Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultras...

The acoel worm Hofstenia miamia (H. miamia) has recently emerged as a model organism for studying wh

ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...

Embryogenesis is commonly viewed through a tree model of cell differentiation, which does not adequately represent the spatiotemporal modulation of cell multipotency underlying morphogenesis. Here we ...

Kukreja et al. show that blocking cell division in zebrafish does not affect differentiation of major cell types during gastrulation and segmentation, but it does decelerate differentiation of particu...

Despite the functional importance of the vertebral skeleton, little is known about how individual vertebrae elongate or achieve disproportionate lengths as in the giraffe neck. Rodent tails are an abu...

A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor bind...

Summary: Extreme traits in animals, from the origin of limbs to the loss of tails, capture public attention. This Review argues that scientists should not seek simple explanations for how they evolved...

Housset et al. show that basal bodies of cone photoreceptors in the mouse retina are planar polarized in a light-dependent manner by the action of transducin and G-protein-signaling modulator protein ...

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Embryogenesis is commonly viewed through a tree model of cell differentiation, which does not adequa

Nature Communications - The pluripotency program is maintained by transcription factors from the Sox and POU families. Here they identify SOX and POU factors from unicellular relatives of animals...