The laboratory of Dr. Adrian Krainer at Cold Spring Harbor Laboratory is seeking a highly motivated Postdoctoral Fellow to join an innovative research program and advance a research project focused on mechanistic dissection of a neurodevelopmental genetic disorder and preclinical development of anti

Combining rational drug design, functional studies, and cryo-EM, researchers characterize a selective TRPV1 agonist that promotes desensitization and prolonged pain relief.

Ion-channel conductance levels are controlled by the bending patterns of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-aspartate receptor.

Using cryo-electron microscopy and electrophysiology, this study explains the structural basis for Ca2+ permeation and Mg2+ block in NMDA receptors and identifies a surrounding lipid network that may ...

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NMDAR expression is sufficient to induce B cell recruitment and affinity maturation, resulting in receptor-modulating antibodies that connect anti-cancer immunity and autoimmunity.

During Candida albicans infection, the host restricts zinc to limit fungal growth. Here, the authors present cryo-EM structures of the C. albicans zincophore and genetically show that intact zinc-bind...

As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At Cold Spring Harbor Laboratory (CSHL), scientists have turned their attention to the tiny pores ...

Ion-channel conductance levels are controlled by the bending patterns of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-aspartate receptor.

Banke et al. identified the structural determinants of radiprodil binding and the mechanism by which it inhibits GluN2B-NMDARs. They found that radiprodil

Opening of the NMDA receptor involves bending of the helices lining the ion channel gate.

Discrete activation of N-methyl-D-aspartate receptor (NMDAR) subtypes by glutamate and the co-agonist glycine is fundamental to neuroplasticity. A dis…

Discrete activation of N-methyl-D-aspartate receptor (NMDAR) subtypes by glutamate and the co-agonist glycine is fundamental to neuroplasticity. A dis…

Patient-derived NMDAR mAbs combined with single-particle cryo-electron microscopy reveal multiple GluN1 epitopes and distinct functional effects.

Autoantibodies targeting glutamatergic N-methyl-d-aspartic acid receptors (NMDARs) are found in people with anti-NMDAR encephalitis. Two studies reveal that patient-derived autoantibodies are diverse ...

Anti-NMDA receptor encephalitis is the most common autoimmune encephalitis. Michalski et al. reveal epitope diversity, conformational changes and functional impacts of the autoantibodies using cryo-EM...