Abstract. Standard probabilistic models of coding sequence evolution effectively identify where and when selection acts but remain agnostic to the mechanis

Scott Atlas wants to abolish the National Institutes of Health and let markets take over ("NIH is a government weapon for political power. Abolish it," Washington Post, July 2).

Short linear motifs (SLiMs) within intrinsically disordered protein regions mediate transient interactions crucial for cell physiology. However, the global interaction landscape of human SLiMs remains...

We are so proud of our Chief Scientific Advisor, Dr. Wendie Berg, who was awarded the SBI Gold Medal at this year’s Society of Breast Imaging Annual Meeting — the organization’s highest honor. We are ...

AlphaFold’s success in protein structure predictions has led to similar attempts to predict interactomes. Here, the authors demonstrate that AI-based screens are very limited in discovering truly nove...

In a survey of NIH-funded scientists, 25% said their research had been impacted a great deal or a fair amount by a move away from foreign subawards.

Apportionment file 11511545 (National Library of Medicine and 24 other accounts) retrieved from OMB public records

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI): Inviting Comments and Suggestions on a Framework for the NIH-Wide Strategic Plan for Fis...

Duplicated self-interacting proteins can interact and interfere with each other’s function. Cisneros, Mattenberger, et al. show that selection against interfering loss-of-function alleles extends the ...

ALT: a picture of a person in the water with the words call of the deep below it

Thousands of short open reading frames (sORFs) are translated outside of annotated coding sequences. Recent studies have pioneered searching for sORF-encoded microproteins in mass spectrometry (MS)-based proteomics and peptidomics datasets. Here, we assessed literature-reported MS-based identificati …

Differential isoform usage is identified with high statistical power from spatial transcriptomics data.

Hannah Fry and Dara Ó Briain ask whether a tiny jellyfish holds the secret to immortality.

Variants in the familial hypercholesterolemia gene LDLR—the most important genetic driver of cardiovascular disease—can raise circulating low-density lipoprotein (LDL) cholesterol concentrations and i...

Filter-feeding flying reptile was likely devoured by a dinosaur during the early Cretaceous

The GSA Journals are introducing Functional Genomics and Systems Biology, a new section led by Brenda Andrews and Marian Walhout that highlights systems-level studies of genetic networks and pathways.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...