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Graham Larue

@glarue.bsky.social
77 followers 182 following 42 posts

Bioinfomatician

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Reposted by Graham Larue
C. Brandon Ogbunu @cbo.bsky.social · 27/09/2026
In my latest for @undark.org, I compare AI adoption in science to the Ship of Theseus: "If you swap out every wooden plank on a ship over time, is it still the same vessel?" I argue that science derives authority from something more than data generation + publication. undark.org/2026/09/25/o...
undark.org
AI Presents Science with a ‘Ship of Theseus’ Problem
Opinion | AI can replace each part of the scientific process, leaving the enterprise recognizable but devoid of human judgment.
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Reposted by Graham Larue
Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 24/09/2026
Incredible. First Secretary Mullin claimed that DHS had identified 15,903 noncitizens on Nevada’s voter roll. Then DHS officials told a skeptical Nevada, no no no, that’s just people we flagged. Here are the names of 185 people we KNOW aren’t citizens. All 185 were citizens. DHS got 100% wrong.
When the Department of Homeland Security sent Nevada a list of 185 names last month that it claimed identified noncitizens who had been improperly allowed to register to vote, state election officials got to work.
On Tuesday, the state sent a strongly worded rebuke to the federal government: Every single person on the list was a lawful citizen.
"As for the 185 individuals, our records indicate that they were citizens," Greg D. Ott, a deputy attorney general in Nevada, wrote, according to a copy of a letter sent to Department of Homeland Security officials obtained through open records requests.
"You have provided nothing of substance to suggest otherwise."Following the meeting, Ms. Vogt sent a clarifying email to Nevada officials. "I also wanted to be sure I clarified that we did not reduce the 15,903 to 185," she wrote. "We've manually reviewed some of the 15,903 and confirmed 185 are not U.S. Citizens."
Now, Nevada officials are saying even that 185 number is wrong. They also took issue with a letter D.H.S. sent them in early September, in which the agency reiterated its initial claims about nearly 16,000 noncitizens on the rolls and pressured state officials to review each case in a letter to Nevada officials in early September.
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Graham Larue @glarue.bsky.social · 23/09/2026
On the unreliability of eyewitness testimony: a case study of temporal confusion surrounding a fatal shooting in a Mos Eisley cantina
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Joe Bak-Coleman @jbakcoleman.bsky.social · 20/09/2026
We can simulate fish schools or ants in ways that solve complex problems (gradient detection, bridge building, nest selection) but no one would create this weird soul/no-soul dichotomy to argue they these that multi-agent swarms of extremely simple rules are “thinking”.
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Katelyn Burns @katelynburns.com · 11/09/2026
This is... to me... a denial that trans people exist. The reference to genetic anomalies is common anti-trans language referring to intersex people.
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Waldo Jaquith @waldo.net · 11/09/2026
Here’s how the New York Times describes this moment in their coverage:
At one point Mr. Trump asked attendees to raise their right hands and pledge to him that he would vote with their family and friends.
Dutifully, they did.
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Alejandra Caraballo @esqueer.net · 20/08/2026
One thing I wish people would realize is just how central JK Rowling is to the entire anti-trans ecosystem. Looking at a network node analysis of the top 200 anti-trans X accounts, she is the most central figure spanning both sides of the Atlantic from Republicans to Labour.
A network graph visualization on a dark background showing connections between various accounts. The central, highly connected node is labeled "J.K. Rowling," with lines radiating out to many other nodes color-coded by region (UK, US, etc.). A detail panel on the right displays stats for her account, including her role as "Author & commentator," an in-degree of 153, an out-degree of 84, and 14 million followers.A scatter plot graph on a dark background comparing accounts based on "followers (log)" on the x-axis and "in-degree" on the y-axis. The data points are color-coded by region. J.K. Rowling is highlighted as a major outlier in the top right corner, possessing the highest number of followers and the highest in-degree. Other labeled points lower on the graph include various politicians, individuals, and campaign organizations.
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Hermione, Texas Granger @misterfungi.bsky.social · 11/12/2023
the Wikipedia entry for axolotls reads like a Cake song
Their heads are wide, and their eyes are lidless. Their limbs are underdeveloped and possess long, thin digits.
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Reposted by Graham Larue
The Onion @theonion.com · 21/07/2026
Report: That’s Enough Soccer For Now theonion.com/report-thats-enough-so…
Report: That’s Enough Soccer For Now
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Luke LeBrun @lukelebrun.ca · 15/07/2026
These photos of FNs community members fleeing their homes by boat are genuinely apocalyptic (Photo via Wayne Wastaken of Collins, Ontario, who says his “hometown is gone”) www.facebook.com/share/r/1ArN...
Photo via Wayne Wastaken

Fire clouds over Collins, Ontario as community members flee their homes by boat
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Jason Rasgon @vectorgen.bsky.social · 03/07/2026
In terms of both eh direct costs and indirect effects, we've spent 3 times the NIH budget on the fucking war with Iran, and instead of cures all we got was 5 dollar per gallon gas and the loss of all our allies
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The Onion @theonion.com · 03/05/2026
Overambitious Man Wants To Get 2 Things Done Today
theonion.com
Overambitious Man Wants To Get 2 Things Done Today
AKRON, OH—Saying the expectations he had set for himself were completely unrealistic, friends of local man James Chao expressed skepticism this morning after the 25-year-old announced plans to get two...
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Brandon Bishop @brandontbishop.bsky.social · 01/05/2026
Welcome to the last half of the US federal fiscal year. Here is where we're at with National Science Foundation--the agency that funds basically everything other than biomedical research at American universities--grant numbers. grant-witness.us/funding_curv...
NSF grant curve from link for 2021 through 2026, with each year shown as a different color. By this point in the year, NSF made 3,300 or more grants in 2021-2024 and 2,087 in 2025. This year 737 have been awarded. Both this year and 2025 seem to have an odd slow down about now in the rate of new grants not present in earlier years, in addition to the general lower rates.NSF's geosciences directorate award numbers, basically identical in shape to the overall NSF curves. Prior years saw around 400-500 grants awarded by this point in the fiscal year, 2025 saw only 278 grants awarded, this year has only 95 grants awarded.
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Graham Larue @glarue.bsky.social · 03/05/2026
RELEASE THE KRAKEN
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Graham Larue @glarue.bsky.social · 29/04/2026
Sigh
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Graham Larue @glarue.bsky.social · 25/04/2026
youtube.com/shorts/lyNm2...
youtube.com
Asking AI to Laugh at everything Husk and Chat Animated
YouTube video by Petty Parrot
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Reposted by Graham Larue
Rob DenBleyker @robdenbleyker.com · 18/04/2026
the strait of hormuz needs to have regular, predictable open hours or frankly they are going to lose me as a customer
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Mike Rosenwald @mikerosenwald.bsky.social · 27/03/2026
“Robert Trivers was unlike any other academic I have known,” David A. Haig, an evolutionary biologist at Harvard, wrote in a remembrance of Professor Trivers. “In another life, he might have been a hoodlum.” www.nytimes.com/2026/03/27/s...
nytimes.com
Robert Trivers, Eccentric Scientist Who Probed Human Nature, Dies at 83
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Graham Larue @glarue.bsky.social · 15/03/2026
youtube.com/watch?v=ZWSv...
youtube.com
Do *you* understand ISO?
YouTube video by minutephysics
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Jordan aka Jirdan @slclunk.com · 28/02/2026
I think about this Tony Benn speech much more than I used to
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Joseph Cox @josephcox.bsky.social · 03/03/2026
New from 404 Media: CBP tapped into the online advertising ecosystem to track peoples' movements, according to an internal DHS document. Shows for the first time DHS tracked phones via process for putting ads in ordinary apps—video games, fitness apps, many more www.404media.co/cbp-tapped-i...
404media.co
CBP Tapped Into the Online Advertising Ecosystem To Track Peoples’ Movements
An internal DHS document obtained by 404 Media shows for the first time CBP used location data sourced from the online advertising industry to track phone locations. ICE has bought access to similar t...
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Richard Sever @richardsever.bsky.social · 26/02/2026
That ‘constellation’ model in which repos and servers collaborate to support the aspects of the ecosystem they do best is articulated here. One thing that is needed is better mapping of the graph, discovery. 3/n openrxiv.org/openrxiv-day/
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Matthew Green @matthewdgreen.bsky.social · 25/02/2026
And right on schedule: there goes pseudonymity on the Internet. arxiv.org/abs/2602.16800
arxiv.org
Large-scale online deanonymization with LLMs
We show that large language models can be used to perform at-scale deanonymization. With full Internet access, our agent can re-identify Hacker News users and Anthropic Interviewer participants at hig...
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Graham Larue @glarue.bsky.social · 19/02/2026
media.tenor.com
a woman is playing a piano on a street with the words " making my way downtown " below her
ALT: a woman is playing a piano on a street with the words " making my way downtown " below her
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Reposted by Graham Larue
Thomas Germain @thomasgermain.bsky.social · 18/02/2026
I just did the dumbest thing of my entire career to prove a much more serious point. I tricked ChatGPT and Google, and made them tell other users I’m a competitive hot-dog-eating world champion People are using this trick on a massive scale to make AI tell you lies. I’ll explain how I did it
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Joshua Weitz @joshuasweitz.bsky.social · 16/02/2026
Fascinating chart with one outlier: Warren Buffett. At the low end, giving 0.06% of one's wealth is equivalent to: Net worth -> Lifetime Giving 50K->$30 100K->$60 500K->$300 $1M->$600 Most folks give far more by % in a *single year*. www.forbes.com/sites/forbes...
America's Richest People Are Not its Most Generous
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Dr Hannah M. Rowland @hannahmrowland.bsky.social · 12/02/2026
Happy birthday to Charles Darwin, patron saint of tired scientists, grumpy fieldworkers, and hating your own manuscript.
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Dave Vetter @davidrvetter.bsky.social · 10/02/2026
"A modern-day concentration camp ... People have been killed by the staff here." Irish citizen Seamus Culleton has been in ICE detention since September, despite having a valid work permit and his own business in the US.
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Brooke Weinstein @brookesloci.bsky.social · 07/02/2026
Hello Bluesky! Does Nₑ really explain mutation rate (μ) or genome size (GS) in vertebrates? We find the apparent Nₑ–μ link in Bergeron et al. (2023) is a “back-door” path via generation time, and GS is decoupled from both Nₑ and life-history traits. www.pnas.org/doi/10.1073/... #evobio #PNAS
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Xuebing Wu @xuebingwu.bsky.social · 31/01/2026
Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
biorxiv.org
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Zohran Kwame Mamdani @zohrankmamdani.bsky.social · 20/12/2025
It was such a joy to celebrate Hanukkah with Mandy, Kathryn and their son, Gideon. As Jewish New Yorkers across our city prepare to light candles and mark the seventh night today, I wish you and your families a Hanukkah full of light and love. youtu.be/KIxAKyioXng
youtu.be
Happy Hanukkah
YouTube video by Zohran Mamdani for NYC
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Harmit Singh Malik @harmitmalik.bsky.social · 18/12/2025
I can't believe this still needs to be said (and more loudly): Trans rights are human rights.
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Graham Larue @glarue.bsky.social · 06/12/2025
What’s your “How can one album have so many bangers?” album?
Rage Against the Machine’s eponymous album cover
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Graham Larue @glarue.bsky.social · 26/11/2025
Fucking brutal
An excerpt from the linked article wherein the author accuses the subject of, among other things, mislabeling his y-axis
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Alex Wild @alexwild.bsky.social · 17/11/2025
Screen cap of the xkcd cartoon, "Welcome to the Biology Department. It has been three days since we discovered something existentially horrifying about bugs that makes you question your whole reality."
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dr. rich traditions, JD @helldude.bsky.social · 09/11/2025
theres a whole category of newstertainment thats gotta go. and its "ask a really rich freak who is also evil and directly stealing from you what hes seen on the computer lately that has made him feel bad." the only -- ONLY -- story about this guy worth exploring is: he is getting rich spying on you
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Michael Hendricks 🇨🇦 @michaelhendricks.bsky.social · 07/11/2025
It's irritating that they describe the effects of his racism as limited to causing controversy within science and reputational consequences for himself rather than giving an immeasurable boost, false veneer of legitimacy, and idiot-friendly prestige to modern scientific racism and eugenics.
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Graham Larue @glarue.bsky.social · 26/10/2025
It’s always DNS arstechnica.com/gadgets/2025...
arstechnica.com
A single point of failure triggered the Amazon outage affecting millions
A DNS manager in a single region of Amazon’s sprawling network touched off a 16-hour debacle.
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Olúfẹ́mi O. Táíwò @olufemiotaiwo.bsky.social · 30/09/2025
I fully understand how difficult it is to remain focused on any one particular atrocity but this really ought to be a serious scandal and people need to pay heavy prices for this
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The Onion @theonion.com · 09/09/2025
It Only Tuesday theonion.com/it-only-tuesday-181956…
It Only Tuesday
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 28/08/2025
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions. Descriptions and links in the following two posts.
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Graham Larue @glarue.bsky.social · 12/08/2025
youtu.be/r1bMJekCiBw?...
youtu.be
Joe Rogan Doesn't Understand Graphs
YouTube video by Climate Town
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Will Ratcliff @wcratcliff.bsky.social · 12/08/2025
At first, I felt like I had freaking super powers. Like a PI with a nearly infinite supply of talented lab members, who worked at 1000x speed. It was exhilarating. But then, the cracks started to show. TL;DR: If Claude were my grad student, I'd kick them out of my lab.
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Graham Larue @glarue.bsky.social · 08/08/2025
The “G” is for “Gaslighting”
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Radley Balko @radleybalko.bsky.social · 05/08/2025
Today I learned that when sugarcane farmers burn their fields, a “black snow” falls for months on communities downwind. Under FL law, burns are prohibited when the wind is blowing into wealthy, white neighborhoods. They’re only allowed when it’s blowing into poor, majority black areas.
motherjones.com
Sugarcane burning is a plague on these Black Floridians
“I like to call it 'structured' racism.”
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Matt Novak @paleofuture.bsky.social · 01/08/2025
I grew up on these streets
Screenshot from the computer game Sam and Max Hit the Road

It’s a pixelated animated scene with a cop car, a dog and a rabbit with jokes in the background like a sign that reads “really bad food” and another that reads “guns, liquor, baby needs”
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 29/07/2025
few outcomes, except for 99% of FDA-approved drugs, 174 recipients of 104 Nobel Prizes, training ~30K MDs and ~10K PhDs per year to enter the workforce, and a 34% reduction in age-adjusted cancer deaths since 1990 -- the largest decrease in history
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Graham Larue @glarue.bsky.social · 29/07/2025
I wish there were a better mechanism to flag papers whose core results have subsequently been overturned, and propagate those flags throughout the citation web containing such papers. Would be esp. helpful to jr scientists doing lit review and similar
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The Onion @theonion.com · 14/07/2025
Relaxing Tea Better Fucking Work theonion.com/relaxin...
Relaxing Tea Better Fucking Work
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Anshul Kundaje @anshulkundaje.bsky.social · 28/06/2025
One thing that really bothers me with the new "virtual cell" terminology is that it is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/
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