imageimageHuman progenitors are programmed into ependymal cells in brain organoids via GEMC1 and MCIDAS expression. This strategy recapitulates hallmarks of the adult human V-SVZ niche, providing a pl...

Großer Erfolg für die FAU: Die Deutsche Forschungsgemeinschaft (DFG) hat Prof. Dr. Ruth Beckervordersandforth, Professur für Molekulare Neuropathologie an der Friedrich-Alexander-Universität Erlangen…

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

Comparative anatomical studies of primates and extinct hominins, including Neanderthals, show that the modern human brain is characterised by a disproportionately enlarged neocortex relative to the st...

The viscoelastic properties of tissues influence their morphology and cellular behavior, yet little is known about changes in these properties during brain malformations. Lissencephaly, a severe corti...

Brain-wide birthdate mapping reveals that while hindbrain neurogenesis is transient, forebrain neurogenesis is temporally sustained through spatiotemporal regulation of progenitor mitochondrial functi...

Wu and Nowakowski review the progression of in vitro human brain models, highlighting the applications of assembloids in studying development and disease. They further discuss the current challenges a...

The field of brain organoids has experienced a period of rapid and transformative growth, enabling researchers to investigate complex human biological…

The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease progression. Tumors gro...

The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

Neural development and brain circuit evolution converged in birds and mammals

Periventricular heterotopia (PH) is associated with neurodevelopmental delay. Here authors report patient-derived organoids with FAT4 and DCHS1 mutations mimic PH features, showing hyperactivity, syna...

Chronic exposure to glucocorticoids during brain development leads to priming of the inhibitory neuron lineages in organoids.

Author summary DDX3X mutations are associated with neurodevelopmental disorders, including DDX3X syndrome and autism spectrum disorder. DDX3X is an RNA binding protein whose loss of function impairs b...

The 2025 Gordon Research Conference on Functional Genomics of Human Brain Development and Disease will be held in Ventura, California. Apply today to reserve your spot.

Nature Reviews Molecular Cell Biology - This Roadmap article discusses recent advances in the production and use of brain organoids to understand brain development and associated disorders. The...

Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

An arrayed morphogen screen in human neural organoids over 70 days reveals the design principles of brain regional specification. Deconvolution of multiplexed single-cell RNA sequencing identified critical timing windows and combinatorics that yield rare neural subtypes. Limitations in the neural maturation of Purkinje neuron morphology were overcome by organoid transplantation.

Abstract. In the central nervous system, cell-to-cell interaction is essential for brain plasticity and repair, and its alteration is critically involved i

A single molecular signal enhances the complexity of human brain organoids, inducing the emergence of multiple distinct brain regions.

Nature Protocols - Generation and long-term culture of a human pluripotent stem cell-derived human cerebellar organoid model, which successfully replicates the cellular diversity of the fetal...

A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid counterparts, sho...