🎓 Cum laude! Samuel Schwab uncovers surprising ways bacteria and archaea organise their DNA His supervisor professor Remus Dame puts it rather strongly: ‘He is by far the best PhD student I have supe...

The genomes of organisms across the tree of life are structurally and functionally organized into chromatin. In eukaryotes, within an organelle called…

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Simulating the complete cell cycle of the minimal cell provides a platform to understand the progression of complete states over time. The spatial heterogeneity of the intracellular environment can strongly affect biochemical reactions that control phenotypes.

Presentation

Uncovering the evolutionary diversity of histones

Community science: Since 1996, Alireza Mashaghi has actively advocated for collaborations between disciplines to explore new ways of addressing scientific and societal challenges. The team has a long...

Histones are important organizers of chromatin in eukaryotes and archaea. In eukaryotes, the core histones assemble with DNA to form the octameric nucleosome. In archaea, histones form hypernucleosome...

Asgard archaea are widely considered the closest living relatives of eukaryotes. In this issue of Molecular Cell, Ranawat et al. report high-resolution structures of hypernucleosomes formed by the hodarchaeal HHoB histone, disclosing open and closed chromatin conformations.

DNA-wrapping histone proteins play a central role in chromatin organization, gene expression and regulation in most eukaryotes and archaea. While the …

Abstract. The Escherichia coli H-NS protein is a nucleoid-associated protein involved in gene regulation and DNA compaction. To get more insight into the m

Bacteria face diverse environmental challenges, such as changes in temperature, pH, and osmolarity, and exposure to antibiotics, which necessitate ada…

Histones are fundamental chromatin-organizing proteins in eukaryotes and archaea, where they assemble into (hyper)nucleosomes that wrap DNA. Recent studies have expanded the known repertoire of histon...

Molecular Microbiology is a broad-scope microbiology journal for basic and translational research that contributes to understanding molecular principles in microbes.

Molecular Microbiology is a broad-scope microbiology journal for basic and translational research that contributes to understanding molecular principles in microbes.

In September 2023, the Biology and Physics of Prokaryotic Chromosomes meeting ran at the Lorentz Center in Leiden, The Netherlands. As part of the workshop, those in attendance developed a series of ....

An international scientific conference, bringing together biologists and physicists, to discuss discoveries around bacterial chromosome structure.

Abstract. The transcriptional regulator MucR from Brucella species controls the expression of many genes, including those involved in virulence, by binding

The three-dimensional organization of chromosomes is shaped by genome processes including transcription and replication, such that, active processes can be used to predict chromosome structure. In tu....