Researchers at the Indian Institute of Science (IISc) have implemented an advanced microscopy technique to visualize multiple biomolecules inside the nucleus of a cancer cell simultaneously at incredibly high resolution.

Banerjee, Anand, and colleagues present an expanded speed-optimized DNA-PAINT sequence repertoire. This repertoire allows for improved multiplexing capability in super-resolution imaging, maintaining ...

Proteins SegA and SegB are important for chromosome segregation and organization in archaea of the order Sulfolobales, but mechanisms are unclear. Here, Kabli et al. uncover patterns and mechanisms th...

In September 2023, the Biology and Physics of Prokaryotic Chromosomes meeting ran at the Lorentz Center in Leiden, The Netherlands. As part of the workshop, those in attendance developed a series of ....

The xenogeneic silencer protein Lsr2 from Mycobacterium tuberculosis plays a critical role in its survival and pathogenesis. Lsr2 is a nucleoid-associated protein that interacts with DNA in vivo and r...

NanoPyx optimizes bioimage analysis workflows by dynamically selecting code variations based on input data and hardware. This ensures maximum computational efficiency, enabling fast analysis of large ...

DNA-Points Accumulation for Imaging in Nanoscale Topography (DNA-PAINT) enables multiplexed super-resolution imaging of biological samples. We expand the repertoire of speed-optimized DNA sequences fo...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

The student-led team used synthetic biology to harness clean energy from bacteria while simultaneously capturing and storing carbon dioxide.

Ticks adhere firmly to their host by secreting a protein-rich saliva that eventually forms a solid bioadhesive, but the mechanism underlying this phase transition is not understood. Now it has been sh...

Whereas bonds that strengthen under mechanical stress occur frequently in nature, all synthetic bonds weaken under force. Now, an artificial supramolecular catch bond has been shown to strengthen the ...