A survey finds that academic supervisors can have a huge impact on their students’ mental health.

Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.

High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fr...

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

CRISPRai simultaneously activates and represses two genes in single cells.

Barcoding microbial ribosomal RNA creates a recording of gene transfer events without requiring translation.

Key Points. CH Analysis of a unique and uniform cohort of exclusively healthy individuals exposed to a novel type of selection pressureIdentification of no

Perturb-FISH reveals impacts of perturbations on gene expression and phenotype with single-cell, spatial resolution, allowing study of effects within and between cells.

Plasmid pLARRYv2-EGFP from Dr. Alejo Rodriguez-Fraticelli's lab is published in Cell Stem Cell. 2025 Apr. doi: 10.1016/j.stem.2025.01.012 This plasmid is available through Addgene.

Plasmid pLARRYv2-EGFP from Dr. Alejo Rodriguez-Fraticelli's lab is published in Cell Stem Cell. 2025 Apr. doi: 10.1016/j.stem.2025.01.012 This plasmid is available through Addgene.

Single-cell transcriptomic analysis of bone marrow myeloid progenitor populations reveals early transcriptional priming toward seven different fates and absence of progenitors of mixed lineages, chall...

Intestinal tumours can originate from Lgr5+ intestinal stem cells after genetic activation of the Wnt signalling pathway.

Singh, Fernandez-Perez, et al. use hematopoietic stem cell barcoding to study clones with and without activation of cancer driver mutations, identifying that pre-existing stem cell states can dictate ...

Epidemiological studies have linked dirty air to dementia and other brain disorders. Now researchers are trying to determine how pollutants do their damage, and how much harm they cause.

This work presents a computational tool MethylTree to infer cell lineages based on epimutations on DNA methylation.

Cell types are traditionally thought to be specified and stabilized by gene regulatory networks. Here, we explore how chromatin memory contributes to the specification and stabilization of cell states...

Synthetic organizer cells, engineered to spatially self-assemble around stem cells, can be used to create specific morphogen gradients and systematically guide in vitro development.