Zhang et al. show that NFIs act as evolutionarily conserved global temporal regulators and bidirectionally control the pace of RGP lineage progression and consequently progeny output during neocortical development, providing direct insights into NFI mutation-associated human brain malformations.

Using a combination of microglia-specific conditional mouse knockout and knockin approaches and xenotransplantation of human iPSC-derived microglia, Diaz-Salazar et al. demonstrate that the human-spec...

Associational memory is critically dependent on the CA3 recurrent circuit, at the centre of the hippocampal system. While diversity amongst CA3 pyramidal neurons (PNs) has been long reported, the prin...

Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.

Viral vectors delivered through the brain glymphatics achieve widespread targeting of glial cells.

The Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more...

How human-specific DNA changes shape brain development is poorly understood. Mosti et al. discover a human enhancer, HAR1984, which drives ETV5 and TRA2B expression via human-enriched chromatin intera...

Cell Symposia: Decoding Cellular Complexity: Single Cell Biology in the Era of AI

Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hipp...

The SNARE VAMP7 is essential for an unconventional secretory pathway based on late endosomal secretion. Here the authors show that this secretion functions as an organelle quality-control and stress-c...

第59回日本発生生物学会大会の電子抄録サイトです。

Interactive map of 3.4 million Bluesky users, visualised by their follower pattern.

A fundamental role for division orientation in progenitor output driving cortical and retinal growth is revealed.

Risk associated with genetically defined forms of autism spectrum disorder (ASD) can propagate by means of transcriptional regulation to affect convergently dysregulated pathways, providing insight in...

Gene regulatory changes are considered major drivers of evolutionary innovations, including the cerebellum’s expansion during human evolution, yet they remain largely unexplored. In this study, we com...

Systematic screening of transcription factors reveals conserved mechanisms governing cortical radial glia lineage progression across primates and provides a framework for functional dissecti...

Nature Communications - During development of eutherian females, one of the X-chromosomes is silenced. Here, authors show that alleles on the inactive X-chromosome are dynamically expressed along...