The FDA won’t tell Americans where their generic drugs are made, so ProPublica did it instead. Use information on your prescription label to locate the factory and see inspection reports.

A group of Democratic state lawmakers from Montana are traveling to Minnesota this week, as part of a multi-state effort to push back on what they consider the Trump administration’s “overreach.”

Cell behaviours in multicellular organisms are coordinated via both diffusible molecules and by signals based on direct cell-cell contacts. The mode of cell communication used influences the signalling range. In many developing epithelia, contact-based Notch-Delta lateral inhibition signalling is used to pattern cell fates. While previous work revealed that cells can use protrusions to extend the range of Notch-Delta signalling to alter these patterns, this is not a general feature of epithelia. In addition, it is not known how the complex three-dimensional (3D) shapes of epithelial cells influence cell communication. In exploring this question, we show that epithelial cells at the Drosophila wing margin, which lack basal protrusions, contact different neighbours at different heights along their apico-basal axis, effectively increasing the number of neighbours each cell touches. To quantitatively assess this behaviour, we develop a novel mathematical modelling framework (Multi-layer Signalling Model) to simulate Notch-Delta signalling over data-derived 3D cell topologies. The model predicts that lateral cell surface signalling is essential to tune the spacing between SOPs. In agreement, we show that perturbing cortical stiffness and cell tortuosity in vivo modifies SOP spacing. These results emphasise the importance of 3D cell geometry and topology in fine-tuning signalling range. ### Competing Interest Statement The authors have declared no competing interest. European Molecular Biology Organization, https://ror.org/04wfr2810, ALTF 786-2020 Leverhulme Trust, https://ror.org/012mzw131, RPG-2022-028 Medical Research Council, https://ror.org/03x94j517, MR/W027437/1, MC\_UP\_1201/27

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Parents will still be able to get the hepatitis B vaccine for their children at no cost even though the US Centers for Disease and Control Prevention’s vaccine advisers recommended a major change to t...

The World Laureates Association (WLA) announced its laureates for 2025 in Shanghai on Wednesday, recognizing groundbreaking contributions in the fields of life and mathematical sciences.

RAD52, the primary single-strand annealing (SSA) protein in humans, forms undecameric rings that bind ssDNA within a narrow, positively-charged groove. Whether RAD52 anneals two complementary ssDNAs on the same ring in cis, or between two ring- ssDNA complexes in trans, is unknown. Here, we determined cryo-EM structures of Mgm101, a RAD52 homolog from yeast mitochondria, in complexes with ssDNA, a duplex intermediate of annealing, and B-form dsDNA product. In all states, Mgm101 forms a closed nonadecameric ring that binds the backbone of the first ssDNA at the base of the narrow groove. The second complementary strand binds directly on top of the first to form an extended, unwound, and circular duplex intermediate of annealing. A third complex captures apparent B-form DNA product bound to a novel beta-hairpin motif located on top of the Mgm101 ring, above the primary DNA-binding groove. Mass photometry and native mass spectrometry confirm and further elucidate the complexes formed in solution. Altogether, our data reveal the full SSA pathway of Mgm101 and suggest it anneals two complementary ssDNAs on the same ring in cis. Structural conservation with RAD52 suggests it is likely to use a similar cis mechanism of annealing.

This Medical News article is an interview with the lead author of a new European Society of Cardiology clinical consensus statement on cardiovascular disease prevention and management in COVID-19.

Images of the demolition of parts of the East Wing went viral on Monday, and Treasury’s headquarters next door to the White House has a front-row seat.

Illinois Governor J.B. Pritzker has suggested that state prosecutors might examine the conduct of ICE agents.

CR tests of 23 popular protein powders and shakes found that most contain high levels of lead.