Reposted by Christian LentzProf Jenny Rohn @jennyrohn.bsky.social · 18/09/2026“Bacterial growth is straightforward to measure, complex in origin and exquisitely sensitive to environmental and genetic perturbations.” Fantastic opening sentence to a deeply interesting topic. Never thought about bacterial growth like this before. #MicroSky #Bacteria 23414
Reposted by Christian LentzKeri Backus @keribackus.bsky.social · 28/04/2026Super excited that our SEE-CITE photoaffinity labeling method is now out in @natchem.nature.com rdcu.be/ffBSC. Here we introduce a custom silyl ether cleavable linker between a diazirine photocrosslinker handle and molecules of interest to streamline site-of-labeling analysis for PAL chemoproteomics 14615
Reposted by Christian LentzKim Walker @drwalkermsbanta.bsky.social · 20/04/2026A must-read for anyone interested in #Klebsiella or metal acquisition! 063
Christian Lentz @christianslentz.bsky.social · 13/04/2026Come join us! 4 year PhD position in infection biology/microbiology available associated to our newly funded Clinical Academic Group “Patient-tailored management of bacterial infections in the age of antimicrobial resistance”. Applications via: www.jobbnorge.no/en/available.... @cansuit.bsky.socialjobbnorge.noPhD fellow in infection biology/microbiology (297648) | UiT The Arctic University of NorwayJob title: PhD fellow in infection biology/microbiology (297648), Employer: UiT The Arctic University of Norway, Deadline: Tuesday, April 28, 2026 034
Reposted by Christian LentzAndy Edwards @bugsinblood.bsky.social · 03/12/2025We're advertising for a bacteriology technician and a post-doc to work on AI-guided antibiotic development as part of a large multidisciplinary Fleming Initiative project: www.imperial.ac.uk/jobs/search-... www.imperial.ac.uk/jobs/search-...imperial.ac.ukDescriptionPlease note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment... 01428
Reposted by Christian LentzKim Lane Scheppele @kimlanelaw.bsky.social · 10/12/2025All travelers from ESTA countries (yes the ones on visa waiver programs) will have to disclose 5 years of social media + huge amounts of personal data to enter the US now. All US academic associations should now meet outside the US if we want to meet our international colleagues. 17438233
Reposted by Christian LentzBiozentrum, University of Basel @biozentrum.unibas.ch · 08/12/2025🧪 New research by @basler-lab.bsky.social reveals a surprising microbial trade-off: Pseudomonas aeruginosa activates a defense program to survive “speargun” attacks from rival bacteria, but this defense makes it more vulnerable to antibiotics. @unibas.ch @snsf.ch @nccr-antiresist.bsky.social 👇biozentrum.unibas.chHow bacteria resist hostile attacksSome bacteria use a kind of molecular “speargun” to eliminate their rivals, injecting them with a lethal cocktail. Researchers led by Prof. Marek Basler at the Biozentrum have now discovered that cert... 0147
Reposted by Christian LentzAMR-kleb/staph @s-rowe-conlon.bsky.social · 01/12/2025Thrilled to share our latest paper on antibiotic treatment failure of Klebsiella pneumoniae liver abscesses www.pnas.org/doi/full/10.... @drwalkermsbanta.bsky.socialpnas.orgAntibiotics accumulate in Klebsiella pneumoniae liver abscesses but fail to eliminate antibiotic-tolerant populations | PNASLiver abscesses caused by hypervirulent Klebsiella pneumoniae (hvKp) can lead to severe metastatic complications, with mortality rates ranging from... 074
Reposted by Christian LentzMatt Hutchings @matthutchings.bsky.social · 29/11/2025Sensor kinase interacts directly with two distinct classes of cell wall targeting antibiotics to detect cell envelope stress. Great work onlinelibrary.wiley.com/doi/abs/10.1...onlinelibrary.wiley.comThe Histidine Kinase VraS Interacts with Vancomycin and Penicillins Through its Membrane‐Anchored N‐terminal DomainThe signals triggering activation of VraTSR, a key regulator of the cell wall stress response in Staphylococcus aureus, remain unknown. Combining crosslinking assays with vancomycin- and ampicillin-d.... 065
Reposted by Christian LentzKimberly Kline 🏔 @kimingeneva.bsky.social · 24/11/2025Excited to share our first look at Enterococcus faecium infection biology: diabetic wounds are complex, and E. faecium persists despite early immune responses. In diabetic mice, it shows impaired clearance + sustained neutrophil recruitment, worsening healing. 0187
Reposted by Christian Lentzsimonheilbronner.bsky.social @simonheilbronner.bsky.social · 24/11/2025Really happy to see the final version of this published in @isme-microbes.bsky.social. We show that production of and competition for biotin shapes S. aureus fitness in the context of nasal commensals doi.org/10.1093/isme... Work lead by the amazing Kevser Bilici!doi.orgCompetitive fitness of Staphylococcus aureus against nasal commensals depends on biotin biosynthesis and acquisitionAbstract. The human nasal microbiome can serve as a reservoir for pathogens. In particular, the opportunistic pathogen Staphylococcus aureus can be a membe 12814
Reposted by Christian LentzÁkos T Kovács @evolvedbiofilm.bsky.social · 06/11/2025#ISMEJournal paper from Simon Heilbronner Competitive fitness of Staphylococcus aureus against nasal commensals depends on biotin biosynthesis and acquisition academic.oup.com/ismej/advanc...academic.oup.comCompetitive fitness of Staphylococcus aureus against nasal commensals depends on biotin biosynthesis and acquisitionAbstract. The human nasal microbiome can serve as a reservoir for pathogens. In particular, the opportunistic pathogen Staphylococcus aureus can be a membe 0106
Reposted by Christian LentzKiran R. Patil @kiranrpatil.bsky.social · 17/07/2025Another fantastic study from @lisamaierlab.bsky.social showing how non-antibiotics impact gut ecosytem. Congratulations @ghammeranne.bsky.social et al.! 2149
Reposted by Christian LentzChristian Kost @kostchristian.bsky.social · 28/10/2025#microsky #mevosky @spp2389.bsky.social A PhD position is available in my lab to work on: Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria. Please RT Deadline: 12.11.25 More infos 👇 shorturl.at/rAKAT 04253
Reposted by Christian LentzRonan McCarthy @ronanmccarthy.bsky.social · 23/10/2025the @ukbiofilms.bsky.social I will be advertising several positions for my lab over the next few weeks/months so please do get in touch 052
Reposted by Christian LentzJulia Frunzke @frunzkelab.bsky.social · 08/10/2025Please RT: We have an opening for a junior group leader position in „Phage Biology & Biotechnology“. www.fz-juelich.de/de/karriere/... Interested candidates are encouraged to contact me via email for further details. @spp2330.bsky.social; @mibinet.bsky.socialfz-juelich.deJunior Group Leader - Phage Biology & BiotechnologyAs a leading research institution for microbial biotechnology the Institute of Bio- and Geosciences - Biotechnology (IBG-1, https://www.fz-juelich.de/de/ibg/ibg-1 ) at the Forschungszentrum Jülich foc... 03857
Reposted by Christian LentzAndy Edwards @bugsinblood.bsky.social · 29/09/2025Now published! www.nature.com/articles/s41... Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.nature.comPolymyxin B lethality requires energy-dependent outer membrane disruption - Nature MicrobiologyThe antibiotic polymyxin B requires bacterial metabolic activity to cause sufficient damage to the outer membrane to access the inner membrane, which it permeabilizes via an energy-independent mechanism to kill the cell. 14324
Reposted by Christian LentzMarit Hetland @genomarit.bsky.social · 16/09/2025Thrilled to share this preprint on Klebsiella pneumoniae plasmids in a One Health setting 🦠 Fantastic work by @twinkler.bsky.social! 🎉 @irenlohr.bsky.social @margaretlam.bsky.social 01911
Christian Lentz @christianslentz.bsky.social · 28/08/2025Check out our latest cool work by talented postdoc @ronimiah.bsky.social and team on a programmable, selection-free CRISPRi tool in S.aureus. 051
Reposted by Christian LentzEllinor Alseth @ellinoralseth.bsky.social · 08/08/2025Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you www.jobbnorge.no/en/available...jobbnorge.noResearch position in Microbial Pharmacology and Population Biology (282139) | UiT The Arctic University of NorwayJob title: Research position in Microbial Pharmacology and Population Biology (282139), Employer: UiT The Arctic University of Norway, Deadline: Wednesday, August 27, 2025 16965
Reposted by Christian LentzᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 02/07/2025Don't put all your eggs🥚 in the same basket🧺 𝙋𝙨𝙚𝙪𝙙𝙤𝙢𝙤𝙣𝙖𝙨 𝙖𝙚𝙧𝙪𝙜𝙞𝙣𝙤𝙨𝙖: epigenetic ON/OFF switching of 𝙜𝙡𝙥𝘿 gene → diverse subpopulations in the host Cells with high 𝙜𝙡𝙥𝘿 → increased toxin production and motility Low 𝙜𝙡𝙥𝘿 cells stay stealthy Balances attack and evasion www.pnas.org/doi/10.1073/... 1123
Reposted by Christian LentzJalal Uddin @jalal228.bsky.social · 17/06/2025Pleased to share our lab-optimized chapter in Methods in Molecular Biology: “Activity-Based Protein Profiling of Serine Hydrolases in Bacteria.” Thanks to @christianslentz.bsky.social . doi.org/10.1007/978-...doi.orgActivity-Based Protein Profiling of Serine Hydrolases in Bacteria: Methods and ProtocolsActivity-based protein profiling (ABPP) is a chemoproteomic technique that uses functionalized covalent enzyme inhibitors known as activity-based probes (ABPs) to detect, quantify, and identify active... 011
Reposted by Christian LentzRolf Kümmerli @rkmicrobes.bsky.social · 10/06/2025We are looking for a highly motivated postdoc to work on pathogen interactions. Please send in your application via jobs.uzh.ch/job-vacancie...jobs.uzh.chUZH: Postdoctoral researcher in microbiologyThe Department of Quantitative Biomedicine is an interdisciplinary biomedical research unit that combines basic science with biotechnological and medical research, using both experimental and computat... 02534
Reposted by Christian LentzJan-Willem Veening @veeninglab.com · 10/06/2025New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...wwwfbm.unil.chDMF: Tenure Track Assistant Professor towards Associate Professor in Molecular Microbiology - Site des postulations FBM 0110161
Reposted by Christian LentzMatt Bogyo @mbogyo.bsky.social · 30/05/2025Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work from @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. #chembio link.springer.com/article/10.1...link.springer.comIdentification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation - Nature CommunicationsStaphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. New tools are needed to both image and treat this pathogen. We previously identified a group of S. aureus serine hy... 24112
Reposted by Christian LentzLiselot Dewachter @liselotdewachter.bsky.social · 05/05/2025Job alert 🦠🧪: We are looking for a postdoc (and PhD candidate!) to join our team at UCLouvain/de Duve institute in Brussels, Belgium. You will work on our ERC Starting Grant project aimed at characterizing cell cycle regulation in S. pneumoniae. More information here: dewachterlab.com/join-us/. 0718
Reposted by Christian LentzTheresa Wagner @resawagner.bsky.social · 29/04/2025Happy to see this one out in @commsbio.nature.com www.nature.com/articles/s42... Great collaboration with @sergitp.bsky.socialnature.comExtracellular vesicles of minimalistic Mollicutes as mediators of immune modulation and horizontal gene transfer - Communications BiologyExtracellular vesicles (EVs) of minimalistic Mollicutes mirror the bacterial proteome, elicit immune responses, and mediate plasmid transfer via vesiduction, highlighting the EVs’ roles in host i... 122
Christian Lentz @christianslentz.bsky.social · 14/04/2025More great things happening at #ESCMIDGlobal: PhD candidate @nadiaaftab.bsky.social introducing the concept of differential cultivability of single S. aureus cells under specialized media conditions.. 291
Christian Lentz @christianslentz.bsky.social · 14/04/2025Having a great time at ESCMID Global and proud of postdoc @ronimiah.bsky.social presenting his work on a programmable, selection-free CRISPRi system in S. aureus. 130
Reposted by Christian LentzEllinor Alseth @ellinoralseth.bsky.social · 10/04/2025Mystique is here! When I started my position at @cmdi.bsky.social there were no readily available phage against my A. baumannii focal strain. The solution? Finding my own phage ofc. Mystique is a broad host range Acinetobacter phage, and I'm thrilled to see this work out today #PhageSky 🧪🦠journals.plos.orgMystique, a broad host range Acinetobacter phage, reveals the impact of culturing conditions on phage isolation and infectivityAuthor summary Bacterial infections caused by Acinetobacter baumannii are a major global health concern due to high antibiotic resistance, earning it a critical priority pathogen ranking by the WHO. P... 65018
Reposted by Christian LentzItai Yanai @itaiyanai.bsky.social · 07/04/2025Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob www.nature.com/articles/s41... 123177
Reposted by Christian LentzOlaya Rendueles @olayarendueles.bsky.social · 04/04/2025After a great first session on pathogenesis, the second Klebsiella Seminar Series @klebclub.bsky.social will discuss a variety of different topics. Join us for the lightning talks selected from submitted abstracts 🗓️ Thursday @9AM EDT (3pm Central European Summer Time) #microsky 022
Reposted by Christian LentzThomas Boettcher @thomasboettcher.bsky.social · 02/04/2025Work of our lab @univie.ac.at in close collaboration with the Hauck Lab @uni-konstanz.de was published in @naturemicrobiol.bsky.social today. A compound highly selective in targeting Neisseria gonorrhoeae using a novel mode of action. @cemess.bsky.social medienportal.univie.ac.at/en/media/rec...medienportal.univie.ac.atNew antibiotic for multidrug resistant superbug, that causes gonorrhoeaThis novel antibiotic activates an existing "suicide" mechanism in gonococci 13913
Reposted by Christian LentzVeronika Kuchařová Pettersen @microbioquester.bsky.social · 10/03/2025Are you interested in the milk microbiome and finding strategies to prevent infections? Apply for this PhD position with a highly competitive salary, Northern Lights included. www.jobbnorge.no/en/available...jobbnorge.noPhD Candidate in Microbiology (274648) | UiT The Arctic University of NorwayJob title: PhD Candidate in Microbiology (274648), Employer: UiT The Arctic University of Norway, Deadline: Thursday, March 20, 2025 012
Christian Lentz @christianslentz.bsky.social · 11/02/2025New article out in ACS Infectious Diseases! Using activity-based probes by H. Overkleeft, former PhD candidate @jalal228.bsky.social identified an alpha-amylase family protein of S. aureus supporting virulence during Galleria infection! @monaj66.bsky.social pubs.acs.org/doi/10.1021/...pubs.acs.orgActivity-Based Protein Profiling Identifies an α-Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant Staphylococcus aureusIn search of new putative antimicrobial drug targets in methicillin-resistant Staphylococcus aureus, we aimed to identify and characterize retaining glycosidase activities in this bacterial pathogen. ... 0155
Reposted by Christian LentzMatt Bogyo @mbogyo.bsky.social · 16/01/2025Excited to report our studies that identified a new serine protease secreted by the gut microbe Bacteroides fragilis that regulates pain and inflammation through PAR2 activation. #ChemBio. Check it out!https://www.biorxiv.org/content/10.1101/2025.01.15.633241v1biorxiv.orgIdentification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR2Protease-activated receptor 2 (PAR2) is a central regulator of intestinal barrier function, inflammation and pain. Upregulated intestinal proteolysis and PAR2-signaling are implicated in inflammatory ... 1195
Reposted by Christian LentzUniversity of Basel @unibas.ch · 16/01/2025How do bacteria sense potential threats in their environment and initiate protective measures? Researchers led by @knutdrescher.bsky.social have discovered that fragments of the bacterial cell wall serve as an alarm signal indicating danger in the environment. @biozentrum.bsky.socialunibas.chSophisticated early warning system: How bacteria respond to threatsUniversity of Basel researchers have discovered that bacteria can sense threats in advance through a general danger signal. Bacteria detect when nearby cells are dying and proactively form a protectiv... 0112
Reposted by Christian LentzRolf Kümmerli @rkmicrobes.bsky.social · 16/01/2025We derive iron-siderophore interaction networks among Pseudomonas strains from sequencing data. One key insight: natural strains form dense networks, whereas pathogens are loners. With @frimanscience.bsky.social @zhiyuanli.bsky.social & Nanjing colleagues www.science.org/doi/10.1126/...science.orgSiderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networksCoevolving siderophore genes shape bacterial iron networks, unveiling the complexity of cheating across habitats and lifestyles. 15835
Reposted by Christian LentzCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 11/12/2024Check out this bombshell publication by Michael Fischbach @mfgrp.bsky.social and coworkers @stanford-chemh.bsky.social @stanfordmedicine.bsky.social, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! 🤯 www.nature.com/articles/s41...nature.comDiscovery and engineering of the antibody response to a prominent skin commensal - NatureNature - Discovery and engineering of the antibody response to a prominent skin commensal 624272
Christian Lentz @christianslentz.bsky.social · 09/12/2024Preprint alert from the lab! Exciting new work led by @ronimiah.bsky.social Introducing a programmable, selection-free CRISPRi system in S. aureus. www.biorxiv.org/content/10.1...biorxiv.orgA programmable, selection-free CRISPR interference system in Staphylococcus aureusCommon dCas9-based CRISPR interference (CRISPRi) system for gene regulation requires antibiotic selection and exogenous inducer molecules, posing significant challenges when applied in in vivo bacteri... 071