23/07/2026
Yes, great descriptive visualization by @mullinslab.bsky.social. Will never look at sesame seeds and cats the same again. Looking forward to catching the next wave with @cathygalbraith.bsky.social, @sciencethecat.bsky.social, and @ulrikeboehm.bsky.social
021
Brian English @sciencethecat.bsky.social · 23/07/2026
What would it feel like to go with the flow inside a cell? A lovely new Current Biology Dispatch by Dyche Mullins on work led by Cathy & Jim Galbraith "expands our cellular imagination" to the cell's sluices, pumps, dams. doi.org/10.1016/j.cu... doi.org/10.1038/s414...
doi.org
Redirecting
160
Reposted by Brian English
Luke Lavis @rhodamine110.bsky.social · 17/07/2026
Excited to see this collaboration now in print. Dye chemistry meets AI-designed proteins. Three small, orthogonal tags; lifetime modulation; split versions. Request the free dyes at dyes.janelia.org www.science.org/doi/10.1126/...
science.org
De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging
Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...
010839
Reposted by Brian English
John Bogovic @bogovicj.bsky.social · 17/07/2026
It's an exciting day for #Fiji users! Now read and write @zarr.dev v3 and #OMEZarr v0.5. Don't want a million tiny files in your #zarr? Shard that sucker! Read the details here forum.image.sc/t/fiji-can-r...
forum.image.sc
Fiji can read and write Zarr3 & OME-Zarr v0.5 (new N5 release!)
Updating your Fiji-Latest installation will give you the newest versions of the N5 library, enabling OME-Zarr v0.5 / Zarr v3 support with sharding! What's new? Reading zarr 3 datasets (sharded and u...
05722
Reposted by Brian English
jimgalbraith27.bsky.social @jimgalbraith27.bsky.social · 10/07/2026
@focalplane.bsky.social asked us for the behind the paper story on uncovering Compartmentalized Cytoplasmic Tradewinds. Read about it here. (along with a new YouTube video) A great collaboration with @sciencethecat.bsky.social and @ulrikeboehm.bsky.social focalplane.biologists.com/2026/07/09/c...
focalplane.biologists.com
Cytoplasmic Tradewinds: How Cells Steer Proteins
Six imaging methods reveal cytoplasmic tradewinds: a hidden fluid flow that pushes soluble proteins using a leaky actin-myosin barrier.
0102
Brian English @sciencethecat.bsky.social · 09/07/2026
⚽🇩🇪 We are famous @heloisarts.bsky.social, we are mentioned in the Post as "other German fans" wapo.st/4aEAdrw I'm the one with the face paint 🤣
wapo.st
European soccer fans enjoy a brief fling with America’s air-conditioned culture
Despite a deadly heat wave at home, many say they won’t permanently embrace Americans’ electricity-guzzling amenity.
030
Reposted by Brian English
HHMI @hhmi-science.bsky.social · 28/06/2026
These stunning single-celled organisms can shape-shift & regenerate. Their trumpet-like shape inspired their name: stentor, after the herald in Greek mythology known for his booming voice. 📸: Confocal microscopy by Igor Siwanowicz, HHMI’s Janelia Research Campus
Three stentors
15413
Brian English @sciencethecat.bsky.social · 24/06/2026
The amazing Geoff Daniels stopped by Janelia for a visit. Always great when old friends stop by. Good to see you both, Geoff and John! @abberior.rocks @hhmijanelia.bsky.social
010
Reposted by Brian English
Anders Sejr Hansen @andersshansen.bsky.social · 22/06/2026
(3/n) We engineering a synthetic 339 kb E-P pair in 'vacant' region - Vary E-P dist - +/- CTCF at E and P - See nice dot in RCMC maps - Can track E-P 3D distance and nascent RNA from 2Hz to 6+ hours using Super-Res Live Cell Imaging - Txn strictly dependent on E. - New DNA fluor label: synBsr1 (!)
1113
Reposted by Brian English
Ulrike Boehm @ulrikeboehm.bsky.social · 11/06/2026
I’m thrilled to announce that I am the voice behind a new @zeissgroup.bsky.social campaign focused on photonics—discover more about this exciting field and ZEISS’s pioneering role in it! 😀👉 www.zeiss.com/corporate/en/c/stories/insights/photonics.html
zeiss.com
Technological innovation: Photonics & AI | ZEISS
Discover how ZEISS is advancing artificial intelligence through technological innovations and photonics, enabling advanced microchips and practical AI applications in science, medicine, and industry.
0112
Reposted by Brian English
Randall Munroe @xkcd.com · 17/06/2026
Messi xkcd.com/3260/
Comic. Lionel Messi: World Cup Goals per game. [Graph with x axis as year and y axis as number of goals per game, ranging from 0 to 3. Data points: 2006 (~1/3), 2010 (0), 2014 (~1/2), 2018 (~1/4), 2022 (1), 2026 (3) with parenthetical (so far). Behind the line connecting the points is a grayed out curve showing the trajectory.] [caption] At this rate, by 2040 Messi will be scoring hundreds of goals per game.
443583516
Reposted by Brian English
Helena Klara Jambor @helenajambor.bsky.social · 16/06/2026
😎 to have this out! --> stay tuned, this is a series about 📊#dataviz for #science 🧪
85522
Brian English @sciencethecat.bsky.social · 15/06/2026
All the countries I've lived in: 🇩🇪 (7:1 win) 🇸🇪 (5:1 win) 🇺🇸 (4:1 win) 🍀⚽🍀⚽🍀⚽ I'm clearly a lucky charm and I'm ready to accept immigration proposals.
080
Reposted by Brian English
Rita Strack @ritastrack.bsky.social · 15/05/2025
I especially loved this historical Comment from Sunney Xie in the Focus issue, which describes how the stage was set for coherent Raman microscopy.
0123
Reposted by Brian English
Nature Methods @natmethods.nature.com · 12/06/2026
Our June issue is live! 🎉 www.nature.com/nmeth/volume... On the cover, an absolutely gorgeous image of neurites and mitochondria in a brain organoid, captured using the MOSAIC microscope. Paper here: www.nature.com/articles/s41...
082
Reposted by Brian English
HHMI @hhmi-science.bsky.social · 09/06/2026
#HHMIInvestigator Eric Betzig & team use a single microscope that does the work of a dozen, capturing life in 5D (3D + time + color). But the data it generates is too vast for humans to analyze alone, so they're building "a sherpa to guide us,” i.e. an AI to unlock MOSAIC's potential: bit.ly/3RN2GVj
A rare moment caught in stunning detail: a single cell splitting into three. Seen here in cancerous pig cells, it marks the first time such an event has been captured on video — made possible by MOSAIC's 5D imaging. Courtesy of Advanced Bioimaging Center/UC Berkeley.
051
Reposted by Brian English
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 28/05/2026
The leadership and clarity of @MIT President Sally Kornbluth www.bostonglobe.com/2026/05/26/o...
bostonglobe.com
America built the world’s greatest research engine. Now it’s shrinking. - The Boston Globe
At public and private universities across the country, high-impact science is being damaged and derailed.
412855
Reposted by Brian English
Rita Strack @ritastrack.bsky.social · 23/05/2026
The MOSAIC paper is out in Nature Methods. For the record I went after this paper for *years* and was so happy when they sent it to me/us. www.nature.com/articles/s41...
nature.com
A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms - Nature Methods
MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems r...
27213
Reposted by Brian English
MiaSanDistrict @miasandistrict.bsky.social · 16/05/2026
Thank you @fcspdc.bsky.social for hosting us today ♥️ #washingtondc @fcbayernmunich.bsky.social #fcbayern Love St. Pauli - Hate Racism!
131
Reposted by Brian English
Shades of Blue Network @shadesofbluenw.bsky.social · 17/05/2026
There will never be another Vincent Kompany. Player management skills 100/10
2105
Reposted by Brian English
parafilm is cool dot com @parafilmm.bsky.social · 17/05/2026
Different types of scissors one a white background with the headline Types of Parafilmase
47617
Reposted by Brian English
Nature Methods @natmethods.nature.com · 14/05/2026
Our May issue is live! 🎉 www.nature.com/nmeth/volume... On the cover, volumetric label-free imaging of a live model of the human blood–brain barrier with a self-localized ultrafast pencil beam. Paper here: www.nature.com/articles/s41...
071
Reposted by Brian English
Julia Lazzari-Dean @jlazzaridean.bsky.social · 12/05/2026
We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...
A cartoon overview of triplet tumbling microscopy, comparing data from bound and unbound samples.
416654
Reposted by Brian English
David Solecki @so-lets-kilab70.bsky.social · 05/05/2026
Here’s our newly developed enhancer nucleosome biosensor imaged in primary human fibroblast. Staygold in the biosensor allowed us to image at very high temporal resolution to see some amazing dynamics
0205
Reposted by Brian English
Hank Green @hankgreen.bsky.social · 04/05/2026
NASA just dropped 12,000 photos from the Artemis II mission. Too many to add to ArtemisTimeline.com, so I just put up a tool at ArtemisTimeline.com/vote so that people can vote on small batches allowing for all of the images to be sorted! (yes, I posted this before, but I had to fix something!)
artemistimeline.com
Artemis II Photo Voter
Help surface the best photos from NASA's Artemis II mission. Vote on a random batch, or rank specific moments.
301828312
Brian English @sciencethecat.bsky.social · 03/05/2026
Selfies with some of my legend-friends at the 10th Chesapeake Bay Area Single Molecule Biology Meeting! @jiexiaolab.bsky.social @successprocess.bsky.social #SingleMolecules #Janelia
1100
Reposted by Brian English
cathygalbraith.bsky.social @cathygalbraith.bsky.social · 18/04/2026
It all started with (#2 in the series) New in Nature Methods - spontaneously blinking dyes for live cell super-resolution. No harsh chemicals or damaging light. 2 Nature family papers in two weeks 🤯 @rhodamine110.bsky.social @sciencethecat.bsky.social doi.org/10.1038/s415... doi.org/10.1038/s414...
163
Reposted by Brian English
cathygalbraith.bsky.social @cathygalbraith.bsky.social · 17/04/2026
Just out: A series of spontaneously blinking dyes for super-resolution microscopy with @rhodamine110.bsky.social and an incredible team of collaborators. www.nature.com/articles/s41... It's been an amazing few weeks -- this follows our cytoplasmic tradewinds paper. www.nature.com/articles/s41...
0113
Reposted by Brian English
Luke Lavis @rhodamine110.bsky.social · 15/04/2026
And this one took a while—736 days. I wrote about why there is more behind this paper than the chemistry. communities.springernature.com/posts/736-days
communities.springernature.com
736 Days
2273
Reposted by Brian English
isa-espinosa-m.bsky.social @isa-espinosa-m.bsky.social · 12/04/2026
sOrganellomics is a new strategy to map cell state diversity and functional cell changes across healthy and diseased tissues! Check out the latest version now on BioRxiv - Congratulations @feliciano-lab.bsky.social !!
biorxiv.org
063
Reposted by Brian English
jimgalbraith27.bsky.social @jimgalbraith27.bsky.social · 03/04/2026
How do proteins find their way to the cell's leading edge? @jimgalbraith27.bsky.social & @cathygalbraith.bsky.social break down how bleach line, FLOP, single-particle tracking, FCS & iPALM reveal intracellular fluid flow and an actin-myosin compartment barrier. doi.org/10.1038/s414...
14523
Reposted by Brian English
Ulrike Boehm @ulrikeboehm.bsky.social · 02/04/2026
I'm happy to share a recent study by @cathygalbraith.bsky.social & James Galbraith, along with @sciencethecat.bsky.social & myself. It challenges existing views on intracellular transportation… 🔗 www.nature.com/articles/s41...
0158
Reposted by Brian English
Ulrike Boehm @ulrikeboehm.bsky.social · 01/04/2026
What if cells have undiscovered methods for managing their internal logistics? Our recent work (@cathygalbraith.bsky.social, James A. Galbraith, @sciencethecat.bsky.social & myself) challenges existing views on intracellular transportation 🔗 lnkd.in/dhMDgY5Q
0177
Brian English @sciencethecat.bsky.social · 01/04/2026
So excited to share this work that employs #FCS, TIRF, FRAP, SPT, SIM & #iPALM. Huge thanks to @cathygalbraith.bsky.social, James Galbraith, and @ulrikeboehm.bsky.social (the iPALM wizard) #OpenScience @hhmijanelia.bsky.social #CellBiology #Cytoskeleton #SuperResolution #Microscopy #Actin
171
Reposted by Brian English
Mark Bates @wmarkbates.bsky.social · 31/03/2026
Delighted to share our preprint describing COMET, a new approach to drift correction for #SMLM, which performs exceptionally well in practice. Check out the benchmarking results compared to other methods! :) Thanks to @lreinkensmeier.bsky.social for a superb effort. www.biorxiv.org/cgi/content/...
14620
Reposted by Brian English
voigtvision.bsky.social @voigtvision.bsky.social · 26/03/2026
🚨New Lab Alert!🚨 Superhappy to announce that I will start my lab combining photonics & neuroscience at the Max Planck Center for Physics & Medicine in Erlangen & @mpi-scienceoflight.bsky.social in January 2027! Reach out if you're interested in internships, BSc, MSc & PhD & postdoc projects!
Max Planck Center for Physics and Medicine buildingMax Planck Instittute for the Science of Light building
7455
Reposted by Brian English
Kai Johnsson @kjohnsson.bsky.social · 26/03/2026
A high-affinity split-HaloTag for live-cell protein labeling. And much more. www.nature.com/articles/s41...
nature.com
A high-affinity split-HaloTag for live-cell protein labeling
Nature Communications - Lin and colleagues present high-affinity split-HaloTag pairs for protein tagging and multiplexed labelling. This versatile system allows protein visualisation with diverse...
213353
Reposted by Brian English
Scholar Goggler bot @scholargoggler.bsky.social · 25/03/2026
Brian Patrick English loves writing about cell, imaging, single, living, dynamic, molecules and probably posts about them here too @sciencethecat.bsky.social Create yours at scholargoggler.com
Cloud of words in various colors and sizes on a white background, arranged in the shape of a rectangle. Some of the largest words include cell imaging single living dynamic molecules tracking microscopy single-molecule translation complex michaelis-menten protein reveals RNA super-resolution accessible bacterial coronavirus eif4f enzyme equation fluorescent fluorophores general hcov-oc43 individual inhibition live moleculeCloud of words in various colors and sizes on a black background, arranged in the shape of a rectangle. Some of the largest words include cell imaging single living dynamic molecules tracking microscopy single-molecule translation complex michaelis-menten protein reveals RNA super-resolution accessible bacterial coronavirus eif4f enzyme equation fluorescent fluorophores general hcov-oc43 individual inhibition live moleculeCloud of words in various colors and sizes on a white background, arranged in the shape of a rectangle. Some of the largest words include cell imaging single living dynamic molecules tracking microscopy single-molecule translation complex michaelis-menten protein reveals RNA super-resolution accessible bacterial coronavirus eif4f enzyme equation fluorescent fluorophores general hcov-oc43 individual inhibition live molecule
141
Reposted by Brian English
Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 25/03/2026
And in yesterday's journal club, we discussed this nice paper on transforming antibodies into intrabodies from @tim-stasevich.bsky.social et al. The authors put together a pipeline comprising ProteinMPNN to design a stabler protein sequence for the scaffold while keeping the antigen-binding loops.
science.org
AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications
AI-powered pipeline converts antibodies into functional intrabodies, enabling live-cell imaging of peptides and histone marks.
1237
Reposted by Brian English
HHMI @hhmi-science.bsky.social · 15/03/2026
Beautiful, & built for discovery. These next-gen fluorescent dyes (developed by the Lavis Lab at our Janelia Research Campus) are brighter, more photostable, & more versatile — advancing how scientists visualize biology inside cells.
Fluorescent dyes at the Lavis Lab at Janelia Research Campus
0234
Brian English @sciencethecat.bsky.social · 15/03/2026
Pi-day opening at Cultivate Gallery: Heloisa's DIScomfort Beauty interactive installation @heloisarts.bsky.social #washingtondc #interactiveart #videoinstallation @cultivateprojects.bsky.social
021
Brian English @sciencethecat.bsky.social · 12/03/2026
This Saturday: art by my ♥️ Heloisa!
031
Reposted by Brian English
Ulrike Boehm @ulrikeboehm.bsky.social · 02/03/2026
𝗘𝘅𝗰𝗶𝘁𝗶𝗻𝗴 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁𝘀 𝗶𝗻 𝗠𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆 𝗥𝗲𝗽𝗼𝗿𝘁𝗶𝗻𝗴! If you're involved in creating, processing, or publishing microscopy data, take a look at the new checklist for reporting requirements provided by @quarep-limi.bsky.social in @jcb.org 🔗 rupress.org/jcb/article/...
01914