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Stephen Graham's Lab

@atomicvirology.bsky.social
2.3K followers 800 following 153 posts

Lab in the University of Cambridge 🇬🇧 studying the cell biology, biophysics and structural biology of virus infection. Blame Stephen 🇦🇺 for the content.

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Stephen Graham's Lab @atomicvirology.bsky.social · 26/09/2026
Where in the world is @atomicvirology.bsky.social ?
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Stephen Graham's Lab @atomicvirology.bsky.social · 23/09/2026
Excited to be on my way to the mini herpesvirus workshop in Hannover tomorrow. Almost there... 🚅 4/4...no ✈️!
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Jordan P. Skittrall @skittrallj.bsky.social · 10/09/2026
Funded PhD in Cambridge: "Mathematical and computational methods to discover and characterise critical genetic features in RNA viruses, with application to Rift Valley Fever Virus" Group: skittrallgroup.org Ad: bbsrcdtp.lifesci.cam.ac.uk/project-refe... Info: bbsrcdtp.lifesci.cam.ac.uk/how-apply
Goats in the shade of a thatched hut during an investigation into a Rift Valley fever outbreak in Saudi Arabia, 2000. Courtesy CDC/Abbigail Tumpey
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Chris H. Hill @chillzaa.bsky.social · 24/08/2026
Thrilled to share that our paper describing protein-dependent frameshifting is now out in Molecular Cell @cellpress.bsky.social. Huge congratulations to @jemmabetts.bsky.social for publishing the first research paper from her PhD 🧬🧪🥳 www.sciencedirect.com/science/arti... 1/8
sciencedirect.com
A protein-dependent riboswitch activates ribosomal frameshifting in cardioviruses
Programmed −1 ribosomal frameshifting (PRF) is a translational control mechanism used by RNA viruses to regulate the relative abundance of proteins en…
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Aakash Mukhopadhyay @aakash89.bsky.social · 27/07/2026
Come join us in beautiful Cambridge to uncover the fascinating biology of eukaryotic parasites! #Postdoc #Cambridge #cryoEM #parasitology #cilia #Trypanosoma #Leishmania
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Yo Akiyama @yoakiyama.bsky.social · 21/07/2026
Excited to share our now published paper @cp-cell.bsky.social highlighting advances in modeling the evolution of protein-protein interactions with MSA Pairformer. Big thanks to Zhidian Zhang, Olivia Tang, @eunbelivable.bsky.social @milot.bsky.social @martinsteinegger.bsky.social and @sokrypton.org!
cell.com
Expanding the scope of protein language modeling to protein-protein interactions with MSA Pairformer
Protein language models have excelled at modeling individual proteins, but extending these capabilities to protein complexes remains a major challenge. MSA Pairformer, a parameter-efficient protein la...
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Stephen Graham's Lab @atomicvirology.bsky.social · 17/07/2026
💯 - up until now making MD data accessible has been a real pain, kudos to @wheelerlab.org and colleagues.
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Christophe 🔬 Leterrier @christlet.bsky.social · 16/07/2026
"Our findings likewise suggest that scientific impact does not translate into happiness. This gap reflects a deeper misalignment: the external recognition conferred by citations may not satisfy researchers’ intrinsic psychological needs" doi.org/10.1093/rese...
doi.org
Scientific impact at the expense of happiness? Work/life balance in performance-driven research careers
Abstract. Research evaluation systems place increasing emphasis on scientific impact, yet their consequences for researchers themselves remain underexplore
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Stephen Graham's Lab @atomicvirology.bsky.social · 08/07/2026
Well done to Shrestha, who had a tough slot as second talk of #bunya2026 (straight after the keynote) but did a great job presenting her work on computational affinity maturation of nanobodies against emerging #Oropouche virus variants 💪
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Stephen Graham's Lab @atomicvirology.bsky.social · 08/07/2026
The Cambridge crew after a good dinner in a local bar last night, ready for #bunya2026 to kick off!
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Stephen Graham's Lab @atomicvirology.bsky.social · 08/07/2026
Where in the world is @atomicvirology.bsky.social ...
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Stephen Graham's Lab @atomicvirology.bsky.social · 24/06/2026
Tell a tragic tale in two images...
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Kate Baker @ksbakes.bsky.social · 11/06/2026
I know a lot of people on the fence about frontiers… hopefully this is all you need to come down
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Stephen Graham's Lab @atomicvirology.bsky.social · 09/06/2026
What do you think, should I go and try to reclaim some of my gold from abcam?
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Reese Richardson @reeserichardson.bsky.social · 05/06/2026
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
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James Briscoe @jamesbriscoe.bsky.social · 03/06/2026
Is this the future of peer review? New from @biologyopen.bsky.social: expanded Fast & Fair trial paying reviewers £220 per paper The result: rapid peer review with no drop in quality or change in acceptance rate Paying referees makes peer review faster & fairer www.biorxiv.org/content/10.6...
biorxiv.org
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Frank Noe @franknoe.bsky.social · 03/06/2026
Postdoc openings on experimental data integration integration into BioEmu-next, focusing on cryo-EM and binding affinities. Join us at @msftresearch.bsky.social Cambridge or Berlin. #AI #MachineLearning #Protein #Biology apply.careers.microsoft.com/careers/job/...
apply.careers.microsoft.com
AI for Science Postdoctoral Researcher - Biomolecular AI & Experimental Data Integration | Microsoft Careers
Design and scale experimental datasets for ML Develop workflows that connect noisy experimental signals to actionable model insights 1. Bridging Models with Real-World Experimental Signals Develop met...
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Department of Pharmacology | University of Cambridge @phar.cam.ac.uk · 02/06/2026
The Cambridge Protein Screening Facility has launched their new website! This facility, aims to enable the development of novel antibody binders for research, diagnostics and therapeutics using phage and yeast display. See our news post here: www.phar.cam.ac.uk/news/announc...
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Brett Collins @brettcollins.bsky.social · 30/05/2026
This is an interesting analysis of AlphaFold3. I don't claim to understand all of the technicalities, but the conclusion matches our own anecdotal experience that evolutionary depth is important for the most confident AlphaFold predictions. www.biorxiv.org/content/10.6...
biorxiv.org
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Laurel Oldach @laureloldach.bsky.social · 28/05/2026
Thermo Fisher has responded to research integrity activists who spotted apparent manipulation in its antibody catalog: "In ... preparing antibody images for publication on our website, some images may have been adjusted to clarify for presentation purposes." More: cen.acs.org/research-int...
Headline "Sleuths say Thermo Fisher doctored data to sell antibodies," subhead "Apparent manipulation of validation images in reagent catalog concern researchers," byline Laurel Oldach, image of a pipette loading an SDS-PAGE gel for a western blot
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Stephen Graham's Lab @atomicvirology.bsky.social · 29/05/2026
This is shocking (but also not terribly surprising)! Blatant manipulation of antibody validation data on the Thermo website... As Mulder said, trust no-one 👽
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Reese Richardson @reeserichardson.bsky.social · 28/05/2026
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...
reeserichardson.blog
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
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Shivkumar Lab @shivkumarlab.bsky.social · 22/05/2026
📢 Funded #PhD studentship (UK Home students) for a multidisciplinary project on the disinfection of wastewater using novel technologies. Collaboration with environmental engineering firm Hazen & Sawyer, covering microbiology, virology, chemistry. Apply here: tinyurl.com/28he6ztp @dmu.ac.uk
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Stephen Graham's Lab @atomicvirology.bsky.social · 22/05/2026
Where in the world is @atomicvirology.bsky.social? (And what in the world is going on 👨‍🚒🚒?!)
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Sholto David @sholtodavid.bsky.social · 17/05/2026
Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.
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Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
And so it begins...
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Chris H. Hill @chillzaa.bsky.social · 16/05/2026
We just had our second -80 freezer failure in four years... On a Friday evening of course. All samples transferred safely, thanks to the amazing dedication of my team. Eppendorf CryoCube is disappointing in every possible way - it's neither a cube, nor does it stay cold.
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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 12/05/2026
Want to do a PhD combining cryo-EM, AI-driven binder design, and deep virology in a cutting-edge environment and in an international team? We're hiring @CSSB_Hamburg 🔬 You: curious, rigorous, MSc in biochem, biophysics, virology, related Interested? DM me. Please RT 🙏 #PhDposition #cryoEM #virology
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The Conversation AUNZ @aunz.theconversation.com · 12/05/2026
A virus doesn’t become a pandemic simply because it’s deadly.
theconversation.com
Hantavirus is very different to COVID. Here’s why the ‘Andes virus’ won’t cause the next pandemic
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Ed Hutchinson @socialinfluenza.bsky.social · 05/05/2026
Still time to apply for one of three joint virology PhDs @cvrinfo.bsky.social and @pirbrightinst.bsky.social, including one with myself and the fantastic @peacockflu.bsky.social! Informal enquiries welcome by e-mail (including re the primary location of ours, which is negotiable), deadline 8th May
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Stephen Graham's Lab @atomicvirology.bsky.social · 30/04/2026
Congratulations to @danielacl.bsky.social for winning a poster prize at the @isaricar.bsky.social international conference on antiviral research #ICAR2026 🎉🥳🏅👩‍🔬
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Stephen Graham's Lab @atomicvirology.bsky.social · 29/04/2026
Where in the world is @atomicvirology.bsky.social? #ICAR2026
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Stephen Graham's Lab @atomicvirology.bsky.social · 28/04/2026
My colleague @socialinfluenza.bsky.social has written an absolutely excellent explainer for @theconversation.com about our recent paper with @dalan-bailey.bsky.social identifying a new human surface receptor for alphacoronaviruses: theconversation.com/scientists-h...
theconversation.com
Scientists have found a safer way to hunt for the next pandemic virus
Scientists are learning to spot pandemic threats without touching dangerous pathogens.
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Daniel Hurdiss @danielhurdiss.bsky.social · 23/04/2026
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells www.nature.com/articles/s41...
nature.com
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells - Nature
Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.
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Aris Katzourakis @ariskatzourakis.bsky.social · 23/04/2026
Some bat alphacoronaviruses can exploit an entirely different receptor to enter human cells. This could lead to crossover events could be the first step in future epidemics, though we are not there yet and there would be many more barriers to overcome also. www.nature.com/articles/s41...
nature.com
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells - Nature
Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.
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Wyoming Wormboy @wyomingwormboy.bsky.social · 25/04/2026
Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.
aprecruit.ucsf.edu
Faculty Position – In-Residence
University of California, San Francisco is hiring. Apply now!
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Dalan Bailey @dalan-bailey.bsky.social · 23/04/2026
Took a long time to get this done, 2-3 years on Figure 1 alone but glad it's finally out!! www.nature.com/articles/s41...
nature.com
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells - Nature
Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.
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Nature Portfolio @natureportfolio.nature.com · 23/04/2026
A study in Nature finds that a subset of bat alphacoronaviruses (a major group of coronaviruses) has the potential to enter human cells by exploiting a previously unknown cellular gateway. 🧪
go.nature.com
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells - Nature
Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.
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Stuart Neil @tetherin.bsky.social · 23/04/2026
Fantastic paper by Dalan Bailey and Stephen Graham’s labs and colleagues in Kenya. Bat alphaCoVs don’t use any of the previously known receptors, but some in Kenya can use human CEACAM6, a lung expressed adhesion factor, to enter human cells. www.nature.com/articles/s41...
nature.com
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells - Nature
Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.
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School of Biological Sciences @cambridgebiosci.bsky.social · 22/04/2026
An international team of researchers, including scientists from the University of Cambridge, has identified a new way coronaviruses can enter human cells. 🦠 Prof Stephen Graham explains why this breakthrough matters for future health risks. Read more 👉 www.cam.ac.uk/research/new...
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Stephen Graham's Lab @atomicvirology.bsky.social · 22/04/2026
We did a thing: Scientists find a new way coronaviruses can get into human cells www.cam.ac.uk/research/new...
cam.ac.uk
Scientists find a new way coronaviruses can get into human cells
An international team of researchers has identified an East African bat coronavirus capable of entering human cells.
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Ed Hutchinson @socialinfluenza.bsky.social · 17/04/2026
🚨New pre-print!🚨 Because influenza virions are highly variable in form no single method can show their molecular architecture in detail. Here, we integrate multiple structural and compositional approaches to identify new features of these beautiful virus particles www.biorxiv.org/content/10.6...
An illustration of an apical region of an animal cell in cross section, shown crowded with individual molecules. The plasma membrane is densely occupied by influenza virus glycoproteins, and from the surface bud influenza virions with different morphologies (L-R): spherical, bacilliform, filamentous with a genome, filamentous and empty, filamentous with a helical inner layer, and filamentous with a cofilactin cytoskeleton.
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School of Biological Sciences @cambridgebiosci.bsky.social · 17/04/2026
🔬Fully funded PhD Applications are open for the BBSRC–GSK Transformative Technologies in Pharmaceutical Science programme! Apply by 15 May 2026 👉 www.postgradschl.lifesci.cam.ac.uk/funding/tran... #PharmaceuticalScience #CambridgeUniversity #GSK
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Stephen Graham's Lab @atomicvirology.bsky.social · 15/04/2026
Want to hear the story first hand? If you're at #microbio26 then come to my talk today at 13:15 (virus forum on molecular and cellular biology, meeting room 2).
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Tom Peacock @peacockflu.bsky.social · 14/04/2026
Excited to advertise a fully funded PhD with @socialinfluenza.bsky.social investigating how influenza virus evolution differs between different avian hosts (and how this impacts pandemic potential). Joint between @pirbrightinst.bsky.social + @cvrinfo.bsky.social www.findaphd.com/phds/project...
findaphd.com
FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow on FindAPhD.com
PhD Project - FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow, listed on FindAPhD.com
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Stephen Graham's Lab @atomicvirology.bsky.social · 14/04/2026
Can a single viral protein change how you think 🧠🧐? We think so! Our new preprint shows how herpes simplex virus protein pUL56 turns off neuronal electrical activity. www.biorxiv.org/cgi/content/... 🟦🧵👇
biorxiv.org
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Daniel Nash @danandviruses.bsky.social · 02/04/2026
It finally happened! I had such a great time studying for my PhD here and thank you to both Ade and Jonny for a fun viva!
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Stephen Graham's Lab @atomicvirology.bsky.social · 02/04/2026
Congratulations to Dr @danandviruses.bsky.social on passing his PhD viva in style! 🥳🎉🕺🎓 Many thanks to the examiners Ade Whitehouse and @abelljonny.bsky.social for putting him through his paces (for 4 hours!! 😅) @campathology.bsky.social
Dan even found time to bake a cake for his own post viva partyPost viva party
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Friedemann Weber @friedemann.bsky.social · 23/02/2026
Junior Research Groups (m/f/d) in the field of Infection Biology
jobs.helmholtz-hzi.de
Junior Research Groups (m/f/d) in the field of Infection Biology
Junior Research Groups (m/f/d) in the field of Infection Biology
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Stephen Graham's Lab @atomicvirology.bsky.social · 20/12/2025
You might have missed out on our lab Christmas party this year, but you can still try your hand at our "common lab chemicals" quiz. Apparently me handing out a sheet of chemical drawings is 'not fun', so this year we also had cryptic clues...
This is a lab biochemicals quiz. Seriously, that's the kind of thing I come up with in my spare time. I know, it's weird, right?
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