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Pierre Bourguet

@p-bourguet.bsky.social
685 followers 408 following 36 posts

Biologist studying transposons, gene regulation and chromatin in the Jullien group. Postdoc @ibmp-cnrs.bsky.social (Strasbourg, France).

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Reposted by Pierre Bourguet
André Marques @amarques.bsky.social · 16/09/2026
Out today in Nature: sex without crossovers. Rhynchospora tenuis makes pollen, fertilises and sets seed, yet 0 crossovers in 10,997 pollen nuclei. Chromosome drive and ~87% seed abortion rebuild the mother's genotype, so the offspring are clones. doi.org/10.1038/s415...
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FragileNucleosome @fnucleosome.bsky.social · 03/09/2026
🎤 #FragileNucleosome is back next Wednesday! Hope you enjoyed the summer!Join us next 📅Wednesday to hear about 🧬fascinating research from @mpalamin.bsky.social from Krebs lab and @robertovn.bsky.social from Vos lab. To register if you haven't before: us06web.zoom.us/webinar/regi...
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Peter Andersen @germline.bsky.social · 29/08/2026
We watched piRNAs and transposons across development, saw them dance tightly and wrote a paper about it. It's so cool to see it online and we will make a thread about it all very soon. Stay tuned :-)
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IBMP | Institut de biologie moléculaire des plantes @ibmp-cnrs.bsky.social · 20/08/2026
🧵🌿 Did you know that tRNA gene organization in plants is shaped by strong evolutionary constraints? Uncover how cis-regulatory elements and chromosomal distribution work together to maintain optimal tRNA dosage in @theplantjournal.bsky.social . 🌍🔍 🔗https://urlr.me/sQMAyx
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Gregor Mendel Institute of Molecular Plant Biology @gmivienna.bsky.social · 11/08/2026
The GMI @gmivienna.bsky.social of the @oeaw.bsky.social seeks to appoint a Scientific Director (f/m/x) to lead one of Europe’s premier research institutes in plant biology. Apply by Nov. 15 via GMI.search.director@oeaw.ac.at. More information: www.oeaw.ac.at/de/gmi/join-...
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PM Delaux @pierremarcdelaux.bsky.social · 18/08/2026
[⚠️JOB ALERT⚠️] We are looking for a Research assistant (IE for those familiar with the French system) in molecular biology to run DAPseq in the lab. 18 months contract (to start) Start date: October 1st. Exprience in library prep., in vitro transcription/translation system or DAPseq is a must.
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Silvia Ramundo @sramundo.bsky.social · 19/08/2026
A stress response can be a great starting point for discovering new biology! By following genes regulated during the chloroplast unfolded protein response, we’re discovering novel factors involved in chloroplast homeostasis. Here’s the first one we characterized: www.pnas.org/doi/10.1073/...
pnas.org
VIA1 is a conserved regulator of thylakoid membrane integrity that acts through VIPP1 | PNAS
Thylakoid membranes are indispensable for oxygenic photosynthesis, yet the mechanisms that protect these membranes from photooxidative damage remai...
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Richard Sever @richardsever.bsky.social · 13/08/2026
bioRxiv/medRxiv have been dealing with endless bot attacks recently (plus usual DDOS stuff, etc). Tricky to address without impacting genuine users - many of you affected. Apologies. We're working with our hosting service on solutions & think we're getting there [he shouts in his Red Queen costume].
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Dominique Bergmann @stanfordstomata.bsky.social · 10/08/2026
1/9 🧵New preprint from the lab! A midpoint in a long journey to understand specificity among bHLH transcription factors in plants. Part IV: how does an accessory domain guide specificity of heterodimerizing bHLHs? #PlantSci #TranscriptionFactors #stomata www.biorxiv.org/cgi/content/...
biorxiv.org
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Lior Pachter @lpachter.bsky.social · 30/07/2026
One of the major pains of academia is having to click through labyrinths of webpages to submit papers. Now, thanks to Joe Rich (and AI), problem solved! His tool is called PaperPush and is available at github.com/pachterlab/p... It's super easy to use! 1/🧵
github.com
GitHub - pachterlab/paperpush
Contribute to pachterlab/paperpush development by creating an account on GitHub.
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Silvia Ramundo @sramundo.bsky.social · 24/06/2026
1/7 New preprint: we found that Chlamydomonas carries a giant and unexpectedly elaborate chloroplast RNA polymerase with 12 previously unknown subunits, overturning the idea that the complexity of this organellar enzyme emerged during plant terrestrialization! www.biorxiv.org/content/10.6...
biorxiv.org
The structure of a 2-MDa chloroplast RNA polymerase reveals unexpected evolutionary complexity
Transcription in chloroplasts depends on the Plastid-Encoded RNA polymerase (PEP), a bacterial-derived enzyme whose catalytic core remains encoded by the highly reduced genome inherited from the cyano...
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Sebastian S. Cocioba @atinygreencell.bsky.social · 08/07/2026
@breakliquid.bsky.social and I are delighted to say our OpenEVO preprint is finally live! An open source hand-made turbidostat that's modular, affordable, and made to be customized. Designed with love for the research community. Enjoy!!!💚 www.biorxiv.org/content/10.6...
biorxiv.org
OpenEvo: An Open-Source Platform for Automated Evolution and Analysis
Here we introduce OpenEvo, a fully open-source, low-cost turbidostat platform for automated continuous culture and directed evolution experiments. Existing tools are expensive, complex, or lack open-s...
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Michael Borg @borglab.bsky.social · 07/07/2026
Our group is moving from @mpi-bio-fml.bsky.social to the maritime city of Kiel! ⛵️🩵 I will lead the Department of Marine Plant Development and Physiology @uni-kiel.de 🌱🪸🌊 Look out for opportunities to join us in this exciting & growing hub for Plant, Marine & Evolutionary Biology in North Germany 🇩🇪
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Chung Hyun Cho @chc-evobio.bsky.social · 04/07/2026
Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...
biorxiv.org
Emergence of histone-based chromatin complexity in Asgard archaea
The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...
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Sainsbury Laboratory Cambridge University (SLCU) @slcuplants.bsky.social · 01/06/2026
#PlantSciJobs 🌱 Postdoctoral Research Associate (x2) and Research Assistant (x2) Dr Edwige Moyroud is seeking 2 Postdocs and 2 Research Assistants to join her team investigating petal patterning Applications close: 5 June: Research Assistant bit.ly/4a32ffK 17 June: Postdoc bit.ly/4dT2LOC
Microscopy images of a petal showing petal patterning developing in the young petals. Around the image is 6-stages of hibiscus development from closed bud to open flower. The flower is plit in two to show one flower with a dark purple bullseye and one flower fully white with no pigment petal patterns.
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Eva-Sophie Wallner @eswallner.bsky.social · 27/05/2026
Happy to announce that I have started my own research group at the MPIPZ and that I am looking for a postdoc who would like to investigate Marchantia prothallus development with me! Please spread the word and/or apply if interested :)
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Cedric Feschotte @cedricfeschotte.bsky.social · 07/05/2026
👋 Transposon lovers: registration is now open for the CSHL TE meeting! We have a 🔥 lineup of invited speakers and many slots for short talks selected upon abstract across all areas of TE biology. 🧬➰🧬 #TEsky Abstract deadline: July 10 meetings.cshl.edu/meetings.asp...
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IBMP | Institut de biologie moléculaire des plantes @ibmp-cnrs.bsky.social · 27/04/2026
Pierre Bourguet (@p-bourguet.bsky.social) has been awarded a Marie Skłodowska-Curie Postdoctoral Fellowship for the RegulatoryTEmbryo project at IBMP! His project explores how transposable elements shape plant embryogenesis and rewire developmental gene networks. #MSCA
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Duncan Sproul @sproullab.bsky.social · 17/04/2026
Interesting changes to ERC eligibility, low scores now exclude you from reapplications for up to 3 years.
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Kasia Siudeja @ksiudeja.bsky.social · 08/04/2026
📣📣 Deadline approaching 📣📣 (Please re-post) If you are thinking of starting (or moving) your lab, do not miss the opportunity to apply to join us at the @i2bcparissaclay.bsky.social Diversity of topics, interdisciplinary environment and excellent platform support! Recommended!
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Marintia Nava-García @marintianava.bsky.social · 14/04/2026
Beyond proteins and DNA, #lipids are emerging as key players in nuclear biology - shaping nuclear envelope dynamics, mechanosensing, gene regulation and genome stability. Our new Perspective highlights recent advances, open questions, and future directions 👉 journals.biologists.com/jcs/article/...
journals.biologists.com
Emerging roles of lipids in nuclear function and homeostasis
Summary: Lipids are increasingly recognized as essential regulators of nuclear homeostasis, membrane dynamics, mechanotransduction and genome stability, opening new frontiers for understanding nuclear...
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Denis Duboule @denisduboule.bsky.social · 13/04/2026
Chers Collègues et Amis de Strasbourg, je serai à la Bibliothèque Nationale et Universitaire (BNU) le 21 avril à 18h30 pour partager mes souvenirs d’embryon. Apportez les vôtres! Consultation gratuite.
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Eftychis Frangedakis @e-frangedakis.bsky.social · 13/04/2026
Can someone please help with the identification of these two #hornwort species found by @noodlyscientist.bsky.social outside OIST/Okinawa/Onna-son/Japan
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Ming Tommy Tang @tommytang.bsky.social · 11/04/2026
🧵“What cutoff should I use for p-value, log2FC, or mito content?” This is the most common question I get. Here's why it’s not simple:
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Jaruwatana (Sodai) Lotharukpong @sodail.bsky.social · 31/03/2026
Our work on chromatin evolution in brown algae is finally out! This is also my first "co-first author" paper!! I’m excited to share what we found 👇
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Journal of Experimental Botany @jxbotany.bsky.social · 29/03/2026
🌡️🧬 RESEARCH 🧬🌡️ Arabidopsis plants use a heat-responsive protein pair, HIT4 and PUB49, to loosen tightly packed DNA, helping them survive high temperatures through a newly discovered stress adaptation mechanism – Wu et al. 🔗 doi.org/10.1093/jxb/... #PlantScience 🧪
Fig. 1 (shortened, full legend in paper): Generation of transgenic Arabidopsis for identification of HIT4-interacting proteins using TurboID proximity labeling and MS. (A) Schematic diagram of the constructs used to generate transgenic Arabidopsis lines for TurboID labeling. The experimental construct contains a FLAG-TurboID-HIT4 fusion under control of the native HIT4 promoter, followed by a NOS terminator. The control construct contains a FLAG-TurboID fusion driven by the CaMV 35S promoter with a NOS terminator. (B) Western blot confirming the expression of FLAG-TurboID in both F-TbID/hit4-1 and F-TbID-HIT4/hit4-1 lines, whereas FLAG-TurboID-HIT4 was only detected in F-TbID-HIT4/hit4-1 plants. Rubisco large subunit (Rubisco LS) stained with Coomassie Brilliant Blue (CBB) served as a loading control. Uncropped blots are shown in Supplementary Fig. S1. (C) Complementation analysis of transgenic lines.
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Hugues Renault @huguesrenault.bsky.social · 28/03/2026
Ever wondered how the #cuticle, a hallmark of land plants, was established? In our latest study, we show that the CUTIN SYNTHASE enzyme family was a key driver of this evolutionary innovation. #plantscience ▶️ www.biorxiv.org/content/10.6... A thread 🧵 [1/8]
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GDR EPIPLANT @epiplant.bsky.social · 27/03/2026
🌱🧬 EPIPLANT 2026 is happening soon! Registration for the conference is still open, but places are limited and filling up fast. If you haven’t registered yet, now is the time to secure your spot 👉 epiplant-2026.sciencesconf.org We look forward to welcoming you to Nantes!
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Marc Somssich @somssich.bsky.social · 25/03/2026
The fact that Americans thought Auxin was a “Hoax from Europe” rightfully got some attention in my latest #PlantScienceClassics post. But it’s actually even funnier if you learn about the context & consequence of White speaking these words to Went at the AAAS Meeting in Pittsburgh. #PlantScience 🧪 🧵
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Michela Palamin @mpalamin.bsky.social · 24/03/2026
ChromSMF preprint is out!🚀 tinyurl.com/ChromSMF We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting! In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬 What does this unlock? ⬇️
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EMBL-EBI @ebi.embl.org · 16/03/2026
You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database. This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list. www.ebi.ac.uk/about/news/t...
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Roli Roberts @roliroberts.bsky.social · 23/03/2026
Back in the noughties when I was an academic, my lab did quite a bit of work on (conserved) alternative transcripts. This study in @plosbiology.org presents compelling evidence that most alternative transcripts are deleterious noise journals.plos.org/plosbiology/...
journals.plos.org
Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans
Alternative transcription initiation, splicing and polyadenylation generate extensive transcript diversity in eukaryotes, but its evolutionary significance has been disputed. This study analyses 166 t...
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Nico Rascovan @nrascovan.bsky.social · 18/03/2026
How did farming reach the Southern Andes? Through migration or cultural transmission? Our new paper in @nature.com combines ancient DNA, isotopes, archaeology & paleoclimate to reconstruct 2,000+ years of history in Uspallata, Mendoza. www.nature.com/articles/s41... A Thread🧵 (1/25+)
nature.com
Local agricultural transition, crisis and migration in the Southern Andes - Nature
In the Uspallata Valley, agriculture was adopted by local populations, as evidenced by genetic continuity from earlier hunter-gatherers to farmers; maize-dependent groups from the same regional p...
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Nicolas Mouquet @nmouquet.bsky.social · 09/03/2026
‪ 🌳 Do you want to contribute to research on how humans perceive forests? Take this quick, anonymous 10-min survey 🌲 👉 www.biodiful.org#/forest This will help us explore how people experience forest biodiversity! Please share on 🦋 & tag @biodiful.bsky.social to reach more participants 🙏💚 🌐🌍🦤🦑🪴🍁🧪
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Luuk Schmitz @luukschmitz.bsky.social · 16/03/2026
War is reshaping global markets. I have a paper under review that asks: who wins or loses when supply chains meet geopolitics, and what are the political implications? Since the world is changing faster than our overburdened peer-review system can handle, here's the 📃 + a🧵 osf.io/preprints/so...
As states weaponize supply chains, warnings of deglobalization and aggregate welfare losses have proliferated. But neither has materialized: trade volumes remain high and supply chains continue to span the globe. This paper argues that the surprising resilience of aggregate trade obscures a large-scale redistribution creating K-shaped divergence among firms navigating geoeconomic reordering. Who wins and who loses depends on two dimensions of corporate power: the strategic indispensability of what firms produce and their organizational capacity to reconfigure operations around geopolitical constraints. Because strategic designation attaches to specific outputs rather than broad industry categories, these capacities vary sharply among firms nominally facing identical pressures. Drawing on an original dataset of over 21,000 corporate earnings calls annotated using large language models alongside firm-level financial data, I demonstrate that sector membership explains remarkably little outcome variance. Adaptation operates hierarchically within industries, not between them. Firms controlling chokepoints or possessing reconfiguration capacity capture concentrated gains; those lacking strategic position bear recurring adjustment costs. As these costs cluster in regions previously affected by deindustrialization, supply chain restructuring risks intensifying the geographic polarization that fueled political demand for economic statecraft in the first place.
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Manon Demulder @manondemulder.bsky.social · 11/03/2026
Excited to announce I’m starting a new lab at @gmivienna.bsky.social (Vienna BioCentre) in Sept 2026 We study how carbon fixation is inherited and maintained in algae using cryo-ET, imaging, environmental sampling&more Looking for people who want to build the lab together, get in touch! #teamtomo
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IBMP | Institut de biologie moléculaire des plantes @ibmp-cnrs.bsky.social · 11/03/2026
📢 Postdoc position in plant chromatin biology 🌱 (Strasbourg) Apply before March 30 🔗 www.unistra.fr/fr/recruteme... #PlantBiology #Postdoc
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Hugues Renault @huguesrenault.bsky.social · 10/03/2026
#JobAlert #PhD 🌱 We are offering a PhD project to explore how transcription factors have shaped the evolution of plant protective barriers. We will support suitable candidates in applying to the @unistra.fr Graduate School competition. Interested? Please get in touch for more information!
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Mirouse lab @mirouse-lab.bsky.social · 06/03/2026
📢 PhD position in our lab! (MSCA COFUND) About dystrophin in Drosophila muscle progenitor cells 🧬🪰 #PhDPosition #DevBio #Drosophila #StemCells For candidates from outside France or have lived in France <12 months in the last 3 years. More info 👇 (Project #16) www.muskle.eu/recruitment/
muskle.eu
Open positions - MuSkLE
First competitive call open! The first competitive call in the frame of the MuSkLE programme, which aims at selecting 17 doctoral fellows, opens on 6th March 2026 and closes on 6th May 2026. The open ...
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David Suter @davidsuter.bsky.social · 09/03/2026
How do the H2A.Z histone variant and its dedicated chromatin remodeller SRCAP regulate gene expression ? Beautiful work from @armelletollenaere.bsky.social now published @ www.nature.com/articles/s41...
nature.com
Mechanisms of gene regulation by SRCAP and H2A.Z - Nature Communications
SRCAP depletion causes rapid replacement of H2A.Z by H2A, leading to upregulation of lineage-specific transcription factors. SRCAP also prevents pioneer transcription factor binding by steric hindranc...
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Polina Novikova @pnovik.bsky.social · 04/03/2026
I am happy to announce the launch of a new Arabidopsis genomics resource! Check out arabidopsislyrata.org Now you can easily look at the natural genetic variation across the entire species range of A. lyrata and A. arenosa.
arabidopsislyrata.org
Home | Alyrata Resource
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Jorge Moura de Sousa @jmouradesousa.bsky.social · 02/03/2026
➡️ preprint from the lab! Bacteria have loads of antiviral defences in their mobile genetic elements (MGEs). So when MGEs move between bacteria, the defences move with them, generating a fast turnover of defences in bacteria. But what about the antiviral defence turnover in the MGEs themselves? 🤔 🧵👇
biorxiv.org
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Dolf Weijers @dolfweijers.bsky.social · 03/03/2026
We are very excited to share a new resource from our team: spatial subcellular proteome maps in plants! We developed an MS-based method that registers localizations of about 8000 proteins in Arabidopsis roots in a single experiment. (1/9) www.biorxiv.org/cgi/content/...
biorxiv.org
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John Greally @greally.bsky.social · 01/03/2026
A reminder that we are actively recruiting a geneticist to the Department of Genetics at Albert Einstein College of Medicine careers-einstein.icims.com/jobs/17847/a...
careers-einstein.icims.com
Einstein
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GIIN @genomeiinetwork.bsky.social · 26/02/2026
Another great science appointment is coming up with @centromellone.bsky.social, Michele Pagano and Gergely Róna! Join us live on Tuesday, March 3rd at 5pm (Rome) / 11am (NYC). Zoom link: uniroma1.zoom.us/j/95149984403 Register here to stay in the loop: docs.google.com/forms/d/e/1F...
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The Groth lab @grothlab.bsky.social · 25/02/2026
DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!
cell.com
Post-replicative chromatin accessibility predicts cell fate change
Knudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin in two models of cell identity change. They find that lineage-specific elements are accessible earlier in rep...
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Max Spicer @mfdspicer.bsky.social · 25/02/2026
Excited to share this work done during my PhD here in Vienna! We show how chromatin compaction prevents the release of fragmented DNA in apoptosis, and use new tools to study the mechanism of compaction itself. See our summary/"bluetorial" below & our preprint here: www.biorxiv.org/content/10.6...
biorxiv.org
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The Arabidopsis Information Resource (TAIR) @tairnews.bsky.social · 19/02/2026
🎉📣 #TAIR12, the latest reannotation of the Arabidopsis thaliana genome, is now available under accession number PRJEB100887 on ENA and NCBI! Thank you all the volunteer researchers whose hard work has made this possible! #plantscience #plantbiology 🧪 bit.ly/3ZHtneT
bit.ly
Announcing the publication of TAIR12: Consult the fully reannotated genome on the European Nucleotide Archive - Phoenix Bioinformatics
TAIR (The Arabidopsis Information Resource), together with our nonprofit host Phoenix Bioinformatics, is pleased to announce the public release of TAIR12
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franz @franzanth.bsky.social · 19/02/2026
#InvertebrateShitposting as per @joabaldwin.com's request
6 bad doodles with text under each one.
horseshoe crab is literally the animal horseshoe crab.
shoehorse crab is a crab riding a shoe, cowboy style.
crabshoe horse is a horse wearing literal crabs as shoes.
shoecrab horse is a horse telling a crab to go away.
crabhorse shoe is a pair of shoes, left one crab shaped, right one horse shaped.
horsecrab shoe is literally the same pair of shoes, flipped.
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Max Haase @maxhaase.bsky.social · 18/02/2026
Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14
nature.com
Ancient co-option of LTR retrotransposons as yeast centromeres - Nature
Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...
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