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Christian Lentz

@christianslentz.bsky.social
425 followers 178 following 9 posts

Prof. in Infection Biology at UiT The Arctic University of Norway in Tromsø. Chemical Microbiology and Bacterial Single Cell Studies.

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Reposted by Christian Lentz
Prof Jenny Rohn @jennyrohn.bsky.social · 18/09/2026
“Bacterial growth is straightforward to measure, complex in origin and exquisitely sensitive to environmental and genetic perturbations.” Fantastic opening sentence to a deeply interesting topic. Never thought about bacterial growth like this before. #MicroSky #Bacteria
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Keri Backus @keribackus.bsky.social · 28/04/2026
Super excited that our SEE-CITE photoaffinity labeling method is now out in @natchem.nature.com rdcu.be/ffBSC. Here we introduce a custom silyl ether cleavable linker between a diazirine photocrosslinker handle and molecules of interest to streamline site-of-labeling analysis for PAL chemoproteomics
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Kim Walker @drwalkermsbanta.bsky.social · 20/04/2026
A must-read for anyone interested in #Klebsiella or metal acquisition!
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Christian Lentz @christianslentz.bsky.social · 13/04/2026
Come join us! 4 year PhD position in infection biology/microbiology available associated to our newly funded Clinical Academic Group “Patient-tailored management of bacterial infections in the age of antimicrobial resistance”. Applications via: www.jobbnorge.no/en/available.... @cansuit.bsky.social
jobbnorge.no
PhD fellow in infection biology/microbiology (297648) | UiT The Arctic University of Norway
Job title: PhD fellow in infection biology/microbiology (297648), Employer: UiT The Arctic University of Norway, Deadline: Tuesday, April 28, 2026
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Andy Edwards @bugsinblood.bsky.social · 03/12/2025
We're advertising for a bacteriology technician and a post-doc to work on AI-guided antibiotic development as part of a large multidisciplinary Fleming Initiative project: www.imperial.ac.uk/jobs/search-... www.imperial.ac.uk/jobs/search-...
imperial.ac.uk
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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Kim Lane Scheppele @kimlanelaw.bsky.social · 10/12/2025
All travelers from ESTA countries (yes the ones on visa waiver programs) will have to disclose 5 years of social media + huge amounts of personal data to enter the US now. All US academic associations should now meet outside the US if we want to meet our international colleagues.
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Biozentrum, University of Basel @biozentrum.unibas.ch · 08/12/2025
🧪 New research by @basler-lab.bsky.social reveals a surprising microbial trade-off: Pseudomonas aeruginosa activates a defense program to survive “speargun” attacks from rival bacteria, but this defense makes it more vulnerable to antibiotics. @unibas.ch @snsf.ch @nccr-antiresist.bsky.social 👇
biozentrum.unibas.ch
How bacteria resist hostile attacks
Some bacteria use a kind of molecular “speargun” to eliminate their rivals, injecting them with a lethal cocktail. Researchers led by Prof. Marek Basler at the Biozentrum have now discovered that cert...
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Reposted by Christian Lentz
AMR-kleb/staph @s-rowe-conlon.bsky.social · 01/12/2025
Thrilled to share our latest paper on antibiotic treatment failure of Klebsiella pneumoniae liver abscesses www.pnas.org/doi/full/10.... @drwalkermsbanta.bsky.social
pnas.org
Antibiotics accumulate in Klebsiella pneumoniae liver abscesses but fail to eliminate antibiotic-tolerant populations | PNAS
Liver abscesses caused by hypervirulent Klebsiella pneumoniae (hvKp) can lead to severe metastatic complications, with mortality rates ranging from...
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Reposted by Christian Lentz
Matt Hutchings @matthutchings.bsky.social · 29/11/2025
Sensor kinase interacts directly with two distinct classes of cell wall targeting antibiotics to detect cell envelope stress. Great work onlinelibrary.wiley.com/doi/abs/10.1...
onlinelibrary.wiley.com
The Histidine Kinase VraS Interacts with Vancomycin and Penicillins Through its Membrane‐Anchored N‐terminal Domain
The signals triggering activation of VraTSR, a key regulator of the cell wall stress response in Staphylococcus aureus, remain unknown. Combining crosslinking assays with vancomycin- and ampicillin-d....
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Reposted by Christian Lentz
Kimberly Kline 🏔 @kimingeneva.bsky.social · 24/11/2025
Excited to share our first look at Enterococcus faecium infection biology: diabetic wounds are complex, and E. faecium persists despite early immune responses. In diabetic mice, it shows impaired clearance + sustained neutrophil recruitment, worsening healing.
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simonheilbronner.bsky.social @simonheilbronner.bsky.social · 24/11/2025
Really happy to see the final version of this published in @isme-microbes.bsky.social. We show that production of and competition for biotin shapes S. aureus fitness in the context of nasal commensals doi.org/10.1093/isme... Work lead by the amazing Kevser Bilici!
doi.org
Competitive fitness of Staphylococcus aureus against nasal commensals depends on biotin biosynthesis and acquisition
Abstract. The human nasal microbiome can serve as a reservoir for pathogens. In particular, the opportunistic pathogen Staphylococcus aureus can be a membe
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Ákos T Kovács @evolvedbiofilm.bsky.social · 06/11/2025
#ISMEJournal paper from Simon Heilbronner Competitive fitness of Staphylococcus aureus against nasal commensals depends on biotin biosynthesis and acquisition academic.oup.com/ismej/advanc...
academic.oup.com
Competitive fitness of Staphylococcus aureus against nasal commensals depends on biotin biosynthesis and acquisition
Abstract. The human nasal microbiome can serve as a reservoir for pathogens. In particular, the opportunistic pathogen Staphylococcus aureus can be a membe
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Reposted by Christian Lentz
Kiran R. Patil @kiranrpatil.bsky.social · 17/07/2025
Another fantastic study from @lisamaierlab.bsky.social showing how non-antibiotics impact gut ecosytem. Congratulations @ghammeranne.bsky.social et al.!
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Christian Kost @kostchristian.bsky.social · 28/10/2025
#microsky #mevosky @spp2389.bsky.social A PhD position is available in my lab to work on: Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria. Please RT Deadline: 12.11.25 More infos 👇 shorturl.at/rAKAT
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Ronan McCarthy @ronanmccarthy.bsky.social · 23/10/2025
the @ukbiofilms.bsky.social I will be advertising several positions for my lab over the next few weeks/months so please do get in touch
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Julia Frunzke @frunzkelab.bsky.social · 08/10/2025
Please RT: We have an opening for a junior group leader position in „Phage Biology & Biotechnology“. www.fz-juelich.de/de/karriere/... Interested candidates are encouraged to contact me via email for further details. @spp2330.bsky.social; @mibinet.bsky.social
fz-juelich.de
Junior Group Leader - Phage Biology & Biotechnology
As a leading research institution for microbial biotechnology the Institute of Bio- and Geosciences - Biotechnology (IBG-1, https://www.fz-juelich.de/de/ibg/ibg-1 ) at the Forschungszentrum Jülich foc...
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Andy Edwards @bugsinblood.bsky.social · 29/09/2025
Now published! www.nature.com/articles/s41... Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
nature.com
Polymyxin B lethality requires energy-dependent outer membrane disruption - Nature Microbiology
The antibiotic polymyxin B requires bacterial metabolic activity to cause sufficient damage to the outer membrane to access the inner membrane, which it permeabilizes via an energy-independent mechanism to kill the cell.
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Marit Hetland @genomarit.bsky.social · 16/09/2025
Thrilled to share this preprint on Klebsiella pneumoniae plasmids in a One Health setting 🦠 Fantastic work by @twinkler.bsky.social! 🎉 @irenlohr.bsky.social @margaretlam.bsky.social
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Christian Lentz @christianslentz.bsky.social · 28/08/2025
Check out our latest cool work by talented postdoc @ronimiah.bsky.social and team on a programmable, selection-free CRISPRi tool in S.aureus.
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Ellinor Alseth @ellinoralseth.bsky.social · 08/08/2025
Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you www.jobbnorge.no/en/available...
jobbnorge.no
Research position in Microbial Pharmacology and Population Biology (282139) | UiT The Arctic University of Norway
Job title: Research position in Microbial Pharmacology and Population Biology (282139), Employer: UiT The Arctic University of Norway, Deadline: Wednesday, August 27, 2025
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 02/07/2025
Don't put all your eggs🥚 in the same basket🧺 𝙋𝙨𝙚𝙪𝙙𝙤𝙢𝙤𝙣𝙖𝙨 𝙖𝙚𝙧𝙪𝙜𝙞𝙣𝙤𝙨𝙖: epigenetic ON/OFF switching of 𝙜𝙡𝙥𝘿 gene → diverse subpopulations in the host Cells with high 𝙜𝙡𝙥𝘿 → increased toxin production and motility Low 𝙜𝙡𝙥𝘿 cells stay stealthy Balances attack and evasion www.pnas.org/doi/10.1073/...
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Jalal Uddin @jalal228.bsky.social · 17/06/2025
Pleased to share our lab-optimized chapter in Methods in Molecular Biology: “Activity-Based Protein Profiling of Serine Hydrolases in Bacteria.” Thanks to @christianslentz.bsky.social . doi.org/10.1007/978-...
doi.org
Activity-Based Protein Profiling of Serine Hydrolases in Bacteria: Methods and Protocols
Activity-based protein profiling (ABPP) is a chemoproteomic technique that uses functionalized covalent enzyme inhibitors known as activity-based probes (ABPs) to detect, quantify, and identify active...
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Reposted by Christian Lentz
Rolf Kümmerli @rkmicrobes.bsky.social · 10/06/2025
We are looking for a highly motivated postdoc to work on pathogen interactions. Please send in your application via jobs.uzh.ch/job-vacancie...
jobs.uzh.ch
UZH: Postdoctoral researcher in microbiology
The Department of Quantitative Biomedicine is an interdisciplinary biomedical research unit that combines basic science with biotechnological and medical research, using both experimental and computat...
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Jan-Willem Veening @veeninglab.com · 10/06/2025
New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
wwwfbm.unil.ch
DMF: Tenure Track Assistant Professor towards Associate Professor in Molecular Microbiology - Site des postulations FBM
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Matt Bogyo @mbogyo.bsky.social · 30/05/2025
Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work from @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. #chembio link.springer.com/article/10.1...
link.springer.com
Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation - Nature Communications
Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. New tools are needed to both image and treat this pathogen. We previously identified a group of S. aureus serine hy...
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Liselot Dewachter @liselotdewachter.bsky.social · 05/05/2025
Job alert 🦠🧪: We are looking for a postdoc (and PhD candidate!) to join our team at UCLouvain/de Duve institute in Brussels, Belgium. You will work on our ERC Starting Grant project aimed at characterizing cell cycle regulation in S. pneumoniae. More information here: dewachterlab.com/join-us/.
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Theresa Wagner @resawagner.bsky.social · 29/04/2025
Happy to see this one out in @commsbio.nature.com www.nature.com/articles/s42... Great collaboration with @sergitp.bsky.social
nature.com
Extracellular vesicles of minimalistic Mollicutes as mediators of immune modulation and horizontal gene transfer - Communications Biology
Extracellular vesicles (EVs) of minimalistic Mollicutes mirror the bacterial proteome, elicit immune responses, and mediate plasmid transfer via vesiduction, highlighting the EVs’ roles in host i...
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Christian Lentz @christianslentz.bsky.social · 14/04/2025
More great things happening at #ESCMIDGlobal: PhD candidate @nadiaaftab.bsky.social introducing the concept of differential cultivability of single S. aureus cells under specialized media conditions..
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Christian Lentz @christianslentz.bsky.social · 14/04/2025
Having a great time at ESCMID Global and proud of postdoc @ronimiah.bsky.social presenting his work on a programmable, selection-free CRISPRi system in S. aureus.
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Ellinor Alseth @ellinoralseth.bsky.social · 10/04/2025
Mystique is here! When I started my position at @cmdi.bsky.social there were no readily available phage against my A. baumannii focal strain. The solution? Finding my own phage ofc. Mystique is a broad host range Acinetobacter phage, and I'm thrilled to see this work out today #PhageSky 🧪🦠
journals.plos.org
Mystique, a broad host range Acinetobacter phage, reveals the impact of culturing conditions on phage isolation and infectivity
Author summary Bacterial infections caused by Acinetobacter baumannii are a major global health concern due to high antibiotic resistance, earning it a critical priority pathogen ranking by the WHO. P...
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Itai Yanai @itaiyanai.bsky.social · 07/04/2025
Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob www.nature.com/articles/s41...
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Olaya Rendueles @olayarendueles.bsky.social · 04/04/2025
After a great first session on pathogenesis, the second Klebsiella Seminar Series @klebclub.bsky.social will discuss a variety of different topics. Join us for the lightning talks selected from submitted abstracts 🗓️ Thursday @9AM EDT (3pm Central European Summer Time) #microsky
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Thomas Boettcher @thomasboettcher.bsky.social · 02/04/2025
Work of our lab @univie.ac.at in close collaboration with the Hauck Lab @uni-konstanz.de was published in @naturemicrobiol.bsky.social today. A compound highly selective in targeting Neisseria gonorrhoeae using a novel mode of action. @cemess.bsky.social medienportal.univie.ac.at/en/media/rec...
medienportal.univie.ac.at
New antibiotic for multidrug resistant superbug, that causes gonorrhoea
This novel antibiotic activates an existing "suicide" mechanism in gonococci
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Veronika Kuchařová Pettersen @microbioquester.bsky.social · 10/03/2025
Are you interested in the milk microbiome and finding strategies to prevent infections? Apply for this PhD position with a highly competitive salary, Northern Lights included. www.jobbnorge.no/en/available...
jobbnorge.no
PhD Candidate in Microbiology (274648) | UiT The Arctic University of Norway
Job title: PhD Candidate in Microbiology (274648), Employer: UiT The Arctic University of Norway, Deadline: Thursday, March 20, 2025
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Christian Lentz @christianslentz.bsky.social · 11/02/2025
New article out in ACS Infectious Diseases! Using activity-based probes by H. Overkleeft, former PhD candidate @jalal228.bsky.social identified an alpha-amylase family protein of S. aureus supporting virulence during Galleria infection! @monaj66.bsky.social pubs.acs.org/doi/10.1021/...
pubs.acs.org
Activity-Based Protein Profiling Identifies an α-Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant Staphylococcus aureus
In search of new putative antimicrobial drug targets in methicillin-resistant Staphylococcus aureus, we aimed to identify and characterize retaining glycosidase activities in this bacterial pathogen. ...
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Matt Bogyo @mbogyo.bsky.social · 16/01/2025
Excited to report our studies that identified a new serine protease secreted by the gut microbe Bacteroides fragilis that regulates pain and inflammation through PAR2 activation. #ChemBio. Check it out!https://www.biorxiv.org/content/10.1101/2025.01.15.633241v1
biorxiv.org
Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR2
Protease-activated receptor 2 (PAR2) is a central regulator of intestinal barrier function, inflammation and pain. Upregulated intestinal proteolysis and PAR2-signaling are implicated in inflammatory ...
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University of Basel @unibas.ch · 16/01/2025
How do bacteria sense potential threats in their environment and initiate protective measures? Researchers led by @knutdrescher.bsky.social have discovered that fragments of the bacterial cell wall serve as an alarm signal indicating danger in the environment. @biozentrum.bsky.social
unibas.ch
Sophisticated early warning system: How bacteria respond to threats
University of Basel researchers have discovered that bacteria can sense threats in advance through a general danger signal. Bacteria detect when nearby cells are dying and proactively form a protectiv...
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Rolf Kümmerli @rkmicrobes.bsky.social · 16/01/2025
We derive iron-siderophore interaction networks among Pseudomonas strains from sequencing data. One key insight: natural strains form dense networks, whereas pathogens are loners. With @frimanscience.bsky.social @zhiyuanli.bsky.social & Nanjing colleagues www.science.org/doi/10.1126/...
science.org
Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks
Coevolving siderophore genes shape bacterial iron networks, unveiling the complexity of cheating across habitats and lifestyles.
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 11/12/2024
Check out this bombshell publication by Michael Fischbach @mfgrp.bsky.social and coworkers @stanford-chemh.bsky.social @stanfordmedicine.bsky.social, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! 🤯 www.nature.com/articles/s41...
nature.com
Discovery and engineering of the antibody response to a prominent skin commensal - Nature
Nature - Discovery and engineering of the antibody response to a prominent skin commensal
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Christian Lentz @christianslentz.bsky.social · 09/12/2024
Preprint alert from the lab! Exciting new work led by @ronimiah.bsky.social Introducing a programmable, selection-free CRISPRi system in S. aureus. www.biorxiv.org/content/10.1...
biorxiv.org
A programmable, selection-free CRISPR interference system in Staphylococcus aureus
Common dCas9-based CRISPR interference (CRISPRi) system for gene regulation requires antibiotic selection and exogenous inducer molecules, posing significant challenges when applied in in vivo bacteri...
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