In this Review, Dimmeler and Augustin discuss microvascular aging as an emerging key driver of tissue dysfunction and systemic decline, highlighting how single-cell and multiomic approaches are uncove...

AMP-activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direc...

AMP-activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direc...

Whole-slide histopathological images from 40 tissue types reveal morphological changes associated with aging, which, when paired with transcriptomic data from blood, are used to develop aging clocks that reflect tissue structural integrity and organ-level physiological fitness in health and disease.

Gao et al. show that yeast grow faster by proportionally increasing mRNA and ribosome concentrations to increase actively translating ribosomes, while elongation remains constant. A mass-action model ...

Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...

Archaea and bacteria routinely live side by side in microbial communities and must interact at least on occasion. Whether such cross-Domain interactions are dominated by mutual disregard, co-operation...

The main function of mitochondria is to generate ATP by oxidizing pyruvate to CO2. Rauseo et al. show that matrix pyruvate is also converted to lactate, which is released to the cytosol via the MPC to...

Cas9 structures explain topology sensing and off-target activation.

First introduced into laboratories in 1881, agar remains indispensable as a culture medium.

King's College London is seeking outstanding and motivated students to join our university and the Agency for Science, Technology and Research (A*STAR).

Help Eliano Santos raise money to support British Heart Foundation

Malignant tumors are characterized by diverse metabolic stresses, including nutrient shortages, hypoxia, and buildup of metabolic by-products. To understand how cancer cells adapt to such challenges, ...

Martinez-Martinez et al. combine a host-microbe-drug-nutrient screen with multi-omics to reveal how the cancer-associated microbiota modulates chemotherapy. They identify 2-methylisocitrate, a microbi...

CroAge Project, Founded by the Europe Union

It is widely accepted that susceptibility to infection increases with age. The reason often invoked is the dysregulation of the immune system, which is both cause and consequence of ageing. However, w...

Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

Research Associate (Fixed Term) in the Department of Genetics at the University of Cambridge.

Peroxiredoxins are highly conserved thiol peroxidases essential for peroxide detoxification, redox signaling, and chaperone activity. Prx1/AhpC-type peroxiredoxins are found throughout the eukaryotic ...

Skeletal muscle fatigue occurs, in part, from accumulation of hydrogen (H+) and phosphate (Pi); however, the molecular basis through which these ions inhibit function is not fully understood. Therefore, we examined the effects of these metabolites on myosin-actin cross-bridge kinetics and mechanical properties in skeletal muscle fibers from older (65-75 years) adults. Slow-contracting myosin heavy chain (MHC) I and fast-contracting MHC IIA fibers were examined under control (5 mM Pi, pH 7.0) and fatigue (30 mM Pi, pH 6.2) conditions at maximal calcium-activation (5 mM ATP) and rigor (0 mM ATP). In MHC I and IIA fibers, fatigue decreased force per fiber size (23-37%), which was accompanied by reduced strongly bound myosin head characteristics (number and/or stiffness; 21-47%) and slower cross-bridge kinetics (longer myosin attachment times (22-46%) and reduced rates of force production (20-33%)) compared with control. MHC I myofilaments became stiffer with fatigue, a potential mechanism to increase force production. In rigor, which causes the myosin that can bind actin to be strongly bound, fatigue decreased force per fiber size (32-33%) in MHC I and IIA fibers, indicating less force was generated per cross-bridge. By replacing ATP with 2-deoxy-ATP (dATP), the fatigue-induced slowing of cross-bridge kinetics in MHC I and IIA fibers was reversed and reduced force production in MHC I fibers was partially improved, revealing potential mechanisms to help mitigate fatigue in older adults. Overall, our results identify novel fiber type-specific changes in cross-bridge kinetics, force per cross-bridge, and myofilament stiffness that help explain fatigue in older adults.

Nature Metabolism, Published online: 03 March 2025; doi:10.1038/s42255-025-01225-wZuhra and Petrosino et al. report evidence that cyanide acts as a regulatory gasotransmitter in mammalian cells, where it is shown to affect cellular bioenergetics, most…

Advanced proteomic organ ageing is associated with the long-term risk of age-related diseases. In most cases, faster ageing of a specific organ increases susceptibility to morbidity affecting multiple...

Tang, Yue, Xu and colleagues map the proteome of several thousand individuals over a 9-year period to identify potential biomarkers of ageing and of age-associated diseases.

This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.

Blocking the activity of a protein called p21 stops lung cancer cells entering a ‘sleep-like’ state that allows them to survive chemotherapy. Blocking p21 causes more cancer cells to die and reduces t...

PhD Project - PhD Studentship in Unravelling chromatin composition and interactome in ESKAPE pathogens at University of Cambridge, listed on FindAPhD.com

Recent progress in understanding senescence has spurred interest in the development of approaches that target senescent cells. This Review assesses the current status of senotherapies, such as senolyt...

Endogenous mitochondrial NAD(P)H fluorescence enables label-free and subcellular resolution quantification of aging, prediction of remaining lifespan and tracking of age-dependent changes to mitochond...

The inner surface of the heart has a meshwork of muscles called trabeculae. McGurk et al. report the genetic regulation of these complex structures across common and rare variants, revealing pathways ...