The graphical abstract illustrates a model in which TDP-43 C-terminal fragments undergo Ste24-suppressed, Sec61/Sec66-dependent noncanonical ER entry in budding yeast. ER entry is facilitated by resi...

Tauopathies are neurodegenerative diseases characterized by misfolded tau accumulation and lysosomal dysfunction. Pathogenic mutant Tau stalls lysosomes in iPSC-derived neurons upstream of Tau accumu...

Clathrin plaques (magenta) form large, flat membrane-associated lattices embedded within the cortical actin cytoskeleton, and can be distinguished from individual clathrin-coated pits (yellow). These....

Distinct clathrin-independent endocytic (CIE) routes support specialized cellular functions across different contexts. Created with Biorender.com.

Overview of ferroptosis in osteoporosis (OP): physiological mechanisms (lysosomal Fe2+ release, mitochondrial ROS, and NINJ1 activation), aging-related systemic amplification and early prevention, bo....

Syntaxin12 maintains endolysosomal trafficking and lysosomal homeostasis in glioblastoma cells. Syntaxin12 depletion disrupts lysosomal organization, impairs endolysosomal progression and mTOR-lysoso...

Nup85 is a protein that plays a critical role in nucleocytoplasmic transport, facilitating the movement of macromolecules, including proteins and RNA, between the nucleus and the cytoplasm. Additiona...

Just as Antelope Canyon transforms familiar rock into an unexpected hidden landscape, the topological inversion of Src reveals an unforeseen extracellular facet of kinase signaling in cancer. Antelop...

Variable-angle total internal reflection fluorescence structured illumination microscopy (vaTIRF-SIM) links nanoscale lateral organization with axial progression during clathrin-mediated endocytosis....

Loss of the cargo receptor Erv14 in Saccharomyces cerevisiae results in sensitivity to calcium, zinc, neutral extracellular pH, and elevated temperature. Furthermore, cells deleted in the ERV14 exhib...

Fluorescent proteins fused with nuclear (NLS) or nucleolar (NoLS) localization signals are commonly used for live assessment of protein accumulation in the nucleus and nucleolus. We present a standar...

Oxytocin (OT) plays an important role in regulating social behavior, and dysregulation of the oxytocinergic system leads to social impairments, such as autism spectrum disorder. Central OT release is...

KIF5B and dynein regulate Golgi organization and localization- Role in regulating MT acetylation: In control (CNT) cells, active Arf1 facilitates the recruitment of KIF5B and dynein to the Golgi, mai....

Upon VEGF binding, VEGFR2 is autophosphorylated and recruits downstream signaling molecules, leading to protein kinase D (PKD)1 phosphorylation. We found that PKD1 phosphorylates KIF13B, a kinesin-3 ...

The SNARE VAMP7 is essential for an unconventional secretory pathway based on late endosomal secretion. Here the authors show that this secretion functions as an organelle quality-control and stress-c...

While proteins bearing N-terminal signal or leader sequences are secreted via the ER-Golgi-plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequen...

Mechanisms of sEV uptake:① Membrane fusion.② Endocytosis.③ Receptor-ligand interaction.

Copper homeostasis is maintained in the cell by epigenetic regulation, and various metabolic processes. Regulated copper homeostasis balances normal protein trafficking, amino acid metabolism, etc., ...

Chagas disease, caused by Trypanosoma cruzi, remains a major treatment challenge due to variations in host immunity and parasite strains. We found that small extracellular vesicles (EVs) from infecte...

This review mainly discusses the role of ferroptosis in cervical cancer from four aspects: underlying mechanisms, stage-specific sensitivity, ferroptosis-related targets and biomarkers, and clinical ...

Traffic is a cell biology and biochemistry journal devoted to intracellular transport, covering subcellular trafficking, membrane dynamics, organelle function & more.

Dans le cadre d’un essai clinique analogue à ceux qui sont utilisés pour tester les médicaments, des scientifiques ont étudié les impacts sur la santé d’une alimentation riche en aliments ultratransfo...

In this study, we characterize tubular recycling endosomes and demonstrate that they are dynamic and undergo biogenesis upon CD98 internalization and fission over time. We identify CD2AP and CIN85 as...