Molecular clock and preservation of early microfossil assemblages suggest that eukaryotes were present and already diverse more than ~1600 million ...

Naked mole-rat (Heterocephalus glaber) queens produce isopropyl myristate, a low-volatility ester that high-ranking animals detect and avoid, which alters prolactin and progesterone in other females t...

Folddisco enables protein structural motif search in million scale databases.

Abstract. Phylogenetic trees are often inferred from protein sequences sampled from diverse taxa across the tree of life. The compositions of these amino a

Immune systems in animals, plants, and bacteria often rely on intracellular nucleotide signaling, which viruses can block by sequestering or degrading these signals. We identified structural and bioph...

A structural catalogue of the Asgard archaeal pangenome reveals hundreds of eukaryotic-like proteins that suggest a higher degree of cellular complexity in the archaeal ancestor of eukaryotes.

Protein structure-based searches enable the functional annotation of many plant proteins for which sequence-based methods fall short.

Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

A new type of mRNA splicing mechanism discovered in Caenorhabditis elegans that detects and removes inverted repeats also occurs in human cells, thereby providing another strategy to protect against t...

By leveraging both deep learning and hidden Markov models, Helixer achieves broad taxonomic coverage for ab initio gene annotation of eukaryotic genomes from fungi, plants, vertebrates and invertebrat...

Two ticks found on an 1873 electric eel specimen mark the first recorded case of ticks parasitizing a fish—but only documented just this year.

Toll/interleukin-1 receptor (TIR) domains are important for immune signaling across humans, plants and bacteria. These domains were recently found to produce immune signaling molecules in plant immuni...

Analysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.0–2.25 billion years ago as a result of mitochondrial endosymbiosis with complex archaea that already possessed an elaborated cytoskeleton, membrane trafficking, endomembrane, phagocytotic machinery and a nucleus.

Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...

Comparisons of 154 genomes from 21 animal phyla and outgroups have been used to reconstruct ancestral adaptation to life on land across 11 distinct terrestrialization events, revealing strong evidence for convergent genomic evolution across the animal kingdom and recurring periods of terrestrial colonization.

The phylogeny of the Archaea continues to be revisited and revised as new groups are discovered and phylogenetic methods improve, but key questions about their early evolution remain. It has been sugg...

For over a century, evolutionary biologists have been motivated to understand the mechanisms through which organisms adapt to their environments. Coloration and pigmentation are remarkably variable wi...

The most recent common ancestor of the stony coral Scleractinia dates to about 460 million years ago and was probably a solitary, heterotrophic and free-living organism.

The rapid advancement of DNA sequencing technologies and computational algorithms has led to an unprecedented surge in genomic data, driven by several large-scale sequencing projects worldwide. Orthol...

Phylogenetic variation, recombination rate evolution, and comparative genome structure and organization have typically been explored in isolation. The chromosomal and genomic context of selected genet...

Determining the principles underlying the origin of novel characters has been a fundamental goal of evolutionary biology. Yet, key mechanisms remain poorly understood, hindered by the lack of a genera...

Scientists electrically culled invasive fish in a 20-year battle—but the fish fought back with rapid evolution