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InterPro @interprodb.bsky.social · 03/09/2026

🚀 InterPro 110.0 is live! ✨ Updated to NCBIFam 20.0 ✨ 854 new InterPro entries Explore the latest annotations and discover new protein insights. Explore it now: www.ebi.ac.uk/interpro/

ebi.ac.uk

InterPro

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a s...

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InterPro @interprodb.bsky.social · 30/01/2026

🚀 InterPro 108.0 is live! ✨ Updated to Pfam 38.1 and NCBIFam 18.0 ✨ 1,911 InterPro entries Explore the latest annotations and discover new protein insights. Explore it now: www.ebi.ac.uk/interpro/

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InterPro @interprodb.bsky.social · 23/10/2025

🚀InterPro 107.0 is live! ✨Updated to Pfam 38.0 ✨1,068 new InterPro entries Explore the latest annotations and discover new protein insights. Explore it now: interpro.ebi.ac.uk

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InterPro @interprodb.bsky.social · 02/10/2025

Quinoa thrives at 4,000m altitude where many crops struggle. Heat Shock Proteins helps protect plant cells from environmental stress. These molecular mechanisms in traditional crops may inform climate-resilient agriculture strategies. 💻🧪 More info: proteinswebteam.github.io/interpro-blo...

InterPro page with a list of the quinoa sequences in UniProtKB that belong to the HSP70 family.

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InterPro @interprodb.bsky.social · 17/09/2025

Interested in studying Parkinson's disease? Have a look at our blog post below

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Reposted by InterPro

Ensembl @ensembl.org · 02/09/2025

📢 Happy to announce that Ensembl 115 and Ensembl Genomes 62 are out! This release features ~120000 new protein coding transcripts in human GRCh38, 2 new cattle, 7 new plants and 20 new metazoa! 🧬🐮 🫛🪲 Read more here ➡️ zurl.co/poyXM

zurl.co

Ensembl 115 has been released! – Ensembl Blog

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InterPro @interprodb.bsky.social · 27/08/2025

Feature Spotlight: Taxonomy Sunburst Discover the taxonomic breadth of your InterPro entry at a glance with our dynamic sunburst chart! 🕸️ 💻🧪🧬

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InterPro @interprodb.bsky.social · 08/08/2025

InterProScan 6 (beta) is here 🎉 A Nextflow-powered, containerised overhaul for scalable, reproducible protein annotation—decoupled software/data, automated data handling, and smoother runs across HPC and cloud. Feedback welcome! github.com/ebi-pf-team/... 💻🧪🧬

InterProScan 6 (beta)
Nextflow - Containerised - Reproducible outputs
Start with FASTA file
InterProScan workflow:
Annotate proteins (and nucleotides) with families, domains & sites
Select analyses (e.g. Pfam, PANTHER, CDD, NCBIFAM...)
Optional: GO and pathway annotations
Output formats: JSON, TSV, XML, GFF3

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InterPro @interprodb.bsky.social · 18/07/2025

🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool! 🎤 Multiple talks & 📊 posters on protein analysis & classification 💻🧪

Poster A-098: Pfam database in 2025 – towards expanding protein families coverage
Nicole Morveli Flores
Session A: 21/07/2025
10:00 – 11:20 and
16:00 – 16:40 BST
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

InterProScan 6: a modern large-scale protein function annotation pipeline
Matthias Blum
21/07/2025 14:20
Room 03A
Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

Poster A-205: Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation
Emma Hobbs
Session A: 21/07/2025
10:00 – 11:20 and
16:00 – 16:40 BST
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

Accelerating protein family classification in InterPro with AI innovations
Matthias Blum
22/07/2025 16:40
Room 12
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

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InterPro @interprodb.bsky.social · 18/07/2025

🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool! Join us July 20-24 at the world's largest #bioinformatics conference! #ISMBECCB2025 #ProteinAnalysis #ComputationalBiology 💻🧪

The InterPro/Pfam team members attending ISMB/ECCB 2025: Alex Bateman, Emma Hobbs, Matthias Blum, Nicole Morvelli, Antonina Andreeva
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

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InterPro @interprodb.bsky.social · 07/07/2025

🧬✨ Excited to present at @jobim2025.bsky.social this week in Bordeaux! 🎤 Talk 08/07 16:50, amphi E: Pfam: embracing AI/ML by @typhainepl.bsky.social 📊 Poster #97: InterPro: Accelerating Protein Annotation with AI by @matthiasblum.bsky.social 💻🧪

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Reposted by InterPro

EMBL-EBI Training @training.ebi.embl.org · 26/06/2025

Level up your protein prediction skills with the updated EMBL-EBI Training AlphaFold practical course. Now featuring #AlphaFold Server and AlphaFold 3. Start your training today: www.ebi.ac.uk/training/onl... AlphaFold, developed by @ebi.embl.org‬ and Google DeepMind.

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InterPro @interprodb.bsky.social · 26/06/2025

Does taste depend on our genes? Discover how variations in taste receptors—from TAS2Rs that gate bitterness to olfactory genes that make cilantro taste soapy—and even pain receptors for spice shape what we love (and hate) on our plates. Read more: proteinswebteam.github.io/interpro-blo... 💻🧪👅🧬

Schematic diagram showing taste signal transmission between the tongue (with taste buds that contain taste cells harbouring GPCRs) and brain. Taste GPCRs are activated by specific food compounds, recruit specific G proteins that further induce intracellular calcium release. Adapted from [https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28:_Biosignaling_-_Capstone_Volume_I/28.18:_Signal_Transduction_-_Taste_(Gustation)].

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InterPro @interprodb.bsky.social · 20/06/2025

🚀 InterPro 106.0 is now live! ✨ Updated to Pfam 37.4 ✨ 683 new entries added ✨ Enhanced protein classification coverage Explore the latest annotations and discover new protein insights. Explore it now: interpro.ebi.ac.uk 💻🧪🧬 #Bioinformatics #ProteinScience #Pfam #EMBLEBI

New entries:
683 new entries with:
613 Pfam
78 NCBIfam
30 CDD
4 PANTHER
...

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Reposted by InterPro

Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 16/06/2025

What’s new in the redesigned PDBe entry pages? 🧪 Cleaner layout 🧪 Interactive 3D viewers 🧪 Contextual annotations 🧪 Easier navigation See for yourself: wwwdev.ebi.ac.uk/pdbe/entry/p... #PDBeBeta #Bioinformatics #Biochemistry #Science

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Reposted by InterPro

EMBL-EBI @ebi.embl.org · 12/06/2025

InterPro just got one of its biggest updates ever. Now with 1.8 billion AI-driven protein annotations, AlphaFold-based TED domains, and viral proteins from the Big Fantastic Virus Database (BFVD). See it all at www.ebi.ac.uk/interpro 🖥️🧬 @interprodb.bsky.social

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InterPro @interprodb.bsky.social · 03/06/2025

🦠🧬Exciting news! BFVD predicted viral protein structures are now available in @InterProDB! For the first time, explore InterPro functional annotations directly on 3D structures of viral proteins not covered by AlphaFold DB. This bridges a critical gap in structural virology research.

CATH-Gene3D annotation visualised on BFVD structure prediction of UniProt A0A075FDU7

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InterPro @interprodb.bsky.social · 20/05/2025

We are saddened to hear of the passing of Daniel Kahn, the creator of the ProDom database. His pioneering work in protein domain classification laid important groundwork for InterPro and the wider bioinformatics community. We honour his lasting contributions. 🧬🕊️

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InterPro @interprodb.bsky.social · 15/05/2025

🧬 MAJOR UPDATE: InterPro-N matches now available in InterPro! 1.8 billion AI-driven protein annotations developed with Google DeepMind are now live. ✨ Look for the sparkles icon to identify them 📊 Options menu lets you view: InterPro only | InterPro-N-only | Stacked 💻🧪

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InterPro @interprodb.bsky.social · 08/05/2025

🔍 NEW: TED domains in InterPro 105.0! For the first time, see AlphaFold-derived structural domains directly alongside InterPro annotations in one powerful visualisation. Bridging the sequence-structure divide in protein analysis. 💻🧪 Explore now: www.ebi.ac.uk/interpro/pro...

TED domains alongside InterPro annotations for UniProt P05067

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InterPro @interprodb.bsky.social · 01/05/2025

📝 Check out our new blog post highlighting the groundbreaking features in InterPro 105.0! Learn how InterPro-N, TED domains and viral protein structures are transforming protein classification: ebi.ac.uk/about/news/u...

InterPro 105.0: AI for protein classification
InterPro 105.0 is now live. This AI-driven update makes it easier than ever to explore the protein universe

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InterPro @interprodb.bsky.social · 24/04/2025

📢InterPro release 105.0 is live! ✨Update to Pfam 37.3, PROSITE patterns 2025_01 PROSITE profiles 2025_01 and HAMAP 2025_01 ✨342 new entries ✨Addition of InterPro-N annotations ✨Addition of BFVD structure predictions from @martinsteinegger.bsky.social's lab Have a look: ebi.ac.uk/interpro/htt... 💻🧪🆕

Databases updates
Pfam 37.3
PROSITE patterns 2025_01
PROSITE profiles 2025_01
HAMAP 2025_01

New entries
342 new entries with:
318 Pfam
40 NCBIfam
12 Prosite profiles
6 PANTHER
5 CDD

New features
InterPro-N annotations
BFVD structure predictions
Simplified structure pages

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InterPro @interprodb.bsky.social · 11/04/2025

Missed our latest webinar about LLM generated summaries for protein classification at InterPro delivered by @matthiasblum.bsky.social? The recording is now available: lnkd.in/ei4fKGXd

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InterPro @interprodb.bsky.social · 02/04/2025

Want to use the InterPro API but not sure how to start? Join this upcoming workshop, where @typhainepl.bsky.social will guide you through the fundamentals and practical applications. Discover how to integrate this powerful tool into your workflow! Register now to secure your spot. 💻🧪

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Reposted by InterPro

Ensembl @ensembl.org · 25/03/2025

Are you going to ISMB/ECCB 2025 @iscb.bsky.social in Liverpool 🇬🇧? Register for our tutorial on 'Genomic Variant Interpretation & prioritisation for clinical research'. More info: tinyurl.com/ahav9djn #genomics #bioinformatics

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InterPro @interprodb.bsky.social · 25/02/2025

🆕 New version of InterProScan: 5.73-104.0 3 ways to use it: 1️⃣ Sequence search on the InterPro website: ebi.ac.uk/interpro/sea... 2️⃣ Local installation: interproscan-docs.readthedocs.io/en/v5/Instal... 3️⃣ Local installation using a container: interproscan-docs.readthedocs.io/en/v5/HowToU... 💻🧪

InterProScan Version: 5.73-104.0
6th February 2025

Databases updates:
Pfam 37.2
NCBIfam 17.0
CDD 3.21

Ways to access:
1) InterPro website: sequence search
2) Local installation
Software download
Docker container

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Reposted by InterPro

InterPro @interprodb.bsky.social · 06/02/2025

🔈InterPro release 104.0 is live! ✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21. ✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪

Databases udpates:
Pfam 37.2, NCBIfam 17.0, CDD 3.21

661 new entries, containing:
663 Pfam
5 NCBIfam
5 PANTHER
9 CDD

New features:
Redesigned protein viewer for sequence searches
Wikipedia articles for Pfam clans
Addition of PTM from the PRIDE database

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InterPro @interprodb.bsky.social · 14/02/2025

New webinar series featuring InterPro, register now!

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Reposted by InterPro

Gonzalo Parra @gonzaparra.bsky.social · 13/02/2025

RT please: Just 1.5 months away from our joint 3DBioinfo/3DSIG amazing conference! These are our two great keynote speakers! @rolanddunbrack.bsky.social & @silviaosuna.bsky.social! Check our preliminary programme here: www.iscb.org/3dbioinfo202... Registration link: www.iscb.org/3dbioinfo202...

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InterPro @interprodb.bsky.social · 06/02/2025

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Reposted by InterPro

Europe PMC @europepmc.org · 30/01/2025

1/ 🌟At Europe PMC, we are at the heart of open science ♥️🔓 Our mission? To support open science, promote innovation, and connect publications with other research outputs to empower users worldwide. But how do we do it? Let’s break it down 🧵👇

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InterPro @interprodb.bsky.social · 31/01/2025

🧬🧪💻 New blog post: Diving deep into the key proteins behind Parkinson's disease. From α-synuclein to LRRK2, we're unravelling the molecular mysteries that could hold the key to treatment breakthroughs. Read more: proteinswebteam.github.io/interpro-blo... #Parkinsons #Neuroscience

Parkinson's disease molecular mechanisms.
Source: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61393-3/fulltext#fig3

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InterPro @interprodb.bsky.social · 24/01/2025

🔍 Lost in InterPro data? Our redesigned Help page has you covered! From quick answers to deep dives into protein families, find exactly what you need at www.ebi.ac.uk/interpro/help/ 💻🧪

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Reposted by InterPro

EMBL-EBI @ebi.embl.org · 16/12/2024

Prediction confidence scores help #AlphaFold users gauge the reliability of protein structure predictions. 🖥️🧬 But things get more challenging for protein families. A new method helps improve low confidence predictions within protein families. academic.oup.com/bioinformati...

Protein structure prediction from the AlphaFold Database

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InterPro @interprodb.bsky.social · 16/01/2025

🆕The member database signature pages have undergone a thoughtful reorganisation to improve information accessibility. 1) Curation data are now in Overview 2) HMM information and logo are now in Profile HMM Have a look: www.ebi.ac.uk/interpro/ent...

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InterPro @interprodb.bsky.social · 10/01/2025

🆕We've implemented a new “Curation status” filter to help users distinguish between different types of entries (curated vs AI) in the Browse by InterPro and Member DB, have a look: www.ebi.ac.uk/interpro/ent... 💻🧪

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InterPro @interprodb.bsky.social · 23/12/2024

2024 was a big year for InterPro! 🎉 🔹 Celebrated InterPro 100 with new features 🤖 Added AI-generated entries 🌟 Improved tools & navigation 📚 Expanded data with new signatures 💬 Joined Bluesky to connect with you! Thank you for your support—here’s to 2025! 🚀 💻🧪

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InterPro @interprodb.bsky.social · 12/12/2024

📣 A new version of InterProScan (5.72-103.0) is available. You can download it here: ebi.ac.uk/interpro/abo... More info and documentation: interproscan-docs.readthedocs.io/en/latest/Re... 🧪💻🧬

InterProScan 5.72-103.0 release notes:
Synchronized with InterPro version 103.0.
The addition of 1029 InterPro entries.
An update to Pfam (37.1).
Integration of 1019 new methods from the CDD (7), NCBIfam (2), PANTHER (1), PIRSF (1), Pfam (1008) databases.

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InterPro @interprodb.bsky.social · 09/12/2024

📝 Just published: Our latest blog walks you through InterPro's major updates - from redesigned protein views to improved data exploration. Read more: proteinswebteam.github.io/interpro-blo...

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InterPro @interprodb.bsky.social · 29/11/2024

InterPro release 103.0 is live! 💻🧪 ✨Update to Pfam 37.1 ✨1029 new entries, including 1019 signatures from the Pfam (1008), NCBIfam (2), PIRSF (1), PANTHER (1), CDD (7) databases. Have a look: ebi.ac.uk/interpro/

InterPro release 103.0: 28th November 2024

1029 new entries containing:
1008 Pfam
2 NCBIfam
1 PIRSF
1 PANTHER
7 CDD

New features:
Redesigned protein viewer
Improved dataset browsing
Streamlined website navigation
Member database entry page updates

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InterPro @interprodb.bsky.social · 19/11/2024

We’re delighted to have joined BlueSky to engage with the scientific community about protein families, protein domains and related data. Follow us for updates on protein classification, domain characterisation and new features added to the InterPro website.

InterPro: a database classifying proteins
Content: 13 resources in one places
Content: over 46,000 entries describing protein families and protein domains
Part of Elixir and Global biodata coalition
Training available on the EMBL-EBI training platform

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