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Hans-Rudolf Hotz

@hrhotz.bsky.social
291 followers 157 following 118 posts

Molecular Biologist turned Bioinformatician working in the Computational Biology facility at the Friedrich Miescher Institute in Basel Open Science, Training/Mentoring, #UseGalaxy, Bioconductor

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Hans-Rudolf Hotz @hrhotz.bsky.social · 02/10/2026
(finally) on my way to Freiburg to catch up with the latest development on @galaxyproject.bsky.social @galaxytraining.bsky.social
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Daniela Schneider @schnda.fedihum.org.ap.brid.gy · 01/10/2026
Today was the kickoff of our new #EU project on #AI Readiness for Social Impact #ai4social We from @galaxyfreiburg are excited to be part of this #EOSC project with more than 10 partners. During the next years we will mostly contribute to developing an AI-ready infrastructure platform and […]
fedihum.org
Original post on fedihum.org
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Bioconductor @bioconductor.bsky.social · 02/10/2026
#BioC2026 brought the Bioconductor community together in Seattle for three days of science, software and community building. From inspiring talks & posters to workshops, package demos, and the hackathon, it was a great celebration of 25 years of Bioconductor. Read the full recap: bit.ly/4e9Kopr
blog.bioconductor.org
BioC2026 conference recap – Bioconductor community blog
Highlights from the 2026 North American Bioconductor Conference in Seattle, Washington
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Galaxy Project @galaxyproject.bsky.social · 30/09/2026
🧬 New on the GTN: explore how protein structure can influence ligand-binding site predictions using SIMORGH, ColabFold, and structural ensembles. See how deep learning and Galaxy can help account for protein dynamics in binding-site analysis. training.galaxyproject.org/training-mat...
training.galaxyproject.org
Statistics and Machine Learning / Comparing ligand-binding site predictions across different protein structure modalities using SIMORGH / Hands-on: Comparing ligand-binding site predictions across dif...
Statistical Analyses for omics data and machine learning using Galaxy tools
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Hans-Rudolf Hotz @hrhotz.bsky.social · 30/09/2026
unfortunately, no mention of @galaxyproject.bsky.social 😞
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ELIXIR Europe @elixir-europe.org · 30/09/2026
🔬The second #ELIXIR_STEERS policy brief, Better software, better research, sets out 5️⃣ recommendations to strengthen Europe’s research software ecosystem. Read the news release and discover the recommendations: loom.ly/hCUxzds #FP10
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Galaxy Project @galaxyproject.bsky.social · 25/09/2026
🔬 Lab data 🤝 Galaxy analysis A new openBIS integration lets you browse and import lab files directly into Galaxy, run your analyses, and send results back to openBIS. Fewer manual file transfers, smoother workflows. galaxyproject.org/news/2026-09... #usegalaxy #OpenScience
galaxyproject.org
Connecting openBIS and Galaxy: from lab data to analysis and back
Browse openBIS files in Galaxy, analyse them, and return results to your lab notebook
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Galaxy Project @galaxyproject.bsky.social · 23/09/2026
🦠🛠️ Join the **microGalaxy Tool Development Hackathon** on October 14! Help update highly used metagenomics tools in Galaxy’s IUC repository and contribute alongside the microGalaxy community. 🌐 Online + free to participate 🔗 galaxyproject.org/news/2026-09... #usegalaxy #microGalaxy #Metagenomics
galaxyproject.org
microGalaxy Hackathon for Tool Development
Join the microGalaxy community on October 14th to update outdated metagenomics tools in the IUC repository!
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#SingleCell preprints @prepub-singlecell.bsky.social · 21/09/2026
Gravlax: an annotation-independent molecular evidence archive for single-cell RNA-seq #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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Rob Patro @robp.bsky.social · 21/09/2026
It's here! new preprint: Gravlax, an annotation-independent molecular evidence archive for scRNA-seq. A count matrix freezes one annotation. Molecules never change. Instead, gravlax keeps the evidence. Requantify, query, and discover under any annotation. 🧵 www.biorxiv.org/content/10.6...
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Joel Lüthi @joelluethi.bsky.social · 21/09/2026
I'm happy to announce the fall 2026 Open Bioimaging Practices Meetup schedule. We'll have 3 exciting meetings about developments in the OME-Zarr space: - OME-Zarr viewers - Multiplexed Image analysis in OME-Zarr - Spatial OMICs in OME-Zarr See www.biovisioncenter.uzh.ch/en/events/Op... (🧵 1/10)
biovisioncenter.uzh.ch
Open Bioimaging Practices Meetups
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Bioinformatics Advances @bioinfoadv.bsky.social · 18/09/2026
We lost a giant of our field this March and we are happy to be able to share this tribute: "Phil Bourne (1953–2026): From small molecules to big data—the journey of a multifaceted visionary".  Read the tribute here: doi.org/10.1093/bioadv/vbag239
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Galaxy Project @galaxyproject.bsky.social · 17/09/2026
The Image Analysis in Galaxy community is happy to share the first publication on bioimage data analysis, management and community practices in Galaxy galaxyproject.org/news/2026-09-16-b… #UseGalaxy #GalaxyProject #EOSC
Galaxy single-cell and spatial omics graphical abstract
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BF Francis Ouellette @bffo.bsky.social · 17/09/2026
From Thomas Sharpton (at @oregonstate.edu ) in @plos.org #Computational #Biology | A practical risk framework for large language model use in life science research | #Bioinformatics #Education #LLM #PromptDesign #Framework #Research #LifeSciences | 🧬 🖥️ 🧪 🔓 ⬇️ journals.plos.org/ploscompbiol...
journals.plos.org
A practical risk framework for large language model use in life science research
Responsible use of large language models (LLMs) in life science research demands a unified approach to risk, yet existing guidance treats prompting and verification as separate topics rather than as i...
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Galaxy Project @galaxyproject.bsky.social · 17/09/2026
📣 Introduction to the Data Analysis Platform Galaxy (in German) 📍 Freiburg, Germany 📅 2 December 2026 🔗 More info & registration: galaxyproject.org/events/2026-12-02… #UseGalaxy #GalaxyProject #EOSC #EuroScienceGateway
galaxyproject.org
Introduction to the Data Analysis Platform Galaxy (in German)
Galaxy Community Hub
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Paul Gardner @ppgardne.bsky.social · 18/09/2026
How not to build a lncRNA annotation tool: 1. assume the genome & transcriptome consists of only lncRNAs and mRNAs:
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Paul Gardner @ppgardne.bsky.social · 18/09/2026
You can read more about why these approaches universally perform terribly here: rnajournal.cshlp.org/content/31/9...
rnajournal.cshlp.org
Evaluating computational tools for protein-coding sequence detection: Are they up to the task?
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
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Hans-Rudolf Hotz @hrhotz.bsky.social · 17/09/2026
by @bebatut.bsky.social on @galaxyproject.bsky.social
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BF Francis Ouellette @bffo.bsky.social · 17/09/2026
From the @bioinfoadv.bsky.social journal | Phil Bourne (1953–2026): from small molecules to big data—the journey of a multifaceted visionary | #Bioinformatics #Pioneer @rcsbpdb.bsky.social @iscb.bsky.social #PLOSCBTSR #OpenScience #OpenAccess #DataScience |🧬🖥️🧪🔓❤️ ⬇️ academic.oup.com/bioinformati...
academic.oup.com
Phil Bourne (1953–2026): from small molecules to big data—the journey of a multifaceted visionary
Abstract. Born in London in 1953 and raised in Australia, Phil Bourne spent over four decades in science moving across scales: from crystal structures to t
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Scott C Edmunds @scedmunds.bsky.social · 16/09/2026
Just realised its #PeerReviewWeek, so I thought I'd re-share my piece from last year on why we need a FAIR Principles for Peer Review doi.org/10.59350/dpr...
FAIR principles of peer review infographic
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BF Francis Ouellette @bffo.bsky.social · 16/09/2026
From @plos.org #Computational #Biology | Ten quick tips for spatial transcriptomics analysis | #Bioinformatics #Education #PLOSCBQT #Histology #Genomics #Transcriptomics #OpenScience | 🧬🖥️🧪🔓 ⬇️ journals.plos.org/ploscompbiol...
journals.plos.org
Ten quick tips for spatial transcriptomics analysis
Author summary Spatial transcriptomics (ST) lets researchers measure gene expression while preserving the tissue location of each measurement. Where a cell sits, and which cells surround it, shape how...
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Hans-Rudolf Hotz @hrhotz.bsky.social · 16/09/2026
we have an opening in our group at @fmiscience.bsky.social - contact @mbstadler.bsky.social or me to get more details: www.fmi.ch/education-ca...
fmi.ch
Friedrich Miescher Institute, open position
Friedrich Miescher Institute, open position
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Jalview @jalview.bsky.social · 15/09/2026
👓 Visualising sequence alignments in 3D? Jalview enables multiple structures to be visualised with Chimera, ChimeraX, PyMOL and Jmol — helping scientists and educators bring biology to life. 📺 Explore the editor's functionality: www.youtube.com/watch?v=pbms... www.youtube.com/watch?v=yRBL...
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FMI science @fmiscience.bsky.social · 15/09/2026
Now in @natneuro.nature.com: work from @rainerfriedrichlab.bsky.social shows that, in zebrafish, learning to tell smells apart reshapes activity across groups of neurons, making key odors easier to distinguish and offering clues to how the brain may organize memories. www.fmi.ch/news-events/...
fmi.ch
Learning reshapes the brain’s map of smell
The brain is constantly taking in sights, sounds and smells, and learning helps it decide which ones matter. Working in zebrafish, FMI neuroscientists have found that learning to tell smells apart cha...
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Bérénice Batut @bebatut.bsky.social · 14/09/2026
🎉 Thrilled to have co-led FAIRyMAGs with Paul Zierep! We used @galaxyproject.bsky.social to implement FAIR workflows and @galaxytraining.bsky.social training materials (also available on YouTube)
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Hans-Rudolf Hotz @hrhotz.bsky.social · 15/09/2026
with @mbstadler.bsky.social from @fmiscience.bsky.social
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Hans-Rudolf Hotz @hrhotz.bsky.social · 14/09/2026
This week, the small scale @galaxyproject.bsky.social admins will meet on Thursday (September 17th): galaxyproject.org/events/2026-...
galaxyproject.org
Small Scale Galaxy Admins Meeting
Galaxy Community Hub
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RNA Society Journal @rnajournal.bsky.social · 11/09/2026
A systematic evaluation of the sources of non-uniform coverage in RNA-Seq and limitations of current practices bit.ly/3Se2ZJx
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Michael Love @mikelove.bsky.social · 12/09/2026
I wrote a post about how slice_sample() and other slice_* functions work in #tidyomics #Bioconductor tidyomics.github.io/tidyomicsBlo...
tidyomics.github.io
Slicing in tidyomics – tidyomicsBlog
How to use dplyr-style slice operations on omics data objects in the tidyomics project.
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Rainer Friedrich @rainerfriedrichlab.bsky.social · 10/09/2026
Just out in Nat Neurosci: disentangling of neural odor manifolds in "olfactory cortex" of adult zebrafish after learning. Great work by Bo, Nesibe et al and wonderful collaboration with @sueyeonchung.bsky.social that fundamentally changed my view of olfactory cortex. www.nature.com/articles/s41...
rdcu.be
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UCSC Genome Browser @genomebrowser.bsky.social · 10/09/2026
New on hg38: Google DeepMind's AlphaGenome Variant Impact (AVI) scores, all 8.8 billion possible single-base changes. It scores non-coding DNA too, flagging things like the TERT promoter mutations common in cancer. See our news for more: bit.ly/GenomeBrowser...
AVI scores at the TERT locus on hg38, one subtrack per alternate allele. Scores stay high across the highlighted promoter, shown in red as EH38E3622530, and fall to background either side. The two promoter mutations most often seen in cancer sit inside it, beyond the end of every TERT transcript.
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Galaxy Project @galaxyproject.bsky.social · 10/09/2026
At IUSSI 2026 in Freiburg, Mina Hojat Ansari presented how reproducible, multi-layer metagenomic analysis in Galaxy helps investigate termite gut microbiome recovery after molting. galaxyproject.org/news/2026-09-08-g… #UseGalaxy #GalaxyProject #EOSC
Group photograph of participants at the 20th International Congress of IUSSI in FreiburgTitle slide of Mina Hojat Ansari’s IUSSI 2026 presentation on termite gut microbiome reassembly using Galaxy
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Galaxy Project @galaxyproject.bsky.social · 09/09/2026
The latest Galaxy newsletter is here! 📰✨ Catch up on Galaxy 26.1, Galaxy Labs, UseGalaxy Canada, research and training highlights, community news, jobs, and upcoming events across the Galaxy ecosystem. galaxyproject.org/news/2026-09... #usegalaxy #GalaxyProject
galaxyproject.org
Galaxy Newsletter September 2026
Explore Galaxy 26.1 and Galaxy Labs, welcome UseGalaxy Canada, see how Galaxy Australia is simplifying data movement, discover Galaxy-powered wildlife ecology and public-health workflows, and find job...
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Galaxy Project @galaxyproject.bsky.social · 09/09/2026
Only a handful of spots remain for the 2nd Galaxy Tool Development Workshop in Freiburg (7-9 October 2026). Registration closes on 11 September, and remote participation is available. galaxyproject.org/news/2026-09-09-t… #UseGalaxy #GalaxyProject #EOSC
galaxyproject.org
Last Few Spots left - Galaxy Tool Development Workshop, Registration Closes 14 September
Only a handful of spots remain for the 2nd Galaxy Tool Development Workshop in Freiburg (7-9 October 2026). Registration closes on 11 September, and remote participation is available.
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Galaxy Project @galaxyproject.bsky.social · 09/09/2026
Galaxy Training Academy 2026 brought together more than 2,200 registrations from 108 countries for a free, global week of self-paced Galaxy training across 11 tracks. galaxyproject.org/news/2026-09-08-g… #UseGalaxy #GalaxyProject #EOSC
Global distribution of registrations for Galaxy Training Academy 2026Galaxy Training Academy 2026 Meet the Experts schedule
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Dr. Leonid Kostrykin @kostrykin.bsky.social · 09/09/2026
Our article about Galaxy as a workbench for bioimage data management & analysis, training & community practices, has been published in the Journal of Microscopy (Wiley). Congratulations to all authors and contributors. Special thanks to @beatrizserrano.bsky.social. CC @denbi.bsky.social #UseGalaxy
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BF Francis Ouellette @bffo.bsky.social · 01/09/2026
From Greg Wilson in arXiv | Twelve Quick Tips for Managing IT Disasters in Small Research Software Teams | #Informatics #OpenScience #Research #IT #DisastersPlanning #NotYetAPLOSCBQT | 🖥️🧪🔥🔓 ⬇️ arxiv.org/abs/2608.27196
arxiv.org
Twelve Quick Tips for Managing IT Disasters in Small Research Software Teams
In 2025, the US government launched an unprecedented series of attacks on its own scientific research groups. A year later GitHub dropped below 90% availability for the first time, while wildfires in ...
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Hans-Rudolf Hotz @hrhotz.bsky.social · 09/09/2026
in case you still believe that @galaxyproject.bsky.social cannot be used for image analysis: onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Bioimage management and analysis in Galaxy: Tools, workflows, training, and community practices
Image analysis in the life sciences is constrained by fragmented software ecosystems, heterogeneous data formats, and limited reproducibility. These barriers hinder the reuse of image analysis method...
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Ensembl @ensembl.org · 08/09/2026
AlphaGenome Variant Impact (AVI) scores, developed by Google DeepMind, predict how likely variants across the whole human genome are to impact gene regulation. AVI scores are available in the Ensembl Variant Effect Predictor to enable easy access into variant analysis workflows.
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BF Francis Ouellette @bffo.bsky.social · 08/09/2026
From @colmanoc.bsky.social and colleagues in #OUP 's #DATABASE journal | The INSDC specifications--foundations for a #FAIR and global INSDC | #Bioinformatics #OpenScience #OpenData #INSDC #GenBank @enasequence.bsky.social #DDBJ #NCBI CC/ @ebi.embl.org | 🧬🖥️🧪🔓 ⬇️ academic.oup.com/database/art...
academic.oup.com
The INSDC specifications—foundations for a FAIR and global INSDC
Abstract. Members of the International Nucleotide Sequence Database Collaboration (INSDC; https://www.insdc.org/) collect, exchange, and preserve comprehen
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Ensembl @ensembl.org · 04/09/2026
The new Ensembl VEP web interface just got upgraded for human GRCh38 variants! Add scores from AlphaMissense, REVEL, CADD, and SpliceAI. Link gnomAD frequencies, ClinVar & GWAS Catalog phenotypes to your data. Try it at- ensembl.org/tools/vep  Blog- www.ensembl.info/2026/09/04/n...
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Alliance of Genome Resources @alliancegenome.bsky.social · 02/09/2026
Alliancegenome.org version 9.1.0 is live, with fresh data and improved features.
alliancegenome.org
Alliance of Genome Resources
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UCSC Genome Browser @genomebrowser.bsky.social · 04/09/2026
See how any mouse gene's expression shifts through development! New ENCODE Expression default tracks on mm10/mm39 show bulk RNA-seq across 17 tissues and 8 stages, from embryonic day 10.5 to birth. See our news for more info: bit.ly/UCSCencodeExp...
Expression of Gap43 across the developmental time course on mm10. Each bar is one sample, colored by tissue and darkening with developmental age. Expression rises through development and is highest in the four neural tissues on the right of the chart.
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Daniela Schneider @schnda.fedihum.org.ap.brid.gy · 03/09/2026
Marking it's first anniversary, I took the time to upgrade our "Intro to #digitalHumanities" #tutorial that guides you through the #workflow system #usegalaxy for #humanities and #socialsciences. free, open and online. Check it out here: gxy.io/GTN:T00557
training.galaxyproject.org
Redirecting…
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InterPro @interprodb.bsky.social · 03/09/2026
🚀 InterPro 110.0 is live! ✨ Updated to NCBIFam 20.0 ✨ 854 new InterPro entries Explore the latest annotations and discover new protein insights. Explore it now: www.ebi.ac.uk/interpro/
ebi.ac.uk
InterPro
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a s...
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BF Francis Ouellette @bffo.bsky.social · 03/09/2026
From #OUP s @bioinfoadv.bsky.social journal | Usage and impact of global biodata resources | #Bioinformatics #Database #OpenScience #OpenData #GlobalBiodataCoalition | 🧬🖥️🧪🔓 CC/ @ebi.embl.org @elixir-europe.org ⬇️ academic.oup.com/bioinformati...
academic.oup.com
Usage and impact of global biodata resources
AbstractMotivation. Biodata resources constitute a critical, large-scale, and globally distributed infrastructure underpinning life science research, yet t
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Galaxy Project @galaxyproject.bsky.social · 03/09/2026
Welcome, UseGalaxy Canada! 🇨🇦 UseGalaxy.ca is now part of the UseGalaxy.* family, expanding access to free, powerful, reproducible Galaxy infrastructure for researchers in Canada and beyond. Explore: usegalaxy.ca #usegalaxy #GalaxyProject #OpenScience
usegalaxy.ca
Galaxy
Galaxy is a community-driven web-based analysis platform for life science research.
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Ensembl @ensembl.org · 02/09/2026
Want a quick tour of the new Ensembl? Check out our new material on the EMBL-EBI Training site! It's free to access - give it a try and see what genomes are available on Ensembl now. 🧬
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de.NBI & ELIXIR Germany @denbi.bsky.social · 02/09/2026
🚨 REGISTRATION IS NOW OPEN for BioHackathon Germany 2026! 🚨 The wait is over—you can now officially secure your spot! Work on 13 cutting-edge projects in Spatial Omics, RNA models & FAIR data. ⚠️ On-site seats are limited! 👉 Register now: www.denbi.de/de-nbi-event... #Bioinformatics #OpenScience
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Galaxy Project @galaxyproject.bsky.social · 01/09/2026
🦠 Same species ≠ same strain. A new GTN tutorial shows how SameStr can identify shared microbial strains across metagenomic samples, including donor engraftment after fecal microbiota transplantation. Try it in Galaxy: training.galaxyproject.org/training-mat... #usegalaxy #Microbiome
training.galaxyproject.org
Microbiome / Detection of shared microbial strains with SameStr / Hands-on: Detection of shared microbial strains with SameStr
A microbiome is the community of microorganisms that can usually be found living together in any given habitat. Microbiome research has grown substantially over the past decade in terms of the range o...
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