A survey finds that academic supervisors can have a huge impact on their students’ mental health.

Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.

High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fr...

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

CRISPRai simultaneously activates and represses two genes in single cells.

Barcoding microbial ribosomal RNA creates a recording of gene transfer events without requiring translation.

Key Points. CH Analysis of a unique and uniform cohort of exclusively healthy individuals exposed to a novel type of selection pressureIdentification of no

Perturb-FISH reveals impacts of perturbations on gene expression and phenotype with single-cell, spatial resolution, allowing study of effects within and between cells.

Plasmid pLARRYv2-EGFP from Dr. Alejo Rodriguez-Fraticelli's lab is published in Cell Stem Cell. 2025 Apr. doi: 10.1016/j.stem.2025.01.012 This plasmid is available through Addgene.

Singh, Fernandez-Perez, et al. use hematopoietic stem cell barcoding to study clones with and without activation of cancer driver mutations, identifying that pre-existing stem cell states can dictate ...

Epidemiological studies have linked dirty air to dementia and other brain disorders. Now researchers are trying to determine how pollutants do their damage, and how much harm they cause.

This work presents a computational tool MethylTree to infer cell lineages based on epimutations on DNA methylation.

Cell types are traditionally thought to be specified and stabilized by gene regulatory networks. Here, we explore how chromatin memory contributes to the specification and stabilization of cell states...

Synthetic organizer cells, engineered to spatially self-assemble around stem cells, can be used to create specific morphogen gradients and systematically guide in vitro development.

Clonal hematopoiesis becomes increasingly common with age. Here the authors track stem cell dynamics in monozygotic twins and provide evidence that clonal hematopoiesis in later life reflects weak sel...

Szalay et al. discuss cross-kingdom similarities and differences in 3D chromatin folding in relation to gene regulation, including in bacteria, archaea, mammals and plants. This comparison reveals cer...

Kukreja et al. show that blocking cell division in zebrafish does not affect differentiation of major cell types during gastrulation and segmentation, but it does decelerate differentiation of particu...

A multiomic atlas of human embryonic joint and cranium development enables detailed analysis of bone and cartilage maturation.

DNA methylation is a critical epigenetic modification that regulates gene expression and plays a significant role in development and disease processes. Here, we present the Cytosine-phosphate-Guanine ...

Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …

Developmental Dynamics of Tissue Formation

The authors carried out massively parallel mRNA decay measurements on over 50,000 mRNAs, revealing the interactions controlling mRNA stability in bacteria. Biophysical modeling and machine learning we...