Tengo 34 años: me quedan muchos para lograr algo en ciencia, pero nunca se sabe. Soy de las islas Orcadas: piérdase allí en mayo. Tengo pareja barcelonesa. Espero hallar en cerebros vivos humanos lo q...

The authors present a dense connectomic reconstruction of a 0.1 mm3 hippocampal CA3 volume and reveal spatial gradients, high convergence and cell-type-selective feedforward inhibition of inputs to py...

Stories of chance encounters at home and abroad and the influence of his programmes around the world

In the hippocampus, complex processing of sensory stimuli occurs even in the unconscious state.

Using multicellular patch-clamp recording, the authors show that the hippocampal CA3 autoassociative network undergoes pruning of CA3–CA3 synapses and downregulation of synaptic efficacy during postna...

New research across Scotland's Northwoods Rewilding Network has revealed striking biodiversity gains on rewilded land, with bird diversity increasing by more than 260% and pollinating insects rising m...

AMPA receptors (AMPARs) are multimodal transducers of glutamatergic signals throughout the brain. Their diversity is exemplified in the cerebellum; at afferent synapses, AMPARs mediate high-frequency ...

Abstract figure legend Summary of the study where simulated recordings (left) were used to characterise the effect of incomplete detection on mini (mPSC) analysis. Recording noise levels (red) determ...

Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute’s Janelia Research Campus is a pio...

The hippocampus, critical for learning and memory, is dogmatically described as a trisynaptic circuit where dentate gyrus granule cells (GCs), CA3 pyr…

A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...

The mossy fiber (MF) connections to pyramidal cells in hippocampal CA3 are hypothesized to participate in pattern separation and memory encoding, yet no large–scale neuronal wiring diagram exists for ...

Abstract. Molecular cloning through in vivo assembly (IVA) is an efficient homology-based approach that can achieve complex cloning operations in a single

A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...

The prefrontal - hippocampal - entorhinal system is perhaps the most widely-studied circuit in cognitive and systems neuroscience, due to its role in supporting cognitive functions such as working mem...

Whether and how slow wave activity (SWA) and the underlying membrane potential UP and DOWN states initiate mechanisms that augment memory functions in humans are not fully understood. Here authors use...

Human hippocampal CA3 networks use sparse and broad synaptic connectivity, and their recurrent synapses employ reliability, precision, and long integration times to enhance memory capacity. Thus, the human hippocampus is distinct from both rodent counterparts and human neocortical circuits.

Hippocampal area CA2 is unique in many ways, largely based on the complement of genes expressed there. We and others have observed that CA2 neurons exhibit a uniquely robust tropism for adeno-associat...