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Wendy Figueroa

@wfigueroac3.bsky.social
246 followers 355 following 5 posts

Postdoc @Cambridge University and the Wellcome Sanger Institute. Pathogens evolution: Horizontal Gene Transfer🧬, Phages, Mutational hotspots, AMR, virulence 🇲🇽

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Reposted by Wendy Figueroa
Craig MacLean @craigmaclean.bsky.social · 03/06/2026
Excited to share this new paper from the lab: academic.oup.com/ismej/articl...! See thread below
academic.oup.com
Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug-resistance plasmids
Abstract. Phage therapy offers an alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are promising the
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Reposted by Wendy Figueroa
Daniel Cazares @danielcazares.bsky.social · 11/05/2026
Happy to share that our latest research on the eco-evolutionary dynamics of MDR plasmids and PDPs is now out (open access vAuthor) in The ISME Journal doi.org/10.1093/isme... Here, we explored how plasmid-dependent phages (PDPs) act as a selective pressure against the spread of multidrug resistance
doi.org
Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug resistance plasmids
Abstract. Phage therapy offers a promising alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are part
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Wendy Figueroa @wfigueroac3.bsky.social · 06/04/2026
Out in @natcomms.nature.com! We show that while most MGEs are blocked by RM systems🛡️, the chromosome is still mobile! 🧬And that cells with defective systems act as "gateways" for HGT. Can you find the hidden Easter egg🐇🥚? Hint: There's a nod to my 🇲🇽 heritage in one of the figures! rdcu.be/fbUC8
rdcu.be
Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution
Nature Communications - The efficiency of horizontal gene transfer between different bacterial lineages is often unclear. Here, Figueroa et al. show that lateral transduction is the primary driver...
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Reposted by Wendy Figueroa
José R Penadés @jrpenades.bsky.social · 05/04/2026
Latest from the lab! Between clinical S. aureus, most gene transfer mechanisms are blocked, yet lateral transduction remains highly efficient. Restriction modification-defective strains act as gateways for horizontal gene transfer, enabling DNA flow across populations. rdcu.be/fbNQK
rdcu.be
Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution
Nature Communications - The efficiency of horizontal gene transfer between different bacterial lineages is often unclear. Here, Figueroa et al. show that lateral transduction is the primary driver...
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Reposted by Wendy Figueroa
Ross Fitzgerald @jrossfitz.bsky.social · 18/02/2026
Great work by Jamie Gorzynski and Josh-Harling-Lee from the group providing insights into the evolutionary origins of bacterial lineages. A collaboration with @jrpenades.bsky.social @wfigueroac3.bsky.social. #Staph Cell Reports www.cell.com/cell-reports...
cell.com
Bacterial defense systems and host ecology drive the evolution of intra-species lineages
Staphylococcus aureus lineages vary widely in the frequency of gene exchange and the diversity of genome content. Gorzynski and Harling-Lee et al. show that both host ecology and the horizontal acquis...
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Wendy Figueroa @wfigueroac3.bsky.social · 16/02/2026
Excited to share our latest paper c/w @jrpenades.bsky.social @jrossfitz.bsky.social et al! We found that S. aureus lineages have different pangenome structures driven by HGT, with horizontally-acquired defence systems (T1RM) being major drivers of lineage emergence 👇 www.cell.com/cell-reports...
cell.com
Bacterial defense systems and host ecology drive the evolution of intra-species lineages
Staphylococcus aureus lineages vary widely in the frequency of gene exchange and the diversity of genome content. Gorzynski and Harling-Lee et al. show that both host ecology and the horizontal acquis...
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Reposted by Wendy Figueroa
Alfonso Santos Lopez @asantoslopez.bsky.social · 22/10/2025
Do plasmids really move around that much? Well, maybe not always Thrilled to have contributed to this story with two of my favourite microbiologists: @jrpenades.bsky.social & @sanmillan.bsky.social This great work was led by Akshay Sabnis & @wfigueroac3.bsky.social www.cell.com/cell-reports...
cell.com
Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...
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Wendy Figueroa @wfigueroac3.bsky.social · 22/10/2025
✨New paper from @jrpenades.bsky.social and @sanmillan.bsky.social labs. We found that non-conjugative plasmids 🧬 tend to have low mobility to promote functional diversity ⚔️💊 in bacterial communities🦠🦠. Brilliant work by Akshay, @asantoslopez.bsky.social and others. www.cell.com/cell-reports...
cell.com
Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...
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Reposted by Wendy Figueroa
Alvaro San Millan @sanmillan.bsky.social · 22/10/2025
New paper with my (amazing) friend and mentor @jrpenades.bsky.social Really looking forward to see what plasmid aficionados think of this one!! With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others www.cell.com/cell-reports...
cell.com
Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...
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Reposted by Wendy Figueroa
John Lees @johnlees.bacpop.org · 15/10/2025
We are running a hackathon at EBI in Feb: biomics.bacpop.org If you are at EMBL, ETH Zurich, GRC or GIMM working on a biological problem in data science or programming, consider putting a project forwards!
biomics.bacpop.org
BIOMICS hackathon at EMBL-EBI
Hackathon held in Hinxton 2026
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Reposted by Wendy Figueroa
Michael Brockhurst @brockhurstlab.bsky.social · 09/10/2025
Three Bicentenary research fellowships on offer at @officialuom.bsky.social @fbmh-uom.bsky.social for exceptional ECRs with <3y postdoc experience 3yrs salary + £30k pa research expenses Do you have a great idea & want to join @mermanchester.bsky.social? www.bmh.manchester.ac.uk/research/sup...
bmh.manchester.ac.uk
Bicentenary Early Career Research Fellowships | Biology, Medicine and Health | University of Manchester
Find out about and apply for a Bicentenary Early Career Research Fellowship.
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Reposted by Wendy Figueroa
Craig MacLean @craigmaclean.bsky.social · 09/10/2025
New pre-print www.biorxiv.org/content/10.1... Plasmid-dependent phage (PDPs) are ubiquitous, but the selective pressures that they impose on plasmids are not well understood. Project led by Daniel Cazares in collaboration with @brockhurstlab.bsky.social! #phagesky#microsky
biorxiv.org
Trade-offs between phage resistance and conjugative ability shape the ecological and evolutionary response of a multidrug resistance plasmid to plasmid-dependent phage
Phage therapy is a promising alternative to antibiotics to treat multidrug resistant infections. Plasmid dependent phages (PDPs) are particularly attractive as therapeutics because they can both kill ...
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Reposted by Wendy Figueroa
Adrian Cazares @cazares-adr.bsky.social · 06/10/2025
Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics We just did that to study the history of #AMR spread @science.org doi.org/10.1126/scie... If you like time travel & biology, this 🧵is for you👇
doi.org
Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...
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Reposted by Wendy Figueroa
EMBL-EBI @ebi.embl.org · 26/09/2025
Antimicrobial resistance (AMR) causes over a million deaths each year, and is rising. Scientists analysed 40,000 bacterial plasmids across 100 years and six continents, to reveal that a few plasmids evolved after antibiotic use to drive most multi-drug resistance. www.ebi.ac.uk/about/news/r... 🧬💻
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Reposted by Wendy Figueroa
Sandhya Koushika @wormlockholmes.bsky.social · 27/09/2025
Super interesting-dig in Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance | Science www.science.org/doi/10.1126/...
science.org
Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...
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Reposted by Wendy Figueroa
Science News @scinews.bsky.social · 27/09/2025
Modern plasmids have evolved through complex microevolution and fusion events into a distinct group of highly recombinogenic, multi-replicon, self-transmissible plasmids that now pose the highest risk to resistance dissemination, and therefore to human health. www.science.org/doi/10.1126/...
science.org
Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...
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Reposted by Wendy Figueroa
Wellcome Sanger Institute @sangerinstitute.bsky.social · 26/09/2025
Samples from 1917 have helped identify the genetic culprits responsible for the spread of treatment-resistant infections 🔎 By mapping plasmid evolution since the pre-antibiotic era, experts found that a minority of plasmids cause most of the multidrug resistance in the world 🧵
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Reposted by Wendy Figueroa
Zamin Iqbal @zaminiqbal.bsky.social · 25/09/2025
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols. Thread 1/n
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